KR20060061406A - 프라바스타틴을 제조하기 위한 미생물학적인 방법 - Google Patents

프라바스타틴을 제조하기 위한 미생물학적인 방법 Download PDF

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Publication number
KR20060061406A
KR20060061406A KR1020067009407A KR20067009407A KR20060061406A KR 20060061406 A KR20060061406 A KR 20060061406A KR 1020067009407 A KR1020067009407 A KR 1020067009407A KR 20067009407 A KR20067009407 A KR 20067009407A KR 20060061406 A KR20060061406 A KR 20060061406A
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KR
South Korea
Prior art keywords
formula
compound
broth
pravastatin
strain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020067009407A
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English (en)
Korean (ko)
Inventor
안토니아 제켈
아틸라 코냐
이스트반 바르타
에바 일코이
지올지 소모지
가보 암브루스
지울라 호르바스
카롤리 알브레트
이스트반 엠 자보
니 수토 줄리안나 모제스
자노스 살랏
아틸라 안도르
라스즈로 비린식
산도르 보로스
일디코 랑
니 이글로이 마르짓 비들로
Original Assignee
인스티튜트 포 드럭 리서치 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 인스티튜트 포 드럭 리서치 리미티드 filed Critical 인스티튜트 포 드럭 리서치 리미티드
Publication of KR20060061406A publication Critical patent/KR20060061406A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungi isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020067009407A 1999-02-03 2000-02-03 프라바스타틴을 제조하기 위한 미생물학적인 방법 Ceased KR20060061406A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11845899P 1999-02-03 1999-02-03
US60/118,458 1999-02-03
US13475999P 1999-05-18 1999-05-18
US60/134,759 1999-05-18

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020017009821A Division KR100648541B1 (ko) 1999-02-03 2000-02-03 프라바스타틴을 제조하기 위한 미생물학적인 방법

Publications (1)

Publication Number Publication Date
KR20060061406A true KR20060061406A (ko) 2006-06-07

Family

ID=26816384

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020067009407A Ceased KR20060061406A (ko) 1999-02-03 2000-02-03 프라바스타틴을 제조하기 위한 미생물학적인 방법
KR1020017009821A Expired - Fee Related KR100648541B1 (ko) 1999-02-03 2000-02-03 프라바스타틴을 제조하기 위한 미생물학적인 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020017009821A Expired - Fee Related KR100648541B1 (ko) 1999-02-03 2000-02-03 프라바스타틴을 제조하기 위한 미생물학적인 방법

Country Status (27)

Country Link
EP (1) EP1154979B1 (https=)
JP (2) JP3645491B2 (https=)
KR (2) KR20060061406A (https=)
CN (3) CN1260344C (https=)
AR (2) AR023368A1 (https=)
AT (1) ATE294771T1 (https=)
AU (2) AU774438B2 (https=)
BG (1) BG105778A (https=)
BR (1) BR0009180A (https=)
CA (1) CA2361701C (https=)
CZ (1) CZ20012761A3 (https=)
DE (1) DE60019898T2 (https=)
ES (1) ES2240072T3 (https=)
HK (1) HK1042686B (https=)
HR (1) HRP20010577B1 (https=)
HU (1) HUP0200650A3 (https=)
IL (1) IL144697A0 (https=)
IS (1) IS6036A (https=)
MX (1) MXPA01007807A (https=)
NO (1) NO20013818L (https=)
PL (1) PL350317A1 (https=)
PT (1) PT1154979E (https=)
RU (1) RU2004127981A (https=)
SK (1) SK10932001A3 (https=)
TR (2) TR200600009T2 (https=)
WO (1) WO2000046175A1 (https=)
YU (1) YU55701A (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
EP1798214A3 (en) * 1999-11-30 2007-08-01 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Process for recovering statin compounds from a fermentation broth
JP3881240B2 (ja) * 1999-11-30 2007-02-14 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 醗酵ブロスからスタチン化合物を回収するための方法
SK8312002A3 (en) 1999-12-14 2003-05-02 Biogal Gyogyszergyar Novel forms of pravastatin sodium
CN1468098A (zh) * 2000-10-05 2004-01-14 �ݰ¸Ƕ�ҩ�����޹�˾ 基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠和包含普伐他汀钠的组合物
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
JP3463875B2 (ja) 2001-08-06 2003-11-05 三共株式会社 プラバスタチンを精製する方法
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
KR101124180B1 (ko) * 2003-04-25 2012-03-27 벨큐라 테라퓨틱스 인코포레이티드 （２ｓ, ３ｓ）-3-〔〔（１ｓ）-１-이소부톡시메틸-３-메틸부틸〕카르바모일〕옥시란-２-카르복실산의 염
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
CA2546377A1 (en) 2003-11-24 2005-06-09 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
US20110130450A1 (en) * 2008-04-02 2011-06-02 Aad Johannes Bouman Pravastatin extraction
EP3714959A1 (en) * 2019-03-29 2020-09-30 Basf Se Isolation of small molecules from the fermentation broth of a eukaryotic microorganism
CN117164541B (zh) * 2022-05-27 2025-09-30 黑龙江华瑞生物科技有限公司 一种从美伐他汀母液中分离纯化美伐他汀的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4545235B2 (ja) * 1996-03-28 2010-09-15 ディーエスエム アイピー アセッツ ビー．ブイ． 顆粒状微生物バイオマスの製造法とそのバイオマスからの貴重化合物の単離法

Also Published As

Publication number Publication date
SK10932001A3 (sk) 2002-06-04
AU3356700A (en) 2000-08-25
AU774438B2 (en) 2004-06-24
HUP0200650A2 (en) 2002-08-28
BR0009180A (pt) 2002-03-26
TR200103127T2 (tr) 2002-04-22
HRP20010577A2 (en) 2002-12-31
KR20010112257A (ko) 2001-12-20
BG105778A (bg) 2002-05-31
JP4197312B2 (ja) 2008-12-17
PT1154979E (pt) 2005-08-31
TR200600009T2 (tr) 2006-08-21
PL350317A1 (en) 2002-12-02
HK1042686A1 (en) 2002-08-23
NO20013818D0 (no) 2001-08-03
ES2240072T3 (es) 2005-10-16
CA2361701A1 (en) 2000-08-10
CN1260344C (zh) 2006-06-21
CN1347400A (zh) 2002-05-01
EP1154979A4 (en) 2004-05-26
CN1177793C (zh) 2004-12-01
YU55701A (sh) 2004-07-15
JP2005047924A (ja) 2005-02-24
DE60019898T2 (de) 2006-08-10
NO20013818L (no) 2001-10-03
HRP20010577B1 (en) 2005-12-31
RU2004127981A (ru) 2006-03-10
CZ20012761A3 (cs) 2002-05-15
HK1042686B (en) 2005-10-14
KR100648541B1 (ko) 2006-11-24
IS6036A (is) 2001-08-02
AU2004214559A1 (en) 2004-10-21
IL144697A0 (en) 2002-06-30
CN1537935A (zh) 2004-10-20
JP2002535977A (ja) 2002-10-29
DE60019898D1 (de) 2005-06-09
WO2000046175A1 (en) 2000-08-10
CA2361701C (en) 2007-04-10
HUP0200650A3 (en) 2008-03-28
JP3645491B2 (ja) 2005-05-11
MXPA01007807A (es) 2003-06-04
ATE294771T1 (de) 2005-05-15
AR023368A1 (es) 2002-09-04
CN1590363A (zh) 2005-03-09
EP1154979B1 (en) 2005-05-04
AR061765A2 (es) 2008-09-17
EP1154979A1 (en) 2001-11-21

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