BR0307293A - Processo para preparação de perindopril de alta pureza e intermediários úteis na sìntese - Google Patents

Processo para preparação de perindopril de alta pureza e intermediários úteis na sìntese

Info

Publication number
BR0307293A
BR0307293A BR0307293-2A BR0307293A BR0307293A BR 0307293 A BR0307293 A BR 0307293A BR 0307293 A BR0307293 A BR 0307293A BR 0307293 A BR0307293 A BR 0307293A
Authority
BR
Brazil
Prior art keywords
synthesis
high purity
preparing high
intermediates useful
perindopril
Prior art date
Application number
BR0307293-2A
Other languages
English (en)
Inventor
Gyula Simig
Tibor Mezei
Marta Porcs-Makkay
Attila Mandi
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BR0307293A publication Critical patent/BR0307293A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE PERINDO-PRIL DE ALTA PUREZA E INTERMEDIáRIOS úTEIS NA SìNTESE". A presente invenção refere-se a ácido 1-{2(S)-[1(S)-(etoxicarbonil)butilamino]propionil}-(3aS,7aS)octaidroin dol-2(S)-carboxílico da Fórmula I e o seu sal t-butilamina da Fórmula I<39> livre de contaminações deriváveis de diciclohexil carbodilmida, e um processo para a sua preparação. A invenção também refere-se a novos intermediários da fórmula geral III (onde R representa alquila inferior ou aril-alquila inferior). O composto da Fórmula I - perindopril - é um conhecido inibidor de ACE.
BR0307293-2A 2002-01-30 2003-01-29 Processo para preparação de perindopril de alta pureza e intermediários úteis na sìntese BR0307293A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02290206A EP1333026B1 (en) 2002-01-30 2002-01-30 Process for the preparation of high purity perindopril and intermediates useful in the synthesis
PCT/IB2003/000691 WO2003064388A2 (en) 2002-01-30 2003-01-29 Process for the preparation of high purity perindopril and intermediates useful in the synthesis

Publications (1)

Publication Number Publication Date
BR0307293A true BR0307293A (pt) 2004-12-21

Family

ID=8185713

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0307293-2A BRPI0307293B1 (pt) 2002-01-30 2003-01-29 Processo para preparação de perindopril de alta pureza
BR0307293-2A BR0307293A (pt) 2002-01-30 2003-01-29 Processo para preparação de perindopril de alta pureza e intermediários úteis na sìntese

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0307293-2A BRPI0307293B1 (pt) 2002-01-30 2003-01-29 Processo para preparação de perindopril de alta pureza

Country Status (36)

Country Link
US (2) US7326794B2 (pt)
EP (1) EP1333026B1 (pt)
JP (1) JP4171423B2 (pt)
KR (1) KR100673701B1 (pt)
CN (1) CN1300111C (pt)
AP (1) AP1741A (pt)
AR (1) AR038340A1 (pt)
AT (1) ATE365714T1 (pt)
AU (1) AU2003206055B2 (pt)
BG (1) BG66126B1 (pt)
BR (2) BRPI0307293B1 (pt)
CA (1) CA2474003C (pt)
CY (1) CY1106721T1 (pt)
CZ (1) CZ305892B6 (pt)
DE (1) DE60220877T2 (pt)
DK (1) DK1333026T3 (pt)
EA (1) EA009277B1 (pt)
EE (1) EE05428B1 (pt)
ES (1) ES2289060T3 (pt)
GE (1) GEP20063899B (pt)
HK (1) HK1076101A1 (pt)
HR (1) HRP20040781B8 (pt)
HU (1) HU227591B1 (pt)
ME (1) ME00444B (pt)
MX (1) MXPA04007444A (pt)
NO (1) NO330223B1 (pt)
NZ (1) NZ534168A (pt)
OA (1) OA12759A (pt)
PL (1) PL212354B1 (pt)
PT (1) PT1333026E (pt)
RS (1) RS52465B (pt)
SI (1) SI1333026T1 (pt)
SK (1) SK287866B6 (pt)
UA (1) UA77756C2 (pt)
WO (1) WO2003064388A2 (pt)
ZA (1) ZA200405548B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4677611B2 (ja) * 2003-10-21 2011-04-27 レ ラボラトワール セルヴィエ 結晶ペリンドプリルエルブミンの新規な調製方法
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
LT1729739T (lt) * 2004-03-29 2016-11-10 Les Laboratoires Servier Kietos farmacinės kompozicijos gamybos būdas
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
PT1679072E (pt) 2005-01-06 2008-12-22 Ipca Lab Ltd Processo para a síntese de derivados de ácido (2s,3as,7as)-1-(s)-alanil-octa-hidro-1h-indole-2-carboxílico e utilização na síntese de perindopril
US7710739B2 (en) 2005-04-28 2010-05-04 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device and display device
WO2006137082A1 (en) * 2005-06-23 2006-12-28 Ramesh Babu Potluri Process for industrially viable preparation of perindopril erbumine
US20070032661A1 (en) * 2005-08-03 2007-02-08 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of perindopril
WO2007020012A1 (en) * 2005-08-12 2007-02-22 Lek Pharmaceuticals D.D. A process for the preparation of perindopril erbumine
EP1792896A1 (en) * 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
EP2044010B1 (en) 2006-05-12 2014-01-08 EGIS Gyógyszergyár Nyilvánosan Müködõ Részvénytársaság New pharmaceutical intermediates in the synthesis of ace-inihibitors and the use thereof
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK144769C (da) 1979-12-06 1982-12-13 Voelund Vaskerimaskiner Tromlevaskemaskine med varmeveksler
US4565819A (en) * 1979-12-07 1986-01-21 Adir Substituted imino diacids, their preparation and pharmaceutical compositions which contain them
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IN156096B (pt) 1981-03-19 1985-05-11 Usv Pharma Corp
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
SI9600169A (en) 1996-05-22 1997-12-31 Krka Tovarna Zdravil Process for preparation of compounds with ace inhibitory effect
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
AR036187A1 (es) 2001-07-24 2004-08-18 Adir Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario

Also Published As

Publication number Publication date
EP1333026B1 (en) 2007-06-27
WO2003064388A3 (en) 2004-02-05
CA2474003C (en) 2009-06-02
SK3292004A3 (en) 2004-12-01
SI1333026T1 (sl) 2007-10-31
SK287866B6 (sk) 2012-02-03
AU2003206055B2 (en) 2008-07-17
PL358514A1 (en) 2003-07-28
EP1333026A1 (en) 2003-08-06
AP2004003091A0 (en) 2004-09-30
EE200400107A (et) 2004-10-15
KR100673701B1 (ko) 2007-01-24
US7279595B2 (en) 2007-10-09
JP2005521667A (ja) 2005-07-21
DK1333026T3 (da) 2007-10-22
AR038340A1 (es) 2005-01-12
MXPA04007444A (es) 2005-06-17
ATE365714T1 (de) 2007-07-15
RS66704A (en) 2007-02-05
CY1106721T1 (el) 2012-05-23
RS52465B (en) 2013-02-28
DE60220877D1 (de) 2007-08-09
HUP0300231A3 (en) 2004-04-28
HRP20040781B1 (en) 2008-12-31
KR20040078680A (ko) 2004-09-10
JP4171423B2 (ja) 2008-10-22
NO20043472L (no) 2004-08-20
HU227591B1 (hu) 2011-09-28
CZ305892B6 (cs) 2016-04-27
HUP0300231A2 (hu) 2003-08-28
ME00444B (me) 2011-10-10
CZ2004906A3 (cs) 2004-12-15
HRP20040781A2 (en) 2004-12-31
ES2289060T3 (es) 2008-02-01
US7326794B2 (en) 2008-02-05
EA200400929A1 (ru) 2005-06-30
OA12759A (en) 2006-07-04
US20070197821A1 (en) 2007-08-23
EE05428B1 (et) 2011-06-15
BRPI0307293B1 (pt) 2018-03-06
HK1076101A1 (en) 2006-01-06
PT1333026E (pt) 2007-09-17
AP1741A (en) 2007-05-16
HRP20040781A8 (en) 2009-01-31
CN1622936A (zh) 2005-06-01
NO330223B1 (no) 2011-03-07
EA009277B1 (ru) 2007-12-28
ZA200405548B (en) 2006-09-27
BG108858A (en) 2005-05-31
WO2003064388A2 (en) 2003-08-07
BG66126B1 (bg) 2011-06-30
HRP20040781B8 (en) 2009-01-31
DE60220877T2 (de) 2008-04-10
HU0300231D0 (en) 2003-03-28
UA77756C2 (uk) 2007-01-15
NZ534168A (en) 2006-11-30
US20050119492A1 (en) 2005-06-02
CA2474003A1 (en) 2003-08-07
PL212354B1 (pl) 2012-09-28
GEP20063899B (en) 2006-08-10
CN1300111C (zh) 2007-02-14

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 17A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2551 DE 26-11-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.