UA98767C2 - Фармацевтичні проміжні сполуки в синтезі інгібіторів ацетилхолінестерази (асе) - Google Patents

Фармацевтичні проміжні сполуки в синтезі інгібіторів ацетилхолінестерази (асе)

Info

Publication number
UA98767C2
UA98767C2 UAA200814258A UAA200814258A UA98767C2 UA 98767 C2 UA98767 C2 UA 98767C2 UA A200814258 A UAA200814258 A UA A200814258A UA A200814258 A UAA200814258 A UA A200814258A UA 98767 C2 UA98767 C2 UA 98767C2
Authority
UA
Ukraine
Prior art keywords
general formula
compounds
ace
inhibitors
synthesis
Prior art date
Application number
UAA200814258A
Other languages
English (en)
Russian (ru)
Inventor
Марта Поркс-Маккай
Дьюла Сіміг
Тібор Мезей
Пандур Ангела Вересне
Дьюла Лукаш
Original Assignee
Егіш Дьйодьсердьяр Нільваношан Мюкьодо Ресвеньтаршашаг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0600404A external-priority patent/HU227111B1/hu
Priority claimed from HU0600403A external-priority patent/HU229278B1/hu
Application filed by Егіш Дьйодьсердьяр Нільваношан Мюкьодо Ресвеньтаршашаг filed Critical Егіш Дьйодьсердьяр Нільваношан Мюкьодо Ресвеньтаршашаг
Publication of UA98767C2 publication Critical patent/UA98767C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Сполуки загальної Формули (І), де R1 є арилом або алкілом; R2 є алкілом; R3 є алкілом або аралкілом, є цінними фармацевтичними проміжними сполуками, які можуть бути одержані шляхом взаємодії сполуки загальної Формули (IV) (де значення R1 і R2 є такими, як визначено вище) щонайменше з 2 молярними еквівалентами сполуки загальної Формули (VI) (де Х є галогеном або трет-бутилоксикарбонілоксигрупою і R3 є таким, як визначено вище). Відомі сполуки загальної Формули (II) (де R1 і R2 є такими, як визначено вище) одержують шляхом взаємодії сполук загальної Формули (І) з тіонілхлоридом. Сполуки загальної Формули (І) є новими проміжними сполуками, корисними в синтезі фармацевтичнo активних інгредієнтів, зокрема, при одержанні інгібіторів ацетилхолінестерази (АСЕ), наприклад еналаприлу, периндоприлу або раміприлу.
UAA200814258A 2006-05-12 2007-05-11 Фармацевтичні проміжні сполуки в синтезі інгібіторів ацетилхолінестерази (асе) UA98767C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0600404A HU227111B1 (en) 2006-05-12 2006-05-12 Process for production of perindopril and intermediates applied in the process
HU0600403A HU229278B1 (en) 2006-05-12 2006-05-12 Process for the manufacturing of pharmaceutically active substances with ace - inhibitor effect and intermediates thereof and the novel intermediates
PCT/HU2007/000039 WO2007132277A1 (en) 2006-05-12 2007-05-11 New pharmaceutical intermediates in the synthesis of ace- inhibitors and the use thereof

Publications (1)

Publication Number Publication Date
UA98767C2 true UA98767C2 (uk) 2012-06-25

Family

ID=89986777

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200814258A UA98767C2 (uk) 2006-05-12 2007-05-11 Фармацевтичні проміжні сполуки в синтезі інгібіторів ацетилхолінестерази (асе)

Country Status (8)

Country Link
US (1) US7960558B2 (uk)
EP (1) EP2044010B1 (uk)
JP (1) JP5230609B2 (uk)
KR (1) KR101396899B1 (uk)
EA (1) EA015450B1 (uk)
IL (1) IL195221A (uk)
UA (1) UA98767C2 (uk)
WO (1) WO2007132277A1 (uk)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3664351B1 (en) 2015-02-25 2021-03-31 LG Electronics Inc. Method and device for receiving signal by using resource unit including plurality of subcarriers

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1983468A (en) * 1930-04-02 1934-12-04 Sprague Specialties Co Process and apparatus for making corrugated tubes
US1993535A (en) * 1931-05-04 1935-03-05 Higgin Mfg Co Metal frame storm window
US1987471A (en) * 1932-07-28 1935-01-08 Miller Co Lighting unit
US2644808A (en) 1948-12-07 1953-07-07 Du Pont Nu-carboanhydrides and polymers therefrom
US4686295A (en) 1982-03-10 1987-08-11 Usv Pharmaceutical Corporation N-carboxy anhydride intermediates
US4496541A (en) 1983-01-12 1985-01-29 Usv Pharmaceutical Corporation Compounds for treating hypertension
JPS6248696A (ja) 1985-08-27 1987-03-03 Kanegafuchi Chem Ind Co Ltd Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法
SI9200213A (en) 1992-09-16 1994-03-31 Krka Process for preparing alkyl-l-alanil-l-proline derivates
US6262274B1 (en) * 2000-10-13 2001-07-17 Everlight Usa, Inc. Process for preparing N-[1-(S)-ethyoxycarbonyl-3-phenylpropyl]-L-ananine N-carboxyanhydride
AR036187A1 (es) 2001-07-24 2004-08-18 Adir Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario
DE60220877T2 (de) * 2002-01-30 2008-04-10 Les Laboratoires Servier Verfahren zur Herstellung von hochreinem Perindopril und Zwischenverbindungen nützlich in der Synthese

Also Published As

Publication number Publication date
EP2044010A1 (en) 2009-04-08
IL195221A0 (en) 2009-08-03
JP5230609B2 (ja) 2013-07-10
KR20090007610A (ko) 2009-01-19
US20100286404A1 (en) 2010-11-11
US7960558B2 (en) 2011-06-14
IL195221A (en) 2016-05-31
KR101396899B1 (ko) 2014-05-19
EA200802320A1 (ru) 2009-04-28
EP2044010B1 (en) 2014-01-08
EA015450B1 (ru) 2011-08-30
JP2009536938A (ja) 2009-10-22
WO2007132277A1 (en) 2007-11-22

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