BRPI0509897A - aparelho e método para distribuição transdérmica de múltiplas vacinas - Google Patents

aparelho e método para distribuição transdérmica de múltiplas vacinas

Info

Publication number
BRPI0509897A
BRPI0509897A BRPI0509897-1A BRPI0509897A BRPI0509897A BR PI0509897 A BRPI0509897 A BR PI0509897A BR PI0509897 A BRPI0509897 A BR PI0509897A BR PI0509897 A BRPI0509897 A BR PI0509897A
Authority
BR
Brazil
Prior art keywords
array
active agent
immunologically active
regions
biocompatible coating
Prior art date
Application number
BRPI0509897-1A
Other languages
English (en)
Inventor
Joseph C Trautman
Peter E Daddona
Michel J N Cormier
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0509897A publication Critical patent/BRPI0509897A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

APARELHO E MéTODO PARA DISTRIBUIçãO TRANSDéRMICA DE MúLTIPLAS VACINAS. a presente invenção refere-se a um aparelho e método para a distribuição transdérmica de um agente imunologicamente ativo compreendendo um sistema de distribuição possuindo um conjunto de microprojeções que inclui uma pluraridade de microprojeções que são adaptadas para perfurar o stratum corneum e entrar na camada epidérmica subjacente,ou as camadas de ipiderme e derme, o conjunto de microprojeção uma pluraridade de regiões de conjunto, cada uma das regiões de conjunto, cada uma das regiões de conjunto posuindo um revesimento biocompatível diferente na mesma,onde pelo menos um dos revestimentos de região de conjunto iclui um agente imunologicamente ativo. Em uma modalidade, cada revestimento nas regiões de conjunto inclui um agente imunologicamente ativo diferente. Em outra modalidade,o revestimento biocompatível em uma primeira região de conjunto inclui um agente imunologicamente ativo e o revestimento biocompatível em uma segunda região de conjunto inclui um adjuvante de aumento de resposta imune.
BRPI0509897-1A 2004-04-13 2005-03-18 aparelho e método para distribuição transdérmica de múltiplas vacinas BRPI0509897A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56195304P 2004-04-13 2004-04-13
PCT/US2005/009152 WO2005103303A2 (en) 2004-04-13 2005-03-18 Apparatus and method for transdermal delivery of multiple vaccines

Publications (1)

Publication Number Publication Date
BRPI0509897A true BRPI0509897A (pt) 2007-08-07

Family

ID=35197563

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509897-1A BRPI0509897A (pt) 2004-04-13 2005-03-18 aparelho e método para distribuição transdérmica de múltiplas vacinas

Country Status (12)

Country Link
US (1) US20050271684A1 (pt)
EP (1) EP1735469A2 (pt)
JP (1) JP2007537783A (pt)
KR (1) KR20070011481A (pt)
CN (1) CN101120101A (pt)
AR (1) AR048545A1 (pt)
AU (1) AU2005235990A1 (pt)
BR (1) BRPI0509897A (pt)
CA (1) CA2562642A1 (pt)
MX (1) MXPA06011971A (pt)
TW (1) TW200600107A (pt)
WO (1) WO2005103303A2 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
WO2005112463A2 (en) * 2004-05-19 2005-11-24 Alza Corporation Method and formulation for transdermal delivery of immunologically active agents
WO2007127815A2 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
EP2664323B1 (en) 2007-04-16 2020-07-29 Corium, Inc. Solvent-cast microneedle arrays containing active
DE102007060599A1 (de) * 2007-12-15 2009-06-18 Merck Patent Gmbh Verfahren zur Extraktion von Membranproteinen
US20110020392A1 (en) * 2008-10-14 2011-01-27 Salubrious Pharmaceutical, Llc Process for treatment of rheumatoid arthritis, tremors/parkinson's disease, multiple sclerosis and non-viral based cancers
WO2010047426A1 (en) * 2008-10-25 2010-04-29 Youn-Sung Kim Structure of needle for syringe
ES2547654T3 (es) * 2008-10-31 2015-10-07 Tremrx, Inc. Vacunación con vectores poxvirales mediante alteración mecánica epidérmica
US8691502B2 (en) * 2008-10-31 2014-04-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
AU2010238605B2 (en) * 2009-04-24 2015-10-29 Corium Pharma Solutions, Inc. Methods for manufacturing microprojection arrays
US9545455B2 (en) * 2009-04-29 2017-01-17 Pravin K. Muniyappa Device and method for the diagnosis of gastrointestinal allergy
JP6327852B2 (ja) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス
JP5225364B2 (ja) 2010-12-08 2013-07-03 住友ゴム工業株式会社 ストリップ、その製造方法および空気入りタイヤの製造方法
WO2012151272A2 (en) * 2011-05-02 2012-11-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
CA2896188C (en) 2012-12-21 2021-02-23 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
US10245422B2 (en) 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
WO2014142135A1 (ja) 2013-03-12 2014-09-18 武田薬品工業株式会社 マイクロニードルパッチ
RU2711567C2 (ru) 2013-03-15 2020-01-17 Кориум, ИНК. Микрочип для доставки лекарственного средства и способы его использования
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
CN106061546A (zh) * 2014-02-10 2016-10-26 Lts勒曼治疗系统股份公司 微针系统及其制造方法
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
WO2016114213A1 (ja) 2015-01-13 2016-07-21 凸版印刷株式会社 経皮投与デバイス
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
KR102444230B1 (ko) 2016-09-13 2022-09-19 알레간 인코포레이티드 안정화된 비단백질 클로스트리듐 독소 조성물
US11241563B2 (en) 2016-12-22 2022-02-08 Johnson & Johnson Consumer Inc. Microneedle arrays and methods for making and using
JP7313683B2 (ja) * 2017-07-24 2023-07-25 株式会社バイオセレンタック ワクチンアジュバント及びマイクロニードル製剤
WO2019190267A1 (ko) * 2018-03-30 2019-10-03 랩앤피플주식회사 멀티형 마이크로 니들
JP2021529760A (ja) 2018-06-29 2021-11-04 ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッドＪｏｈｎｓｏｎ ＆ Ｊｏｈｎｓｏｎ Ｃｏｎｓｕｍｅｒ Ｉｎｃ． 活性物質の送達のための三次元マイクロ流体デバイス
US11697009B2 (en) * 2019-09-06 2023-07-11 Industry-Academic Cooperation Foundation, Yonsei University Microneedle patch, micro needle system and method of fabricating the same
US11796548B2 (en) 2020-04-22 2023-10-24 The United States Of America, As Represented By The Secretary Of Agriculture Continuous stable cell line for identification of infectious African swine fever virus in clinical samples
CN115068602B (zh) * 2022-08-22 2022-11-01 北京华诺泰生物医药科技有限公司 一种表面改性氧化铝的复合疫苗佐剂、制备方法及应用

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) * 1964-09-08 Means for vaccinating
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
DE3113984C2 (de) * 1981-04-07 1983-12-01 Bodenseewerk Perkin-Elmer & Co GmbH, 7770 Überlingen Doppelmonochromator
US4877612A (en) * 1985-05-20 1989-10-31 Frank M. Berger Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5487726A (en) * 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5659578A (en) * 1994-11-23 1997-08-19 At&T Wireless Services, Inc. High rate Reed-Solomon concatenated trellis coded 16 star QAM system for transmission of data over cellular mobile radio
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
ZA975326B (en) * 1996-06-18 1998-01-14 Alza Corp Device and method for enhancing transdermal flux of agents being delivered or sampled.
US5743960A (en) * 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5916524A (en) * 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5741554A (en) * 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
ES2244106T3 (es) * 1997-12-11 2005-12-01 Alza Corporation Dispositivo para mejorar el flujo transdermico de agentes.
AU739616B2 (en) * 1997-12-11 2001-10-18 Alza Corporation Device for enhancing transdermal agent flux
EP1037687B8 (en) * 1997-12-11 2008-10-22 Alza Corporation Device for enhancing transdermal agent flux
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
WO1999064580A1 (en) * 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
EP1335711B1 (en) * 2000-09-08 2007-07-25 Alza Corporation Transdermal device
WO2002030281A1 (en) * 2000-10-13 2002-04-18 Alza Corporation Microblade array impact applicator
DE60138411D1 (de) * 2000-10-13 2009-05-28 Alza Corp Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
AU9681701A (en) * 2000-10-13 2002-04-22 Alza Corp Microprotrusion member retainer for impact applicator
US7537795B2 (en) * 2000-10-26 2009-05-26 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
EP1345646A2 (en) * 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002074173A1 (en) * 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
ATE444773T1 (de) * 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
BR0210628A (pt) * 2001-06-29 2004-08-10 Becton Dickinson Co Liberação intradérmica de vacinas e agentes terapêuticos genéticos via microcânula
WO2003048031A2 (en) * 2001-11-30 2003-06-12 Alza Corporation Methods and apparatuses for forming microprojection arrays
DE60223844T2 (de) * 2001-12-20 2008-08-28 Alza Corp., Mountain View Mikrovorsprünge zum durchstechen der haut mit stechtiefensteuerung
EP1483019A4 (en) * 2002-03-11 2007-07-04 Altea Therapeutics Corp TRANSDERMALES MEDICAMENT PAVING SYSTEM, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THE APPLICATION THEREOF
AR040302A1 (es) * 2002-06-28 2005-03-23 Alza Corp Dispositivos para la liberacion transdermica de farmacos, que presentan microprotrusiones recubiertas
AR040819A1 (es) * 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
ES2437565T3 (es) * 2003-06-30 2014-01-13 Alza Corporation Formulaciones para microproyecciones revestidas que contienen contraiones no volátiles
EP1638468B1 (en) * 2003-06-30 2007-08-15 Alza Corporation Method for coating skin piercing microprojections
KR20060037320A (ko) * 2003-07-02 2006-05-03 알자 코포레이션 미세돌출부 어레이 면역화 패치 및 방법
BRPI0415967A (pt) * 2003-10-28 2007-01-23 Alza Corp aplicação de conjugados de polìmero de peptìdeos e proteìnas terapêuticos através de microprojeções revestidas
ES2377647T3 (es) * 2003-10-31 2012-03-29 Alza Corporation Aplicador auto-actuado para ordenamiento de microproyecciones
US20050106209A1 (en) * 2003-11-13 2005-05-19 Mahmoud Ameri Composition and apparatus for transdermal delivery
EP1734993A4 (en) * 2004-04-01 2009-10-21 Alza Corp DEVICE AND METHOD FOR THE TRANSDERMAL DISTRIBUTION OF THE GRIP VACCINE
AU2005244734A1 (en) * 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents

Also Published As

Publication number Publication date
CA2562642A1 (en) 2005-11-03
CN101120101A (zh) 2008-02-06
EP1735469A2 (en) 2006-12-27
TW200600107A (en) 2006-01-01
AU2005235990A1 (en) 2005-11-03
KR20070011481A (ko) 2007-01-24
US20050271684A1 (en) 2005-12-08
AR048545A1 (es) 2006-05-03
JP2007537783A (ja) 2007-12-27
WO2005103303A2 (en) 2005-11-03
MXPA06011971A (es) 2007-04-16
WO2005103303A3 (en) 2007-10-18

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