JP4382356B2 - 微小突起アレイ免疫感作貼付剤および方法 - Google Patents
微小突起アレイ免疫感作貼付剤および方法 Download PDFInfo
- Publication number
- JP4382356B2 JP4382356B2 JP2002583019A JP2002583019A JP4382356B2 JP 4382356 B2 JP4382356 B2 JP 4382356B2 JP 2002583019 A JP2002583019 A JP 2002583019A JP 2002583019 A JP2002583019 A JP 2002583019A JP 4382356 B2 JP4382356 B2 JP 4382356B2
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- array
- skin
- reservoir
- microprojections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002649 immunization Methods 0.000 title description 30
- 230000003053 immunization Effects 0.000 title description 30
- 238000000034 method Methods 0.000 title description 17
- 210000003491 skin Anatomy 0.000 claims description 81
- 239000002671 adjuvant Substances 0.000 claims description 54
- 239000003795 chemical substances by application Substances 0.000 claims description 51
- 238000000576 coating method Methods 0.000 claims description 50
- 230000000890 antigenic effect Effects 0.000 claims description 48
- 239000011248 coating agent Substances 0.000 claims description 43
- 229960005486 vaccine Drugs 0.000 claims description 36
- 230000028993 immune response Effects 0.000 claims description 28
- MXMOFDISXOBSJM-BHACDBBJSA-N C[C@H](NC(=O)[C@@H](C)O[C@@H]1[C@@H](NC(C)=O)[C@H](O)O[C@H](CO)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1N)C(=O)N[C@H](CCC(N)=O)C(O)=O Chemical compound C[C@H](NC(=O)[C@@H](C)O[C@@H]1[C@@H](NC(C)=O)[C@H](O)O[C@H](CO)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1N)C(=O)N[C@H](CCC(N)=O)C(O)=O MXMOFDISXOBSJM-BHACDBBJSA-N 0.000 claims description 27
- 229950001715 glucosaminylmuramyl dipeptide Drugs 0.000 claims description 27
- 108700026361 glucosaminylmuramyl-2-alanine-D-isoglutamine Proteins 0.000 claims description 27
- 210000000434 stratum corneum Anatomy 0.000 claims description 18
- 230000002708 enhancing effect Effects 0.000 claims description 14
- 230000000149 penetrating effect Effects 0.000 claims description 13
- 238000011068 loading method Methods 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 9
- 230000002238 attenuated effect Effects 0.000 claims description 7
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 6
- 229920002498 Beta-glucan Polymers 0.000 claims description 6
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims description 6
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims description 6
- 229910052751 metal Inorganic materials 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 238000002255 vaccination Methods 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 241000700605 Viruses Species 0.000 claims description 5
- 239000000853 adhesive Substances 0.000 claims description 5
- 230000001070 adhesive effect Effects 0.000 claims description 5
- 230000037368 penetrate the skin Effects 0.000 claims description 5
- VDCRFBBZFHHYGT-IOSLPCCCSA-N 2-amino-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-enyl-3h-purine-6,8-dione Chemical compound O=C1N(CC=C)C=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O VDCRFBBZFHHYGT-IOSLPCCCSA-N 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 4
- 102000009016 Cholera Toxin Human genes 0.000 claims description 4
- 108010049048 Cholera Toxin Proteins 0.000 claims description 4
- 102000004895 Lipoproteins Human genes 0.000 claims description 4
- 108090001030 Lipoproteins Proteins 0.000 claims description 4
- DNUXJWBKTMJNEP-JVSLBXKQSA-N [(2R)-3-[(2S)-2-[[(4R)-4-[[(2S)-2-[[(2R)-2-[(2R,3R,4R,5R)-2-acetamido-4-[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,6-dihydroxy-1-oxohexan-3-yl]oxypropanoyl]amino]propanoyl]amino]-5-amino-5-oxopentanoyl]amino]propanoyl]oxy-2-hexadecanoyloxypropyl] hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COC(=O)[C@H](C)NC(=O)CC[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]([C@@H](NC(C)=O)C=O)[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)[C@H](O)CO)C(N)=O)OC(=O)CCCCCCCCCCCCCCC DNUXJWBKTMJNEP-JVSLBXKQSA-N 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 4
- 229960003971 influenza vaccine Drugs 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229920001282 polysaccharide Polymers 0.000 claims description 4
- 239000005017 polysaccharide Substances 0.000 claims description 4
- 229960003127 rabies vaccine Drugs 0.000 claims description 4
- 229940083538 smallpox vaccine Drugs 0.000 claims description 4
- 229940021648 varicella vaccine Drugs 0.000 claims description 4
- 229920001503 Glucan Polymers 0.000 claims description 3
- 229920001202 Inulin Polymers 0.000 claims description 3
- 108700003135 N-acetylglucosamine-N-acetylmuramyl-alanyl-isoglutaminyl-alanyl-glycerol dipalmitoyl Proteins 0.000 claims description 3
- 229920001106 Pleuran Polymers 0.000 claims description 3
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 3
- 229960005097 diphtheria vaccines Drugs 0.000 claims description 3
- 229960002520 hepatitis vaccine Drugs 0.000 claims description 3
- 229960002751 imiquimod Drugs 0.000 claims description 3
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims description 3
- 229940029339 inulin Drugs 0.000 claims description 3
- 229950005634 loxoribine Drugs 0.000 claims description 3
- 229940041323 measles vaccine Drugs 0.000 claims description 3
- JMUHBNWAORSSBD-WKYWBUFDSA-N mifamurtide Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)COP(O)(=O)OCCNC(=O)[C@H](C)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O JMUHBNWAORSSBD-WKYWBUFDSA-N 0.000 claims description 3
- 229960005225 mifamurtide Drugs 0.000 claims description 3
- 229920001542 oligosaccharide Polymers 0.000 claims description 3
- 150000002482 oligosaccharides Chemical class 0.000 claims description 3
- 239000010409 thin film Substances 0.000 claims description 3
- 238000012546 transfer Methods 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 2
- 208000005647 Mumps Diseases 0.000 claims description 2
- 208000010805 mumps infectious disease Diseases 0.000 claims description 2
- PIJXCSUPSNFXNE-QRZOAFCBSA-N N-acetyl-4-(N-acetylglucosaminyl)muramoyl-L-alanyl-D-isoglutamine Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@@H]1[C@@H](NC(C)=O)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 PIJXCSUPSNFXNE-QRZOAFCBSA-N 0.000 claims 2
- 229920003649 Terramid Polymers 0.000 claims 2
- 230000003511 endothelial effect Effects 0.000 claims 2
- 229940042470 lyme disease vaccine Drugs 0.000 claims 2
- 229940095293 mumps vaccine Drugs 0.000 claims 1
- -1 murapalmitine Chemical compound 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 108010058846 Ovalbumin Proteins 0.000 description 98
- 229940092253 ovalbumin Drugs 0.000 description 94
- 102000036639 antigens Human genes 0.000 description 30
- 108091007433 antigens Proteins 0.000 description 30
- 239000000427 antigen Substances 0.000 description 28
- 241001465754 Metazoa Species 0.000 description 26
- 238000003491 array Methods 0.000 description 19
- 239000000243 solution Substances 0.000 description 17
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 15
- 230000035515 penetration Effects 0.000 description 13
- 241000700198 Cavia Species 0.000 description 11
- 230000001965 increasing effect Effects 0.000 description 11
- 238000007920 subcutaneous administration Methods 0.000 description 11
- 230000005875 antibody response Effects 0.000 description 10
- 239000007924 injection Substances 0.000 description 10
- 238000002347 injection Methods 0.000 description 10
- 238000007918 intramuscular administration Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 210000004207 dermis Anatomy 0.000 description 7
- 210000002615 epidermis Anatomy 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 206010015150 Erythema Diseases 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000000740 bleeding effect Effects 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 231100000321 erythema Toxicity 0.000 description 6
- 229920002521 macromolecule Polymers 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 231100000673 dose–response relationship Toxicity 0.000 description 5
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 206010030113 Oedema Diseases 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 238000007390 skin biopsy Methods 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 3
- 238000000540 analysis of variance Methods 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 238000005530 etching Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000000799 fluorescence microscopy Methods 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000006193 liquid solution Substances 0.000 description 3
- 239000006194 liquid suspension Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000010936 titanium Substances 0.000 description 3
- 229910052719 titanium Inorganic materials 0.000 description 3
- 230000037317 transdermal delivery Effects 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 108091061960 Naked DNA Proteins 0.000 description 2
- 206010040914 Skin reaction Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 description 2
- 230000008350 antigen-specific antibody response Effects 0.000 description 2
- MJAMCTLGWXIKOT-UHFFFAOYSA-M benzyl-dimethyl-[2-[2-[2-methyl-4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]azanium;hydroxide Chemical compound [OH-].CC1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 MJAMCTLGWXIKOT-UHFFFAOYSA-M 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
- 239000004327 boric acid Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000008199 coating composition Substances 0.000 description 2
- 238000002716 delivery method Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 210000001821 langerhans cell Anatomy 0.000 description 2
- 230000004807 localization Effects 0.000 description 2
- 229920001684 low density polyethylene Polymers 0.000 description 2
- 239000004702 low-density polyethylene Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 229940066827 pertussis vaccine Drugs 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000035483 skin reaction Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000008223 sterile water Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229940021747 therapeutic vaccine Drugs 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- CNBOKXFMODKQCT-UHFFFAOYSA-N 1-(4-aminoimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol Chemical compound C1=CC=CC2=C3N(CC(C)(O)C)C=NC3=C(N)N=C21 CNBOKXFMODKQCT-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 206010003041 Application site erythema Diseases 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 description 1
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 235000004391 Chenopodium capitatum Nutrition 0.000 description 1
- 244000038022 Chenopodium capitatum Species 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000711549 Hepacivirus C Species 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 241000701806 Human papillomavirus Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000589242 Legionella pneumophila Species 0.000 description 1
- 208000016604 Lyme disease Diseases 0.000 description 1
- 108700024476 N-acetylmuramyl-alanylglutamine methyl ester Proteins 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 229920001218 Pullulan Polymers 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
- 241000710799 Rubella virus Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 241001505901 Streptococcus sp. 'group A' Species 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 241000589886 Treponema Species 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000009056 active transport Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical class [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 108700042119 disaccharide tripeptide Proteins 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000003426 epidermal langerhans cell Anatomy 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000005558 fluorometry Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 229940115932 legionella pneumophila Drugs 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- OXSVRXKURHXDIV-OTVXWGLQSA-N methyl (2r)-2-[[(2s)-2-[2-[(2s,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoylamino]propanoyl]amino]-5-amino-5-oxopentanoate Chemical compound NC(=O)CC[C@H](C(=O)OC)NC(=O)[C@H](C)NC(=O)C(C)O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O)[C@@H]1NC(C)=O OXSVRXKURHXDIV-OTVXWGLQSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 238000001259 photo etching Methods 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000002992 thymic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- 238000010865 video microscopy Methods 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Description
LeClercら,"Antibody Response to a Foreign Epitope Expressed at the Suface of Recombinant Bacteria:Importance of the Route of Immunization,"Vaccine,1989.7:pp 242−248 Parent du Chateletら,Vaccine,Vol.15,pp 449−458(1997) Glennら,Nature,Vol.391,pp 851(1998) Tangら,Nature,Vol.388,pp 729−730(1997) Fanら,Nature Biotechnology,Vol.17,pp 870−872(1999) Fichteliusら,Int.Arch.Allergy,1970,Vol.37,pp 607−620 Sauder,J.Invest.Dermatol,1990,Vol.95,pp 105s−107s Bos,J.D.編 Skin Imuune System(SIS),Cutaneous Immunology and Clinical Immunodermatology,第2版,1997,CRC プレス(CRC Press),pp 43−146 Glennら,"Transcutaneous Immunization:A Human Vaccine Delivery Strategy Using a Patch",Nature Medicine,Vol.6,No.12,2000年12月,pp 1403−1406
Claims (28)
- 微小突起アレイであって、複数の角質層を貫通する微小突起を有し、前記微小突起は約500μm未満の深さまで皮膚を貫通することにより角質層中に孔を切断するよう適合される大きさを有する該アレイ;ならびに
抗原性作用物質および免疫応答増強アジュバントを含有するリザーバであって、該リザーバは、微小突起の先端の表面上の固体のコーティングの形態であり、かつ該コーティングは、微小突起の先端の最初の150μMに適用されており、該リザーバは、前記微小突起に関して前記孔と作用物質およびアジュバントを移す関係にあるように配置される該リザーバ、
を含んで成る皮内ワクチン送達装置であって;
該装置は、該装置が対象の皮膚に対して1時間適用された後に、対象の皮膚に対して抗原性作用物質の少なくとも50%を送達する、前記装置。 - 免疫応答増強アジュバントが、リン酸アルミニウムゲル、水酸化アルミニウム、藻類グルカン、β−グルカン、コレラトキシンBサブユニット、熱ショックタンパク質(HSP)、γ−イヌリン、GMDP(N−アセチルグルコサミン−(β1−4)−N−アセチルムラミル−L−アラニル−D−グルタミン)、GTP−GDP、イミキモド(Imiquimod)、インムテル[ImmTher]TM(DTP−GDP)、ロキソリビン(Loxoribine)、MPL(R)、MTP−PE、ムラメチド(Murametide)、プルーラン(Pleuran)(β−グルカン)、ムラパルミチン(Murapalmitine)、QS−21、S−28463(4−アミノ−α,α−ジメチル−1H−イミダゾ[4,5−c]キノリン−1−エタノール)、スクラボペプチド(Sclavo Peptide)(1L−1β 163−171ペプチド)およびテラミド[Theramide]TMよりなる群から選択される、請求項1記載の皮内ワクチン送達装置。
- アジュバントがグルコサミニルムラミルジペプチドを含んで成る、請求項1記載の皮内ワクチン送達装置。
- アレイが皮膚接触領域を有し、かつ、前記リザーバが、前記アレイの皮膚接触領域1cm2あたり最低約0.2μgの抗原性作用物質負荷を有する、請求項1記載の内皮ワクチン送達装置。
- 前記アレイが皮膚接触領域を有し、かつ、前記リザーバが、前記アレイの前記皮膚接触領域1cm2あたり最低約2μgの抗原性作用物質負荷を有する、請求項1記載の内皮ワクチン送達装置。
- 抗原性作用物質が、タンパク質、多糖、オリゴ糖、リポタンパク質、弱毒化もしくは殺されたウイルス、弱毒化もしくは殺された細菌およびそれらの混合物よりなる群から選択される、請求項1記載の皮内ワクチン送達装置。
- 前記抗原性作用物質がワクチンを含んで成る、請求項1記載の皮内ワクチン送達装置。
- 前記ワクチンが、インフルエンザワクチン、ライム病ワクチン、狂犬病ワクチン、麻疹ワクチン、流行性耳下腺炎ワクチン、水痘ワクチン、天然痘ワクチン、肝炎ワクチンおよびジフテリアワクチンよりなる群から選択される、請求項7記載の皮内ワクチン送達装置。
- 前記アレイが金属より構成されかつ接着性の裏打ちを包含する、請求項1記載の皮内ワクチン送達装置。
- 前記アレイが約5cm2までの皮膚接触領域を有する、請求項1記載の皮内ワクチン送達装置。
- リザーバ中の抗原性作用物質負荷に対するアジュバント負荷の重量比が約0.5:1ないし50:1の範囲にある、請求項1記載の皮内ワクチン送達装置。
- リザーバ中の抗原性作用物質負荷に対するアジュバント負荷の重量比が約1:1ないし10:1の範囲にある、請求項1記載の皮内ワクチン送達装置。
- 前記リザーバが微小突起上に乾燥した固体のコーティングを含んで成る、請求項1記載の皮内ワクチン送達装置。
- 前記リザーバが前記アレイに積層された薄膜を含んで成る、請求項1記載の皮内ワクチン送達装置。
- 約500μm未満の深さまで皮膚を貫通するよう適合された大きさを有する皮膚を貫通する複数の微小突起を有する微小突起アレイと、抗原性作用物質および免疫応答増強アジュバントとを含有するリザーバとを含んで成る、哺乳動物のワクチン接種のための装置であって、該リザーバは、微小突起の先端の表面上の固体のコーティングの形態であり、かつ該コーティングは、微小突起の先端の最初の150μMに適用されており、該リザーバは、前記微小突起を皮膚に貫通させることによって前記抗原性作用物質および前記アジュバントを、前記リザーバから哺乳動物に皮内で送達させるために、微小突起に関して微小突起を貫通することにより形成される角質層中の切傷に作用物質およびアジュバントを移す関係にあるように配置されており、かつ該装置は、該装置が患者の皮膚に対して1時間適用された後に、対象の皮膚に対して抗原性作用物質の少なくとも50%を送達する、装置。
- 免疫応答増強アジュバントが、リン酸アルミニウムゲル、水酸化アルミニウム、藻類グルカン、β−グルカン、コレラトキシンBサブユニット、熱ショックタンパク質(HSP)、γ−イヌリン、GMDP(N−アセチルグルコサミン−(β1−4)−N−アセチルムラミル−L−アラニル−D−グルタミン)、GTP−GDP、イミキモド(Imiquimod)、インムテル[ImmTher]TM(DTP−GDP)、ロキソリビン(Loxoribine)、MPL(R)、MTP−PE、ムラメチド(Murametide)、プルーラン(Pleuran)(β−グルカン)、ムラパルミチン(Murapalmitine)、QS−21、S−28463(4−アミノ−α,α−ジメチル−1H−イミダゾ[4,5−c]キノリン−1−エタノール)、スクラボペプチド(Sclavo Peptide)(1L−1β 163−171ペプチド)およびテラミド[Theramide]TMよりなる群から選択される、請求項15記載の装置。
- アジュバントがグルコサミニルムラミルジペプチドを含んで成る、請求項15記載の装置。
- アレイが皮膚接触領域を有し、かつ、前記リザーバが、前記アレイの皮膚接触領域1cm2あたり最低約0.2μgの抗原性作用物質負荷を有する、請求項15記載の装置。
- 前記アレイが皮膚接触領域を有し、かつ、前記リザーバが、前記アレイの前記皮膚接触領域1cm2あたり最低約2μgの抗原性作用物質負荷を有する、請求項15記載の装置。
- 抗原性作用物質が、タンパク質、多糖、オリゴ糖、リポタンパク質、弱毒化もしくは殺されたウイルス、弱毒化もしくは殺された細菌およびそれらの混合物よりなる群から選択される、請求項15記載の装置。
- 前記抗原性作用物質がワクチンを含んで成る、請求項15記載の装置。
- 前記ワクチンが、インフルエンザワクチン、ライム病ワクチン、狂犬病ワクチン、麻疹ワクチン、流行性耳下腺炎ワクチン、水痘ワクチン、天然痘ワクチン、肝炎ワクチンおよびジフテリアワクチンよりなる群から選択される、請求項21記載の装置。
- 前記アレイが金属より構成されかつ接着性の裏打ちを包含する、請求項15記載の装置。
- 前記アレイが約5cm2までの皮膚接触領域を有する、請求項15記載の装置。
- リザーバ中の抗原性作用物質負荷に対するアジュバント負荷の重量比が約0.5:1ないし50:1の範囲にある、請求項15記載の装置。
- リザーバ中の抗原性作用物質負荷に対するアジュバント負荷の重量比が約1:1ないし10:1の範囲にある、請求項15記載の装置。
- 前記リザーバが微小突起上に乾燥した固体のコーティングを含んで成る、請求項15記載の装置。
- 前記リザーバが前記アレイに積層された薄膜を含んで成る、請求項15記載の装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28557201P | 2001-04-20 | 2001-04-20 | |
US34255201P | 2001-12-20 | 2001-12-20 | |
PCT/US2002/012659 WO2002085446A2 (en) | 2001-04-20 | 2002-04-22 | Microprojection array immunization patch and method |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2004538048A JP2004538048A (ja) | 2004-12-24 |
JP4382356B2 true JP4382356B2 (ja) | 2009-12-09 |
Family
ID=26963264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002583019A Expired - Lifetime JP4382356B2 (ja) | 2001-04-20 | 2002-04-22 | 微小突起アレイ免疫感作貼付剤および方法 |
Country Status (11)
Country | Link |
---|---|
US (3) | US20020193729A1 (ja) |
EP (1) | EP1383571A2 (ja) |
JP (1) | JP4382356B2 (ja) |
KR (1) | KR20040014502A (ja) |
CN (1) | CN100467083C (ja) |
BR (1) | BR0209041A (ja) |
CA (1) | CA2444551C (ja) |
IL (1) | IL158479A0 (ja) |
MX (1) | MXPA03009601A (ja) |
NO (1) | NO20034683L (ja) |
WO (1) | WO2002085446A2 (ja) |
Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3436512B2 (ja) * | 1999-12-28 | 2003-08-11 | 株式会社デンソー | アクセル装置 |
US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
US6821281B2 (en) | 2000-10-16 | 2004-11-23 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
US20020193729A1 (en) * | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
IL158480A0 (en) * | 2001-04-20 | 2004-05-12 | Alza Corp | Microprojection array having a beneficial agent containing coating |
AU2002367977B2 (en) | 2001-08-13 | 2008-06-19 | University Of Rochester | Transcutaneous immunization against papillomavirus with papillomavirus virus-like particles |
JP2005511248A (ja) * | 2001-10-29 | 2005-04-28 | ベクトン・ディキンソン・アンド・カンパニー | 物質を送達するための方法およびデバイス |
US20040137004A1 (en) * | 2002-03-19 | 2004-07-15 | Glenn Gregory M | Patch for transcutaneous immunization |
EP1501567B1 (en) | 2002-05-06 | 2018-02-21 | Becton, Dickinson and Company | Device for controlling drug pharmacokinetics |
MXPA05006740A (es) | 2002-12-20 | 2005-10-05 | 3M Innovative Properties Co | Imidazoquinolinas arilo-sustituidas. |
US8993327B2 (en) * | 2003-04-07 | 2015-03-31 | Ut-Battelle, Llc | Parallel macromolecular delivery and biochemical/electrochemical interface to cells employing nanostructures |
US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
BRPI0412029A (pt) | 2003-06-30 | 2006-09-05 | Alza Corp | formulações para microprojeções revestidas contendo contra-ìons não-voláteis |
US20050025778A1 (en) * | 2003-07-02 | 2005-02-03 | Cormier Michel J.N. | Microprojection array immunization patch and method |
CA2530996C (en) | 2003-07-03 | 2013-05-07 | Corium International, Inc. | Wound dressing, ingredient delivery device and iv hold-down, and method relating to same |
CA2534821A1 (en) * | 2003-08-04 | 2005-02-24 | Alza Corporation | Method and device for enhancing transdermal agent flux |
BRPI0413558A (pt) | 2003-08-12 | 2006-10-17 | 3M Innovative Properties Co | compostos contendo imidazo substituìdo por hidroxilamina |
US7766902B2 (en) * | 2003-08-13 | 2010-08-03 | Wisconsin Alumni Research Foundation | Microfluidic device for drug delivery |
US8961477B2 (en) * | 2003-08-25 | 2015-02-24 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
AU2004266161A1 (en) * | 2003-08-26 | 2005-03-03 | Alza Corporation | Device and method for intradermal cell implantation |
KR101106812B1 (ko) | 2003-08-27 | 2012-01-19 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 아릴옥시 및 아릴알킬렌옥시 치환된 이미다조퀴놀린 |
WO2005023190A2 (en) | 2003-09-05 | 2005-03-17 | 3M Innovative Properties Company | Treatment for cd5+ b cell lymphoma |
US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
CA2540541C (en) | 2003-10-03 | 2012-03-27 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
AU2004286232A1 (en) * | 2003-10-23 | 2005-05-12 | Alza Corporation | Compositions of stabilized DNA for coating microprojections |
WO2005042054A2 (en) * | 2003-10-24 | 2005-05-12 | Alza Corporation | Pretreatment method and system for enhancing transdermal drug delivery |
JP2007511527A (ja) | 2003-11-14 | 2007-05-10 | スリーエム イノベイティブ プロパティズ カンパニー | オキシム置換イミダゾ環化合物 |
CN1906192A (zh) | 2003-11-14 | 2007-01-31 | 3M创新有限公司 | 羟胺取代的咪唑环化合物 |
JP4891088B2 (ja) | 2003-11-25 | 2012-03-07 | スリーエム イノベイティブ プロパティズ カンパニー | 置換されたイミダゾ環系および方法 |
CN1886171A (zh) * | 2003-11-28 | 2006-12-27 | 艾克若克斯Dds有限公司 | 快速经皮施用的方法和系统 |
EP1701955A1 (en) | 2003-12-29 | 2006-09-20 | 3M Innovative Properties Company | Arylalkenyl and arylalkynyl substituted imidazoquinolines |
WO2005066169A2 (en) | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides |
GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
CA2560840C (en) | 2004-03-24 | 2014-05-06 | Corium International, Inc. | Transdermal delivery device |
WO2005094531A2 (en) | 2004-03-24 | 2005-10-13 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
CA2562932A1 (en) * | 2004-04-01 | 2005-10-27 | Alza Corporation | Apparatus and method for transdermal delivery of influenza vaccine |
MXPA06011971A (es) * | 2004-04-13 | 2007-04-16 | Johnson & Johnson | Aparato y metodo para suministro transdermico de multiples vacunas. |
WO2005112984A2 (en) | 2004-05-13 | 2005-12-01 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents |
CA2566759A1 (en) * | 2004-05-19 | 2005-11-24 | Alza Corporation | Method and formulation for transdermal delivery of immunologically active agents |
US8017779B2 (en) | 2004-06-15 | 2011-09-13 | 3M Innovative Properties Company | Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
US7915281B2 (en) | 2004-06-18 | 2011-03-29 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method |
WO2006009826A1 (en) | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
WO2006038923A2 (en) | 2004-06-18 | 2006-04-13 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
US20070292445A1 (en) * | 2004-07-06 | 2007-12-20 | Transpharma Medical Ltd. | Delivery system for transdermal immunization |
US20060030811A1 (en) * | 2004-08-03 | 2006-02-09 | Wong Patrick S | Method and device for enhancing transdermal agent flux |
CN101014381A (zh) * | 2004-09-08 | 2007-08-08 | 阿尔扎公司 | 具有改善的皮肤粘附力和顺应性的微突物阵列 |
AU2005314563B2 (en) * | 2004-11-03 | 2011-06-30 | Seqirus UK Limited | Influenza vaccination |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
AU2005306426B2 (en) * | 2004-11-18 | 2011-04-28 | 3M Innovative Properties Company | Masking method for coating a microneedle array |
JP5015787B2 (ja) | 2004-11-18 | 2012-08-29 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイの接触コーティング法 |
WO2006055795A1 (en) * | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
ATE483493T1 (de) * | 2004-12-10 | 2010-10-15 | 3M Innovative Properties Co | Medizinische vorrichtung |
AU2005322898B2 (en) | 2004-12-30 | 2011-11-24 | 3M Innovative Properties Company | Chiral fused (1,2)imidazo(4,5-c) ring compounds |
ES2392648T3 (es) | 2004-12-30 | 2012-12-12 | 3M Innovative Properties Company | Compuestos quirales sustituidos que contienen un núcleo 1,2-imidazo-4,5-c condensado |
EP1844201B1 (en) | 2005-02-04 | 2016-08-24 | 3M Innovative Properties Company | Aqueous gel formulations containing immune response modifiers |
JP2008530113A (ja) | 2005-02-11 | 2008-08-07 | コーリー ファーマシューティカル グループ,インコーポレイテッド | オキシムおよびヒドロキシラミン置換イミダゾ[4,5−c]環化合物および方法 |
JP4793806B2 (ja) * | 2005-03-22 | 2011-10-12 | Tti・エルビュー株式会社 | イオントフォレーシス装置 |
JP2008535832A (ja) | 2005-04-01 | 2008-09-04 | コーリー ファーマシューティカル グループ,インコーポレイテッド | ピラゾロピリジン−1,4−ジアミン、およびそのアナログ |
JP2008538550A (ja) | 2005-04-01 | 2008-10-30 | コーリー ファーマシューティカル グループ,インコーポレイテッド | ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての1−置換ピラゾロ(3,4−c)環状化合物 |
WO2007002523A2 (en) | 2005-06-24 | 2007-01-04 | 3M Innovative Properties Company | Collapsible patch with microneedle array |
US20070009542A1 (en) * | 2005-07-05 | 2007-01-11 | Galit Levin | Method and device for transdermal immunization |
DE602006020738D1 (de) | 2005-08-01 | 2011-04-28 | Hisamitsu Pharmaceutical Co | Adjuvans oder pharmazeutische zubereitung zur transdermalen oder transmukosalen verabreichung |
CN101912288A (zh) * | 2005-09-02 | 2010-12-15 | 因特赛尔美国公司 | 经皮递送疫苗和透皮递送药物的装置及其应用 |
WO2007033015A1 (en) * | 2005-09-12 | 2007-03-22 | Alza Corporation | Coatable transdermal delivery microprojection assembly |
US20070078376A1 (en) * | 2005-09-30 | 2007-04-05 | Smith Gregory A | Functionalized microneedles transdermal drug delivery systems, devices, and methods |
WO2007061781A1 (en) * | 2005-11-18 | 2007-05-31 | 3M Innovative Properties Company | Coatable compositions, coatings derived therefrom and microarrays having such coatings |
US8554317B2 (en) * | 2005-11-30 | 2013-10-08 | 3M Innovative Properties Company | Microneedle arrays and methods of use thereof |
WO2007124411A1 (en) | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
US7906506B2 (en) | 2006-07-12 | 2011-03-15 | 3M Innovative Properties Company | Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods |
US8076124B2 (en) * | 2007-01-17 | 2011-12-13 | Ut-Battelle, Llc | Method and apparatus for sustaining viability of biological cells on a substrate |
CA2676221C (en) | 2007-01-22 | 2016-12-20 | Corium International, Inc. | Applicators for microneedles |
US20100047327A1 (en) | 2007-01-31 | 2010-02-25 | Tetsuji Kuwahara | Adjuvant for Transdermal or Transmucosal Administration and Pharmaceutical Preparation Containing the Same |
US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
EP2146689B1 (en) | 2007-04-16 | 2020-08-12 | Corium, Inc. | Solvent-cast microneedle arrays containing active |
EP2200666B1 (en) * | 2007-10-09 | 2014-12-03 | Syneron Medical Ltd. | Magnetic patch coupling |
AU2008332738B2 (en) | 2007-12-05 | 2013-08-15 | Syneron Medical Ltd. | A disposable electromagnetic energy applicator and method of using it |
US9220678B2 (en) | 2007-12-24 | 2015-12-29 | The University Of Queensland | Coating method |
CN101938951B (zh) | 2008-01-17 | 2013-06-12 | 赛诺龙医疗公司 | 用于个人使用的毛发去除装置及使用该装置的方法 |
WO2009093230A2 (en) | 2008-01-24 | 2009-07-30 | Syneron Medical Ltd. | A device, apparatus, and method of adipose tissue treatment |
AU2009212106B9 (en) | 2008-02-07 | 2014-05-22 | Vaxxas Pty Limited | Patch production |
US8506966B2 (en) | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
AU2009250341A1 (en) | 2008-05-23 | 2009-11-26 | The University Of Queensland | Analyte detection using a needle projection patch |
US8795259B2 (en) * | 2008-08-01 | 2014-08-05 | Wisconsin Alumni Research Foundation | Drug delivery platform incorporating hydrogel pumping mechanism with guided fluid flow |
US8986250B2 (en) * | 2008-08-01 | 2015-03-24 | Wisconsin Alumni Research Foundation | Drug delivery platform utilizing hydrogel pumping mechanism |
MX2011002987A (es) | 2008-09-21 | 2011-07-20 | Syneron Medical Ltd | Un metodo y aparato para el tratamiento personal de la piel. |
CN102307590A (zh) | 2009-02-10 | 2012-01-04 | 诺华有限公司 | 具有减少量的角鲨烯的流感疫苗 |
US8606366B2 (en) | 2009-02-18 | 2013-12-10 | Syneron Medical Ltd. | Skin treatment apparatus for personal use and method for using same |
CA2759850C (en) * | 2009-04-24 | 2019-10-22 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
CN102039000B (zh) * | 2009-10-20 | 2015-08-26 | 苏州纳通生物纳米技术有限公司 | 一种透皮给药试剂盒 |
US8834423B2 (en) * | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
US8328757B2 (en) * | 2010-01-08 | 2012-12-11 | Wisconsin Alumni Research Foundation | Bladder arrangement for microneedle-based drug delivery device |
JP6327852B2 (ja) | 2010-05-04 | 2018-05-23 | コリウム インターナショナル, インコーポレイテッド | 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス |
US9943673B2 (en) | 2010-07-14 | 2018-04-17 | Vaxxas Pty Limited | Patch applying apparatus |
US20140037694A1 (en) | 2011-02-25 | 2014-02-06 | Hisamitsu Pharmaceutical Co., Inc. | Adjuvant for transdermal or transmucosal administration and pharmaceutical preparation containing same |
WO2012145739A1 (en) | 2011-04-21 | 2012-10-26 | Trustees Of Tufts College | Compositions and methods for stabilization of active agents |
US11179553B2 (en) | 2011-10-12 | 2021-11-23 | Vaxxas Pty Limited | Delivery device |
US9289331B2 (en) | 2011-12-23 | 2016-03-22 | Sca Hygiene Products Ab | Disposable absorbent product with elastic leg opening regions and related methods |
MX370579B (es) * | 2012-05-01 | 2019-12-17 | Univ Pittsburgh Commonwealth Sys Higher Education | Arreglos de microagujas cargadas en la punta para insercion transdermica. |
CA2896188C (en) | 2012-12-21 | 2021-02-23 | Corium International, Inc. | Microarray for delivery of therapeutic agent and methods of use |
CN105188747A (zh) * | 2013-02-01 | 2015-12-23 | 葛兰素史密斯克莱生物公司 | 包含toll样受体激动剂的免疫组合物的皮内递送 |
US10245422B2 (en) * | 2013-03-12 | 2019-04-02 | Corium International, Inc. | Microprojection applicators and methods of use |
CA2906541C (en) | 2013-03-15 | 2022-06-21 | Corium International, Inc. | Microarray for delivery of therapeutic agent and methods of use |
EP2968751B1 (en) | 2013-03-15 | 2022-11-30 | Corium, Inc. | Multiple impact microprojection applicators |
US10384045B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
WO2015034807A2 (en) | 2013-09-05 | 2015-03-12 | Merck Sharp & Dohme Corp. | Methods of immunization with varicella zoster virus antigen |
JP6114401B2 (ja) | 2013-10-31 | 2017-04-12 | 久光製薬株式会社 | アジュバント組成物、これを含むアジュバント製剤、及びキット |
US10881729B2 (en) | 2014-04-18 | 2021-01-05 | Children's Medical Center Corporation | Vaccine adjuvant compositions |
US20160058992A1 (en) * | 2014-08-29 | 2016-03-03 | Corium International, Inc. | Microstructure array for delivery of active agents |
US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
EP4218892A1 (en) | 2015-02-02 | 2023-08-02 | Vaxxas Pty Limited | Microprojection array applicator |
US10441768B2 (en) | 2015-03-18 | 2019-10-15 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
WO2017004067A1 (en) | 2015-06-29 | 2017-01-05 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
US11103259B2 (en) | 2015-09-18 | 2021-08-31 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
US11684763B2 (en) | 2015-10-16 | 2023-06-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices |
WO2017120322A1 (en) | 2016-01-05 | 2017-07-13 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
WO2017123652A1 (en) * | 2016-01-11 | 2017-07-20 | Verndari, Inc. | Microneedle compositions and methods of using same |
EP3412312B1 (en) | 2016-02-03 | 2021-08-25 | Cosmed Pharmaceutical Co., Ltd. | Coating liquid for microneedles, microneedle-coating substance, and microneedle array |
EP3532093A1 (en) | 2016-09-19 | 2019-09-04 | Vaxess Technologies, Inc. | Vaccine formulations with increased stability |
KR102038751B1 (ko) * | 2016-11-18 | 2019-10-30 | 연세대학교 산학협력단 | 복합 제형이 적용된 마이크로니들 어레이 및 이의 제조방법 |
JP7152787B2 (ja) | 2017-03-31 | 2022-10-13 | ヴァクザス ピーティーワイ リミテッド | 表面をコーティングするための装置および方法 |
US11175128B2 (en) | 2017-06-13 | 2021-11-16 | Vaxxas Pty Limited | Quality control of substrate coatings |
EP3661587A4 (en) | 2017-08-04 | 2021-06-09 | Vaxxas Pty Limited | COMPACT HIGH MECHANICAL ENERGY STORAGE AND LOW RELEASE FORCE ACTUATOR FOR MICROPROJECTION NETWORK (PRM) PATCH DELIVERY |
EP3752185A1 (en) | 2018-02-15 | 2020-12-23 | Icon Genetics GmbH | Immunogenic composition and vaccine for generating an immune response to norovirus |
US11938178B2 (en) | 2018-07-09 | 2024-03-26 | Dbv Technologies | Optimized epicutaneous vaccination |
WO2020198785A1 (en) * | 2019-03-29 | 2020-10-08 | Vaxxas Pty Ltd | Vaccination using high-density microprojection array patch |
Family Cites Families (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3123212A (en) * | 1964-03-03 | Multiple disposable intracutaneous injector package | ||
US2619962A (en) * | 1948-02-19 | 1952-12-02 | Res Foundation | Vaccination appliance |
US2876770A (en) * | 1955-10-10 | 1959-03-10 | Raymond A White | Shielded hypodermic syringe |
US2893392A (en) * | 1958-01-08 | 1959-07-07 | American Cyanamid Co | Article of manufacture for intracutaneous injections |
US3072122A (en) * | 1959-01-15 | 1963-01-08 | Rosenthal Sol Roy | Package for transcutaneous injection |
US3221739A (en) * | 1962-03-26 | 1965-12-07 | Rosenthal Sol Roy | Injection device |
US3221740A (en) * | 1962-08-31 | 1965-12-07 | Rosenthal Sol Roy | Injection device |
US3675766A (en) | 1970-02-04 | 1972-07-11 | Sol Roy Rosenthal | Multiple puncture injector device |
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US3678150A (en) * | 1971-07-27 | 1972-07-18 | American Cyanamid Co | Process for improving the stability of ppd, qt and histoplasmin on tine applicators |
BE795384A (fr) * | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
JPS60193925A (ja) * | 1984-03-13 | 1985-10-02 | Chemo Sero Therapeut Res Inst | 凍結乾燥製剤化ワクチン |
SE8501990D0 (sv) * | 1985-04-24 | 1985-04-24 | Pharmacia Ab | Beleggningsforfarande |
EP0238618A1 (en) | 1985-10-04 | 1987-09-30 | The Upjohn Company | Pseudorabies virus protein |
US4795432A (en) * | 1987-02-19 | 1989-01-03 | Karczmer Claude M | Shield assembly for hypodermic injection devices |
US4955868A (en) * | 1988-11-28 | 1990-09-11 | Edward Klein | Disposable safety medical syringe |
US4978343A (en) * | 1990-01-16 | 1990-12-18 | Dysarz Edward D | Trap in barrel one handed retractable safety syringe |
US5112307A (en) * | 1990-04-24 | 1992-05-12 | Habley Medical Technology Corp. | Dental syringe having a medication filled carpule and an automatically-detaching piston stem |
IT219694Z2 (it) * | 1990-05-25 | 1993-04-26 | Habley Medical Technology Corp | Siringa di sicurezza, monouso |
FR2669540A1 (fr) * | 1990-11-26 | 1992-05-29 | Berthier Michel | Dispositif porte-aiguille pour seringue d'injection. |
US5106379A (en) * | 1991-04-09 | 1992-04-21 | Leap E Jack | Syringe shielding assembly |
ES1017717Y (es) * | 1991-05-30 | 1993-12-16 | Serrano Gonzalez | Protector de agujas hipodermicas auto-retractiles. |
US5919466A (en) * | 1993-10-01 | 1999-07-06 | Gerbu Biotechnik Gmbh | Method for improving the yield of immunoantibodies in the vaccination of animals and humans |
US5478314A (en) * | 1994-12-27 | 1995-12-26 | Malenchek; Robert | Non-reusable syringe |
US5554122A (en) * | 1995-03-23 | 1996-09-10 | Emanuel; Carolina | Disposable syringe |
AU5740496A (en) * | 1995-05-22 | 1996-12-11 | General Hospital Corporation, The | Micromechanical device and method for enhancing delivery of compounds through the skin |
US5688241A (en) * | 1996-04-15 | 1997-11-18 | Asbaghi; Hooman Ali | Automatic non-reusable needle guard |
AU3399197A (en) | 1996-06-18 | 1998-01-07 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
TW330907B (en) * | 1996-09-09 | 1998-05-01 | Riso Kagaku Corp | The ink container and ink supplied device for packing ink container |
EP0934093B1 (en) * | 1996-09-17 | 2003-01-15 | Deka Products Limited Partnership | System for delivery of drugs by transport |
US6918901B1 (en) * | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
WO1999029364A1 (en) * | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
EP1037687B8 (en) * | 1997-12-11 | 2008-10-22 | Alza Corporation | Device for enhancing transdermal agent flux |
ATE302041T1 (de) * | 1997-12-11 | 2005-09-15 | Alza Corp | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses |
US5980494A (en) * | 1997-12-22 | 1999-11-09 | Robert Malenchek | Safety syringe |
US6091975A (en) * | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
SI1031346T1 (en) | 1999-01-27 | 2002-08-31 | Idea Ag | Noninvasive vaccination through the skin |
DE60007290T2 (de) | 1999-01-28 | 2004-09-23 | Cyto Pulse Sciences, Inc. | Einbringen von makromolekülen in zellen |
AU3957400A (en) | 1999-04-16 | 2000-11-02 | Novo Nordisk A/S | Dry, mouldable drug formulation |
US6623457B1 (en) * | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
US6537242B1 (en) * | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
RU2277390C2 (ru) * | 2000-10-13 | 2006-06-10 | Алза Корпорейшн | Аппликатор для силового воздействия комплектом микроножей |
IL155389A0 (en) * | 2000-10-13 | 2003-11-23 | Alza Corportion | Microprotrusion member retainer for impact applicator |
PL360998A1 (en) * | 2000-10-13 | 2004-09-20 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
US7419481B2 (en) * | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
MXPA03003815A (es) * | 2000-10-26 | 2004-08-12 | Johnson & Johnson | Dispositivos de suministro transdermico de farmaco que tienen microrresaltos recubiertos. |
US6855372B2 (en) * | 2001-03-16 | 2005-02-15 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
US20020193729A1 (en) * | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
IL158480A0 (en) * | 2001-04-20 | 2004-05-12 | Alza Corp | Microprojection array having a beneficial agent containing coating |
US6527742B1 (en) * | 2001-11-14 | 2003-03-04 | Robert C. Malenchek | Safety syringe |
EP1485317A2 (en) * | 2001-11-30 | 2004-12-15 | Alza Corporation | Methods and apparatuses for forming microprojection arrays |
RU2314760C2 (ru) * | 2001-12-20 | 2008-01-20 | Алза Корпорейшн | Микровыступы, пробивающие кожу, имеющие средство регулирования глубины пробивки |
KR20050054483A (ko) * | 2002-06-28 | 2005-06-10 | 알자 코포레이션 | 코팅된 미세돌출부를 갖는 경피용 약물 전달 장치 |
TW200409657A (en) * | 2002-08-08 | 2004-06-16 | Alza Corp | Transdermal vaccine delivery device having coated microprotrusions |
CA2516547A1 (en) * | 2002-09-30 | 2004-04-15 | Alza Corporation | Drug delivery device having coated microprojections incorporating vasoconstrictors |
AR042815A1 (es) * | 2002-12-26 | 2005-07-06 | Alza Corp | Dispositivo de suministro de agente activo que tiene miembros compuestos |
AU2003901382A0 (en) * | 2003-03-25 | 2003-04-10 | Robert Baird Watson | Hypodermic syringe |
US6926697B2 (en) * | 2003-05-13 | 2005-08-09 | Robert Malenchek | Adaptor for converting a non-safety syringe into a safety syringe |
US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
BRPI0412029A (pt) * | 2003-06-30 | 2006-09-05 | Alza Corp | formulações para microprojeções revestidas contendo contra-ìons não-voláteis |
US20050025778A1 (en) * | 2003-07-02 | 2005-02-03 | Cormier Michel J.N. | Microprojection array immunization patch and method |
US20050089554A1 (en) * | 2003-10-24 | 2005-04-28 | Cormier Michel J. | Apparatus and method for enhancing transdermal drug delivery |
CN1897883A (zh) * | 2003-10-28 | 2007-01-17 | 阿尔扎公司 | 通过涂覆的微喷射体释放治疗用肽和蛋白的聚合物缀合物 |
EP1680154B1 (en) * | 2003-10-31 | 2012-01-04 | ALZA Corporation | Self-actuating applicator for microprojection array |
EP1682012A4 (en) * | 2003-11-13 | 2008-09-24 | Alza Corp | COMPOSITION AND APPARATUS FOR TRANSDERMAL DELIVERY |
CA2552754A1 (en) * | 2004-01-09 | 2005-08-04 | Alza Corporation | Frequency assisted transdermal agent delivery method and system |
CA2562932A1 (en) * | 2004-04-01 | 2005-10-27 | Alza Corporation | Apparatus and method for transdermal delivery of influenza vaccine |
MXPA06011971A (es) * | 2004-04-13 | 2007-04-16 | Johnson & Johnson | Aparato y metodo para suministro transdermico de multiples vacunas. |
WO2005112984A2 (en) * | 2004-05-13 | 2005-12-01 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents |
CA2566759A1 (en) * | 2004-05-19 | 2005-11-24 | Alza Corporation | Method and formulation for transdermal delivery of immunologically active agents |
KR20070057954A (ko) * | 2004-09-28 | 2007-06-07 | 알자 코포레이션 | 알룸-애주번트가 있는 면역 활성제의 안정화 |
-
2002
- 2002-04-20 US US10/127,171 patent/US20020193729A1/en not_active Abandoned
- 2002-04-22 JP JP2002583019A patent/JP4382356B2/ja not_active Expired - Lifetime
- 2002-04-22 MX MXPA03009601A patent/MXPA03009601A/es unknown
- 2002-04-22 CA CA002444551A patent/CA2444551C/en not_active Expired - Fee Related
- 2002-04-22 IL IL15847902A patent/IL158479A0/xx unknown
- 2002-04-22 BR BR0209041-4A patent/BR0209041A/pt not_active IP Right Cessation
- 2002-04-22 EP EP02739170A patent/EP1383571A2/en not_active Withdrawn
- 2002-04-22 WO PCT/US2002/012659 patent/WO2002085446A2/en active IP Right Grant
- 2002-04-22 KR KR10-2003-7013730A patent/KR20040014502A/ko not_active Application Discontinuation
- 2002-04-22 CN CNB028123743A patent/CN100467083C/zh not_active Expired - Fee Related
-
2003
- 2003-10-20 NO NO20034683A patent/NO20034683L/no not_active Application Discontinuation
-
2005
- 2005-11-04 US US11/267,563 patent/US20060074377A1/en not_active Abandoned
-
2009
- 2009-02-06 US US12/367,318 patent/US20090143724A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO20034683D0 (no) | 2003-10-20 |
CN1602216A (zh) | 2005-03-30 |
US20090143724A1 (en) | 2009-06-04 |
NO20034683L (no) | 2003-12-09 |
CA2444551C (en) | 2009-11-17 |
WO2002085446A2 (en) | 2002-10-31 |
JP2004538048A (ja) | 2004-12-24 |
BR0209041A (pt) | 2005-01-18 |
MXPA03009601A (es) | 2004-12-06 |
CA2444551A1 (en) | 2002-10-31 |
US20060074377A1 (en) | 2006-04-06 |
CN100467083C (zh) | 2009-03-11 |
US20020193729A1 (en) | 2002-12-19 |
WO2002085446A3 (en) | 2003-03-06 |
KR20040014502A (ko) | 2004-02-14 |
EP1383571A2 (en) | 2004-01-28 |
IL158479A0 (en) | 2004-05-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4382356B2 (ja) | 微小突起アレイ免疫感作貼付剤および方法 | |
EP1439870B1 (en) | Device for the delivery of a substance | |
US20050025778A1 (en) | Microprojection array immunization patch and method | |
US20050271684A1 (en) | Apparatus and method for transdermal delivery of multiple vaccines | |
US20080226687A1 (en) | Drug delivery and method having coated microprojections incorporating vasoconstrictors | |
JP2006516205A (ja) | 被覆された微小突起を有する経皮ワクチン送達装置 | |
KR20070011252A (ko) | 초음파 보조 경피 백신전달방법 및 시스템 | |
JP2004528900A (ja) | 有益な作用物質を含有するコーティングを有する微小突起アレイ | |
AU2007203302B2 (en) | Microprojection array immunization patch and method | |
ZA200309003B (en) | Microprojection array immunization patch and method. | |
AU2002311839A1 (en) | Microprojection array immunization patch and method | |
NZ529030A (en) | Microprojection array immunization patch and method | |
Sullivan | Polymer microneedles for transdermal delivery of biopharmaceuticals |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050421 |
|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20080427 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080610 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080826 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080902 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20081209 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090202 |
|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20090130 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090428 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20090824 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20090917 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20121002 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |