CO5690574A2 - Nuevos compuestos derivados de indolina como inhibidores de la colesterol-actiltransferasa (acat) y uso medico del mismo - Google Patents

Nuevos compuestos derivados de indolina como inhibidores de la colesterol-actiltransferasa (acat) y uso medico del mismo

Info

Publication number
CO5690574A2
CO5690574A2 CO05013959A CO05013959A CO5690574A2 CO 5690574 A2 CO5690574 A2 CO 5690574A2 CO 05013959 A CO05013959 A CO 05013959A CO 05013959 A CO05013959 A CO 05013959A CO 5690574 A2 CO5690574 A2 CO 5690574A2
Authority
CO
Colombia
Prior art keywords
acat
actiltranspherase
indolina
cholesterol
inhibitors
Prior art date
Application number
CO05013959A
Other languages
English (en)
Inventor
Shouji Kamiya
Miho Ikai
Kenji Takahashiy
Tadatsugu Tarumi
Masayasu Kasai
Akihisa Yoshimi
Hiroaki Shirahase
Original Assignee
Kyoto Pharma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharma Ind filed Critical Kyoto Pharma Ind
Publication of CO5690574A2 publication Critical patent/CO5690574A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

1.- Un nuevo compuesto de indolina representado por Ia fórmula (I) en dondeR1 y R3 son los mismos o diferentes y cada uno es un átomo de hidrógeno, grupo alquilo inferior o grupo alcoxi inferior,R2 es -NO2, -NHSO2R6 [R6 es grupo alquilo, grupo arilo o - NHR7 (R7 es átomo de hidrógeno, -COR13 (R13 es átomo de hidrógeno o grupo alquilo inferior) o grupo alcoxicarbonilo inferior)], -NHCONH2 o grupo alquilo inferior sustituido por -NHSO2R6 [R6 es grupo alquilo, grupo arilo o - NHR7 (R7 es átomo de hidrógeno, -COR13 (R13 es átomo de hidrógeno o grupo alquilo inferior) o grupo alcoxicarbonilo inferior)],R4 es átomo de hidrógeno, grupo alquilo, opcionalmente sustituido por grupo hidroxi, -COR13 (R13 es átomo de hidrógeno o grupo alquilo inferior), grupo alquenilo inferior, grupo alcoxi inferior-alquilo inferior, grupo alquiltio inferior-alquilo inferior, grupo cicloalquilo, o grupo cicloalquilalquilo;R5 es grupo alquilo, grupo cicloalquilo, o grupo arilo;R12 es átomo de hidrógeno, grupo alquilo inferior, grupo alcoxi inferior-alquilo inferior o grupo alquiltio inferior-alquilo inferior; o una sal farmacéuticamente aceptable del mismo.2.- El nuevo compuesto de indolina según la reivindicación 1, en donde, en la fórmula (I), R1 y R3 son los mismos o diferentes y cada uno es átomo de hidrógeno, grupo alquilo inferior, o grupo alcoxi inferior, R2 es -NO2, -NHSO2R6 [R6 es grupo alquilo, grupo arilo o -NHR7 (R7 es átomo de hidrógeno, -COR13 (R13 es átomo de hidrógeno o grupo alquilo inferior), o grupo alcoxicarbonilo inferior)], -NHCONH2 o grupo alquilo inferior sustituido por -NHSO2R6 [R6 es grupo alquilo, grupo arilo o -NHR7 (R7 es átomo de hidrógeno, -COR13 (R13 es átomo de hidrógeno o grupo alquilo inferior) o grupo alcoxicarbonilo inferior)], R4 es átomo de hidrógeno, grupo alquilo, grupo cicloalquilo o cicloalquilalquilo, R5 es grupo alquilo, grupo cicloalquilo o grupo arilo, y R12 es átomo de hidrógeno, o una sal farmacéuticamente aceptable del mismo.
CO05013959A 2002-07-17 2005-02-16 Nuevos compuestos derivados de indolina como inhibidores de la colesterol-actiltransferasa (acat) y uso medico del mismo CO5690574A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2002208878 2002-07-17

Publications (1)

Publication Number Publication Date
CO5690574A2 true CO5690574A2 (es) 2006-10-31

Family

ID=30112861

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05013959A CO5690574A2 (es) 2002-07-17 2005-02-16 Nuevos compuestos derivados de indolina como inhibidores de la colesterol-actiltransferasa (acat) y uso medico del mismo

Country Status (22)

Country Link
US (1) US7429612B2 (es)
EP (1) EP1541553B1 (es)
JP (1) JP4485357B2 (es)
CN (1) CN100349868C (es)
AT (1) ATE469884T1 (es)
AU (1) AU2003252638B8 (es)
BR (1) BR0312734A (es)
CA (1) CA2492669A1 (es)
CO (1) CO5690574A2 (es)
DE (1) DE60332851D1 (es)
DK (1) DK1541553T3 (es)
HK (1) HK1083839A1 (es)
IL (1) IL166313A0 (es)
MX (1) MXPA05000749A (es)
NO (1) NO20050834L (es)
NZ (1) NZ538226A (es)
PL (1) PL374919A1 (es)
RS (1) RS20050127A (es)
RU (1) RU2318808C2 (es)
TW (1) TWI285196B (es)
WO (1) WO2004007450A1 (es)
ZA (1) ZA200501297B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011076931A1 (de) 2011-06-03 2012-12-06 Basf Se Wässrige Lösung, enthaltend Acrylsäure und deren konjugierte Base
JP2018052818A (ja) * 2015-01-28 2018-04-05 武田薬品工業株式会社 スルホンアミド化合物

Family Cites Families (31)

* Cited by examiner, † Cited by third party
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US4013404A (en) * 1970-12-06 1977-03-22 American Cyanamid Company Method of dyeing hair with indolines, indoles and indazoles
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
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US4956372A (en) 1987-10-02 1990-09-11 Kyorin Pharmaceutical Co., Ltd. Cyclic anthranilic acid derivatives and process for their preparation
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JPH02117651A (ja) 1988-01-20 1990-05-02 Yamanouchi Pharmaceut Co Ltd ジウレア誘導体及びその製造法
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Also Published As

Publication number Publication date
PL374919A1 (en) 2005-11-14
EP1541553B1 (en) 2010-06-02
EP1541553A1 (en) 2005-06-15
WO2004007450A1 (ja) 2004-01-22
US20060128787A1 (en) 2006-06-15
MXPA05000749A (es) 2005-04-28
CA2492669A1 (en) 2004-01-22
TWI285196B (en) 2007-08-11
EP1541553A4 (en) 2007-04-11
AU2003252638A1 (en) 2004-02-02
CN100349868C (zh) 2007-11-21
CN1681781A (zh) 2005-10-12
TW200407304A (en) 2004-05-16
NO20050834L (no) 2005-04-15
IL166313A0 (en) 2006-01-15
DE60332851D1 (de) 2010-07-15
US7429612B2 (en) 2008-09-30
RU2318808C2 (ru) 2008-03-10
JP4485357B2 (ja) 2010-06-23
HK1083839A1 (en) 2006-07-14
RU2005104238A (ru) 2005-08-27
JPWO2004007450A1 (ja) 2005-11-10
ATE469884T1 (de) 2010-06-15
RS20050127A (en) 2007-06-04
AU2003252638B2 (en) 2009-02-05
NZ538226A (en) 2006-08-31
AU2003252638B8 (en) 2009-03-05
DK1541553T3 (da) 2010-09-20
ZA200501297B (en) 2006-10-25
BR0312734A (pt) 2005-04-26

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