DE60318317D1 - Acylaminothiazolderivate und ihre vewrendung als beta-amyloid inhibitoren - Google Patents

Acylaminothiazolderivate und ihre vewrendung als beta-amyloid inhibitoren

Info

Publication number
DE60318317D1
DE60318317D1 DE60318317T DE60318317T DE60318317D1 DE 60318317 D1 DE60318317 D1 DE 60318317D1 DE 60318317 T DE60318317 T DE 60318317T DE 60318317 T DE60318317 T DE 60318317T DE 60318317 D1 DE60318317 D1 DE 60318317D1
Authority
DE
Germany
Prior art keywords
acylaminothiazol
beta
utilization
derivatives
amyloid inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60318317T
Other languages
English (en)
Other versions
DE60318317T2 (de
Inventor
Sylvie Baltzer
Bruno Schoentjes
Dorsselaer Viviane Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of DE60318317D1 publication Critical patent/DE60318317D1/de
Application granted granted Critical
Publication of DE60318317T2 publication Critical patent/DE60318317T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
DE60318317T 2002-07-17 2003-07-11 Acylaminothiazolderivate und ihre vewrendung als beta-amyloid inhibitoren Expired - Lifetime DE60318317T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0209061 2002-07-17
FR0209061A FR2842523A1 (fr) 2002-07-17 2002-07-17 Derives d'acylaminothiazole, leur preparation et leur application en therapeutique
PCT/FR2003/002194 WO2004009565A2 (fr) 2002-07-17 2003-07-11 Derives d'acylaminothiazole, leur utilisation comme inhibiteurs de beta-amyloi

Publications (2)

Publication Number Publication Date
DE60318317D1 true DE60318317D1 (de) 2008-02-07
DE60318317T2 DE60318317T2 (de) 2009-07-09

Family

ID=29797510

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60318317T Expired - Lifetime DE60318317T2 (de) 2002-07-17 2003-07-11 Acylaminothiazolderivate und ihre vewrendung als beta-amyloid inhibitoren

Country Status (14)

Country Link
US (2) US7291636B2 (de)
EP (1) EP1525193B1 (de)
JP (1) JP4680593B2 (de)
AR (1) AR040570A1 (de)
AT (1) ATE382040T1 (de)
AU (1) AU2003269018A1 (de)
CY (1) CY1107903T1 (de)
DE (1) DE60318317T2 (de)
DK (1) DK1525193T3 (de)
ES (1) ES2297198T3 (de)
FR (1) FR2842523A1 (de)
PT (1) PT1525193E (de)
TW (1) TWI313680B (de)
WO (1) WO2004009565A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2842523A1 (fr) * 2002-07-17 2004-01-23 Sanofi Synthelabo Derives d'acylaminothiazole, leur preparation et leur application en therapeutique
KR20050070046A (ko) * 2002-10-09 2005-07-05 화이자 프로덕츠 인크. 퇴행성신경 장애 치료를 위한 티아졸 화합물
TWI349550B (en) * 2003-12-26 2011-10-01 A thiazole derivative and adenosine a2a receptor antagonist containing the same
FR2865206B1 (fr) * 2004-01-16 2009-02-06 Sanofi Synthelabo Derives d'acylaminothiazole, leur preparation et leur application en therapeutique
DK1709018T3 (da) 2004-01-16 2011-11-14 Sanofi Sa Acylaminothiazolderivater og anvendelse deraf som beta-amyloid-hæmmere
NZ548531A (en) * 2004-01-16 2010-01-29 Sanofi Aventis Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics
FR2873370B1 (fr) * 2004-07-22 2006-10-20 Sanofi Synthelabo Derives d'acylaminothiazole, leur preparation et leur application en therapeutique
US7384968B2 (en) 2004-04-01 2008-06-10 Pfizer Inc. Thiazole-amine compounds for the treatment of neurodegenerative disorders
US20050222227A1 (en) * 2004-04-01 2005-10-06 Pfizer Inc Oxazole-amine compounds for the treatment of neurodegenerative disorders
JP4866851B2 (ja) 2004-08-03 2012-02-01 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 神経変性疾患の処置のための１−フェニルアルカンカルボン酸の誘導体
ES2389062T3 (es) * 2006-01-18 2012-10-22 Amgen, Inc Compuestos de tiazol como inhibidores de proteína cinasa B (PKB)
WO2007116901A1 (ja) * 2006-04-05 2007-10-18 Banyu Pharmaceutical Co., Ltd. 新規アリールアミド誘導体
CN100415709C (zh) * 2006-05-15 2008-09-03 西北大学 β-(3,4-二羟基苯基)-α-羟基丙酸冰片酯、其合成方法和用途
DE102006048042A1 (de) * 2006-10-11 2008-04-17 Bayer Healthcare Ag Acylaminoimidazole und Acylaminothiazole
WO2009011871A2 (en) * 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of pkb
EP2173728A2 (de) 2007-07-17 2010-04-14 Amgen Inc. Heterocyclische pkb-modulatoren
JP2012505263A (ja) * 2008-10-14 2012-03-01 アクテリオン ファーマシューティカルズ リミテッド フェネチルアミド誘導体及びそれらのヘテロシクリル類似体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3796800A (en) * 1971-11-22 1974-03-12 Uniroyal Inc Anti-inflammatory triazole compositions and methods for using same
FR2546520B1 (fr) * 1983-05-27 1985-08-30 Sanofi Sa Nouveaux composes antibiotiques derives des cephalosporines
US5712270A (en) * 1995-11-06 1998-01-27 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity
CA2267065A1 (en) * 1996-11-22 1998-05-28 Elan Pharmaceuticals, Inc. N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositionscomprising same, and methods for inhibiting beta-amyloid peptide release a nd/or its synthesis by use of such compounds
FR2842523A1 (fr) * 2002-07-17 2004-01-23 Sanofi Synthelabo Derives d'acylaminothiazole, leur preparation et leur application en therapeutique
KR20050070046A (ko) * 2002-10-09 2005-07-05 화이자 프로덕츠 인크. 퇴행성신경 장애 치료를 위한 티아졸 화합물

Also Published As

Publication number Publication date
TW200413341A (en) 2004-08-01
WO2004009565A2 (fr) 2004-01-29
TWI313680B (en) 2009-08-21
ATE382040T1 (de) 2008-01-15
JP2005538086A (ja) 2005-12-15
EP1525193A2 (de) 2005-04-27
FR2842523A1 (fr) 2004-01-23
US20080051436A1 (en) 2008-02-28
WO2004009565A3 (fr) 2004-04-08
DE60318317T2 (de) 2009-07-09
PT1525193E (pt) 2008-02-25
US7291636B2 (en) 2007-11-06
DK1525193T3 (da) 2008-04-28
JP4680593B2 (ja) 2011-05-11
CY1107903T1 (el) 2013-09-04
EP1525193B1 (de) 2007-12-26
ES2297198T3 (es) 2008-05-01
US20050182104A1 (en) 2005-08-18
AU2003269018A1 (en) 2004-02-09
US7795289B2 (en) 2010-09-14
AR040570A1 (es) 2005-04-13

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