AR046697A1 - Metodo y sistema de administracion transdermica de agente asistido por frecuencia - Google Patents

Metodo y sistema de administracion transdermica de agente asistido por frecuencia

Info

Publication number
AR046697A1
AR046697A1 ARP040103975A ARP040103975A AR046697A1 AR 046697 A1 AR046697 A1 AR 046697A1 AR P040103975 A ARP040103975 A AR P040103975A AR P040103975 A ARP040103975 A AR P040103975A AR 046697 A1 AR046697 A1 AR 046697A1
Authority
AR
Argentina
Prior art keywords
biologically active
active agent
microprojections
frequency
agent
Prior art date
Application number
ARP040103975A
Other languages
English (en)
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of AR046697A1 publication Critical patent/AR046697A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un aparato y método para administrar transdérmicamente un agente biológicamente activo que comprende un sistema de administración que tiene una parte (o sistema) con microproyecciones que incluye una pluralidad de microproyecciones ( o conjunto de las mismas) que se adaptan para penetrar a través del estrato córneo en la capa de epidermis subyacente, o en las capas de epidermis y dermis, una formulación que contiene el agente biológicamente activo y un aparato inductor de oscilaciones. En una realización, el agente biológicamente activo está contenido en un recubrimiento biocompatible que es aplicado a la parte con microproyecciones. En una realización adicional, el sistema de administración incluye un paquete de gel que tiene una formulación de hidrogel que contiene el agente que es dispuesta sobre la parte con microproyecciones después de la aplicación a la piel de un paciente. En una realización alternativa, el agente biológicamente activo está contenido tanto en el recubrimiento como en la formulación del hidrogel.
ARP040103975A 2004-01-09 2004-10-29 Metodo y sistema de administracion transdermica de agente asistido por frecuencia AR046697A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53527504P 2004-01-09 2004-01-09

Publications (1)

Publication Number Publication Date
AR046697A1 true AR046697A1 (es) 2005-12-21

Family

ID=34806918

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040103975A AR046697A1 (es) 2004-01-09 2004-10-29 Metodo y sistema de administracion transdermica de agente asistido por frecuencia

Country Status (12)

Country Link
US (1) US20050153873A1 (es)
EP (1) EP1706176A4 (es)
JP (1) JP2007519446A (es)
KR (1) KR20060134050A (es)
CN (1) CN1946452A (es)
AR (1) AR046697A1 (es)
AU (1) AU2004314416A1 (es)
BR (1) BRPI0417757A (es)
CA (1) CA2552754A1 (es)
MX (1) MXPA06007832A (es)
TW (1) TW200600132A (es)
WO (1) WO2005069758A2 (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
MX2007001667A (es) * 2004-08-11 2007-10-02 Johnson & Johnson Aparato y metodo para el suministro transdermico de peptidos natriureticos.
US8048017B2 (en) 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
CA2629193C (en) * 2005-11-18 2016-03-29 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
WO2007059289A1 (en) * 2005-11-18 2007-05-24 3M Innovative Properties Company Microneedle arrays and methods of preparing same
US8554317B2 (en) 2005-11-30 2013-10-08 3M Innovative Properties Company Microneedle arrays and methods of use thereof
JP2009539508A (ja) 2006-06-15 2009-11-19 シーガル アイピー ピーティーワイ リミテッド 送達システム及び方法
DE102006028987A1 (de) * 2006-06-24 2007-12-27 Lts Lohmann Therapie-Systeme Ag Ultraschallverstärktes transdermales therapeutisches System
US9539593B2 (en) 2006-10-23 2017-01-10 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
US20080214987A1 (en) 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
WO2008145323A1 (en) * 2007-05-31 2008-12-04 F. Hoffmann-La Roche Ag Pharmaceutical formulation for interferons
BRPI0814986A2 (pt) 2007-08-06 2015-02-03 Serenity Pharmaceuticals Corp Métodos e dispositivos para a distribuição de fármaco desmopresina.
JP5419702B2 (ja) * 2007-10-18 2014-02-19 久光製薬株式会社 マイクロニードルデバイス
JP5508272B2 (ja) * 2007-10-29 2014-05-28 トランスファーマ メディカル リミテッド 垂直的なパッチ乾燥
US20090157003A1 (en) * 2007-12-14 2009-06-18 Jones Daniel W Method And Apparatus For Occlusion Prevention And Remediation
CN103961792B (zh) * 2007-12-17 2016-09-21 新世界药品有限公司 整合的真皮内递送、诊断和通讯系统
PT2296686E (pt) * 2008-05-21 2014-05-23 Ferring Bv Desmopressina orodispersível para aumentar o período inicial de sono não perturbado por noctúria
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
CA2730995C (en) * 2008-07-17 2016-11-22 Micell Technologies, Inc. Drug delivery medical device
CA2735983A1 (en) * 2008-09-10 2010-03-18 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
IT1394690B1 (it) * 2008-10-23 2012-07-13 Carli De Metodo di trattamento dermocosmetico della cute mediante applicazione di composizioni contenenti ngf.
EP2392378B1 (en) * 2009-01-30 2017-03-15 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
US8747362B2 (en) 2009-06-10 2014-06-10 Hisamitsu Pharmaceutical Co., Inc Microneedle device
CN102470179A (zh) 2009-07-23 2012-05-23 久光制药株式会社 微针阵列
US7803762B1 (en) 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
US20120309691A1 (en) * 2010-02-04 2012-12-06 Dapeng Zhou Tumor targeted delivery of immunomodulators by nanopolymers
EP2636424A1 (de) * 2012-03-09 2013-09-11 LTS LOHMANN Therapie-Systeme AG Therapeutisches System mit hohlen Mikronadeln
EP4194028A1 (en) * 2013-03-15 2023-06-14 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators
DE102013005197A1 (de) * 2013-03-25 2014-09-25 Michael Horstmann Schwingendes Mikronadelpflaster
EP3139990A4 (en) 2014-05-06 2018-01-17 Mupharma Pty Ltd Non-invasive agent applicator
CN104056346B (zh) * 2014-06-16 2017-04-26 游学秋 异平面微针阵列及其制作方法
WO2016074040A2 (en) * 2014-11-12 2016-05-19 Mupharma Pty Ltd Non-invasive agent applicator
JP6449057B2 (ja) * 2015-03-10 2019-01-09 国立研究開発法人産業技術総合研究所 ナノニードルアレイを用いた細胞への物質導入法
CN109803672A (zh) 2016-09-13 2019-05-24 阿勒根公司 稳定的非蛋白质梭菌毒素组合物
CA3079421A1 (en) * 2017-10-16 2019-04-25 Massachusetts Institute Of Technology Compositions and methods to enhance ultrasound-mediated delivery of pharmaceutical agents
CN108969879B (zh) * 2018-06-05 2021-06-22 南京工业大学 一种复合微针及微针贴片
DE102019105694A1 (de) * 2019-03-06 2020-09-10 Lts Lohmann Therapie-Systeme Ag Mikronadelarray aufweisend ein wärmeerzeugendes Element
US20230039698A1 (en) * 2019-12-19 2023-02-09 Trimph Ip Pty Ltd Biocompatible Material

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT99344A (pt) * 1990-10-29 1993-12-31 Alza Corp Dispositivo para aplicacao iontoforetica e metodo para o hidratar
US6041253A (en) * 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US6234990B1 (en) * 1996-06-28 2001-05-22 Sontra Medical, Inc. Ultrasound enhancement of transdermal transport
CA2259437C (en) * 1996-07-03 2006-12-05 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
JP2002500075A (ja) * 1998-01-08 2002-01-08 ソントラ メディカル， インコーポレイテッド 超音波伝達で増強される経皮輸送
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6620123B1 (en) * 1999-12-17 2003-09-16 Sontra Medical, Inc. Method and apparatus for producing homogenous cavitation to enhance transdermal transport

Also Published As

Publication number Publication date
WO2005069758A3 (en) 2006-05-18
TW200600132A (en) 2006-01-01
EP1706176A2 (en) 2006-10-04
WO2005069758A2 (en) 2005-08-04
MXPA06007832A (es) 2007-01-26
BRPI0417757A (pt) 2007-04-10
CA2552754A1 (en) 2005-08-04
KR20060134050A (ko) 2006-12-27
AU2004314416A1 (en) 2005-08-04
US20050153873A1 (en) 2005-07-14
CN1946452A (zh) 2007-04-11
EP1706176A4 (en) 2008-06-25
JP2007519446A (ja) 2007-07-19

Similar Documents

Publication Publication Date Title
AR046697A1 (es) Metodo y sistema de administracion transdermica de agente asistido por frecuencia
AR048827A1 (es) Aparato y metodo para la administracion transdermica de agentes basados en fentanil
AR046823A1 (es) Sistema y metodo de administracion de vacuna transdermica asistida por ultrasonido
Lee et al. Bleomycin-coated microneedles for treatment of warts
MXPA06013168A (es) Aparato y metodo para el suministro transdermico de agentes de la hormona paratiroidea.
EP2001453A4 (en) APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE AGENTS FOR TREATING OR PREVENTING OSTEOPENIA
BRPI0509493A (pt) aparelho e método para a liberação transdérmica de vacina da influenza
CN102657914B (zh) 高渗透效率的微针透皮输入贴
AR046307A1 (es) Metodo de pretratamiento y sistema para mejorar la administracion transdermica de drogas
AR047229A1 (es) Administracion de conjugados polimericos de peptidos y proteinas terapeuticos por medio de microproyecciones revestidas
TW200618830A (en) Micorprojection apparatus and system with low infection potential
AR040819A1 (es) Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
NO20034684L (no) Mikroprojeksjonsanordning med belegg inneholdende et fordelaktig middel
MXPA03003815A (es) Dispositivos de suministro transdermico de farmaco que tienen microrresaltos recubiertos.
AR046696A1 (es) Aplicador auto-accionante para grupo de microproyecciones
TW200616660A (en) Apparatus and method for transdermal delivery of natriuretic peptides
Xue et al. Drug-eluting microneedles for self-administered treatment of keloids
AR050608A1 (es) Aparato y metodo para administracion transdermica de factores de crecimiento endotelial vascular
TW200738252A (en) Apparatus and method for transdermal delivery of Epoetin-based agents
WO2008115586A1 (en) Apparatus and method for transdermal delivery of a triptan agonist
CA2569285A1 (en) Methods of device-assisted drug delivery
Kaur et al. Advancement in microneedles as minimally invasive delivery system for pharmaceutical and biomedical application: A review
Jain et al. Transdermal Drug Delivery
Zempsky Topical anaesthetics and analgesics
TW200602019A (en) Apparatus and method for transdermal delivery of parathyroid hormone agents

Legal Events

Date Code Title Description
FA Abandonment or withdrawal