CR9430A - N-hidroxiamidas omega-sustituidas con grupos triciclos como inhibidores de histona desacetilasa, su preparacion y uso en formulaciones farmaceuticas - Google Patents

N-hidroxiamidas omega-sustituidas con grupos triciclos como inhibidores de histona desacetilasa, su preparacion y uso en formulaciones farmaceuticas

Info

Publication number
CR9430A
CR9430A CR9430A CR9430A CR9430A CR 9430 A CR9430 A CR 9430A CR 9430 A CR9430 A CR 9430A CR 9430 A CR9430 A CR 9430A CR 9430 A CR9430 A CR 9430A
Authority
CR
Costa Rica
Prior art keywords
omega
inhibitors
substituted
hydroxiamides
tricycles
Prior art date
Application number
CR9430A
Other languages
English (en)
Inventor
Guido Antonio
Dimoulas Tula
Giannotti Danilo
Harmat Nicholas
Original Assignee
Menarini Int Operations Lu Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Int Operations Lu Sa filed Critical Menarini Int Operations Lu Sa
Publication of CR9430A publication Critical patent/CR9430A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Se describen nuevas N-hidroxiamidas de acidos n-alquil carboxilicos omega sustituidos con oportuno sistema triciclico caracterizado por un anillo central de siete miembros que tienen la actividad como inhibidores de la histona desacetilasa (HDAC).
CR9430A 2001-04-23 2007-10-11 N-hidroxiamidas omega-sustituidas con grupos triciclos como inhibidores de histona desacetilasa, su preparacion y uso en formulaciones farmaceuticas CR9430A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01109428 2001-04-23

Publications (1)

Publication Number Publication Date
CR9430A true CR9430A (es) 2008-04-25

Family

ID=8177162

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9430A CR9430A (es) 2001-04-23 2007-10-11 N-hidroxiamidas omega-sustituidas con grupos triciclos como inhibidores de histona desacetilasa, su preparacion y uso en formulaciones farmaceuticas

Country Status (16)

Country Link
US (1) US6512123B2 (es)
EP (1) EP1385837B1 (es)
JP (1) JP4142453B2 (es)
KR (1) KR100591501B1 (es)
CN (1) CN1310904C (es)
AR (1) AR035455A1 (es)
AT (1) ATE306480T1 (es)
AU (1) AU2002254991B2 (es)
BR (1) BR0209064A (es)
CA (1) CA2442994A1 (es)
CR (1) CR9430A (es)
DE (1) DE60206616T2 (es)
ES (1) ES2249572T3 (es)
MX (1) MXPA03009132A (es)
WO (1) WO2002085883A1 (es)
ZA (1) ZA200307793B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US6822267B1 (en) * 1997-08-20 2004-11-23 Advantest Corporation Signal transmission circuit, CMOS semiconductor device, and circuit board
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2004067480A2 (en) * 2003-01-25 2004-08-12 Oxford Glycosciences (Uk) Ltd Substituted phenylurea derivatives as hdac inhibitors
JP2006520796A (ja) * 2003-03-17 2006-09-14 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼインヒビター
PT2238982E (pt) * 2003-06-27 2013-01-22 Astellas Pharma Inc Agente terapêutico para o sarcoma de tecidos moles
EP1713460A2 (en) * 2003-12-10 2006-10-25 Wisconsin Alumni Research Foundation Fk228 analogs and their use as hdac-inhibitors
WO2005065681A1 (en) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer
US20050137234A1 (en) * 2003-12-19 2005-06-23 Syrrx, Inc. Histone deacetylase inhibitors
US20060128660A1 (en) * 2004-12-10 2006-06-15 Wisconsin Alumni Research Foundation FK228 analogs and methods of making and using the same
EP1824831A2 (en) * 2004-12-16 2007-08-29 Takeda San Diego, Inc. Histone deacetylase inhibitors
IT1362675B (it) * 2005-03-15 2009-06-25 Menarini Internat Operations Luxembourg Sa N-idrossiammidi -sostituiti con gruppi triciclici come inibitori dell'istone deacelitasi,loro preparazione ed impiego in formulazioni farmaceutiche
EP2491926B1 (en) 2005-03-22 2018-05-09 President and Fellows of Harvard College Treatment of protein degradation disorders
JP2008540574A (ja) * 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
UA99810C2 (ru) * 2005-05-13 2012-10-10 Топотаргет Юк Лимитед Фармацевтические составы, которые содержат ингибиторы деацетилазы гистонов
BRPI0613429A2 (pt) 2005-07-14 2009-02-10 Takeda San Diego Inc inibidores de histona desacetilase
WO2007077111A1 (en) * 2005-12-30 2007-07-12 F. Hoffmann-La Roche Ag Compounds and methods for carbazole synthesis
WO2007084390A2 (en) * 2006-01-13 2007-07-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
MX2008010462A (es) 2006-02-14 2009-04-17 Harvard College Inhibidores de histona desacetilasa.
CA2642273C (en) 2006-02-14 2016-09-20 President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
CN101484156B (zh) * 2006-05-03 2015-11-25 哈佛大学校长及研究员协会 组蛋白脱乙酰基酶和微管蛋白脱乙酰基酶抑制剂
ES2288803B1 (es) * 2006-07-07 2008-12-16 Universidad De Granada Derivados de benzo(d)isotiazoles como inhibidores de las histonas desacetilasas.
AU2013205135B2 (en) * 2006-10-28 2015-11-05 Forum Pharmaceuticals Inc. Inhibitors of histone deacetylase
CN103275067B (zh) * 2006-10-28 2015-09-02 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
WO2010011296A2 (en) 2008-07-23 2010-01-28 President And Fellows Of Harvard College Deacetylase inhibitors and uses thereof
JP2012051804A (ja) * 2008-12-26 2012-03-15 Kyoto Univ Ｅｇ５阻害剤
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
US10106488B2 (en) * 2014-01-28 2018-10-23 Nippon Shokubai Co., Ltd. Hydrogenation reaction method
US10011611B2 (en) 2015-08-14 2018-07-03 Reaction Biology Corp. Histone deacetylase inhibitors and methods for use thereof
WO2023020416A1 (zh) * 2021-08-16 2023-02-23 勤浩医药（苏州）有限公司 三环化合物、包含其的药物组合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2208893A1 (de) 1972-02-25 1973-08-30 Boehringer Mannheim Gmbh Tricyclische alpha-oxy-carbonsaeurederivate und verfahren zur herstellung derselben
US5369108A (en) * 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
ZA938897B (en) * 1992-12-01 1994-08-01 Smithkline Beecham Corp Antioxidant neuroprotective use of and method of treatment using hydroxycarbazole compounds
NZ333063A (en) * 1996-09-04 2000-12-22 Warner Lambert Co Dibenzofuran sulfonamide derivatives as matrix metalloproteinase inhibitors
AUPO721997A0 (en) * 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
US6770644B1 (en) * 1999-09-24 2004-08-03 Ono Pharmaceuticals Co., Ltd. Hydroxamic acid derivatives, process for the production thereof and drug containing the same as the active ingredient

Also Published As

Publication number Publication date
DE60206616D1 (de) 2006-02-23
ATE306480T1 (de) 2005-10-15
EP1385837B1 (en) 2005-10-12
CN1507441A (zh) 2004-06-23
AU2002254991B2 (en) 2007-07-19
ZA200307793B (en) 2005-01-06
MXPA03009132A (es) 2004-02-12
JP2005503341A (ja) 2005-02-03
ES2249572T3 (es) 2006-04-01
WO2002085883A1 (en) 2002-10-31
KR100591501B1 (ko) 2006-06-19
BR0209064A (pt) 2004-08-10
JP4142453B2 (ja) 2008-09-03
CA2442994A1 (en) 2002-10-31
CN1310904C (zh) 2007-04-18
DE60206616T2 (de) 2006-07-13
US6512123B2 (en) 2003-01-28
AR035455A1 (es) 2004-05-26
EP1385837A1 (en) 2004-02-04
KR20030090771A (ko) 2003-11-28
US20020183513A1 (en) 2002-12-05

Similar Documents

Publication Publication Date Title
CR9430A (es) N-hidroxiamidas omega-sustituidas con grupos triciclos como inhibidores de histona desacetilasa, su preparacion y uso en formulaciones farmaceuticas
NI200700222A (es) N-hydroxiamidas omega-sustituidas con grupos triciclicos como inhibidores de histona de desacetilasa, su preparación y su uso en formulaciones farmacéuticas.
PT102854B (pt) Sistema de aplicacao de medicamento bioadesivo
EA200501586A1 (ru) Фармацевтические продукты
DE60313597D1 (de) Topische pharmazeutische zusammensetzungen mit proanthocyanidinen, glycyrrhetinic säure und telmesteine zur behandlung von dermatitis
BR0301247B1 (pt) sistema cirérgico de passagem de lÍquido.
EA200301250A1 (ru) Фармацевтические композиции, содержащие слаборастворимые и/или чувствительные к кислотам лекарственные средства и нейтрализованные кислотные полимеры
BR9916894A (pt) ácidos sulfohidroxâmicos e sulfohidroxamatos eseu uso como inibidores de mek
NO20014134D0 (no) Forbindelser med kondensert ring og anvendelse derav som legemidler
BRPI0010891B8 (pt) geração de microespuma terapêutica.
MA27018A1 (fr) Forme dosifiee pharmaceutique de mesylate de nelfinavir amorphe.
BR0003632B1 (pt) absorvente Íntimo adaptado para ser usado em uma porÇço entre as pernas de uma roupa debaixo.
IT1318319B1 (it) Composizione di gomma, procedimento per produrre la stessa e manicottoutilizzante la composizione di gomma.
EA200401227A1 (ru) Система доставки лекарства с контролируемым высвобождением, включающая правастатин
BR0010418B1 (pt) microorganismo de salmonella, composiÇço de vacina e uso do referido microorganismo.
BR0114903A (pt) 7-azaindóis, sua aplicação como inibidores da fosfodiesterase 4 e processos para a sua preparação
NO20023551D0 (no) Ibuprofen-inneholdende aktivt middel-preparat
BR9713370A (pt) Processos para fabricação de metoprolol e de uma preparação farmacêutica, e, metoprolol
FR2845917B1 (fr) Composition pharmaceutique associant le tenatoprazole et un anti-inflammatoire
AR042652A1 (es) Bromhidrato de escitalopram y un metodo para su preparacion
TR199900548A3 (tr) Düsük kesme kuvvetli taneleme kullanilarak dozaj birimlerinin yapimi.
EA200300727A1 (ru) Производные 2h-1-бензопирана, способы их получения и их фармацевтические композиции
EA200100802A1 (ru) Применение тианептина при приготовлении лекарственных средств, предназначенных для лечения нейродегенеративных патологий
ATE270551T1 (de) Kombinationspräparat aus 2-methylthiazolidin-2,4- dicarbonsäure und paracetamol
IT1320854B1 (it) Sistema per la fermentazione di sostanze vegetali, in particolare peruva.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)