BR0009180A - Processo microbiológico para a preparação de pravastatin - Google Patents

Processo microbiológico para a preparação de pravastatin

Info

Publication number
BR0009180A
BR0009180A BR0009180-4A BR0009180A BR0009180A BR 0009180 A BR0009180 A BR 0009180A BR 0009180 A BR0009180 A BR 0009180A BR 0009180 A BR0009180 A BR 0009180A
Authority
BR
Brazil
Prior art keywords
formula
compound
preparation
hydroxylating
product formed
Prior art date
Application number
BR0009180-4A
Other languages
English (en)
Portuguese (pt)
Inventor
Antonia Jekkel
Istvan Barta
Ildiko Lang
Margit Bidlo
Janos Salat
Karoly Albrecht
Julianna Mozes
Istvan M Szabo
Eva Ilkoy
Gyorgy Somogyi
Gabor Ambrus
Gyula Horvath
Attila Andor
Laszlo Birincsik
Sandor Boros
Attila Konya
Original Assignee
Inst Drug Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Drug Res Ltd filed Critical Inst Drug Res Ltd
Publication of BR0009180A publication Critical patent/BR0009180A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungi isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR0009180-4A 1999-02-03 2000-02-03 Processo microbiológico para a preparação de pravastatin BR0009180A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11845899P 1999-02-03 1999-02-03
US13475999P 1999-05-18 1999-05-18
PCT/US2000/002993 WO2000046175A1 (en) 1999-02-03 2000-02-03 Microbial process for preparing pravastatin

Publications (1)

Publication Number Publication Date
BR0009180A true BR0009180A (pt) 2002-03-26

Family

ID=26816384

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009180-4A BR0009180A (pt) 1999-02-03 2000-02-03 Processo microbiológico para a preparação de pravastatin

Country Status (27)

Country Link
EP (1) EP1154979B1 (https=)
JP (2) JP3645491B2 (https=)
KR (2) KR20060061406A (https=)
CN (3) CN1260344C (https=)
AR (2) AR023368A1 (https=)
AT (1) ATE294771T1 (https=)
AU (2) AU774438B2 (https=)
BG (1) BG105778A (https=)
BR (1) BR0009180A (https=)
CA (1) CA2361701C (https=)
CZ (1) CZ20012761A3 (https=)
DE (1) DE60019898T2 (https=)
ES (1) ES2240072T3 (https=)
HK (1) HK1042686B (https=)
HR (1) HRP20010577B1 (https=)
HU (1) HUP0200650A3 (https=)
IL (1) IL144697A0 (https=)
IS (1) IS6036A (https=)
MX (1) MXPA01007807A (https=)
NO (1) NO20013818L (https=)
PL (1) PL350317A1 (https=)
PT (1) PT1154979E (https=)
RU (1) RU2004127981A (https=)
SK (1) SK10932001A3 (https=)
TR (2) TR200600009T2 (https=)
WO (1) WO2000046175A1 (https=)
YU (1) YU55701A (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
EP1798214A3 (en) * 1999-11-30 2007-08-01 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Process for recovering statin compounds from a fermentation broth
JP3881240B2 (ja) * 1999-11-30 2007-02-14 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 醗酵ブロスからスタチン化合物を回収するための方法
SK8312002A3 (en) 1999-12-14 2003-05-02 Biogal Gyogyszergyar Novel forms of pravastatin sodium
CN1468098A (zh) * 2000-10-05 2004-01-14 �ݰ¸Ƕ�ҩ�����޹�˾ 基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠和包含普伐他汀钠的组合物
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
JP3463875B2 (ja) 2001-08-06 2003-11-05 三共株式会社 プラバスタチンを精製する方法
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
KR101124180B1 (ko) * 2003-04-25 2012-03-27 벨큐라 테라퓨틱스 인코포레이티드 （２ｓ, ３ｓ）-3-〔〔（１ｓ）-１-이소부톡시메틸-３-메틸부틸〕카르바모일〕옥시란-２-카르복실산의 염
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
CA2546377A1 (en) 2003-11-24 2005-06-09 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
US20110130450A1 (en) * 2008-04-02 2011-06-02 Aad Johannes Bouman Pravastatin extraction
EP3714959A1 (en) * 2019-03-29 2020-09-30 Basf Se Isolation of small molecules from the fermentation broth of a eukaryotic microorganism
CN117164541B (zh) * 2022-05-27 2025-09-30 黑龙江华瑞生物科技有限公司 一种从美伐他汀母液中分离纯化美伐他汀的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4545235B2 (ja) * 1996-03-28 2010-09-15 ディーエスエム アイピー アセッツ ビー．ブイ． 顆粒状微生物バイオマスの製造法とそのバイオマスからの貴重化合物の単離法

Also Published As

Publication number Publication date
KR20060061406A (ko) 2006-06-07
SK10932001A3 (sk) 2002-06-04
AU3356700A (en) 2000-08-25
AU774438B2 (en) 2004-06-24
HUP0200650A2 (en) 2002-08-28
TR200103127T2 (tr) 2002-04-22
HRP20010577A2 (en) 2002-12-31
KR20010112257A (ko) 2001-12-20
BG105778A (bg) 2002-05-31
JP4197312B2 (ja) 2008-12-17
PT1154979E (pt) 2005-08-31
TR200600009T2 (tr) 2006-08-21
PL350317A1 (en) 2002-12-02
HK1042686A1 (en) 2002-08-23
NO20013818D0 (no) 2001-08-03
ES2240072T3 (es) 2005-10-16
CA2361701A1 (en) 2000-08-10
CN1260344C (zh) 2006-06-21
CN1347400A (zh) 2002-05-01
EP1154979A4 (en) 2004-05-26
CN1177793C (zh) 2004-12-01
YU55701A (sh) 2004-07-15
JP2005047924A (ja) 2005-02-24
DE60019898T2 (de) 2006-08-10
NO20013818L (no) 2001-10-03
HRP20010577B1 (en) 2005-12-31
RU2004127981A (ru) 2006-03-10
CZ20012761A3 (cs) 2002-05-15
HK1042686B (en) 2005-10-14
KR100648541B1 (ko) 2006-11-24
IS6036A (is) 2001-08-02
AU2004214559A1 (en) 2004-10-21
IL144697A0 (en) 2002-06-30
CN1537935A (zh) 2004-10-20
JP2002535977A (ja) 2002-10-29
DE60019898D1 (de) 2005-06-09
WO2000046175A1 (en) 2000-08-10
CA2361701C (en) 2007-04-10
HUP0200650A3 (en) 2008-03-28
JP3645491B2 (ja) 2005-05-11
MXPA01007807A (es) 2003-06-04
ATE294771T1 (de) 2005-05-15
AR023368A1 (es) 2002-09-04
CN1590363A (zh) 2005-03-09
EP1154979B1 (en) 2005-05-04
AR061765A2 (es) 2008-09-17
EP1154979A1 (en) 2001-11-21

Similar Documents

Publication Publication Date Title
BR0009180A (pt) Processo microbiológico para a preparação de pravastatin
BR0013156A (pt) Hidroxilação de compactina em pravastatina através de micromonospora
ATE490332T1 (de) Verfahren zur vitaminherstellung
ATE317911T1 (de) Verfahren zur herstellung von l-aminosäuren durch fermentation
RU2002103376A (ru) Гидроксилирование компактина до правастатина с помощью micromonospora
FR2671561A1 (fr) Procede et milieu d'identification de bacteries du genre listeria.
ATE235548T1 (de) Methode für die reinigung kovalent geschlossener zirkulärer dns
JO1764B1 (en) A microbiological process for the mefenolin preparation process
ATE256674T1 (de) Verfahren zur herstellung von mycophenolsäure und derivaten davon
KR840002903A (ko) 하이포미크로비움속의 미생물 및 수용액내에서 메틸그룹을 함유한 화합물을 분해시키는 방법
ATE486967T1 (de) Herstellung von thiamin durch fermentation
MacKechnie et al. Microcycle sporogenesis of Bacillus cereus in a chemically defined medium
JPS6254433B2 (https=)
BR9911437A (pt) Processo para a remoção de monÈmero de amida indesejável de uma preparação de poliamida
EP1205461A4 (en) METHOD FOR CLEANING FLUORINATED HYDROXYL COMPOUNDS
BRPI0409074A (pt) processos de fermentação com baixas concentrações de nutrientes contendo carbono e nitrogênio
KR920002795A (ko) 항생제 발히마이신, 이의 제조방법 및 약제로서 이의 용도
JPH067798B2 (ja) 微生物によるエチレンの製造法
JPS5953838B2 (ja) β−ヒドロキシ吉草酸の製造方法
JPH02119785A (ja) ２−オキソ−４−フェニル酪酸の製造方法
TH76755A (th) กลุ่มแบคทีเรียเพาะเลี้ยง
JPS5847497A (ja) ５−ヒドロキシメチルシトシンの製造法
JPS639832B2 (https=)
WO2020161760A1 (ja) サーモスポロスリックス・ハザケンシス（Ｔｈｅｒｍｏｓｐｏｒｏｔｈｒｉｘ ｈａｚａｋｅｎｓｉｓ）由来の抗菌活性物質
RU98124016A (ru) Фрагменты днк, определяющие повышенную устойчивость бактерий escherichia coli к аминокислотам или их аналогам, и способ получения l-аминокислот

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 10 (IX) DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.