HUP0300231A2 - Eljárás nagy tisztaságú perindopril előállítására és az eljárásban használt intermedierek, a vegyületet tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Eljárás nagy tisztaságú perindopril előállítására és az eljárásban használt intermedierek, a vegyületet tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0300231A2 HUP0300231A2 HU0300231A HUP0300231A HUP0300231A2 HU P0300231 A2 HUP0300231 A2 HU P0300231A2 HU 0300231 A HU0300231 A HU 0300231A HU P0300231 A HUP0300231 A HU P0300231A HU P0300231 A2 HUP0300231 A2 HU P0300231A2
- Authority
- HU
- Hungary
- Prior art keywords
- compound
- preparation
- synthesis
- pharmaceutical compositions
- high purity
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 2
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title abstract 2
- 229960002582 perindopril Drugs 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000005541 ACE inhibitor Substances 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000003940 butylamines Chemical class 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány (I) képletű 1-{2(S)-[1(S)-(etoxikarbonil)butilamino]propionil)-(3aS,7aS)oktahidroindol-2(S)-karbonsavra és annak (I') képletű terc-butil-aminsójára vonatkozik,amely mentes diciklohexil-karbodiimidből származtathatószennyezésektől. A találmány a vegyületek előállítására szolgálóeljárást, valamint az eljárásban szereplő új (III) általános képletűintermediereket[a képletben R jelentése rövid szénláncú alkil- vagyaril-(rövid szénláncú alkil)-csoport] is magában foglalja. Az (I)képletű vegyület - a perindopril - ismert ACE inhibitor. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02290206A EP1333026B1 (en) | 2002-01-30 | 2002-01-30 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| HU0300231D0 HU0300231D0 (en) | 2003-03-28 |
| HUP0300231A2 true HUP0300231A2 (hu) | 2003-08-28 |
| HUP0300231A3 HUP0300231A3 (en) | 2004-04-28 |
| HU227591B1 HU227591B1 (hu) | 2011-09-28 |
Family
ID=8185713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300231A HU227591B1 (hu) | 2002-01-30 | 2003-01-29 | Eljárás nagy tisztaságú perindopril elõállítására és az eljárásnál használható intermedierek |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US7326794B2 (hu) |
| EP (1) | EP1333026B1 (hu) |
| JP (1) | JP4171423B2 (hu) |
| KR (1) | KR100673701B1 (hu) |
| CN (1) | CN1300111C (hu) |
| AP (1) | AP1741A (hu) |
| AR (1) | AR038340A1 (hu) |
| AT (1) | ATE365714T1 (hu) |
| AU (1) | AU2003206055B2 (hu) |
| BG (1) | BG66126B1 (hu) |
| BR (2) | BRPI0307293B1 (hu) |
| CA (1) | CA2474003C (hu) |
| CY (1) | CY1106721T1 (hu) |
| CZ (1) | CZ305892B6 (hu) |
| DE (1) | DE60220877T2 (hu) |
| DK (1) | DK1333026T3 (hu) |
| EA (1) | EA009277B1 (hu) |
| EE (1) | EE05428B1 (hu) |
| ES (1) | ES2289060T3 (hu) |
| GE (1) | GEP20063899B (hu) |
| HK (1) | HK1076101A1 (hu) |
| HR (1) | HRP20040781B8 (hu) |
| HU (1) | HU227591B1 (hu) |
| ME (1) | ME00444B (hu) |
| MX (1) | MXPA04007444A (hu) |
| NO (1) | NO330223B1 (hu) |
| NZ (1) | NZ534168A (hu) |
| OA (1) | OA12759A (hu) |
| PL (1) | PL212354B1 (hu) |
| PT (1) | PT1333026E (hu) |
| RS (1) | RS52465B (hu) |
| SI (1) | SI1333026T1 (hu) |
| SK (1) | SK287866B6 (hu) |
| UA (1) | UA77756C2 (hu) |
| WO (1) | WO2003064388A2 (hu) |
| ZA (1) | ZA200405548B (hu) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60330603D1 (de) * | 2003-10-21 | 2010-01-28 | Servier Lab | Verfahren zur herstellung kristallinem perindopril erbumin |
| SI21704A (en) * | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia |
| WO2005094793A1 (en) * | 2004-03-29 | 2005-10-13 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for preparing a solid pharmaceutical composition |
| SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| SI21881A (sl) | 2004-10-15 | 2006-04-30 | Diagen, Smartno Pri Ljubljani, D.O.O. | Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine |
| ES2255872B1 (es) * | 2004-12-31 | 2007-08-16 | Quimica Sintetica, S.A. | Procedimiento para la preparacion de perindopril erbumina. |
| ES2314583T4 (es) | 2005-01-06 | 2009-05-18 | Ipca Laboratories Limited | Proceso para sintesis de los derivados del acido (2s,3as,7as)-1-(s)-alanil-octahidro-1h-indol-2-carboxilico y su utilizacion en la sintesis de perindropil. |
| US7710739B2 (en) | 2005-04-28 | 2010-05-04 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device and display device |
| WO2006137082A1 (en) * | 2005-06-23 | 2006-12-28 | Ramesh Babu Potluri | Process for industrially viable preparation of perindopril erbumine |
| US20070032661A1 (en) * | 2005-08-03 | 2007-02-08 | Glenmark Pharmaceuticals Limited | Process for the preparation of intermediates of perindopril |
| UA92613C2 (ru) * | 2005-08-12 | 2010-11-25 | Лек Фармасьютиклз Д.Д. | Способ получения кристаллической формы d эрбумина периндоприла |
| EP1792896A1 (en) * | 2005-12-01 | 2007-06-06 | KRKA, tovarna zdravil, d.d., Novo mesto | Process for the preparation of perindopril and salts thereof |
| UA98767C2 (uk) * | 2006-05-12 | 2012-06-25 | Егіш Дьйодьсердьяр Нільваношан Мюкьодо Ресвеньтаршашаг | Фармацевтичні проміжні сполуки в синтезі інгібіторів ацетилхолінестерази (асе) |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK144769C (da) | 1979-12-06 | 1982-12-13 | Voelund Vaskerimaskiner | Tromlevaskemaskine med varmeveksler |
| FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| US4565819A (en) * | 1979-12-07 | 1986-01-21 | Adir | Substituted imino diacids, their preparation and pharmaceutical compositions which contain them |
| IN156096B (hu) | 1981-03-19 | 1985-05-11 | Usv Pharma Corp | |
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| SI9600169A (en) | 1996-05-22 | 1997-12-31 | Krka Tovarna Zdravil | Process for preparation of compounds with ace inhibitory effect |
| FR2807431B1 (fr) | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| AR036187A1 (es) | 2001-07-24 | 2004-08-18 | Adir | Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario |
| FR2827860B1 (fr) | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
-
2002
- 2002-01-30 ES ES02290206T patent/ES2289060T3/es not_active Expired - Lifetime
- 2002-01-30 DE DE60220877T patent/DE60220877T2/de not_active Expired - Lifetime
- 2002-01-30 DK DK02290206T patent/DK1333026T3/da active
- 2002-01-30 SI SI200230586T patent/SI1333026T1/sl unknown
- 2002-01-30 EP EP02290206A patent/EP1333026B1/en not_active Expired - Lifetime
- 2002-01-30 PT PT02290206T patent/PT1333026E/pt unknown
- 2002-01-30 AT AT02290206T patent/ATE365714T1/de active
-
2003
- 2003-01-29 PL PL358514A patent/PL212354B1/pl unknown
- 2003-01-29 UA UA20040807143A patent/UA77756C2/uk unknown
- 2003-01-29 RS YU66704A patent/RS52465B/en unknown
- 2003-01-29 US US10/503,272 patent/US7326794B2/en not_active Expired - Fee Related
- 2003-01-29 ZA ZA200405548A patent/ZA200405548B/xx unknown
- 2003-01-29 AP APAP/P/2004/003091A patent/AP1741A/en active
- 2003-01-29 OA OA1200400196A patent/OA12759A/en unknown
- 2003-01-29 KR KR1020047011731A patent/KR100673701B1/ko not_active IP Right Cessation
- 2003-01-29 GE GE5686A patent/GEP20063899B/en unknown
- 2003-01-29 WO PCT/IB2003/000691 patent/WO2003064388A2/en active Application Filing
- 2003-01-29 ME MEP-2008-674A patent/ME00444B/me unknown
- 2003-01-29 EA EA200400929A patent/EA009277B1/ru not_active IP Right Cessation
- 2003-01-29 CN CNB038027143A patent/CN1300111C/zh not_active Expired - Fee Related
- 2003-01-29 CZ CZ2004-906A patent/CZ305892B6/cs not_active IP Right Cessation
- 2003-01-29 NZ NZ534168A patent/NZ534168A/en not_active IP Right Cessation
- 2003-01-29 CA CA002474003A patent/CA2474003C/en not_active Expired - Fee Related
- 2003-01-29 HU HU0300231A patent/HU227591B1/hu not_active IP Right Cessation
- 2003-01-29 SK SK329-2004A patent/SK287866B6/sk not_active IP Right Cessation
- 2003-01-29 MX MXPA04007444A patent/MXPA04007444A/es active IP Right Grant
- 2003-01-29 JP JP2003564011A patent/JP4171423B2/ja not_active Expired - Fee Related
- 2003-01-29 AU AU2003206055A patent/AU2003206055B2/en not_active Ceased
- 2003-01-29 BR BRPI0307293-2A patent/BRPI0307293B1/pt unknown
- 2003-01-29 EE EEP200400107A patent/EE05428B1/xx not_active IP Right Cessation
- 2003-01-29 BR BR0307293-2A patent/BR0307293A/pt not_active IP Right Cessation
- 2003-01-30 AR ARP030100263A patent/AR038340A1/es not_active Application Discontinuation
-
2004
- 2004-08-20 NO NO20043472A patent/NO330223B1/no not_active IP Right Cessation
- 2004-08-27 HR HR20040781A patent/HRP20040781B8/xx not_active IP Right Cessation
- 2004-08-27 BG BG108858A patent/BG66126B1/bg unknown
-
2005
- 2005-09-16 HK HK05108134A patent/HK1076101A1/xx not_active IP Right Cessation
-
2007
- 2007-04-20 US US11/788,454 patent/US7279595B2/en not_active Expired - Fee Related
- 2007-07-12 CY CY20071100925T patent/CY1106721T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |