BR0110553A - Fosforamidatos de bis-(n,n'-bis-(2-haloetil)amino) como agentes antitumor - Google Patents

Fosforamidatos de bis-(n,n'-bis-(2-haloetil)amino) como agentes antitumor

Info

Publication number
BR0110553A
BR0110553A BR0110553-1A BR0110553A BR0110553A BR 0110553 A BR0110553 A BR 0110553A BR 0110553 A BR0110553 A BR 0110553A BR 0110553 A BR0110553 A BR 0110553A
Authority
BR
Brazil
Prior art keywords
bis
haloethyl
phosphoramidates
amino
antitumor agents
Prior art date
Application number
BR0110553-1A
Other languages
English (en)
Portuguese (pt)
Inventor
Jason R Herr
Robert T Lum
Steven R Schow
Fanying Meng
Michael R Kozlowski
Pavel Zhichkin
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Publication of BR0110553A publication Critical patent/BR0110553A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR0110553-1A 2000-05-02 2001-05-02 Fosforamidatos de bis-(n,n'-bis-(2-haloetil)amino) como agentes antitumor BR0110553A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02
PCT/US2001/014290 WO2001083496A1 (en) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents

Publications (1)

Publication Number Publication Date
BR0110553A true BR0110553A (pt) 2003-04-01

Family

ID=24249433

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0110553-1A BR0110553A (pt) 2000-05-02 2001-05-02 Fosforamidatos de bis-(n,n'-bis-(2-haloetil)amino) como agentes antitumor

Country Status (25)

Country Link
EP (2) EP1278759B1 (cg-RX-API-DMAC10.html)
JP (1) JP4249928B2 (cg-RX-API-DMAC10.html)
KR (1) KR100729980B1 (cg-RX-API-DMAC10.html)
CN (1) CN1182143C (cg-RX-API-DMAC10.html)
AR (1) AR029072A1 (cg-RX-API-DMAC10.html)
AT (2) ATE313549T1 (cg-RX-API-DMAC10.html)
AU (2) AU6115301A (cg-RX-API-DMAC10.html)
BR (1) BR0110553A (cg-RX-API-DMAC10.html)
CA (1) CA2407606C (cg-RX-API-DMAC10.html)
CZ (1) CZ20023615A3 (cg-RX-API-DMAC10.html)
DE (2) DE60116081T2 (cg-RX-API-DMAC10.html)
DK (2) DK1607399T3 (cg-RX-API-DMAC10.html)
EA (1) EA006852B1 (cg-RX-API-DMAC10.html)
ES (2) ES2337154T3 (cg-RX-API-DMAC10.html)
HU (1) HUP0300688A3 (cg-RX-API-DMAC10.html)
IL (2) IL152325A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA02010813A (cg-RX-API-DMAC10.html)
NO (2) NO328854B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ522189A (cg-RX-API-DMAC10.html)
PL (1) PL207005B1 (cg-RX-API-DMAC10.html)
PT (1) PT1607399E (cg-RX-API-DMAC10.html)
TW (1) TWI308569B (cg-RX-API-DMAC10.html)
UA (1) UA74574C2 (cg-RX-API-DMAC10.html)
WO (1) WO2001083496A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200208591B (cg-RX-API-DMAC10.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
US9879267B2 (en) * 2008-03-14 2018-01-30 Genentech, Inc. Genetic variations associated with drug resistance
CN118834240A (zh) 2019-05-13 2024-10-25 深圳艾欣达伟医药科技有限公司 含氟化合物及抗癌医药用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
CA2407606C (en) 2008-07-15
DE60116081D1 (en) 2006-01-26
HUP0300688A3 (en) 2005-02-28
DK1278759T3 (da) 2006-02-13
ZA200208591B (en) 2004-03-04
JP4249928B2 (ja) 2009-04-08
NO331833B1 (no) 2012-04-16
EP1607399A3 (en) 2006-01-04
CN1182143C (zh) 2004-12-29
EP1607399B1 (en) 2010-01-20
PL207005B1 (pl) 2010-10-29
PT1607399E (pt) 2010-02-02
AR029072A1 (es) 2003-06-04
PL358155A1 (en) 2004-08-09
HK1050368A1 (en) 2003-06-20
EA006852B1 (ru) 2006-04-28
NO20025240L (no) 2002-12-04
AU6115301A (en) 2001-11-12
HK1084119A1 (en) 2006-07-21
NO20025240D0 (no) 2002-11-01
HUP0300688A2 (hu) 2003-07-28
WO2001083496A1 (en) 2001-11-08
DE60116081T2 (de) 2006-08-03
NO20093371L (no) 2002-12-04
IL152325A (en) 2011-04-28
DK1607399T3 (da) 2010-05-10
KR100729980B1 (ko) 2007-06-20
CA2407606A1 (en) 2001-11-08
IL152325A0 (en) 2003-05-29
NZ522189A (en) 2004-04-30
ATE455779T1 (de) 2010-02-15
ES2253380T3 (es) 2006-06-01
AU2001261153B2 (en) 2005-04-07
MXPA02010813A (es) 2004-02-26
EP1607399A2 (en) 2005-12-21
ES2337154T3 (es) 2010-04-21
JP2003531913A (ja) 2003-10-28
EP1278759A1 (en) 2003-01-29
TWI308569B (en) 2009-04-11
UA74574C2 (en) 2006-01-16
ATE313549T1 (de) 2006-01-15
KR20020094000A (ko) 2002-12-16
CN1427844A (zh) 2003-07-02
NO328854B1 (no) 2010-05-31
EA200201154A1 (ru) 2003-04-24
CZ20023615A3 (cs) 2003-04-16
EP1278759B1 (en) 2005-12-21
DE60141181D1 (de) 2010-03-11

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time