AR047229A1 - Administracion de conjugados polimericos de peptidos y proteinas terapeuticos por medio de microproyecciones revestidas - Google Patents

Administracion de conjugados polimericos de peptidos y proteinas terapeuticos por medio de microproyecciones revestidas

Info

Publication number
AR047229A1
AR047229A1 ARP040103915A ARP040103915A AR047229A1 AR 047229 A1 AR047229 A1 AR 047229A1 AR P040103915 A ARP040103915 A AR P040103915A AR P040103915 A ARP040103915 A AR P040103915A AR 047229 A1 AR047229 A1 AR 047229A1
Authority
AR
Argentina
Prior art keywords
microprojections
administration
peptides
covered
therapeutic proteins
Prior art date
Application number
ARP040103915A
Other languages
English (en)
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of AR047229A1 publication Critical patent/AR047229A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00893Material properties pharmaceutically effective
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un aparato para la administracion por vía transdérmica de un agente biologicamente activo a un paciente, que comprende una pieza con microproyecciones que cuenta con una pluralidad de microproyecciones que están adaptadas para perforar el estrato corneo del usuario de nicotina, donde la pieza con microproyecciones tiene un revestimiento biocompatible dispuesto sobre la misma que incluye un agente biologicamente activo seleccionado del grupo formado por conjugados de péptidos y proteínas. Método para administracion transdérmica.
ARP040103915A 2003-10-28 2004-10-27 Administracion de conjugados polimericos de peptidos y proteinas terapeuticos por medio de microproyecciones revestidas AR047229A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51539803P 2003-10-28 2003-10-28

Publications (1)

Publication Number Publication Date
AR047229A1 true AR047229A1 (es) 2006-01-11

Family

ID=34572834

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040103915A AR047229A1 (es) 2003-10-28 2004-10-27 Administracion de conjugados polimericos de peptidos y proteinas terapeuticos por medio de microproyecciones revestidas

Country Status (11)

Country Link
US (1) US20050106227A1 (es)
EP (1) EP1677687A4 (es)
JP (1) JP2007535337A (es)
KR (1) KR20070001886A (es)
CN (1) CN1897883A (es)
AR (1) AR047229A1 (es)
AU (1) AU2004287059A1 (es)
BR (1) BRPI0415967A (es)
CA (1) CA2543280A1 (es)
TW (1) TW200539907A (es)
WO (1) WO2005044985A2 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0914178T3 (da) * 1996-06-18 2003-04-22 Alza Corp Anordning til forøgelse af transdermal afgivelse eller prøveudtagning af et middel
BR0114628A (pt) * 2000-10-13 2004-01-20 Alza Corp Membro de retenção em microprojeção para aplicador de impacto
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
CZ20031037A3 (cs) * 2000-10-13 2003-10-15 Alza Corporation Zařízení a způsob probodnutí kůže mikrovýčnělky
JP4659336B2 (ja) * 2000-10-26 2011-03-30 アルザ・コーポレーシヨン 被覆された微細突出物を有する経皮的薬剤配達装置
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US8961477B2 (en) * 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds
AU2004286232A1 (en) * 2003-10-23 2005-05-12 Alza Corporation Compositions of stabilized DNA for coating microprojections
EP1675539A4 (en) * 2003-10-24 2007-09-12 Alza Corp METHOD AND SYSTEM FOR PRETREATMENT FOR IMPROVING TRANSDERMAL DRUG DELIVERY
BRPI0415986A (pt) * 2003-10-28 2007-01-23 Alza Corp método e aparelho para reduzir a incidência do uso de tabaco
KR20060099523A (ko) 2003-10-31 2006-09-19 알자 코포레이션 미세 돌출부 어레이를 위한 자가 작동 어플리케이터
MXPA06005677A (es) * 2003-11-21 2006-12-14 Johnson & Johnson Metodo y sistema de suministro transdermico de vacuna asistido por ultrasonido.
WO2005103303A2 (en) * 2004-04-13 2005-11-03 Alza Corporation Apparatus and method for transdermal delivery of multiple vaccines
ES2568259T3 (es) * 2004-05-13 2016-04-28 Alza Corporation Aparato y método para la administración transdérmica de agentes de hormona paratiroidea
MX2007002795A (es) * 2004-09-08 2008-03-05 Johnson & Johnson Arreglo de microproyeccion con adhesion y adaptacion a la piel, mejoradas.
KR101246015B1 (ko) 2004-11-18 2013-03-20 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 어레이를 접촉 코팅하는 방법
KR101224257B1 (ko) * 2004-11-18 2013-01-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 어레이를 코팅하기 위한 마스킹 방법
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
JP4913030B2 (ja) * 2005-01-31 2012-04-11 株式会社バイオセレンタック 経皮吸収製剤、経皮吸収製剤保持シート、及び経皮吸収製剤保持用具
EP1904158B1 (en) * 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
CN101267896A (zh) * 2005-09-12 2008-09-17 阿尔扎公司 可涂覆的透皮给药微突起组合件
WO2007061964A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Methods for coating microneedles
US20070293816A1 (en) * 2006-04-25 2007-12-20 Alza Corporation Microprojection Array Application with Grouped Microprojections for High Drug Loading
US20070299388A1 (en) * 2006-04-25 2007-12-27 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
AU2011258288B2 (en) 2010-05-28 2015-02-12 Kindeva Drug Delivery L.P. Aqueous formulations for coating microneedle arrays
AU2012256403B2 (en) 2011-03-17 2016-10-20 Corning Incorporated Synthetic coating for cell culture
JP6033280B2 (ja) * 2011-04-22 2016-11-30 ラジウス ヘルス,インコーポレイテッド PTH、PTHrP、および関連ペプチドの薬剤送達方法
WO2012150475A1 (en) * 2011-05-05 2012-11-08 Corning Incorporated Synthetic composition and coating for cell culture.
JP5870551B2 (ja) * 2011-08-26 2016-03-01 大日本印刷株式会社 マイクロニードルデバイスの製造方法
KR101724655B1 (ko) * 2014-06-02 2017-04-13 주식회사 아모라이프사이언스 마이크로 니들 패치 및 그의 제조 방법
AU2016256470B2 (en) 2015-04-29 2020-10-15 Radius Pharmaceuticals, Inc. Methods of treating cancer
CN105833424A (zh) * 2016-03-21 2016-08-10 南通纺织丝绸产业技术研究院 一种丝素蛋白微针贴及其制备方法
LT3565542T (lt) 2017-01-05 2024-07-10 Radius Pharmaceuticals, Inc. Polimorfinės rad1901-2hcl formos
CN112423844B (zh) 2018-07-04 2024-08-13 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US2893392A (en) * 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3221739A (en) * 1962-03-26 1965-12-07 Rosenthal Sol Roy Injection device
US3221740A (en) * 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
FR2474856A1 (fr) * 1980-01-31 1981-08-07 Merieux Inst Dispositif scarificateur
SE8501990D0 (sv) * 1985-04-24 1985-04-24 Pharmacia Ab Beleggningsforfarande
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5147296A (en) * 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5169382A (en) * 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5487726A (en) * 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
US5741554A (en) * 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5916524A (en) * 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5738728A (en) * 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus
US5743960A (en) * 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
AU739616B2 (en) * 1997-12-11 2001-10-18 Alza Corporation Device for enhancing transdermal agent flux
ES2244106T3 (es) * 1997-12-11 2005-12-01 Alza Corporation Dispositivo para mejorar el flujo transdermico de agentes.
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6537242B1 (en) * 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
BR0114628A (pt) * 2000-10-13 2004-01-20 Alza Corp Membro de retenção em microprojeção para aplicador de impacto
CZ20031037A3 (cs) * 2000-10-13 2003-10-15 Alza Corporation Zařízení a způsob probodnutí kůže mikrovýčnělky
US6573237B2 (en) * 2001-03-16 2003-06-03 Eli Lilly And Company Protein formulations
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections

Also Published As

Publication number Publication date
BRPI0415967A (pt) 2007-01-23
AU2004287059A1 (en) 2005-05-19
CA2543280A1 (en) 2005-05-19
US20050106227A1 (en) 2005-05-19
WO2005044985A3 (en) 2005-10-20
KR20070001886A (ko) 2007-01-04
WO2005044985A2 (en) 2005-05-19
EP1677687A2 (en) 2006-07-12
CN1897883A (zh) 2007-01-17
TW200539907A (en) 2005-12-16
JP2007535337A (ja) 2007-12-06
EP1677687A4 (en) 2008-09-17

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