UY28127A1 - Nuevos enantiomeros (r) y (s) de derivados del acido tiofeno hidroxamico - Google Patents
Nuevos enantiomeros (r) y (s) de derivados del acido tiofeno hidroxamicoInfo
- Publication number
- UY28127A1 UY28127A1 UY28127A UY28127A UY28127A1 UY 28127 A1 UY28127 A1 UY 28127A1 UY 28127 A UY28127 A UY 28127A UY 28127 A UY28127 A UY 28127A UY 28127 A1 UY28127 A1 UY 28127A1
- Authority
- UY
- Uruguay
- Prior art keywords
- hydroxamic
- acid derivatives
- thiophen
- enantiomers
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuesto de fórmula I en donde Ar, R1 y R2 tienen los significados definidos en la especificación, un proceso para la elaboración de estos compuestos y medicamentos con actividad inhibidora de HDAC conteniendo tal compuesto.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02028038 | 2002-12-16 | ||
PCT/EP2003/014235 WO2004054999A1 (en) | 2002-12-16 | 2003-12-15 | Enantiomers of thiophene hydroxamic acid derivatives and their use as hdac inhibitors |
EP03789278A EP1575933A1 (en) | 2002-12-16 | 2003-12-15 | Enantiomers of thiophene hydroxamic acid derivatives and their use as hdac inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
UY28127A1 true UY28127A1 (es) | 2004-06-30 |
Family
ID=32524005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY28127A UY28127A1 (es) | 2002-12-16 | 2003-12-15 | Nuevos enantiomeros (r) y (s) de derivados del acido tiofeno hidroxamico |
Country Status (18)
Country | Link |
---|---|
US (1) | US7098241B2 (es) |
EP (1) | EP1575933A1 (es) |
JP (1) | JP2006513181A (es) |
KR (1) | KR100781929B1 (es) |
CN (1) | CN100391954C (es) |
AR (1) | AR042459A1 (es) |
AU (1) | AU2003293882A1 (es) |
BR (1) | BR0317348A (es) |
CA (1) | CA2507629A1 (es) |
CL (1) | CL2003002611A1 (es) |
GT (1) | GT200300285A (es) |
PA (1) | PA8592101A1 (es) |
PE (1) | PE20040913A1 (es) |
PL (1) | PL377696A1 (es) |
RU (1) | RU2348625C2 (es) |
TW (1) | TW200418825A (es) |
UY (1) | UY28127A1 (es) |
WO (1) | WO2004054999A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2206709A3 (en) * | 2001-06-11 | 2011-06-29 | Virochem Pharma Inc. | Thiophene derivatives as antiviral agents for flavivirus infection |
KR101058696B1 (ko) | 2002-12-10 | 2011-08-22 | 바이로켐 파마 인코포레이티드 | 후라비바이러스 감염의 치료 또는 예방을 위한 화합물과방법 |
US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
CN1964962A (zh) * | 2004-06-14 | 2007-05-16 | 霍夫曼-拉罗奇有限公司 | 噻吩异羟肟酸衍生物以及它们作为hdac抑制剂的应用 |
CA2566512A1 (en) * | 2004-06-14 | 2005-12-22 | F. Hoffmann-La Roche Ag | Hydroxamates, their manufacture and use as pharmaceutical agents |
WO2005121134A1 (en) * | 2004-06-14 | 2005-12-22 | F. Hoffmann-La Roche Ag | Thiophene derivatives, their manufacture and use as pharmaceutical agents |
AP2007004245A0 (en) * | 2005-05-13 | 2007-12-31 | Virochem Pharma Inc | Compounds and methods for the treatment or prevention of flavivirus infections |
CA2615105A1 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
GB0518237D0 (en) * | 2005-09-07 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
GB0522130D0 (en) * | 2005-10-31 | 2005-12-07 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
GB0603041D0 (en) * | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
EA201101492A1 (ru) | 2006-11-15 | 2012-09-28 | Вирокем Фарма Инк. | Аналоги тиофена для лечения или предупреждения флавивирусных инфекций |
AR074797A1 (es) | 2008-10-10 | 2011-02-16 | Japan Tobacco Inc | Compuesto de fluoreno , composiciones farmaceuticas , inhibidores de pdhk y pdhk2 , metodos de tratamiento , usos de los mismos y kit comercial |
US20110212969A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
WO2011106627A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
WO2012019772A1 (en) * | 2010-08-12 | 2012-02-16 | Institut De Recherche Pour Le Developpement (I.R.D) | Method for treating protozoan parasitic diseases |
WO2012112447A2 (en) * | 2011-02-14 | 2012-08-23 | Dana-Farber Cancer Institute, Inc. | Histone deacetylase inhibitors and methods of use thereof |
WO2013052110A1 (en) * | 2011-10-03 | 2013-04-11 | The Trustees Of Columbia University In The City Of New York | Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1 |
NO2975028T3 (es) | 2013-03-15 | 2018-07-21 | ||
CN103159646B (zh) * | 2013-03-19 | 2014-10-22 | 广东药学院 | 一种异羟肟酸类化合物及其制备方法和应用 |
WO2015100363A1 (en) | 2013-12-23 | 2015-07-02 | The Trustees Of Columbia University In The City Of New York | Selective hdac6 inhibitors |
TWI773657B (zh) | 2015-12-18 | 2022-08-11 | 美商亞德利克斯公司 | 作爲非全身tgr5促效劑之經取代之4-苯基吡啶化合物 |
US10981877B2 (en) | 2016-07-29 | 2021-04-20 | Japan Tobacco Inc. | Production method for pyrazole-amide compound |
Family Cites Families (52)
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BE661226A (fr) | 1965-03-17 | 1965-09-17 | Acides arylacethydroxamiques, amides correspondants et procedes de preparation. | |
NL6406688A (es) * | 1964-06-05 | 1965-12-06 | ||
GB1200886A (en) * | 1966-09-23 | 1970-08-05 | Allen & Hanburys Ltd | Phenylaminoethanol derivatives |
US4173652A (en) * | 1976-12-18 | 1979-11-06 | Akzona Incorporated | Pharmaceutical hydroxamic acid compositions and uses thereof |
NL7614113A (nl) | 1976-12-18 | 1978-06-20 | Akzo Nv | Hydroxamzuren. |
JPS5436229A (en) | 1977-08-25 | 1979-03-16 | Hokuriku Pharmaceutical | Substituted acetohydroxam derivative |
JPS57145838A (en) | 1981-03-05 | 1982-09-09 | Hodogaya Chem Co Ltd | P-benzyloxybenzoic acid derivative and herbicide containing the same |
JPS57149254A (en) | 1981-03-10 | 1982-09-14 | Hodogaya Chem Co Ltd | M-benzyloxybenzamide derivative and herbicide containing the same |
GB8320702D0 (en) | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agents |
US4769461A (en) * | 1986-09-16 | 1988-09-06 | American Home Products Corporation | Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents |
GB8728051D0 (en) | 1987-12-01 | 1988-01-06 | Leo Pharm Prod Ltd | Chemical compounds |
JPH01216961A (ja) | 1988-02-25 | 1989-08-30 | Takeda Chem Ind Ltd | 12−リポキシゲネース阻害剤 |
DE3903989A1 (de) * | 1989-02-10 | 1990-09-20 | Basf Ag | Diphenylheteroalkylderivate, ihre herstellung und daraus hergestellte arzneimittel und kosmetika |
US5091533A (en) | 1990-03-12 | 1992-02-25 | Merck Frosst Canada, Inc. | 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors |
JPH04217950A (ja) | 1990-03-28 | 1992-08-07 | Asahi Chem Ind Co Ltd | ヒドロキサム酸誘導体および酵素阻害剤ならびに抗潰瘍剤 |
JPH03291264A (ja) | 1990-04-06 | 1991-12-20 | Japan Tobacco Inc | ジメチルアニリン誘導体、その製造方法及びそれを有効成分として含有するガン細胞分化誘導検査試薬及び制癌剤 |
JPH04187666A (ja) | 1990-11-20 | 1992-07-06 | Asahi Chem Ind Co Ltd | シクロヘキサンカルボン酸アミド誘導体及び酵素阻害剤ならびに抗潰瘍剤 |
US5700811A (en) * | 1991-10-04 | 1997-12-23 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
US5369108A (en) * | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
EP0544166A3 (en) | 1991-11-26 | 1993-11-03 | Hoffmann La Roche | Cephalosporinderivatives |
WO1994002533A1 (en) | 1992-07-16 | 1994-02-03 | The Dow Chemical Company | Thiodiphenol copolycarbonates and their use as components of multilayered polymeric reflective bodies |
US5783593A (en) | 1993-11-04 | 1998-07-21 | Abbott Laboratories | Inhibitors of squalene synthetase and protein farnesyltransferase |
US5776983A (en) * | 1993-12-21 | 1998-07-07 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
US6008257A (en) * | 1994-01-28 | 1999-12-28 | Bayer Aktiengesellschaft | Hydroxamic-acid derivatives, method of preparing them and their use as fungicides |
GB9420557D0 (en) | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
DE69622031T2 (de) | 1995-04-10 | 2002-12-12 | Fujisawa Pharmaceutical Co | INDOLDERIVATE ALS cGMP-PDE INHIBITOREN |
JPH09165387A (ja) | 1995-09-08 | 1997-06-24 | Univ Princeton | 非古典的抗葉酸剤 |
AU7392696A (en) | 1995-10-04 | 1997-04-28 | Warner-Lambert Company | Compounds, compositions and methods for inhibiting the binding of proteins containing an sh2 domain to cognate phosphorylated proteins |
FR2746098B1 (fr) | 1996-03-14 | 1998-04-30 | Composes propynyl biaromatiques | |
AUPO118896A0 (en) | 1996-07-23 | 1996-08-15 | Fujisawa Pharmaceutical Co., Ltd. | New use |
DK0915832T3 (da) | 1996-08-05 | 2003-02-03 | Prolinx Inc | Kompleksdannende reagenser til boronforbindelser og højstabile komplekser |
US6174905B1 (en) | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
JPH10114654A (ja) | 1996-10-09 | 1998-05-06 | Fujisawa Pharmaceut Co Ltd | 新規用途 |
AU743901B2 (en) | 1996-10-16 | 2002-02-07 | Wyeth Holdings Corporation | Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloprote inase and tace inhibitors |
US6392010B1 (en) * | 1996-12-19 | 2002-05-21 | Aventis Pharmaceuticals Inc. | Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds |
JPH10182583A (ja) | 1996-12-25 | 1998-07-07 | Mitsui Chem Inc | 新規ヒドロキサム酸誘導体 |
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JP2001513771A (ja) | 1997-02-27 | 2001-09-04 | アメリカン・サイアナミド・カンパニー | マトリクス金属プロテイナーゼ阻害薬としてのn−ヒドロキシ−2−(アルキル、アリール、またはヘテロアリールスルファニル、スルフィニルまたはスルホニル)−3−置換アルキル、アリールまたはヘテロアリールアミド |
US6696449B2 (en) | 1997-03-04 | 2004-02-24 | Pharmacia Corporation | Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors |
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JPH10287634A (ja) | 1997-04-11 | 1998-10-27 | Otsuka Pharmaceut Co Ltd | ベンゼン誘導体 |
HUP0002659A3 (en) | 1997-06-17 | 2002-11-28 | Schering Corp | Benzo-5,6-cyclohepta[1,2-b]pyridine derivatives, pharmaceutical compositions containing them and their use |
DE69824433D1 (en) | 1997-08-28 | 2004-07-15 | Biovitrum Ab | Proteintyrosinphosphatase inhibitoren |
JP4125868B2 (ja) | 1997-09-09 | 2008-07-30 | 塩野義製薬株式会社 | 4−置換安息香酸誘導体およびそれを有効成分として含有する制癌剤 |
CN1138760C (zh) | 1997-10-06 | 2004-02-18 | 惠氏控股公司 | 作为基质金属蛋白酶和tace抑制剂的邻亚磺酰氨基二环杂芳基异羟肟酸的制备和用途 |
BR9813069A (pt) | 1997-10-15 | 2000-08-22 | American Home Prod | Arilóxi-alquil-dialquilaminas |
ID25639A (id) | 1998-02-19 | 2000-10-19 | American Cyanamid Co | Alkil, aril atau heteroarilamida tersubstitusi n-hidroksi-2-(alkil, aril, atau heteroaril sulfanil, sulfinil atau sulfonil)-3 sebagai inhibitor matriks mataloproteinase |
EP0960882A1 (en) * | 1998-05-19 | 1999-12-01 | Hoechst Marion Roussel Deutschland GmbH | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists |
CA2391952C (en) | 1999-11-23 | 2012-01-31 | Methylgene Inc. | Inhibitors of histone deacetylase |
WO2001070675A2 (en) | 2000-03-24 | 2001-09-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US6784173B2 (en) * | 2001-06-15 | 2004-08-31 | Hoffmann-La Roche Inc. | Aromatic dicarboxylic acid derivatives |
AU2002352443A1 (en) * | 2001-12-21 | 2003-07-15 | Consejo Superior De Investigaciones Cientificas | Compounds and their therapeutic use related to the phosphorylating activity of the enzyme gsk-3 |
-
2003
- 2003-12-10 US US10/732,633 patent/US7098241B2/en not_active Expired - Fee Related
- 2003-12-10 TW TW092134881A patent/TW200418825A/zh unknown
- 2003-12-11 PE PE2003001262A patent/PE20040913A1/es not_active Application Discontinuation
- 2003-12-11 PA PA20038592101A patent/PA8592101A1/es unknown
- 2003-12-12 CL CL200302611A patent/CL2003002611A1/es unknown
- 2003-12-12 GT GT200300285A patent/GT200300285A/es unknown
- 2003-12-12 AR ARP030104605A patent/AR042459A1/es unknown
- 2003-12-15 AU AU2003293882A patent/AU2003293882A1/en not_active Abandoned
- 2003-12-15 KR KR1020057011170A patent/KR100781929B1/ko not_active IP Right Cessation
- 2003-12-15 EP EP03789278A patent/EP1575933A1/en not_active Withdrawn
- 2003-12-15 RU RU2005122447/04A patent/RU2348625C2/ru not_active IP Right Cessation
- 2003-12-15 CA CA002507629A patent/CA2507629A1/en not_active Abandoned
- 2003-12-15 BR BR0317348-8A patent/BR0317348A/pt not_active IP Right Cessation
- 2003-12-15 PL PL377696A patent/PL377696A1/pl not_active Application Discontinuation
- 2003-12-15 WO PCT/EP2003/014235 patent/WO2004054999A1/en active Application Filing
- 2003-12-15 UY UY28127A patent/UY28127A1/es not_active Application Discontinuation
- 2003-12-15 JP JP2004560408A patent/JP2006513181A/ja not_active Ceased
- 2003-12-15 CN CNB2003801059568A patent/CN100391954C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN100391954C (zh) | 2008-06-04 |
AU2003293882A1 (en) | 2004-07-09 |
PL377696A1 (pl) | 2006-02-06 |
CN1726204A (zh) | 2006-01-25 |
US20040122079A1 (en) | 2004-06-24 |
KR100781929B1 (ko) | 2007-12-04 |
TW200418825A (en) | 2004-10-01 |
GT200300285A (es) | 2004-07-14 |
US7098241B2 (en) | 2006-08-29 |
BR0317348A (pt) | 2005-11-16 |
CL2003002611A1 (es) | 2005-01-14 |
KR20050089157A (ko) | 2005-09-07 |
PE20040913A1 (es) | 2005-01-18 |
RU2005122447A (ru) | 2006-05-27 |
RU2348625C2 (ru) | 2009-03-10 |
JP2006513181A (ja) | 2006-04-20 |
EP1575933A1 (en) | 2005-09-21 |
PA8592101A1 (es) | 2004-11-02 |
CA2507629A1 (en) | 2004-07-01 |
AR042459A1 (es) | 2005-06-22 |
WO2004054999A1 (en) | 2004-07-01 |
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