ATE423117T1 - Heterocyclische 7-aminoalkylidenylchinolone und - naphthyridone - Google Patents

Heterocyclische 7-aminoalkylidenylchinolone und - naphthyridone

Info

Publication number
ATE423117T1
ATE423117T1 AT04783671T AT04783671T ATE423117T1 AT E423117 T1 ATE423117 T1 AT E423117T1 AT 04783671 T AT04783671 T AT 04783671T AT 04783671 T AT04783671 T AT 04783671T AT E423117 T1 ATE423117 T1 AT E423117T1
Authority
AT
Austria
Prior art keywords
aminoalkylidenylquinolones
naphthyridones
heterocyclic
Prior art date
Application number
AT04783671T
Other languages
English (en)
Inventor
Grant Iii Eugene Bowers
Mark Joseph Macielag
Xiaoqing Xu
Steven David Paget
Michele Ann Weidner-Wells
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE423117T1 publication Critical patent/ATE423117T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT04783671T 2003-09-22 2004-09-09 Heterocyclische 7-aminoalkylidenylchinolone und - naphthyridone ATE423117T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50492403P 2003-09-22 2003-09-22

Publications (1)

Publication Number Publication Date
ATE423117T1 true ATE423117T1 (de) 2009-03-15

Family

ID=34421521

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04783671T ATE423117T1 (de) 2003-09-22 2004-09-09 Heterocyclische 7-aminoalkylidenylchinolone und - naphthyridone

Country Status (24)

Country Link
US (1) US7179805B2 (de)
EP (1) EP1675852B1 (de)
JP (2) JP2007522093A (de)
KR (1) KR101137311B1 (de)
CN (1) CN1997642B (de)
AR (1) AR045805A1 (de)
AT (1) ATE423117T1 (de)
AU (1) AU2004278320B2 (de)
BR (1) BRPI0414573A (de)
CA (1) CA2539349C (de)
CY (1) CY1109424T1 (de)
DE (1) DE602004019555D1 (de)
DK (1) DK1675852T3 (de)
ES (1) ES2321722T3 (de)
IL (1) IL174397A (de)
MY (1) MY176860A (de)
NZ (1) NZ545970A (de)
PL (1) PL1675852T3 (de)
PT (1) PT1675852E (de)
RU (1) RU2350615C2 (de)
SI (1) SI1675852T1 (de)
TW (1) TWI359150B (de)
WO (1) WO2005033108A1 (de)
ZA (1) ZA200603223B (de)

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* Cited by examiner, † Cited by third party
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WO2004066824A2 (en) * 2003-01-24 2004-08-12 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
US7732612B2 (en) * 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
AU2012244358B2 (en) * 2005-03-21 2015-05-28 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
EP1891037A1 (de) * 2005-06-15 2008-02-27 Hetero Drugs Limited Gemifloxacin-verfahren und - polymorphe
JO2752B1 (en) * 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
US7345178B2 (en) 2005-08-04 2008-03-18 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
CA2620933A1 (en) * 2005-09-02 2007-03-08 Pfizer Inc. Hydroxy substituted 1h-imidazopyridines and methods
DK1954697T3 (da) * 2005-10-21 2010-06-14 Glaxo Group Ltd Peri-kondenserede tricykliske forbindelser, der er anvendelige som antibakterielle midler
DE602006013878D1 (de) 2005-12-22 2010-06-02 Glaxo Group Ltd Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel
MX2008012328A (es) * 2006-03-28 2008-10-09 Procter & Gamble Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil- piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinc arboxilico.
WO2007110836A1 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A hydride reduction process for preparing quinolone intermediates
JP2009531418A (ja) 2006-03-28 2009-09-03 ザ プロクター アンド ギャンブル カンパニー キノロン中間体調製のためのカップリング方法
US20080009628A1 (en) * 2006-07-05 2008-01-10 Michael Reuman One-Pot Condensation-Reduction Methods for Preparing Substituted Allylic Alcohols
JP5824213B2 (ja) * 2007-10-05 2015-11-25 センワ バイオサイエンシズ インコーポレイテッド キノロン類似体およびそれに関連する方法
SG176056A1 (en) 2009-05-15 2011-12-29 Redx Pharma Ltd Redox drug derivatives
BR112012017004A2 (pt) * 2010-01-11 2016-04-05 Janssen Pharmaceutica Nv pró-fármacos de ácido (e)-7-(3-(2-amino-1-fluoroetilideno) piperidin-1-il)-1-ciclopropil-6-fluoro-8-metóxi-4-oxo-1,4-diidroquinolina-3-carboxílico
CN104098588B (zh) * 2013-04-02 2016-05-25 广州白云山医药集团股份有限公司白云山制药总厂 一类三环喹诺酮衍生物及其制备方法和用途
WO2015179547A2 (en) * 2014-05-21 2015-11-26 New York University Oxopiperazine helix mimetics for control of hypoxia-inducible gene expression
US10857156B2 (en) 2015-11-20 2020-12-08 Senhwa Biosciences, Inc. Combination therapy of tetracyclic quinolone analogs for treating cancer
US9957282B2 (en) 2015-12-14 2018-05-01 Senhwa Biosciences, Inc. Crystalline forms of quinolone analogs and their salts
CN112334133A (zh) 2018-02-15 2021-02-05 生华生物科技股份有限公司 喹诺酮类似物及其盐、组合物及其使用方法
RU2671573C1 (ru) * 2018-09-03 2018-11-02 Алина Викторовна Шумадалова 2-[6-метил-4-(тиетан-3-илокси)пиримидин-2-илтио]ацетогидразид малеиновой кислоты, проявляющий противомикробную активность

Family Cites Families (13)

* Cited by examiner, † Cited by third party
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JPS605539B2 (ja) * 1980-03-17 1985-02-12 日東紡績株式会社 耐アルカリ性、耐熱性無機質繊維
DK164287A (da) * 1986-03-31 1987-10-01 Sankyo Co Quinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf og deres anvendelse
JPH0262875A (ja) * 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体
CA1332605C (en) * 1988-10-03 1994-10-18 Yasuhiro Nishitani Pyridonecarboxylic acids
US5580872A (en) * 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
JPH06263754A (ja) * 1993-03-12 1994-09-20 Hokuriku Seiyaku Co Ltd 7−アミノピロリジニルキノリン−3−カルボン酸誘導体
CN1053188C (zh) * 1993-10-14 2000-06-07 艾博特公司 喹嗪酮类化合物
US5392154A (en) * 1994-03-30 1995-02-21 Bell Communications Research, Inc. Self-regulating multiwavelength optical amplifier module for scalable lightwave communications systems
IL122296A0 (en) * 1995-06-06 1998-04-05 Abbott Lab Quinolizinone type compounds
PL339408A1 (en) * 1997-09-15 2000-12-18 Procter & Gamble Antimicrobial quinolones, agents containing them and their applications
KR100330409B1 (ko) * 1998-07-23 2002-08-27 한국과학기술원 파장분할다중 방식 다중화/역다중화 장치와 이를 이용한 파장분할다중 방식 수동형 광 가입자망
US6964966B2 (en) * 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments

Also Published As

Publication number Publication date
SI1675852T1 (sl) 2009-06-30
US20050101588A1 (en) 2005-05-12
BRPI0414573A (pt) 2006-11-07
IL174397A (en) 2014-01-30
US7179805B2 (en) 2007-02-20
PL1675852T3 (pl) 2009-07-31
CA2539349C (en) 2012-06-05
DK1675852T3 (da) 2009-05-25
PT1675852E (pt) 2009-03-25
JP2012162529A (ja) 2012-08-30
KR101137311B1 (ko) 2012-04-23
CN1997642A (zh) 2007-07-11
EP1675852B1 (de) 2009-02-18
ZA200603223B (en) 2007-09-26
MY176860A (en) 2020-08-24
RU2350615C2 (ru) 2009-03-27
TWI359150B (en) 2012-03-01
AU2004278320A1 (en) 2005-04-14
IL174397A0 (en) 2006-08-01
JP5431515B2 (ja) 2014-03-05
RU2006109004A (ru) 2007-09-27
EP1675852A1 (de) 2006-07-05
JP2007522093A (ja) 2007-08-09
CY1109424T1 (el) 2014-08-13
AR045805A1 (es) 2005-11-16
WO2005033108A1 (en) 2005-04-14
CN1997642B (zh) 2012-06-13
NZ545970A (en) 2009-05-31
ES2321722T3 (es) 2009-06-10
KR20060097119A (ko) 2006-09-13
AU2004278320B2 (en) 2010-06-24
CA2539349A1 (en) 2005-04-14
DE602004019555D1 (de) 2009-04-02
TW200526654A (en) 2005-08-16

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