NO20050834L - Ny indolinforbindelse og medisinsk anvendelse derav - Google Patents

Ny indolinforbindelse og medisinsk anvendelse derav

Info

Publication number
NO20050834L
NO20050834L NO20050834A NO20050834A NO20050834L NO 20050834 L NO20050834 L NO 20050834L NO 20050834 A NO20050834 A NO 20050834A NO 20050834 A NO20050834 A NO 20050834A NO 20050834 L NO20050834 L NO 20050834L
Authority
NO
Norway
Prior art keywords
indoline compound
medical use
compound
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
NO20050834A
Other languages
English (en)
Inventor
Masayasu Kasai
Akihisa Yoshimi
Hiroaki Shirahase
Shouji Kamiya
Miho Ikai
Kenji Takahashi
Tadatsugu Tarumi
Original Assignee
Kyoto Pharma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharma Ind filed Critical Kyoto Pharma Ind
Publication of NO20050834L publication Critical patent/NO20050834L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer en indolinforbindelse representert ved formel (I) r2 r1 (I) hvori hvert symbol er definert i beskrivelsen, eller et farmasøytisk akseptabelt salt derav, og en farmasøytisk sanmiensetning som innbefatter deime indolinforbindelsen eller et farmasøytisk akseptabelt salt derav. Forbindelsen ifølge oppfinnelsen viser overlegen ACAT inhiberingseffekt og overlegen lipoperoksidsjonsinhiberingseffekt og er anvendelig som en ACAT inhibitor eller en lipoperoksidasjonsinhibitor.
NO20050834A 2002-07-17 2005-02-16 Ny indolinforbindelse og medisinsk anvendelse derav NO20050834L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002208878 2002-07-17
PCT/JP2003/009012 WO2004007450A1 (ja) 2002-07-17 2003-07-16 新規インドリン化合物およびその医薬用途

Publications (1)

Publication Number Publication Date
NO20050834L true NO20050834L (no) 2005-04-15

Family

ID=30112861

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050834A NO20050834L (no) 2002-07-17 2005-02-16 Ny indolinforbindelse og medisinsk anvendelse derav

Country Status (22)

Country Link
US (1) US7429612B2 (no)
EP (1) EP1541553B1 (no)
JP (1) JP4485357B2 (no)
CN (1) CN100349868C (no)
AT (1) ATE469884T1 (no)
AU (1) AU2003252638B8 (no)
BR (1) BR0312734A (no)
CA (1) CA2492669A1 (no)
CO (1) CO5690574A2 (no)
DE (1) DE60332851D1 (no)
DK (1) DK1541553T3 (no)
HK (1) HK1083839A1 (no)
IL (1) IL166313A0 (no)
MX (1) MXPA05000749A (no)
NO (1) NO20050834L (no)
NZ (1) NZ538226A (no)
PL (1) PL374919A1 (no)
RS (1) RS20050127A (no)
RU (1) RU2318808C2 (no)
TW (1) TWI285196B (no)
WO (1) WO2004007450A1 (no)
ZA (1) ZA200501297B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011076931A1 (de) 2011-06-03 2012-12-06 Basf Se Wässrige Lösung, enthaltend Acrylsäure und deren konjugierte Base
JP2018052818A (ja) * 2015-01-28 2018-04-05 武田薬品工業株式会社 スルホンアミド化合物

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013404A (en) * 1970-12-06 1977-03-22 American Cyanamid Company Method of dyeing hair with indolines, indoles and indazoles
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
US4956372A (en) * 1987-10-02 1990-09-11 Kyorin Pharmaceutical Co., Ltd. Cyclic anthranilic acid derivatives and process for their preparation
US5166429A (en) * 1988-01-20 1992-11-24 Yamanouchi Pharmaceutical Co., Ltd. Diurea derivatives useful as medicaments and processes for the preparation thereof
US5227492A (en) * 1988-01-20 1993-07-13 Yamanouchi Pharmaceutical Co., Ltd. Diurea derivatives useful as medicaments and processes for the preparation thereof
JPH02117651A (ja) 1988-01-20 1990-05-02 Yamanouchi Pharmaceut Co Ltd ジウレア誘導体及びその製造法
CN1021819C (zh) * 1988-01-20 1993-08-18 山之内制药株式会社 作为药物有用的双脲衍生物的制备方法
JPH0753714B2 (ja) 1988-07-12 1995-06-07 武田薬品工業株式会社 Ａｃａｔ阻害剤、キノリン誘導体及びその製造法
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
US5258405A (en) * 1990-03-12 1993-11-02 Yamanouchi Pharmaceutical Co., Ltd. Urea derivatives and salts thereof in method for inhibiting the ACAT enzyme
DE69105786T2 (de) 1990-03-12 1995-04-27 Yamanouchi Pharma Co Ltd Harnstoffderivate, deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen.
JPH0466568A (ja) 1990-06-29 1992-03-02 Takeda Chem Ind Ltd 中枢性抗酸化剤化合物
US5256782A (en) * 1990-08-17 1993-10-26 Takeda Chemical Industries, Ltd. Thienopyridine derivatives which are intermediates
JP3086295B2 (ja) 1990-08-17 2000-09-11 武田薬品工業株式会社 チエノピリジン誘導体、その製造法およびａｃａｔ阻害剤
US5143919A (en) * 1990-08-17 1992-09-01 Takeda Chemical Industries, Ltd. Thienopyridine derivatives and their pharmaceutical use
FR2673625B1 (fr) 1991-03-08 1993-05-07 Adir Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
IL101785A0 (en) 1991-05-10 1992-12-30 Fujisawa Pharmaceutical Co Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
CA2121391A1 (en) 1993-04-28 1994-10-29 Atsuyuki Kojima Indoloylguanidine derivatives
US6169107B1 (en) * 1993-04-28 2001-01-02 Sumitomo Pharmaceutical Co., Ltd. Indoloylguanidine derivatives
JP3720395B2 (ja) * 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
JPH08208602A (ja) 1994-10-18 1996-08-13 Sumitomo Pharmaceut Co Ltd インドロイルグアニジン誘導体
CA2160600A1 (en) 1994-10-18 1996-04-19 Masahumi Kitano Indoloylguanidine derivatives
US5767129A (en) * 1995-08-24 1998-06-16 Warner-Lambert Company Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof
EP0866059B1 (en) * 1995-10-05 2001-12-05 Kyoto Pharmaceutical Industries, Ltd. Novel heterocyclic derivatives and medicinal use thereof
US5994040A (en) * 1996-03-04 1999-11-30 Fuji Photo Film Co., Ltd. Processing composition for silver halide photographic light-sensitive material, developer and processing method using the same
JP2002047269A (ja) * 2000-08-01 2002-02-12 Kyoto Pharmaceutical Industries Ltd ヘテロ環化合物の製造方法およびその中間体
JP2002302481A (ja) * 2001-02-02 2002-10-18 Sankyo Co Ltd インドリン誘導体と製造法
JP2006524641A (ja) 2003-04-25 2006-11-02 ハー・ルンドベック・アクチエゼルスカベット 置換されたインドリンおよびインドール誘導体

Also Published As

Publication number Publication date
TW200407304A (en) 2004-05-16
CO5690574A2 (es) 2006-10-31
CN100349868C (zh) 2007-11-21
CN1681781A (zh) 2005-10-12
DK1541553T3 (da) 2010-09-20
ZA200501297B (en) 2006-10-25
NZ538226A (en) 2006-08-31
EP1541553A4 (en) 2007-04-11
RS20050127A (en) 2007-06-04
ATE469884T1 (de) 2010-06-15
RU2318808C2 (ru) 2008-03-10
AU2003252638A1 (en) 2004-02-02
TWI285196B (en) 2007-08-11
AU2003252638B2 (en) 2009-02-05
HK1083839A1 (en) 2006-07-14
MXPA05000749A (es) 2005-04-28
PL374919A1 (en) 2005-11-14
AU2003252638B8 (en) 2009-03-05
JPWO2004007450A1 (ja) 2005-11-10
WO2004007450A1 (ja) 2004-01-22
DE60332851D1 (de) 2010-07-15
EP1541553A1 (en) 2005-06-15
US20060128787A1 (en) 2006-06-15
JP4485357B2 (ja) 2010-06-23
RU2005104238A (ru) 2005-08-27
EP1541553B1 (en) 2010-06-02
CA2492669A1 (en) 2004-01-22
US7429612B2 (en) 2008-09-30
BR0312734A (pt) 2005-04-26
IL166313A0 (en) 2006-01-15

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