ME00444B - Postupak za pripremanje visoko čistog perindoprila i intermedijera korisnih u sintezama - Google Patents

Postupak za pripremanje visoko čistog perindoprila i intermedijera korisnih u sintezama

Info

Publication number
ME00444B
ME00444B MEP-2008-674A MEP67408A ME00444B ME 00444 B ME00444 B ME 00444B ME P67408 A MEP67408 A ME P67408A ME 00444 B ME00444 B ME 00444B
Authority
ME
Montenegro
Prior art keywords
preparation
synthesis
high purity
intermediates useful
perindopril
Prior art date
Application number
MEP-2008-674A
Other languages
English (en)
French (fr)
Inventor
Gyula Simig
Tibor Mezei
Makkay Marta Porcs
Attila Mandi
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of ME00444B publication Critical patent/ME00444B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pronalazak se odnosi na 1-[2(S)-[1(S)-(etoksikarbonil)butilamino]propionil}- (3aS, 7aS)oktahidroindoI-2(S)-karboksilnu kiselinu I njenu terc-butilaminsku so formule I oslobodjenu primesa koje potiču od dicikloheksil karbodiimida I na postupak za njihovo dobijanje. Pronalazak se takodje odnosi na nove intermedijere opšte formule III ) u kojoj R predstavlja oznaku za niži alkil ili aril niži alkil). Jedinjenje formule I/ perindopril poznato je kao ACE inhibitor.
MEP-2008-674A 2002-01-30 2003-01-29 Postupak za pripremanje visoko čistog perindoprila i intermedijera korisnih u sintezama ME00444B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02290206A EP1333026B1 (en) 2002-01-30 2002-01-30 Process for the preparation of high purity perindopril and intermediates useful in the synthesis
PCT/IB2003/000691 WO2003064388A2 (en) 2002-01-30 2003-01-29 Process for the preparation of high purity perindopril and intermediates useful in the synthesis

Publications (1)

Publication Number Publication Date
ME00444B true ME00444B (me) 2011-10-10

Family

ID=8185713

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-674A ME00444B (me) 2002-01-30 2003-01-29 Postupak za pripremanje visoko čistog perindoprila i intermedijera korisnih u sintezama

Country Status (36)

Country Link
US (2) US7326794B2 (me)
EP (1) EP1333026B1 (me)
JP (1) JP4171423B2 (me)
KR (1) KR100673701B1 (me)
CN (1) CN1300111C (me)
AP (1) AP1741A (me)
AR (1) AR038340A1 (me)
AT (1) ATE365714T1 (me)
AU (1) AU2003206055B2 (me)
BG (1) BG66126B1 (me)
BR (2) BRPI0307293B1 (me)
CA (1) CA2474003C (me)
CY (1) CY1106721T1 (me)
CZ (1) CZ305892B6 (me)
DE (1) DE60220877T2 (me)
DK (1) DK1333026T3 (me)
EA (1) EA009277B1 (me)
EE (1) EE05428B1 (me)
ES (1) ES2289060T3 (me)
GE (1) GEP20063899B (me)
HK (1) HK1076101A1 (me)
HR (1) HRP20040781B8 (me)
HU (1) HU227591B1 (me)
ME (1) ME00444B (me)
MX (1) MXPA04007444A (me)
NO (1) NO330223B1 (me)
NZ (1) NZ534168A (me)
OA (1) OA12759A (me)
PL (1) PL212354B1 (me)
PT (1) PT1333026E (me)
RS (1) RS52465B (me)
SI (1) SI1333026T1 (me)
SK (1) SK287866B6 (me)
UA (1) UA77756C2 (me)
WO (1) WO2003064388A2 (me)
ZA (1) ZA200405548B (me)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037788A1 (en) * 2003-10-21 2005-04-28 Lupin Ltd. Novel method for preparation of crystalline perindopril erbumine
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
DK1729739T3 (en) * 2004-03-29 2016-10-31 Servier Lab PROCESS FOR THE PREPARATION OF A solid pharmaceutical composition.
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
PT1679072E (pt) 2005-01-06 2008-12-22 Ipca Lab Ltd Processo para a síntese de derivados de ácido (2s,3as,7as)-1-(s)-alanil-octa-hidro-1h-indole-2-carboxílico e utilização na síntese de perindopril
US7710739B2 (en) 2005-04-28 2010-05-04 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device and display device
WO2006137082A1 (en) * 2005-06-23 2006-12-28 Ramesh Babu Potluri Process for industrially viable preparation of perindopril erbumine
US20070032661A1 (en) * 2005-08-03 2007-02-08 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of perindopril
CN101228179B (zh) * 2005-08-12 2011-02-02 力奇制药公司 制备培哚普利特丁胺的方法
EP1792896A1 (en) * 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
EA015450B1 (ru) * 2006-05-12 2011-08-30 Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг Фармацевтические промежуточные соединения в синтезе ингибиторов ацетилхолинэстеразы (асе) и их применение
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK144769C (da) 1979-12-06 1982-12-13 Voelund Vaskerimaskiner Tromlevaskemaskine med varmeveksler
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4565819A (en) * 1979-12-07 1986-01-21 Adir Substituted imino diacids, their preparation and pharmaceutical compositions which contain them
IN156096B (me) 1981-03-19 1985-05-11 Usv Pharma Corp
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
SI9600169A (en) 1996-05-22 1997-12-31 Krka Tovarna Zdravil Process for preparation of compounds with ace inhibitory effect
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
AR036187A1 (es) * 2001-07-24 2004-08-18 Adir Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario
FR2827860B1 (fr) 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

Also Published As

Publication number Publication date
CA2474003A1 (en) 2003-08-07
MXPA04007444A (es) 2005-06-17
EA009277B1 (ru) 2007-12-28
EE200400107A (et) 2004-10-15
DE60220877D1 (de) 2007-08-09
DE60220877T2 (de) 2008-04-10
US7279595B2 (en) 2007-10-09
CA2474003C (en) 2009-06-02
GEP20063899B (en) 2006-08-10
US7326794B2 (en) 2008-02-05
KR20040078680A (ko) 2004-09-10
EE05428B1 (et) 2011-06-15
AU2003206055B2 (en) 2008-07-17
EA200400929A1 (ru) 2005-06-30
NO20043472L (no) 2004-08-20
SI1333026T1 (sl) 2007-10-31
KR100673701B1 (ko) 2007-01-24
US20070197821A1 (en) 2007-08-23
CN1622936A (zh) 2005-06-01
JP2005521667A (ja) 2005-07-21
PT1333026E (pt) 2007-09-17
HRP20040781A8 (en) 2009-01-31
HRP20040781B8 (en) 2009-01-31
NZ534168A (en) 2006-11-30
AP1741A (en) 2007-05-16
UA77756C2 (uk) 2007-01-15
WO2003064388A3 (en) 2004-02-05
AR038340A1 (es) 2005-01-12
CZ305892B6 (cs) 2016-04-27
ZA200405548B (en) 2006-09-27
HU227591B1 (hu) 2011-09-28
PL358514A1 (en) 2003-07-28
NO330223B1 (no) 2011-03-07
DK1333026T3 (da) 2007-10-22
BRPI0307293B1 (pt) 2018-03-06
CZ2004906A3 (cs) 2004-12-15
HUP0300231A2 (hu) 2003-08-28
WO2003064388A2 (en) 2003-08-07
HRP20040781B1 (en) 2008-12-31
CN1300111C (zh) 2007-02-14
RS52465B (en) 2013-02-28
ATE365714T1 (de) 2007-07-15
BG66126B1 (bg) 2011-06-30
AP2004003091A0 (en) 2004-09-30
EP1333026B1 (en) 2007-06-27
HU0300231D0 (en) 2003-03-28
SK3292004A3 (en) 2004-12-01
OA12759A (en) 2006-07-04
HRP20040781A2 (en) 2004-12-31
HK1076101A1 (en) 2006-01-06
JP4171423B2 (ja) 2008-10-22
SK287866B6 (sk) 2012-02-03
CY1106721T1 (el) 2012-05-23
PL212354B1 (pl) 2012-09-28
BR0307293A (pt) 2004-12-21
EP1333026A1 (en) 2003-08-06
BG108858A (en) 2005-05-31
HUP0300231A3 (en) 2004-04-28
US20050119492A1 (en) 2005-06-02
ES2289060T3 (es) 2008-02-01
RS66704A (en) 2007-02-05

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