HUP0300688A3 - Bis-(n,n'-bis(2-haloethyl)amino)phosphoramidates as antitumor agents - Google Patents

Bis-(n,n'-bis(2-haloethyl)amino)phosphoramidates as antitumor agents

Info

Publication number
HUP0300688A3
HUP0300688A3 HU0300688A HUP0300688A HUP0300688A3 HU P0300688 A3 HUP0300688 A3 HU P0300688A3 HU 0300688 A HU0300688 A HU 0300688A HU P0300688 A HUP0300688 A HU P0300688A HU P0300688 A3 HUP0300688 A3 HU P0300688A3
Authority
HU
Hungary
Prior art keywords
bis
haloethyl
phosphoramidates
amino
antitumor agents
Prior art date
Application number
HU0300688A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Telik Inc South San Francisco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc South San Francisco filed Critical Telik Inc South San Francisco
Publication of HUP0300688A2 publication Critical patent/HUP0300688A2/hu
Publication of HUP0300688A3 publication Critical patent/HUP0300688A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HU0300688A 2000-05-02 2001-05-02 Bis-(n,n'-bis(2-haloethyl)amino)phosphoramidates as antitumor agents HUP0300688A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02
PCT/US2001/014290 WO2001083496A1 (en) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents

Publications (2)

Publication Number Publication Date
HUP0300688A2 HUP0300688A2 (hu) 2003-07-28
HUP0300688A3 true HUP0300688A3 (en) 2005-02-28

Family

ID=24249433

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300688A HUP0300688A3 (en) 2000-05-02 2001-05-02 Bis-(n,n'-bis(2-haloethyl)amino)phosphoramidates as antitumor agents

Country Status (25)

Country Link
EP (2) EP1278759B1 (cg-RX-API-DMAC10.html)
JP (1) JP4249928B2 (cg-RX-API-DMAC10.html)
KR (1) KR100729980B1 (cg-RX-API-DMAC10.html)
CN (1) CN1182143C (cg-RX-API-DMAC10.html)
AR (1) AR029072A1 (cg-RX-API-DMAC10.html)
AT (2) ATE313549T1 (cg-RX-API-DMAC10.html)
AU (2) AU6115301A (cg-RX-API-DMAC10.html)
BR (1) BR0110553A (cg-RX-API-DMAC10.html)
CA (1) CA2407606C (cg-RX-API-DMAC10.html)
CZ (1) CZ20023615A3 (cg-RX-API-DMAC10.html)
DE (2) DE60116081T2 (cg-RX-API-DMAC10.html)
DK (2) DK1607399T3 (cg-RX-API-DMAC10.html)
EA (1) EA006852B1 (cg-RX-API-DMAC10.html)
ES (2) ES2337154T3 (cg-RX-API-DMAC10.html)
HU (1) HUP0300688A3 (cg-RX-API-DMAC10.html)
IL (2) IL152325A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA02010813A (cg-RX-API-DMAC10.html)
NO (2) NO328854B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ522189A (cg-RX-API-DMAC10.html)
PL (1) PL207005B1 (cg-RX-API-DMAC10.html)
PT (1) PT1607399E (cg-RX-API-DMAC10.html)
TW (1) TWI308569B (cg-RX-API-DMAC10.html)
UA (1) UA74574C2 (cg-RX-API-DMAC10.html)
WO (1) WO2001083496A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200208591B (cg-RX-API-DMAC10.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
US9879267B2 (en) * 2008-03-14 2018-01-30 Genentech, Inc. Genetic variations associated with drug resistance
CN118834240A (zh) 2019-05-13 2024-10-25 深圳艾欣达伟医药科技有限公司 含氟化合物及抗癌医药用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
CA2407606C (en) 2008-07-15
DE60116081D1 (en) 2006-01-26
DK1278759T3 (da) 2006-02-13
ZA200208591B (en) 2004-03-04
JP4249928B2 (ja) 2009-04-08
NO331833B1 (no) 2012-04-16
EP1607399A3 (en) 2006-01-04
CN1182143C (zh) 2004-12-29
EP1607399B1 (en) 2010-01-20
PL207005B1 (pl) 2010-10-29
PT1607399E (pt) 2010-02-02
AR029072A1 (es) 2003-06-04
PL358155A1 (en) 2004-08-09
HK1050368A1 (en) 2003-06-20
EA006852B1 (ru) 2006-04-28
NO20025240L (no) 2002-12-04
AU6115301A (en) 2001-11-12
HK1084119A1 (en) 2006-07-21
NO20025240D0 (no) 2002-11-01
HUP0300688A2 (hu) 2003-07-28
WO2001083496A1 (en) 2001-11-08
DE60116081T2 (de) 2006-08-03
NO20093371L (no) 2002-12-04
IL152325A (en) 2011-04-28
DK1607399T3 (da) 2010-05-10
KR100729980B1 (ko) 2007-06-20
CA2407606A1 (en) 2001-11-08
IL152325A0 (en) 2003-05-29
NZ522189A (en) 2004-04-30
ATE455779T1 (de) 2010-02-15
ES2253380T3 (es) 2006-06-01
AU2001261153B2 (en) 2005-04-07
MXPA02010813A (es) 2004-02-26
BR0110553A (pt) 2003-04-01
EP1607399A2 (en) 2005-12-21
ES2337154T3 (es) 2010-04-21
JP2003531913A (ja) 2003-10-28
EP1278759A1 (en) 2003-01-29
TWI308569B (en) 2009-04-11
UA74574C2 (en) 2006-01-16
ATE313549T1 (de) 2006-01-15
KR20020094000A (ko) 2002-12-16
CN1427844A (zh) 2003-07-02
NO328854B1 (no) 2010-05-31
EA200201154A1 (ru) 2003-04-24
CZ20023615A3 (cs) 2003-04-16
EP1278759B1 (en) 2005-12-21
DE60141181D1 (de) 2010-03-11

Similar Documents

Publication Publication Date Title
IL161881A (en) N,n'-substituted-1,3-diamino-2- hydroxypropane derivatives
IL160081A0 (en) Novel 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
IL157704A0 (en) 4,5-dihydro-1h-pyrazole derivatives having potent cbi-antagonistic activity
AU2409102A (en) Elastic belt for papermaking
AU6807501A (en) 1-aryl-4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
MXPA03000107A (es) Pirroloquinolonas como agentes antivirales.
IL152325A0 (en) Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents
IL154675A0 (en) N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-yl-benzenesulfonamide
IL162310A0 (en) 3,4-Dihydro-1h-isoquinoloin-2-yl-derivatives
PL357443A1 (en) 4-oxo-1,4-dihydro-3-cinnolinecarboxamides as antiviral agents
GB0222844D0 (en) Trouser waist adjuster
IL159965A0 (en) Novel 2,4-diaminothiazole derivatives
TW538693U (en) Elastic braided belt for zipper
ZA200007433B (en) Waist belt holder.
ZA200201279B (en) Anti-HIV agents.
PL371851A1 (en) 3,4-dihydro-1h-isoquinoloin-2-yl-derivatives
TW451639U (en) Positioning buckle for necktie
GB0125857D0 (en) Pocket technical writer 21
DK1177185T3 (da) 4,5,6,7-tetrahydroindazolderivater som antitumormidler
AU148709S (en) Garment pocket
GB0000505D0 (en) Endless jigsaw
SI1470127T1 (sl) N,n-dimetilirani n-zamenjani porfirini
AU2002360317A8 (en) Therapeutic anti-hiv (iv9) compounds
PT1056744E (pt) 2-¬trans-(4-aminociclo-hexil)amino|purinas 6,9-dissubstituidas
GB0121925D0 (en) Inhalation masks

Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished