ATE306480T1 - Trizyclische alkylhydroxamate, ihre herstellung und ihre verwendung als inhibitoren der zellproliferation - Google Patents

Trizyclische alkylhydroxamate, ihre herstellung und ihre verwendung als inhibitoren der zellproliferation

Info

Publication number
ATE306480T1
ATE306480T1 AT02724292T AT02724292T ATE306480T1 AT E306480 T1 ATE306480 T1 AT E306480T1 AT 02724292 T AT02724292 T AT 02724292T AT 02724292 T AT02724292 T AT 02724292T AT E306480 T1 ATE306480 T1 AT E306480T1
Authority
AT
Austria
Prior art keywords
trizyclic
preparation
cell proliferation
proliferation inhibitors
alkyl hydroxamates
Prior art date
Application number
AT02724292T
Other languages
English (en)
Inventor
Adelbert Grossmann
Der Saal Wolfgang Von
Tim Sattelkau
Ulrich Tibes
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE306480T1 publication Critical patent/ATE306480T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)
AT02724292T 2001-04-23 2002-04-19 Trizyclische alkylhydroxamate, ihre herstellung und ihre verwendung als inhibitoren der zellproliferation ATE306480T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01109428 2001-04-23
PCT/EP2002/004349 WO2002085883A1 (en) 2001-04-23 2002-04-19 Tricyclic alkylhydroxamates, their preparation and their use as cell proliferation inhibitors

Publications (1)

Publication Number Publication Date
ATE306480T1 true ATE306480T1 (de) 2005-10-15

Family

ID=8177162

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02724292T ATE306480T1 (de) 2001-04-23 2002-04-19 Trizyclische alkylhydroxamate, ihre herstellung und ihre verwendung als inhibitoren der zellproliferation

Country Status (16)

Country Link
US (1) US6512123B2 (de)
EP (1) EP1385837B1 (de)
JP (1) JP4142453B2 (de)
KR (1) KR100591501B1 (de)
CN (1) CN1310904C (de)
AR (1) AR035455A1 (de)
AT (1) ATE306480T1 (de)
AU (1) AU2002254991B2 (de)
BR (1) BR0209064A (de)
CA (1) CA2442994A1 (de)
CR (1) CR9430A (de)
DE (1) DE60206616T2 (de)
ES (1) ES2249572T3 (de)
MX (1) MXPA03009132A (de)
WO (1) WO2002085883A1 (de)
ZA (1) ZA200307793B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US6822267B1 (en) * 1997-08-20 2004-11-23 Advantest Corporation Signal transmission circuit, CMOS semiconductor device, and circuit board
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2004067480A2 (en) * 2003-01-25 2004-08-12 Oxford Glycosciences (Uk) Ltd Substituted phenylurea derivatives as hdac inhibitors
WO2004082638A2 (en) 2003-03-17 2004-09-30 Syrrx, Inc. Histone deacetylase inhibitors
EP2238982B8 (de) 2003-06-27 2013-01-16 Astellas Pharma Inc. Therapiemittel für Weichgewebesarkom
WO2005058298A2 (en) * 2003-12-10 2005-06-30 Wisconsin Alumni Research Foundation Fk228 analogs and their use as hdac-inhibitors
US20050159470A1 (en) * 2003-12-19 2005-07-21 Syrrx, Inc. Histone deacetylase inhibitors
US20050137234A1 (en) * 2003-12-19 2005-06-23 Syrrx, Inc. Histone deacetylase inhibitors
US20060128660A1 (en) * 2004-12-10 2006-06-15 Wisconsin Alumni Research Foundation FK228 analogs and methods of making and using the same
US7642275B2 (en) * 2004-12-16 2010-01-05 Takeda San Diego, Inc. Histone deacetylase inhibitors
IT1362675B (it) * 2005-03-15 2009-06-25 Menarini Internat Operations Luxembourg Sa N-idrossiammidi -sostituiti con gruppi triciclici come inibitori dell'istone deacelitasi,loro preparazione ed impiego in formulazioni farmaceutiche
AU2006226861B2 (en) 2005-03-22 2012-08-16 Dana-Farber Cancer Institute, Inc. Treatment of protein degradation disorders
WO2006122319A2 (en) * 2005-05-11 2006-11-16 Takeda San Diego, Inc. Histone deacetylase inhibitors
ES2540204T3 (es) * 2005-05-13 2015-07-09 Topotarget Uk Limited Formulaciones farmacéuticas de inhibidores de la HDAC
ZA200800901B (en) 2005-07-14 2010-05-26 Takeda San Diego Inc Histone deacetylase inhibitors
WO2007077111A1 (en) * 2005-12-30 2007-07-12 F. Hoffmann-La Roche Ag Compounds and methods for carbazole synthesis
JP2009525955A (ja) * 2006-01-13 2009-07-16 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
ES2481413T3 (es) 2006-02-14 2014-07-30 The President And Fellows Of Harvard College Inhibidores de histona desacetilasa
CA2642273C (en) 2006-02-14 2016-09-20 President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
JP5497431B2 (ja) * 2006-05-03 2014-05-21 プレジデント アンド フェローズ オブ ハーバード カレッジ ヒストンデアセチラーゼおよびチューブリンデアセチラーゼ阻害剤
ES2288803B1 (es) * 2006-07-07 2008-12-16 Universidad De Granada Derivados de benzo(d)isotiazoles como inhibidores de las histonas desacetilasas.
CL2007003108A1 (es) * 2006-10-28 2008-07-18 Methylgene Inc Envivo Pharmace Compuestos derivados de n-hidroxiamida sustituida con heterociclos, inhibidores de histona desacetilasa; composicion farmaceutica que comprende a dichos compuestos; y uso para tratar una enfermedad del grupo que consiste en enfermedad de huntington,
AU2013205135B2 (en) * 2006-10-28 2015-11-05 Forum Pharmaceuticals Inc. Inhibitors of histone deacetylase
JP5665740B2 (ja) 2008-07-23 2015-02-04 プレジデント アンド フェローズ オブ ハーバード カレッジ デアセチラーゼ阻害剤およびその使用
JP2012051804A (ja) * 2008-12-26 2012-03-15 Kyoto Univ Ｅｇ５阻害剤
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
US10106488B2 (en) * 2014-01-28 2018-10-23 Nippon Shokubai Co., Ltd. Hydrogenation reaction method
WO2017030892A1 (en) 2015-08-14 2017-02-23 Reaction Biology Corp. Histone deacetylase inhibitors and methods for use thereof
WO2023020416A1 (zh) * 2021-08-16 2023-02-23 勤浩医药（苏州）有限公司 三环化合物、包含其的药物组合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2208893A1 (de) 1972-02-25 1973-08-30 Boehringer Mannheim Gmbh Tricyclische alpha-oxy-carbonsaeurederivate und verfahren zur herstellung derselben
US5369108A (en) * 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
ZA938897B (en) * 1992-12-01 1994-08-01 Smithkline Beecham Corp Antioxidant neuroprotective use of and method of treatment using hydroxycarbazole compounds
WO1998009934A1 (en) * 1996-09-04 1998-03-12 Warner-Lambert Company Matrix metalloproteinase inhibitors and their therapeutic uses
AUPO721997A0 (en) * 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
AU7320100A (en) * 1999-09-24 2001-04-24 Ono Pharmaceutical Co. Ltd. Hydroxamic acid derivatives, process for the production thereof and drugs containing the same as the active ingredient

Also Published As

Publication number Publication date
CN1507441A (zh) 2004-06-23
BR0209064A (pt) 2004-08-10
CA2442994A1 (en) 2002-10-31
AU2002254991B2 (en) 2007-07-19
WO2002085883A1 (en) 2002-10-31
ZA200307793B (en) 2005-01-06
MXPA03009132A (es) 2004-02-12
KR100591501B1 (ko) 2006-06-19
EP1385837A1 (de) 2004-02-04
JP4142453B2 (ja) 2008-09-03
ES2249572T3 (es) 2006-04-01
AR035455A1 (es) 2004-05-26
EP1385837B1 (de) 2005-10-12
US6512123B2 (en) 2003-01-28
CN1310904C (zh) 2007-04-18
DE60206616D1 (de) 2006-02-23
CR9430A (es) 2008-04-25
JP2005503341A (ja) 2005-02-03
DE60206616T2 (de) 2006-07-13
KR20030090771A (ko) 2003-11-28
US20020183513A1 (en) 2002-12-05

Similar Documents

Publication Publication Date Title
ATE306480T1 (de) Trizyclische alkylhydroxamate, ihre herstellung und ihre verwendung als inhibitoren der zellproliferation
DE60208661D1 (de) Diaminothiazole und ihre verwendung als cyclinabhängige kinase inhibitoren
FR12C0019I2 (fr) O-cyclopropyle-carboxanilides et leur utilisation comme fongicides
ATE339419T1 (de) Pyrazolenthaltende zusammensetzungen und ihre verwendung als gsk-3 inhibitoren
DE60317093D1 (de) Chinolin-; isochinolin- und chinazolinoxyalkylamide und ihre verwendung als fungizide
ATE424202T1 (de) Substituierte 2-thio-3,5-dicyano-4-phenyl-6- aminopyridine und ihre verwendung
DE60118975D1 (de) Tetrahydropyridinderivate, deren herstellung und deren verwendung als inhibitoren der zellproliferation
DE69926800D1 (de) Benzoheterozyklen und ihre verwendung als mek inhibitoren
DE60036803D1 (de) Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel
DE50207849D1 (de) Substituierte 2-oxy-3,5-dicyano-4-aryl-6-aminopyridine und ihre verwendung
DE60123210D1 (de) Picolinsäure-derivate und ihre verwendung als fungizide
ATE329906T1 (de) Substituierte 2-anilino-benzimidazole und ihre verwendung als nhe-inhibitoren
DE602004028934D1 (de) Benzoä4,5üthienoä2,3-düpyrimidin-4-one und ihre therapeutische verwendung
DE60200427D1 (de) Vernetzbare Fluorelastomerzusammensetzungen, ihre Herstellung und Verwendung
ATE432701T1 (de) Indol-6-sulfonamid-derivate, ihre herstellung und ihre verwendung als 5-ht-6 modulatoren
DE602004010426D1 (de) Mikrobizide zusammensetzungen und ihre verwendung
DE60321958D1 (de) Indazolderivate und ihre verwendung als crf antagonisten
DE50313157D1 (de) Phenylaminopyrimidine und ihre verwendung als rho-kinase inhibitoren
DE50206094D1 (de) Substituierte isoindole und ihre verwendung
ATE362469T1 (de) 2,7-disubstituierteindole und ihre verwendung als 5-ht6 modulatoren
DE60318317D1 (de) Acylaminothiazolderivate und ihre vewrendung als beta-amyloid inhibitoren
DE60230162D1 (de) Polymerisate und ihre verwendung
ATE396994T1 (de) 3-phenylpyridoindolderivate, ihre herstellung und verwendung
DE50008549D1 (de) Triazolotriazinone und ihre verwendung
ATE353083T1 (de) Naphthyridin-derivate und ihre verwendung als fungizide

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1385837

Country of ref document: EP

REN Ceased due to non-payment of the annual fee