ZA200208591B - Bis-(N,N-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents. - Google Patents
Bis-(N,N-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents. Download PDFInfo
- Publication number
- ZA200208591B ZA200208591B ZA200208591A ZA200208591A ZA200208591B ZA 200208591 B ZA200208591 B ZA 200208591B ZA 200208591 A ZA200208591 A ZA 200208591A ZA 200208591 A ZA200208591 A ZA 200208591A ZA 200208591 B ZA200208591 B ZA 200208591B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- substituted
- lower alkyl
- aryl
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56318100A | 2000-05-02 | 2000-05-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200208591B true ZA200208591B (en) | 2004-03-04 |
Family
ID=24249433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200208591A ZA200208591B (en) | 2000-05-02 | 2002-10-23 | Bis-(N,N-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents. |
Country Status (25)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200600091A (en) | 2004-05-21 | 2006-01-01 | Telik Inc | Sulfonylethyl phosphorodiamidates |
| US8198247B2 (en) | 2004-12-21 | 2012-06-12 | Telik, Inc. | Process for and intermediates in the preparation of canfosfamide and its salts |
| US7655799B2 (en) | 2006-11-29 | 2010-02-02 | Telik, Inc. | 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates |
| US7872134B2 (en) | 2007-12-12 | 2011-01-18 | Telik, Inc. | 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates |
| US9879267B2 (en) * | 2008-03-14 | 2018-01-30 | Genentech, Inc. | Genetic variations associated with drug resistance |
| CN118834240A (zh) | 2019-05-13 | 2024-10-25 | 深圳艾欣达伟医药科技有限公司 | 含氟化合物及抗癌医药用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5556942A (en) * | 1991-04-29 | 1996-09-17 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
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2001
- 2001-02-05 UA UA2002119554A patent/UA74574C2/uk unknown
- 2001-05-01 TW TW090110381A patent/TWI308569B/zh not_active IP Right Cessation
- 2001-05-02 AT AT01935025T patent/ATE313549T1/de active
- 2001-05-02 CA CA002407606A patent/CA2407606C/en not_active Expired - Fee Related
- 2001-05-02 AR ARP010102067A patent/AR029072A1/es active IP Right Grant
- 2001-05-02 EP EP01935025A patent/EP1278759B1/en not_active Expired - Lifetime
- 2001-05-02 WO PCT/US2001/014290 patent/WO2001083496A1/en not_active Ceased
- 2001-05-02 KR KR1020027014577A patent/KR100729980B1/ko not_active Expired - Fee Related
- 2001-05-02 CZ CZ20023615A patent/CZ20023615A3/cs unknown
- 2001-05-02 ES ES05020467T patent/ES2337154T3/es not_active Expired - Lifetime
- 2001-05-02 DE DE60116081T patent/DE60116081T2/de not_active Expired - Lifetime
- 2001-05-02 AU AU6115301A patent/AU6115301A/xx active Pending
- 2001-05-02 MX MXPA02010813A patent/MXPA02010813A/es active IP Right Grant
- 2001-05-02 IL IL15232501A patent/IL152325A0/xx unknown
- 2001-05-02 JP JP2001580921A patent/JP4249928B2/ja not_active Expired - Fee Related
- 2001-05-02 PT PT05020467T patent/PT1607399E/pt unknown
- 2001-05-02 HU HU0300688A patent/HUP0300688A3/hu unknown
- 2001-05-02 AU AU2001261153A patent/AU2001261153B2/en not_active Ceased
- 2001-05-02 NZ NZ522189A patent/NZ522189A/en not_active IP Right Cessation
- 2001-05-02 EP EP05020467A patent/EP1607399B1/en not_active Expired - Lifetime
- 2001-05-02 DK DK05020467.6T patent/DK1607399T3/da active
- 2001-05-02 DK DK01935025T patent/DK1278759T3/da active
- 2001-05-02 DE DE60141181T patent/DE60141181D1/de not_active Expired - Lifetime
- 2001-05-02 ES ES01935025T patent/ES2253380T3/es not_active Expired - Lifetime
- 2001-05-02 BR BR0110553-1A patent/BR0110553A/pt active Search and Examination
- 2001-05-02 PL PL358155A patent/PL207005B1/pl not_active IP Right Cessation
- 2001-05-02 CN CNB018089623A patent/CN1182143C/zh not_active Expired - Fee Related
- 2001-05-02 AT AT05020467T patent/ATE455779T1/de active
- 2001-05-02 EA EA200201154A patent/EA006852B1/ru not_active IP Right Cessation
-
2002
- 2002-10-16 IL IL152325A patent/IL152325A/en not_active IP Right Cessation
- 2002-10-23 ZA ZA200208591A patent/ZA200208591B/en unknown
- 2002-11-01 NO NO20025240A patent/NO328854B1/no not_active IP Right Cessation
-
2009
- 2009-11-18 NO NO20093371A patent/NO331833B1/no not_active IP Right Cessation
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