BR0209064A - Hidroxamatos de alquila tricìclicos, sua preparaçãoe seu uso como inibidores de proliferação de células - Google Patents

Hidroxamatos de alquila tricìclicos, sua preparaçãoe seu uso como inibidores de proliferação de células

Info

Publication number
BR0209064A
BR0209064A BR0209064-3A BR0209064A BR0209064A BR 0209064 A BR0209064 A BR 0209064A BR 0209064 A BR0209064 A BR 0209064A BR 0209064 A BR0209064 A BR 0209064A
Authority
BR
Brazil
Prior art keywords
preparation
cell proliferation
tricyclic alkyl
proliferation inhibitors
alkyl hydroxamates
Prior art date
Application number
BR0209064-3A
Other languages
English (en)
Inventor
Adelbert Grossmann
Wolfgang Von Der Saal
Tim Sattelkau
Ulrich Tibes
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0209064A publication Critical patent/BR0209064A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"HIDROXAMATOS DE ALQUILA TRICìCLICOS, SUA PREPARAçãO E SEU USO COMO INIBIDORES DE PROLIFERAçãO DE CéLULAS". A invenção refere-se a compostos de fórmula (I), em que R~ 1~, R~ 2~, A, X, Y e Z têm os significados definidos no relatório descritivo, método de fabricação destes compostos e compostos farmacêuticos com atividade inibidora de HDAC contendo um tal composto.
BR0209064-3A 2001-04-23 2002-04-19 Hidroxamatos de alquila tricìclicos, sua preparaçãoe seu uso como inibidores de proliferação de células BR0209064A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01109428 2001-04-23
PCT/EP2002/004349 WO2002085883A1 (en) 2001-04-23 2002-04-19 Tricyclic alkylhydroxamates, their preparation and their use as cell proliferation inhibitors

Publications (1)

Publication Number Publication Date
BR0209064A true BR0209064A (pt) 2004-08-10

Family

ID=8177162

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0209064-3A BR0209064A (pt) 2001-04-23 2002-04-19 Hidroxamatos de alquila tricìclicos, sua preparaçãoe seu uso como inibidores de proliferação de células

Country Status (16)

Country Link
US (1) US6512123B2 (pt)
EP (1) EP1385837B1 (pt)
JP (1) JP4142453B2 (pt)
KR (1) KR100591501B1 (pt)
CN (1) CN1310904C (pt)
AR (1) AR035455A1 (pt)
AT (1) ATE306480T1 (pt)
AU (1) AU2002254991B2 (pt)
BR (1) BR0209064A (pt)
CA (1) CA2442994A1 (pt)
CR (1) CR9430A (pt)
DE (1) DE60206616T2 (pt)
ES (1) ES2249572T3 (pt)
MX (1) MXPA03009132A (pt)
WO (1) WO2002085883A1 (pt)
ZA (1) ZA200307793B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) * 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US6822267B1 (en) * 1997-08-20 2004-11-23 Advantest Corporation Signal transmission circuit, CMOS semiconductor device, and circuit board
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2004067480A2 (en) * 2003-01-25 2004-08-12 Oxford Glycosciences (Uk) Ltd Substituted phenylurea derivatives as hdac inhibitors
EP1608628A2 (en) 2003-03-17 2005-12-28 Takeda San Diego, Inc. Histone deacetylase inhibitors
PL2238982T3 (pl) 2003-06-27 2013-03-29 Astellas Pharma Inc Środek do terapii mięsaka tkanek miękkich
WO2005058298A2 (en) * 2003-12-10 2005-06-30 Wisconsin Alumni Research Foundation Fk228 analogs and their use as hdac-inhibitors
WO2005065681A1 (en) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer
WO2005066151A2 (en) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20060128660A1 (en) * 2004-12-10 2006-06-15 Wisconsin Alumni Research Foundation FK228 analogs and methods of making and using the same
WO2006066133A2 (en) * 2004-12-16 2006-06-22 Takeda San Diego, Inc. Histone deacetylase inhibitors
IT1362675B (it) * 2005-03-15 2009-06-25 Menarini Internat Operations Luxembourg Sa N-idrossiammidi -sostituiti con gruppi triciclici come inibitori dell'istone deacelitasi,loro preparazione ed impiego in formulazioni farmaceutiche
EP2491926B1 (en) 2005-03-22 2018-05-09 President and Fellows of Harvard College Treatment of protein degradation disorders
US7642253B2 (en) * 2005-05-11 2010-01-05 Takeda San Diego, Inc. Histone deacetylase inhibitors
CA2606598C (en) * 2005-05-13 2014-12-23 Topotarget Uk Limited Pharmaceutical formulations of hdac inhibitors
JP2009501236A (ja) * 2005-07-14 2009-01-15 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
WO2007077111A1 (en) * 2005-12-30 2007-07-12 F. Hoffmann-La Roche Ag Compounds and methods for carbazole synthesis
WO2007084390A2 (en) * 2006-01-13 2007-07-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
AU2007345292B2 (en) 2006-02-14 2013-10-31 Dana-Farber Cancer Institute, Inc. Bifunctional histone deacetylase inhibitors
AU2007214458C1 (en) 2006-02-14 2012-12-06 Dana-Farber Cancer Institute, Inc. Histone deacetylase inhibitors
US8304451B2 (en) * 2006-05-03 2012-11-06 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
ES2288803B1 (es) * 2006-07-07 2008-12-16 Universidad De Granada Derivados de benzo(d)isotiazoles como inhibidores de las histonas desacetilasas.
US8399452B2 (en) * 2006-10-28 2013-03-19 Methylgene Inc. Dibenzo[b,f][1,4]oxazepin-11-yl-N-hydroxybenzamides as HDAC inhibitors
AU2013205135B2 (en) * 2006-10-28 2015-11-05 Forum Pharmaceuticals Inc. Inhibitors of histone deacetylase
US8440716B2 (en) 2008-07-23 2013-05-14 President And Fellows Of Harvard College Deacetylase inhibitors and uses thereof
JP2012051804A (ja) * 2008-12-26 2012-03-15 Kyoto Univ Ｅｇ５阻害剤
US8716344B2 (en) 2009-08-11 2014-05-06 President And Fellows Of Harvard College Class- and isoform-specific HDAC inhibitors and uses thereof
WO2015115410A1 (ja) * 2014-01-28 2015-08-06 株式会社日本触媒 水素化反応方法
WO2017030892A1 (en) 2015-08-14 2017-02-23 Reaction Biology Corp. Histone deacetylase inhibitors and methods for use thereof
WO2023020416A1 (zh) * 2021-08-16 2023-02-23 勤浩医药（苏州）有限公司 三环化合物、包含其的药物组合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2208893A1 (de) 1972-02-25 1973-08-30 Boehringer Mannheim Gmbh Tricyclische alpha-oxy-carbonsaeurederivate und verfahren zur herstellung derselben
US5369108A (en) * 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
ZA938897B (en) * 1992-12-01 1994-08-01 Smithkline Beecham Corp Antioxidant neuroprotective use of and method of treatment using hydroxycarbazole compounds
KR20000068414A (ko) * 1996-09-04 2000-11-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 매트릭스 메탈로프로테이나제 억제제 및 그의 치료적 용도
AUPO721997A0 (en) * 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
EP1215203B1 (en) * 1999-09-24 2005-02-16 Ono Pharmaceutical Co., Ltd. Hydroxamic acid derivatives, process for the production thereof and drugs containing the same as the active ingredient

Also Published As

Publication number Publication date
US6512123B2 (en) 2003-01-28
KR100591501B1 (ko) 2006-06-19
ATE306480T1 (de) 2005-10-15
MXPA03009132A (es) 2004-02-12
ZA200307793B (en) 2005-01-06
DE60206616D1 (de) 2006-02-23
CN1507441A (zh) 2004-06-23
KR20030090771A (ko) 2003-11-28
CR9430A (es) 2008-04-25
JP4142453B2 (ja) 2008-09-03
EP1385837A1 (en) 2004-02-04
CA2442994A1 (en) 2002-10-31
WO2002085883A1 (en) 2002-10-31
AU2002254991B2 (en) 2007-07-19
ES2249572T3 (es) 2006-04-01
US20020183513A1 (en) 2002-12-05
EP1385837B1 (en) 2005-10-12
DE60206616T2 (de) 2006-07-13
JP2005503341A (ja) 2005-02-03
CN1310904C (zh) 2007-04-18
AR035455A1 (es) 2004-05-26

Similar Documents

Publication Publication Date Title
BR0209064A (pt) Hidroxamatos de alquila tricìclicos, sua preparaçãoe seu uso como inibidores de proliferação de células
BR0116402A (pt) Derivados de tetrahidropiridina, sua preparação e sua utilização como inibidores de proliferação celular
BR0307575A (pt) Derivados de sulfonila como inibidores de histona desacetilase
BR0307606A (pt) Derivados de piperazinila, piperidinila e morfolinila como inibidores de histona desacetilase
BR0308081A (pt) Inibidores de histona desacetilase
BR0108678A (pt) Novos compostos
BR0307607A (pt) Derivados de carbonilamino como inibidores de histona desacetilase
BR0307599A (pt) Derivados de sulfonilamino como inibidores de histona deacetilase
BRPI0414111A (pt) inibidores heterocìclicos de mek e métodos de uso dos mesmos
BR0214666A (pt) Derivados de acetileno tendo atividade antagonìstica de mglur5
BR0111667A (pt) Novos compostos
ECSP055671A (es) Nuevas quinazolinonas espirocondensadas y su uso como inhibidores de la fosfodiesteresa
EA200201271A1 (ru) Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
BRPI0312464B8 (pt) compostos inibidores de tirosina quinases, composições farmacêuticas compreendendo os mesmos, processos para fabricação e usos dos mesmos
NO20013220D0 (no) Trombineinhibitorer
SE0301888D0 (sv) New use VII
BRPI0515594A (pt) inibidores da interação entre mdm2 e p53
BRPI0419305B8 (pt) compostos inibidores de p38, composições farmacêuticas compreendendo os mesmos e usos dos referidos compostos na preparação de medicamentos
BR0317348A (pt) EnantiÈmeros de derivados de ácido tiofeno hidroxâmico e seu uso como inibidores de hdac
BRPI0413094A (pt) derivados de quinolina e seu uso em terapia
SE9802206D0 (sv) Novel compounds
BR0315820A (pt) Inibidores de integrase de hiv, composições farmacêuticas e métodos para a sua utilização
SE0203070D0 (en) Novel compounds
BR0211903A (pt) Isoxazolopiridinonas
BRPI0416745A (pt) novos compostos

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A(S) 8A E 9A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011.