BR0209041A - Emplastro de imunização de disposição de microprojeção e método - Google Patents

Emplastro de imunização de disposição de microprojeção e método

Info

Publication number
BR0209041A
BR0209041A BR0209041-4A BR0209041A BR0209041A BR 0209041 A BR0209041 A BR 0209041A BR 0209041 A BR0209041 A BR 0209041A BR 0209041 A BR0209041 A BR 0209041A
Authority
BR
Brazil
Prior art keywords
adjuvant
antigen
plaster
microprojection
microprojections
Prior art date
Application number
BR0209041-4A
Other languages
English (en)
Inventor
Michael J Cormier
James A Matriano
Peter E Daddona
Juanita A Johnson
Wendy A Young
Richard L Keenan
Joseph C Trautman
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BR0209041A publication Critical patent/BR0209041A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Surgical Instruments (AREA)

Abstract

"EMPLASTRO DE IMUNIZAçãO DE DISPOSIçãO DE MICROPROJEçãO E MéTODO". Emplastros de pele (20) possuindo uma disposição de microprojeção (10), um reservatório (18) incluindo um agente antigênico e um adjuvante de aumento de resposta imune, e métodos de uso do mesmo para vacinar animais (por exemplo, seres humanos) é descrito. Em uma concretização preferida, as disposições de microprojeção (10) são compostas por uma folha de titânio microperfurada e fotogravada (14). As microprojeções (12) são cobertas com uma formulação líquida contendo um antígeno vacina e um adjuvante, como dipeptídeo glucosaminil muramila seco, e aplicado à pele do animal para ser vacinado, usando um aplicador de impacto. As microprojeções (12) criam caminhos superficiais através do estrato córneo, para facilitar a permeação do agente antígeno e adjuvante. A dose de antígeno e a profundidade de penetração podem ser controladas. Esta tecnologia possui uma ampla aplicabilidade para uma larga variedade de vacinas terapêuticas, para aumentar a eficácia e a conveniência do uso.
BR0209041-4A 2001-04-20 2002-04-22 Emplastro de imunização de disposição de microprojeção e método BR0209041A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28557201P 2001-04-20 2001-04-20
US34255201P 2001-12-20 2001-12-20
PCT/US2002/012659 WO2002085446A2 (en) 2001-04-20 2002-04-22 Microprojection array immunization patch and method

Publications (1)

Publication Number Publication Date
BR0209041A true BR0209041A (pt) 2005-01-18

Family

ID=26963264

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0209041-4A BR0209041A (pt) 2001-04-20 2002-04-22 Emplastro de imunização de disposição de microprojeção e método

Country Status (11)

Country Link
US (3) US20020193729A1 (pt)
EP (1) EP1383571A2 (pt)
JP (1) JP4382356B2 (pt)
KR (1) KR20040014502A (pt)
CN (1) CN100467083C (pt)
BR (1) BR0209041A (pt)
CA (1) CA2444551C (pt)
IL (1) IL158479A0 (pt)
MX (1) MXPA03009601A (pt)
NO (1) NO20034683L (pt)
WO (1) WO2002085446A2 (pt)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3436512B2 (ja) * 1999-12-28 2003-08-11 株式会社デンソー アクセル装置
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
CN101129327A (zh) * 2001-04-20 2008-02-27 阿尔扎公司 具有包含有益药剂的涂层的微小突出物阵列
ATE471990T1 (de) 2001-08-13 2010-07-15 Univ Rochester Transkutane immunisierung gegen papillomavirus mit virusähnlichen papillomaviruspartikeln
US20030093040A1 (en) * 2001-10-29 2003-05-15 Mikszta John A. Method and device for the delivery of a substance
US20040137004A1 (en) * 2002-03-19 2004-07-15 Glenn Gregory M Patch for transcutaneous immunization
BR0311443A (pt) * 2002-05-06 2005-03-22 Becton Dickinson Co Método e dispositivo para controlar farmacocinética de droga
WO2004058759A1 (en) 2002-12-20 2004-07-15 3M Innovative Properties Company Aryl / hetaryl substituted imidazoquinolines
US8993327B2 (en) * 2003-04-07 2015-03-31 Ut-Battelle, Llc Parallel macromolecular delivery and biochemical/electrochemical interface to cells employing nanostructures
ES2437565T3 (es) 2003-06-30 2014-01-13 Alza Corporation Formulaciones para microproyecciones revestidas que contienen contraiones no volátiles
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
TW200513280A (en) * 2003-07-02 2005-04-16 Alza Corp Microprojection array immunization patch and method
CA2530996C (en) 2003-07-03 2013-05-07 Corium International, Inc. Wound dressing, ingredient delivery device and iv hold-down, and method relating to same
CN1863572A (zh) * 2003-08-04 2006-11-15 阿尔扎公司 提高药剂经皮流通量的方法和装置
MXPA06001669A (es) 2003-08-12 2006-04-28 3M Innovative Properties Co Compuestos que contienen imidazo-oxima sustituidos.
US7766902B2 (en) * 2003-08-13 2010-08-03 Wisconsin Alumni Research Foundation Microfluidic device for drug delivery
US8961477B2 (en) * 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds
EP1660172A1 (en) * 2003-08-26 2006-05-31 Alza Corporation Device and method for intradermal cell implantation
US7897597B2 (en) 2003-08-27 2011-03-01 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
WO2005023190A2 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for cd5+ b cell lymphoma
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
US8871782B2 (en) 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
AU2004286232A1 (en) * 2003-10-23 2005-05-12 Alza Corporation Compositions of stabilized DNA for coating microprojections
EP1675539A4 (en) * 2003-10-24 2007-09-12 Alza Corp METHOD AND SYSTEM FOR PRETREATMENT FOR IMPROVING TRANSDERMAL DRUG DELIVERY
CA2545774A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
CA2545825A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
AU2004293078B2 (en) 2003-11-25 2012-01-19 3M Innovative Properties Company Substituted imidazo ring systems and methods
WO2005051476A1 (en) * 2003-11-28 2005-06-09 Acrux Dds Pty Ltd Method and system for rapid transdermal administration
EP1701955A1 (en) 2003-12-29 2006-09-20 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
CA2551399A1 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
EP1737357B1 (en) 2004-03-24 2019-12-11 Corium, Inc. Transdermal delivery device
EP1730143A2 (en) 2004-03-24 2006-12-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
JP2007530680A (ja) * 2004-04-01 2007-11-01 アルザ・コーポレーシヨン インフルエンザワクチンの経皮デリバリーのための装置および方法
WO2005103303A2 (en) * 2004-04-13 2005-11-03 Alza Corporation Apparatus and method for transdermal delivery of multiple vaccines
ES2568259T3 (es) 2004-05-13 2016-04-28 Alza Corporation Aparato y método para la administración transdérmica de agentes de hormona paratiroidea
CA2566759A1 (en) * 2004-05-19 2005-11-24 Alza Corporation Method and formulation for transdermal delivery of immunologically active agents
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
WO2006009826A1 (en) 2004-06-18 2006-01-26 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
JP2008505685A (ja) * 2004-07-06 2008-02-28 トランスファーマ メディカル リミテッド 経皮免疫処置用送達システム
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
MX2007002795A (es) * 2004-09-08 2008-03-05 Johnson & Johnson Arreglo de microproyeccion con adhesion y adaptacion a la piel, mejoradas.
EP2923711A1 (en) 2004-11-03 2015-09-30 Novartis Vaccines and Diagnostics, Inc. Influenza vaccination
KR101224257B1 (ko) * 2004-11-18 2013-01-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 어레이를 코팅하기 위한 마스킹 방법
KR101246015B1 (ko) 2004-11-18 2013-03-20 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 어레이를 접촉 코팅하는 방법
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
US8267889B2 (en) 2004-11-18 2012-09-18 3M Innovative Properties Company Low-profile microneedle array applicator
EP1819393B1 (en) * 2004-12-10 2010-10-06 3M Innovative Properties Company Medical device
JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
AU2005322898B2 (en) 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
AU2006210392A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune response modifiers
JP2008530113A (ja) 2005-02-11 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド オキシムおよびヒドロキシラミン置換イミダゾ［４，５−ｃ］環化合物および方法
JP4793806B2 (ja) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
WO2006107851A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
AU2006232377A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
EP1904158B1 (en) 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
US20070009542A1 (en) * 2005-07-05 2007-01-11 Galit Levin Method and device for transdermal immunization
DE602006020738D1 (de) 2005-08-01 2011-04-28 Hisamitsu Pharmaceutical Co Adjuvans oder pharmazeutische zubereitung zur transdermalen oder transmukosalen verabreichung
EP1928537B1 (en) * 2005-09-02 2015-01-21 Intercell USA, Inc. Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs
CN101267896A (zh) * 2005-09-12 2008-09-17 阿尔扎公司 可涂覆的透皮给药微突起组合件
JP2009509634A (ja) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 官能基化マイクロニードル経皮薬剤送達システム、装置及び方法
WO2007061964A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Methods for coating microneedles
WO2007064486A1 (en) * 2005-11-30 2007-06-07 3M Innovative Properties Company Microneedle arrays and methods of use thereof
WO2007124411A1 (en) 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8076124B2 (en) 2007-01-17 2011-12-13 Ut-Battelle, Llc Method and apparatus for sustaining viability of biological cells on a substrate
US8821446B2 (en) 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
EP2123296B1 (en) 2007-01-31 2019-05-22 Hisamitsu Pharmaceutical Co., Inc. Adjuvant for transdermal or transmucosal administration and pharmaceutical preparation containing the same
EP2146689B1 (en) 2007-04-16 2020-08-12 Corium, Inc. Solvent-cast microneedle arrays containing active
CA2704740C (en) * 2007-10-09 2016-05-17 Transpharma Ltd. Magnetic patch coupling
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
WO2009072108A2 (en) 2007-12-05 2009-06-11 Syneron Medical Ltd. A disposable electromagnetic energy applicator and method of using it
CA2745339C (en) 2007-12-24 2016-06-28 The University Of Queensland Coating method
KR101626167B1 (ko) 2008-01-17 2016-05-31 시네론 메디컬 리미티드 개인용 모발 제거 장치 및 그 사용 방법
JP2011509791A (ja) 2008-01-24 2011-03-31 シネロン メディカル リミテッド 脂肪組織治療の機器、装置および方法
EP2247527A4 (en) 2008-02-07 2014-10-29 Univ Queensland PATCH PRODUCTION
US8506966B2 (en) 2008-02-22 2013-08-13 Novartis Ag Adjuvanted influenza vaccines for pediatric use
WO2009140735A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents.
US8795259B2 (en) * 2008-08-01 2014-08-05 Wisconsin Alumni Research Foundation Drug delivery platform incorporating hydrogel pumping mechanism with guided fluid flow
US8986250B2 (en) * 2008-08-01 2015-03-24 Wisconsin Alumni Research Foundation Drug delivery platform utilizing hydrogel pumping mechanism
EP2334249B1 (en) 2008-09-21 2013-03-13 Syneron Medical Ltd. A method and apparatus for personal skin treatment
EA201500910A1 (ru) 2009-02-10 2016-04-29 Новартис Аг Вакцины против гриппа со сниженным количеством сквалена
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
AU2010238605B2 (en) * 2009-04-24 2015-10-29 Corium Pharma Solutions, Inc. Methods for manufacturing microprojection arrays
CN102039000B (zh) * 2009-10-20 2015-08-26 苏州纳通生物纳米技术有限公司 一种透皮给药试剂盒
US8834423B2 (en) * 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US8328757B2 (en) * 2010-01-08 2012-12-11 Wisconsin Alumni Research Foundation Bladder arrangement for microneedle-based drug delivery device
CA2798145C (en) 2010-05-04 2022-10-18 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
ES2834200T3 (es) 2011-02-25 2021-06-16 Hisamitsu Pharmaceutical Co Adyuvante para administración transdérmica o transmucosa y preparación farmacéutica que contiene el mismo
CA2833879C (en) 2011-04-21 2023-03-14 David L. Kaplan Compositions and methods for stabilization of active agents
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
US9289331B2 (en) 2011-12-23 2016-03-22 Sca Hygiene Products Ab Disposable absorbent product with elastic leg opening regions and related methods
EP4112112A1 (en) * 2012-05-01 2023-01-04 University of Pittsburgh - Of the Commonwealth System of Higher Education Tip-loaded microneedle arrays for transdermal insertion
AU2013364053B2 (en) 2012-12-21 2018-08-30 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent and methods of use
US9827190B2 (en) 2013-02-01 2017-11-28 Glaxosmithkline Biologicals Sa Intradermal delivery of immunological compositions comprising toll-like receptor 7 agonists
CN105142711B (zh) 2013-03-12 2019-01-22 考里安国际公司 微突起施加器
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
JP6689187B2 (ja) 2013-03-15 2020-04-28 コリウム， インコーポレイテッド 複数の衝突微小突起アプリケータおよび使用方法
CA2906541C (en) 2013-03-15 2022-06-21 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
EP3041505A4 (en) 2013-09-05 2017-04-19 Merck Sharp & Dohme Corp. Methods of immunization with varicella zoster virus antigen
ES2744454T3 (es) 2013-10-31 2020-02-25 Hisamitsu Pharmaceutical Co Composición de adyuvante
US10881729B2 (en) 2014-04-18 2021-01-05 Children's Medical Center Corporation Vaccine adjuvant compositions
JP7109188B2 (ja) * 2014-08-29 2022-07-29 コリウム， インコーポレイテッド 活性剤の送達のための微細構造アレイ
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
EP4218892A1 (en) 2015-02-02 2023-08-02 Vaxxas Pty Limited Microprojection array applicator
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
WO2017054040A1 (en) 2015-09-28 2017-04-06 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
BR112018014109A2 (pt) * 2016-01-11 2018-12-11 Verndari Inc composições de microagulhas e métodos de uso das mesmas
EP3412312B1 (en) 2016-02-03 2021-08-25 Cosmed Pharmaceutical Co., Ltd. Coating liquid for microneedles, microneedle-coating substance, and microneedle array
WO2018053524A1 (en) 2016-09-19 2018-03-22 Vaxess Technologies, Inc. Vaccine formulations with increased stability
KR102038751B1 (ko) * 2016-11-18 2019-10-30 연세대학교 산학협력단 복합 제형이 적용된 마이크로니들 어레이 및 이의 제조방법
DK3606760T3 (da) 2017-03-31 2023-11-06 Vaxxas Pty Ltd Indretning og fremgangsmåde til belægning af overflader
WO2018227246A1 (en) 2017-06-13 2018-12-20 Vaxxas Pty Limited Quality control of substrate coatings
CA3071680A1 (en) 2017-08-04 2019-02-07 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
JP2021514391A (ja) * 2018-02-15 2021-06-10 アイコン ジェネティクス ゲーエムベーハー ノロウイルスに対する免疫応答を生成するための免疫原性組成物及びワクチン
US11938178B2 (en) 2018-07-09 2024-03-26 Dbv Technologies Optimized epicutaneous vaccination
WO2020198785A1 (en) * 2019-03-29 2020-10-08 Vaxxas Pty Ltd Vaccination using high-density microprojection array patch

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US2876770A (en) * 1955-10-10 1959-03-10 Raymond A White Shielded hypodermic syringe
US2893392A (en) * 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3221739A (en) * 1962-03-26 1965-12-07 Rosenthal Sol Roy Injection device
US3221740A (en) * 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3675766A (en) 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
JPS60193925A (ja) * 1984-03-13 1985-10-02 Chemo Sero Therapeut Res Inst 凍結乾燥製剤化ワクチン
SE8501990D0 (sv) * 1985-04-24 1985-04-24 Pharmacia Ab Beleggningsforfarande
AU601378B2 (en) 1985-10-04 1990-09-13 Pharmacia & Upjohn Company Pseudorabies virus protein
US4795432A (en) * 1987-02-19 1989-01-03 Karczmer Claude M Shield assembly for hypodermic injection devices
US4955868A (en) * 1988-11-28 1990-09-11 Edward Klein Disposable safety medical syringe
US4978343A (en) * 1990-01-16 1990-12-18 Dysarz Edward D Trap in barrel one handed retractable safety syringe
US5112307A (en) * 1990-04-24 1992-05-12 Habley Medical Technology Corp. Dental syringe having a medication filled carpule and an automatically-detaching piston stem
IT219694Z2 (it) * 1990-05-25 1993-04-26 Habley Medical Technology Corp Siringa di sicurezza, monouso
FR2669540A1 (fr) * 1990-11-26 1992-05-29 Berthier Michel Dispositif porte-aiguille pour seringue d'injection.
US5106379A (en) * 1991-04-09 1992-04-21 Leap E Jack Syringe shielding assembly
ES1017717Y (es) * 1991-05-30 1993-12-16 Serrano Gonzalez Protector de agujas hipodermicas auto-retractiles.
US5919466A (en) * 1993-10-01 1999-07-06 Gerbu Biotechnik Gmbh Method for improving the yield of immunoantibodies in the vaccination of animals and humans
US5478314A (en) * 1994-12-27 1995-12-26 Malenchek; Robert Non-reusable syringe
US5554122A (en) * 1995-03-23 1996-09-10 Emanuel; Carolina Disposable syringe
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
US5688241A (en) * 1996-04-15 1997-11-18 Asbaghi; Hooman Ali Automatic non-reusable needle guard
DK0914178T3 (da) 1996-06-18 2003-04-22 Alza Corp Anordning til forøgelse af transdermal afgivelse eller prøveudtagning af et middel
TW330907B (en) * 1996-09-09 1998-05-01 Riso Kagaku Corp The ink container and ink supplied device for packing ink container
EP0934093B1 (en) * 1996-09-17 2003-01-15 Deka Products Limited Partnership System for delivery of drugs by transport
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
AU739616B2 (en) * 1997-12-11 2001-10-18 Alza Corporation Device for enhancing transdermal agent flux
ES2244106T3 (es) * 1997-12-11 2005-12-01 Alza Corporation Dispositivo para mejorar el flujo transdermico de agentes.
JP2001525227A (ja) * 1997-12-11 2001-12-11 アルザ・コーポレーション 経皮的薬剤流量を高めるための装置
US5980494A (en) * 1997-12-22 1999-11-09 Robert Malenchek Safety syringe
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
ES2173678T3 (es) 1999-01-27 2002-10-16 Idea Ag Vacunacion no invasiva a traves de la piel.
ATE256484T1 (de) 1999-01-28 2004-01-15 Cyto Pulse Sciences Inc Einbringen von makromolekülen in zellen
JP2002542183A (ja) 1999-04-16 2002-12-10 ノボ ノルディスク アクティーゼルスカブ 成形可能な乾燥した医薬製剤
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6537242B1 (en) * 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
CZ20031037A3 (cs) * 2000-10-13 2003-10-15 Alza Corporation Zařízení a způsob probodnutí kůže mikrovýčnělky
BR0114628A (pt) * 2000-10-13 2004-01-20 Alza Corp Membro de retenção em microprojeção para aplicador de impacto
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
EP1341442B1 (en) * 2000-10-13 2005-06-29 Alza Corporation Microblade array impact applicator
JP4659336B2 (ja) * 2000-10-26 2011-03-30 アルザ・コーポレーシヨン 被覆された微細突出物を有する経皮的薬剤配達装置
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
CN101129327A (zh) * 2001-04-20 2008-02-27 阿尔扎公司 具有包含有益药剂的涂层的微小突出物阵列
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6527742B1 (en) * 2001-11-14 2003-03-04 Robert C. Malenchek Safety syringe
US20030199810A1 (en) * 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
DK1465535T3 (da) * 2001-12-20 2008-04-07 Alza Corp Mikrofremspring til gennemstikning af huden med stikdybdestyring
AR040302A1 (es) * 2002-06-28 2005-03-23 Alza Corp Dispositivos para la liberacion transdermica de farmacos, que presentan microprotrusiones recubiertas
TW200409657A (en) * 2002-08-08 2004-06-16 Alza Corp Transdermal vaccine delivery device having coated microprotrusions
WO2004030743A2 (en) * 2002-09-30 2004-04-15 Alza Corporation Drug delivery device having coated microprojections incorporating vasoconstrictors
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
AU2003901382A0 (en) * 2003-03-25 2003-04-10 Robert Baird Watson Hypodermic syringe
US6926697B2 (en) * 2003-05-13 2005-08-09 Robert Malenchek Adaptor for converting a non-safety syringe into a safety syringe
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
ES2437565T3 (es) * 2003-06-30 2014-01-13 Alza Corporation Formulaciones para microproyecciones revestidas que contienen contraiones no volátiles
TW200513280A (en) * 2003-07-02 2005-04-16 Alza Corp Microprojection array immunization patch and method
WO2005041871A2 (en) * 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
CA2543280A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections
KR20060099523A (ko) * 2003-10-31 2006-09-19 알자 코포레이션 미세 돌출부 어레이를 위한 자가 작동 어플리케이터
AU2004292954A1 (en) * 2003-11-13 2005-06-09 Alza Corporation Composition and apparatus for transdermal delivery
CA2552754A1 (en) * 2004-01-09 2005-08-04 Alza Corporation Frequency assisted transdermal agent delivery method and system
JP2007530680A (ja) * 2004-04-01 2007-11-01 アルザ・コーポレーシヨン インフルエンザワクチンの経皮デリバリーのための装置および方法
WO2005103303A2 (en) * 2004-04-13 2005-11-03 Alza Corporation Apparatus and method for transdermal delivery of multiple vaccines
ES2568259T3 (es) * 2004-05-13 2016-04-28 Alza Corporation Aparato y método para la administración transdérmica de agentes de hormona paratiroidea
CA2566759A1 (en) * 2004-05-19 2005-11-24 Alza Corporation Method and formulation for transdermal delivery of immunologically active agents
CA2579471A1 (en) * 2004-09-28 2006-04-06 Alza Corporation Stabilization of alum-adjuvanted immunologically active agents

Also Published As

Publication number Publication date
JP4382356B2 (ja) 2009-12-09
EP1383571A2 (en) 2004-01-28
MXPA03009601A (es) 2004-12-06
CA2444551A1 (en) 2002-10-31
US20020193729A1 (en) 2002-12-19
CA2444551C (en) 2009-11-17
NO20034683L (no) 2003-12-09
KR20040014502A (ko) 2004-02-14
CN1602216A (zh) 2005-03-30
IL158479A0 (en) 2004-05-12
NO20034683D0 (no) 2003-10-20
JP2004538048A (ja) 2004-12-24
WO2002085446A2 (en) 2002-10-31
US20060074377A1 (en) 2006-04-06
CN100467083C (zh) 2009-03-11
US20090143724A1 (en) 2009-06-04
WO2002085446A3 (en) 2003-03-06

Similar Documents

Publication Publication Date Title
BR0209041A (pt) Emplastro de imunização de disposição de microprojeção e método
TW200513280A (en) Microprojection array immunization patch and method
Matriano et al. Macroflux® microprojection array patch technology: a new and efficient approach for intracutaneous immunization
BRPI0509493A (pt) aparelho e método para a liberação transdérmica de vacina da influenza
BRPI0416822A (pt) método e sistema de liberação de vacina transdérmica com ultra-som
BR0209046A (pt) Disposição de microprojeção que possui um agente benéfico contendo revestimento
BRPI0509897A (pt) aparelho e método para distribuição transdérmica de múltiplas vacinas
BRPI0417022A (pt) sistemas para a aplicação de energia a uma região de corpo, para produzir um mapa de tecido subcutáneo topográfico, e para posicionar um dispositivo médico, aparelho para guiar o movimento de um emissor de energia sobre um corpo de paciente, métodos para aplicar energia a uma região de corpo, para executar um procedimento de terapia de lipoplastia , para destruir tecido gorduroso, para criar um mapa de corpo 3d com os locais de volumes de tecido gorduroso, para escultura de corpo utilizando um mapa de corpo 3d, e para posicionar uma cabeça de terapia de ultra-som no espaço
TW200502017A (en) Active agent delivery device having composite members
AR047229A1 (es) Administracion de conjugados polimericos de peptidos y proteinas terapeuticos por medio de microproyecciones revestidas
DE60213976D1 (de) Vorrichtung zur manipulation von nadeln oder polierarray
AR040819A1 (es) Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
WO2000061184A3 (en) Dry formulation for transcutaneous immunization
BRPI0415466A (pt) método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos
EP2286834A3 (en) Use of skin penetration enhancers and barrier disruption agents to enhance transcutaneous immune response
BRPI0415986A (pt) método e aparelho para reduzir a incidência do uso de tabaco
AR053661A1 (es) Peptido para entregar vacunas via mucosas
HUP0003347A2 (hu) Transzdermális terápiás rendszer (TTS) hatóanyag leadásához és eljárás a bőrre történő alkalmazáshoz
Joshi et al. Technology Update: Laser Ablation Technology for Transdermal Immunization
Kim et al. Pharmaceutical and Immunological Evaluation of Cholera Toxin A1 Subunit as an Adjuvant of Hepatitis B Vaccine Microneedles
CN111432833A (zh) 使用二十面体噬菌体的疫苗接种方法
Donnelly et al. 8 Microneedle-Mediated Vaccines
AU2007203302B2 (en) Microprojection array immunization patch and method
BR0303416A (pt) Processos de obtenção do lipopolissacarìdeo de bordetella pertussis e de obtenção e preparação do lipìdeo-a monofosforilado de bordetella pertussis, uso do lipìdeo-a monofosforilado de bordetella pertussis e vacinas
Donnelly et al. Microneedle-Mediated Vaccines

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: JOHNSON AND JOHNSON (US)

Free format text: TRANSFERIDO DE: ALZA CORPORATION

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2047 DE 30/03/2010.