GT200300285A - Nuevos enantiomeros (r) y (s) de derivados del acido tiofeno hidroxamico - Google Patents

Nuevos enantiomeros (r) y (s) de derivados del acido tiofeno hidroxamico

Info

Publication number
GT200300285A
GT200300285A GT200300285A GT200300285A GT200300285A GT 200300285 A GT200300285 A GT 200300285A GT 200300285 A GT200300285 A GT 200300285A GT 200300285 A GT200300285 A GT 200300285A GT 200300285 A GT200300285 A GT 200300285A
Authority
GT
Guatemala
Prior art keywords
hydroxamic
acid derivatives
thiophen
enantiomers
new
Prior art date
Application number
GT200300285A
Other languages
English (en)
Inventor
Adelbert Grossmann
Frank Herting
Matthias Koerner
Klaus-Peter Kuenkele
Anja Limberg
Olaf Mundigl
Ulrich Tibes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200300285A publication Critical patent/GT200300285A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA GENERAL I EN LA QUE AR,R1,R2, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON INHIBIDORES DE LA DESACETILASA HISTONA (HDAC) POR LO QUE SON DE UTILIDAD EN CUADROS DE HIPERPROLIFERACION CELULAR TALES COMO EL CANCER.
GT200300285A 2002-12-16 2003-12-12 Nuevos enantiomeros (r) y (s) de derivados del acido tiofeno hidroxamico GT200300285A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02028038 2002-12-16

Publications (1)

Publication Number Publication Date
GT200300285A true GT200300285A (es) 2004-07-14

Family

ID=32524005

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200300285A GT200300285A (es) 2002-12-16 2003-12-12 Nuevos enantiomeros (r) y (s) de derivados del acido tiofeno hidroxamico

Country Status (18)

Country Link
US (1) US7098241B2 (es)
EP (1) EP1575933A1 (es)
JP (1) JP2006513181A (es)
KR (1) KR100781929B1 (es)
CN (1) CN100391954C (es)
AR (1) AR042459A1 (es)
AU (1) AU2003293882A1 (es)
BR (1) BR0317348A (es)
CA (1) CA2507629A1 (es)
CL (1) CL2003002611A1 (es)
GT (1) GT200300285A (es)
PA (1) PA8592101A1 (es)
PE (1) PE20040913A1 (es)
PL (1) PL377696A1 (es)
RU (1) RU2348625C2 (es)
TW (1) TW200418825A (es)
UY (1) UY28127A1 (es)
WO (1) WO2004054999A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0210357A (pt) * 2001-06-11 2004-06-29 Shire Biochem Inc Composto e métodos para o tratamento ou a prevenção de infecções pelo flavivìrus
CN100413861C (zh) 2002-12-10 2008-08-27 维勒凯姆制药股份有限公司 用于治疗或预防黄病毒感染的化合物
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
WO2005121119A1 (en) * 2004-06-14 2005-12-22 F. Hoffmann-La Roche Ag Hydroxamates, their manufacture and use as pharmaceutical agents
WO2005121134A1 (en) * 2004-06-14 2005-12-22 F. Hoffmann-La Roche Ag Thiophene derivatives, their manufacture and use as pharmaceutical agents
US7423060B2 (en) * 2004-06-14 2008-09-09 Hoffman-La Roche Inc. Thiophene hydroxamic acid derivatives and their use as HDAC inhibitors
EA016071B1 (ru) * 2005-05-13 2012-01-30 Вирокем Фарма Инк. Соединения и способы лечения или предотвращения флавивирусных инфекций
JP2009501236A (ja) 2005-07-14 2009-01-15 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
GB0518237D0 (en) * 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0522130D0 (en) * 2005-10-31 2005-12-07 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0603041D0 (en) * 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
AU2007321677B2 (en) * 2006-11-15 2013-04-11 Vertex Pharmaceuticals (Canada) Incorporated Thiophene analogues for the treatment or prevention of flavivirus infections
AR074797A1 (es) 2008-10-10 2011-02-16 Japan Tobacco Inc Compuesto de fluoreno , composiciones farmaceuticas , inhibidores de pdhk y pdhk2 , metodos de tratamiento , usos de los mismos y kit comercial
US8546588B2 (en) * 2010-02-26 2013-10-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2011106632A1 (en) * 2010-02-26 2011-09-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2012019772A1 (en) * 2010-08-12 2012-02-16 Institut De Recherche Pour Le Developpement (I.R.D) Method for treating protozoan parasitic diseases
US20140107166A1 (en) * 2011-02-14 2014-04-17 Dana-Farber Cancer Institute, Inc. Histone deacetylase inhibitors and methods of use thereof
EP2763531A4 (en) * 2011-10-03 2015-11-18 Univ Columbia NOVEL MOLECULES THAT INHIBIT HISTONE-DEACETYLASE 6 WITHIN HISTONE-DEACETYLASE 1
BR112015022077A2 (pt) 2013-03-15 2017-07-18 Japan Tobacco Inc composto de pirazol-amida e usos medicinais do mesmo
CN103159646B (zh) * 2013-03-19 2014-10-22 广东药学院 一种异羟肟酸类化合物及其制备方法和应用
WO2015100363A1 (en) 2013-12-23 2015-07-02 The Trustees Of Columbia University In The City Of New York Selective hdac6 inhibitors
TW202246215A (zh) 2015-12-18 2022-12-01 美商亞德利克斯公司 作為非全身ｔｇｒ５促效劑之經取代之４－苯基吡啶化合物
US12084472B2 (en) 2015-12-18 2024-09-10 Ardelyx, Inc. Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
WO2018021508A1 (ja) 2016-07-29 2018-02-01 日本たばこ産業株式会社 ピラゾール－アミド化合物の製造方法
CN116120300B (zh) * 2023-02-21 2024-10-15 贵州大学 一种含异羟肟酸片段的嘧啶类化合物其制备方法和应用

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE661226A (fr) 1965-03-17 1965-09-17 Acides arylacethydroxamiques, amides correspondants et procedes de preparation.
NL6406688A (es) 1964-06-05 1965-12-06
GB1200886A (en) 1966-09-23 1970-08-05 Allen & Hanburys Ltd Phenylaminoethanol derivatives
US4173652A (en) 1976-12-18 1979-11-06 Akzona Incorporated Pharmaceutical hydroxamic acid compositions and uses thereof
NL7614113A (nl) 1976-12-18 1978-06-20 Akzo Nv Hydroxamzuren.
JPS5436229A (en) 1977-08-25 1979-03-16 Hokuriku Pharmaceutical Substituted acetohydroxam derivative
JPS57145838A (en) 1981-03-05 1982-09-09 Hodogaya Chem Co Ltd P-benzyloxybenzoic acid derivative and herbicide containing the same
JPS57149254A (en) 1981-03-10 1982-09-14 Hodogaya Chem Co Ltd M-benzyloxybenzamide derivative and herbicide containing the same
GB8320702D0 (en) 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agents
US4769461A (en) 1986-09-16 1988-09-06 American Home Products Corporation Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents
GB8728051D0 (en) 1987-12-01 1988-01-06 Leo Pharm Prod Ltd Chemical compounds
JPH01216961A (ja) 1988-02-25 1989-08-30 Takeda Chem Ind Ltd １２−リポキシゲネース阻害剤
DE3903989A1 (de) 1989-02-10 1990-09-20 Basf Ag Diphenylheteroalkylderivate, ihre herstellung und daraus hergestellte arzneimittel und kosmetika
US5091533A (en) 1990-03-12 1992-02-25 Merck Frosst Canada, Inc. 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
JPH04217950A (ja) 1990-03-28 1992-08-07 Asahi Chem Ind Co Ltd ヒドロキサム酸誘導体および酵素阻害剤ならびに抗潰瘍剤
JPH03291264A (ja) 1990-04-06 1991-12-20 Japan Tobacco Inc ジメチルアニリン誘導体、その製造方法及びそれを有効成分として含有するガン細胞分化誘導検査試薬及び制癌剤
JPH04187666A (ja) 1990-11-20 1992-07-06 Asahi Chem Ind Co Ltd シクロヘキサンカルボン酸アミド誘導体及び酵素阻害剤ならびに抗潰瘍剤
US5369108A (en) 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US5700811A (en) 1991-10-04 1997-12-23 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and method of use thereof
EP0544166A3 (en) 1991-11-26 1993-11-03 Hoffmann La Roche Cephalosporinderivatives
CA2139325A1 (en) 1992-07-16 1994-02-03 Stephen E. Bales Thiodiphenol copolycarbonates and their use as components of multilayered polymeric reflective bodies
US5783593A (en) 1993-11-04 1998-07-21 Abbott Laboratories Inhibitors of squalene synthetase and protein farnesyltransferase
US5776983A (en) 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US6008257A (en) 1994-01-28 1999-12-28 Bayer Aktiengesellschaft Hydroxamic-acid derivatives, method of preparing them and their use as fungicides
GB9420557D0 (en) 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
US6069156A (en) 1995-04-10 2000-05-30 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives as cGMP-PDE inhibitors
DE69618875D1 (de) 1995-09-08 2002-03-14 Univ Princeton Nicht-klassische Antifolate
WO1997012903A1 (en) 1995-10-04 1997-04-10 Warner-Lambert Company Compounds, compositions and methods for inhibiting the binding of proteins containing an sh2 domain to cognate phosphorylated proteins
FR2746098B1 (fr) 1996-03-14 1998-04-30 Composes propynyl biaromatiques
AUPO118896A0 (en) 1996-07-23 1996-08-15 Fujisawa Pharmaceutical Co., Ltd. New use
RU2171250C2 (ru) 1996-08-05 2001-07-27 Пролинкс, Инк. Производные 2,6-дигидрокси-4-аминометилбензоата
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
JPH10114654A (ja) 1996-10-09 1998-05-06 Fujisawa Pharmaceut Co Ltd 新規用途
WO1998016514A1 (en) 1996-10-16 1998-04-23 American Cyanamid Company Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US6392010B1 (en) 1996-12-19 2002-05-21 Aventis Pharmaceuticals Inc. Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
JPH10182583A (ja) 1996-12-25 1998-07-07 Mitsui Chem Inc 新規ヒドロキサム酸誘導体
EP0960096B1 (en) 1997-01-22 2005-04-06 Aventis Pharmaceuticals Inc. Substituted beta-thiocarboxylic acids
KR20000075809A (ko) 1997-02-27 2000-12-26 윌리암 에이취 캘넌, 에곤 이 버그 매트릭스 메탈로프로테이나제 억제제로서의 ｎ-하이드록시-2-(알킬, 아릴 또는 헤테로아릴 설파닐, 설피닐 또는 설포닐)-3-치환된 알킬, 아릴 또는 헤테로아릴아미드
US6696449B2 (en) 1997-03-04 2004-02-24 Pharmacia Corporation Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
JPH10259176A (ja) 1997-03-17 1998-09-29 Japan Tobacco Inc 血管新生阻害作用を有する新規アミド誘導体及びその用途
JPH10287634A (ja) 1997-04-11 1998-10-27 Otsuka Pharmaceut Co Ltd ベンゼン誘導体
AU7953798A (en) 1997-06-17 1999-01-04 Schering Corporation Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives as farnesyl protein transferase inhibitors
US6353023B1 (en) 1997-08-28 2002-03-05 Pharmacia & Upjohn Company Inhibitors of protein tyrosine phosphatase
JP4125868B2 (ja) 1997-09-09 2008-07-30 塩野義製薬株式会社 ４−置換安息香酸誘導体およびそれを有効成分として含有する制癌剤
PT1021413E (pt) 1997-10-06 2003-10-31 Wyeth Corp A preparacao e utilizacao de acidos orto-sulfonamido heterociclicos biciclicos hidroxamicos como inibidores de metaloproteinases de matriz e de tace
CN1231458C (zh) 1997-10-15 2005-12-14 惠氏公司 新的芳氧基－烷基－二烷基胺类化合物
IL137566A0 (en) 1998-02-19 2001-07-24 American Cyanamid Co N-hydroxy-2-(alkyl, aryl or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted-alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
EP0960882A1 (en) * 1998-05-19 1999-12-01 Hoechst Marion Roussel Deutschland GmbH Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists
ATE514674T1 (de) 1999-11-23 2011-07-15 Methylgene Inc Inhibitoren für histone-deacetylase
AU2001248701A1 (en) 2000-03-24 2001-10-03 Methylgene, Inc. Inhibitors of histone deacetylase
US6784173B2 (en) * 2001-06-15 2004-08-31 Hoffmann-La Roche Inc. Aromatic dicarboxylic acid derivatives
AU2002352443A1 (en) * 2001-12-21 2003-07-15 Consejo Superior De Investigaciones Cientificas Compounds and their therapeutic use related to the phosphorylating activity of the enzyme gsk-3

Also Published As

Publication number Publication date
CA2507629A1 (en) 2004-07-01
RU2348625C2 (ru) 2009-03-10
BR0317348A (pt) 2005-11-16
AR042459A1 (es) 2005-06-22
PL377696A1 (pl) 2006-02-06
CN1726204A (zh) 2006-01-25
US7098241B2 (en) 2006-08-29
WO2004054999A1 (en) 2004-07-01
KR100781929B1 (ko) 2007-12-04
CL2003002611A1 (es) 2005-01-14
TW200418825A (en) 2004-10-01
JP2006513181A (ja) 2006-04-20
PE20040913A1 (es) 2005-01-18
UY28127A1 (es) 2004-06-30
US20040122079A1 (en) 2004-06-24
KR20050089157A (ko) 2005-09-07
CN100391954C (zh) 2008-06-04
PA8592101A1 (es) 2004-11-02
RU2005122447A (ru) 2006-05-27
AU2003293882A1 (en) 2004-07-09
EP1575933A1 (en) 2005-09-21

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