AR042459A1 - Nuevos enantiomeros (r) y (s) de derivados del acido tiofeno hidroxamico - Google Patents

Nuevos enantiomeros (r) y (s) de derivados del acido tiofeno hidroxamico

Info

Publication number
AR042459A1
AR042459A1 ARP030104605A ARP030104605A AR042459A1 AR 042459 A1 AR042459 A1 AR 042459A1 AR P030104605 A ARP030104605 A AR P030104605A AR P030104605 A ARP030104605 A AR P030104605A AR 042459 A1 AR042459 A1 AR 042459A1
Authority
AR
Argentina
Prior art keywords
alkyl
enantiomers
aryl
hydroxamic
phenyl
Prior art date
Application number
ARP030104605A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR042459A1 publication Critical patent/AR042459A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Enantiómeros ( R ) y (S) de derivados del ácido tiofeno hidroxámico, un proceso para la elaboración de estos compuestos y medicamentos con actividad de HDAC conteniendo tal compuesto. Reivindicación 1: Los enantiómeros ( R )- y (S) de los compuestos de fórmula (1) en donde Ar es un grupo arilo o heteroarilo que puede estar sin sustituir o sustituido 1, 2, o 3 veces por: halógeno, fenilo, alquilo, -O-alquilo, -O-fenilo, -O-(CH2)m-O-, -OH, -NO2, -NH2, -NH-alquilo, -N(alquilo)2, -NH-C(O)-alquilo, -SO2alquilo, -SO2NH2, -SO2NH-alquilo, -SO2N(alquilo), -C(O)-NH2, -C(O)-NH-alquilo, -C(O)-N(alquilo)2, o -C(O)-alquilo; R1 es H, fenilo, alquilo, o alquenilo que puede estar sin sustituir o sustituido una o varias veces por halógeno, -OH, -NO2, -NH2, -O-alquilo, -O-arilo, -NH(alquilo), -N(alquilo)2, morfolinilo, 4-metilpiperacinilo, o arilo, o R1 junto con el grupo Ar forma un anillo de tetrahidronaftaleno-, indano- o dibenzosuberano; R2 es H o alquilo, n es 1, 2, o 3; y sales aceptables fisiológicamente de los mismos.
ARP030104605A 2002-12-16 2003-12-12 Nuevos enantiomeros (r) y (s) de derivados del acido tiofeno hidroxamico AR042459A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02028038 2002-12-16

Publications (1)

Publication Number Publication Date
AR042459A1 true AR042459A1 (es) 2005-06-22

Family

ID=32524005

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104605A AR042459A1 (es) 2002-12-16 2003-12-12 Nuevos enantiomeros (r) y (s) de derivados del acido tiofeno hidroxamico

Country Status (18)

Country Link
US (1) US7098241B2 (es)
EP (1) EP1575933A1 (es)
JP (1) JP2006513181A (es)
KR (1) KR100781929B1 (es)
CN (1) CN100391954C (es)
AR (1) AR042459A1 (es)
AU (1) AU2003293882A1 (es)
BR (1) BR0317348A (es)
CA (1) CA2507629A1 (es)
CL (1) CL2003002611A1 (es)
GT (1) GT200300285A (es)
PA (1) PA8592101A1 (es)
PE (1) PE20040913A1 (es)
PL (1) PL377696A1 (es)
RU (1) RU2348625C2 (es)
TW (1) TW200418825A (es)
UY (1) UY28127A1 (es)
WO (1) WO2004054999A1 (es)

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US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
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WO2005121134A1 (en) * 2004-06-14 2005-12-22 F. Hoffmann-La Roche Ag Thiophene derivatives, their manufacture and use as pharmaceutical agents
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Also Published As

Publication number Publication date
GT200300285A (es) 2004-07-14
CA2507629A1 (en) 2004-07-01
RU2348625C2 (ru) 2009-03-10
BR0317348A (pt) 2005-11-16
PL377696A1 (pl) 2006-02-06
CN1726204A (zh) 2006-01-25
US7098241B2 (en) 2006-08-29
WO2004054999A1 (en) 2004-07-01
KR100781929B1 (ko) 2007-12-04
CL2003002611A1 (es) 2005-01-14
TW200418825A (en) 2004-10-01
JP2006513181A (ja) 2006-04-20
PE20040913A1 (es) 2005-01-18
UY28127A1 (es) 2004-06-30
US20040122079A1 (en) 2004-06-24
KR20050089157A (ko) 2005-09-07
CN100391954C (zh) 2008-06-04
PA8592101A1 (es) 2004-11-02
RU2005122447A (ru) 2006-05-27
AU2003293882A1 (en) 2004-07-09
EP1575933A1 (en) 2005-09-21

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