CA2407606C - Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents - Google Patents

Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents Download PDF

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Publication number
CA2407606C
CA2407606C CA002407606A CA2407606A CA2407606C CA 2407606 C CA2407606 C CA 2407606C CA 002407606 A CA002407606 A CA 002407606A CA 2407606 A CA2407606 A CA 2407606A CA 2407606 C CA2407606 C CA 2407606C
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CA
Canada
Prior art keywords
substituted
alkyl
aryl
heteroaryl
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002407606A
Other languages
English (en)
French (fr)
Other versions
CA2407606A1 (en
Inventor
R. Jason Herr
Robert T. Lum
Steven R. Schow
Fanying Meng
Michael R. Kozlowski
Pavel Zhichkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Publication of CA2407606A1 publication Critical patent/CA2407606A1/en
Application granted granted Critical
Publication of CA2407606C publication Critical patent/CA2407606C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002407606A 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents Expired - Fee Related CA2407606C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02
US09/563,181 2000-05-02
PCT/US2001/014290 WO2001083496A1 (en) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents

Publications (2)

Publication Number Publication Date
CA2407606A1 CA2407606A1 (en) 2001-11-08
CA2407606C true CA2407606C (en) 2008-07-15

Family

ID=24249433

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002407606A Expired - Fee Related CA2407606C (en) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents

Country Status (25)

Country Link
EP (2) EP1278759B1 (cg-RX-API-DMAC10.html)
JP (1) JP4249928B2 (cg-RX-API-DMAC10.html)
KR (1) KR100729980B1 (cg-RX-API-DMAC10.html)
CN (1) CN1182143C (cg-RX-API-DMAC10.html)
AR (1) AR029072A1 (cg-RX-API-DMAC10.html)
AT (2) ATE313549T1 (cg-RX-API-DMAC10.html)
AU (2) AU6115301A (cg-RX-API-DMAC10.html)
BR (1) BR0110553A (cg-RX-API-DMAC10.html)
CA (1) CA2407606C (cg-RX-API-DMAC10.html)
CZ (1) CZ20023615A3 (cg-RX-API-DMAC10.html)
DE (2) DE60116081T2 (cg-RX-API-DMAC10.html)
DK (2) DK1607399T3 (cg-RX-API-DMAC10.html)
EA (1) EA006852B1 (cg-RX-API-DMAC10.html)
ES (2) ES2337154T3 (cg-RX-API-DMAC10.html)
HU (1) HUP0300688A3 (cg-RX-API-DMAC10.html)
IL (2) IL152325A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA02010813A (cg-RX-API-DMAC10.html)
NO (2) NO328854B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ522189A (cg-RX-API-DMAC10.html)
PL (1) PL207005B1 (cg-RX-API-DMAC10.html)
PT (1) PT1607399E (cg-RX-API-DMAC10.html)
TW (1) TWI308569B (cg-RX-API-DMAC10.html)
UA (1) UA74574C2 (cg-RX-API-DMAC10.html)
WO (1) WO2001083496A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200208591B (cg-RX-API-DMAC10.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
US9879267B2 (en) * 2008-03-14 2018-01-30 Genentech, Inc. Genetic variations associated with drug resistance
CN118834240A (zh) 2019-05-13 2024-10-25 深圳艾欣达伟医药科技有限公司 含氟化合物及抗癌医药用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
DE60116081D1 (en) 2006-01-26
HUP0300688A3 (en) 2005-02-28
DK1278759T3 (da) 2006-02-13
ZA200208591B (en) 2004-03-04
JP4249928B2 (ja) 2009-04-08
NO331833B1 (no) 2012-04-16
EP1607399A3 (en) 2006-01-04
CN1182143C (zh) 2004-12-29
EP1607399B1 (en) 2010-01-20
PL207005B1 (pl) 2010-10-29
PT1607399E (pt) 2010-02-02
AR029072A1 (es) 2003-06-04
PL358155A1 (en) 2004-08-09
HK1050368A1 (en) 2003-06-20
EA006852B1 (ru) 2006-04-28
NO20025240L (no) 2002-12-04
AU6115301A (en) 2001-11-12
HK1084119A1 (en) 2006-07-21
NO20025240D0 (no) 2002-11-01
HUP0300688A2 (hu) 2003-07-28
WO2001083496A1 (en) 2001-11-08
DE60116081T2 (de) 2006-08-03
NO20093371L (no) 2002-12-04
IL152325A (en) 2011-04-28
DK1607399T3 (da) 2010-05-10
KR100729980B1 (ko) 2007-06-20
CA2407606A1 (en) 2001-11-08
IL152325A0 (en) 2003-05-29
NZ522189A (en) 2004-04-30
ATE455779T1 (de) 2010-02-15
ES2253380T3 (es) 2006-06-01
AU2001261153B2 (en) 2005-04-07
MXPA02010813A (es) 2004-02-26
BR0110553A (pt) 2003-04-01
EP1607399A2 (en) 2005-12-21
ES2337154T3 (es) 2010-04-21
JP2003531913A (ja) 2003-10-28
EP1278759A1 (en) 2003-01-29
TWI308569B (en) 2009-04-11
UA74574C2 (en) 2006-01-16
ATE313549T1 (de) 2006-01-15
KR20020094000A (ko) 2002-12-16
CN1427844A (zh) 2003-07-02
NO328854B1 (no) 2010-05-31
EA200201154A1 (ru) 2003-04-24
CZ20023615A3 (cs) 2003-04-16
EP1278759B1 (en) 2005-12-21
DE60141181D1 (de) 2010-03-11

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Effective date: 20140502