BG64542B1 - ФАРМАЦЕВТИЧЕН СЪСТАВ, ВКЛЮЧВАЩ СЪЕДИНЕНИЕ, ПРИТЕЖАВАЩО АНТИ- Хa АКТИВНОСТ И СЪЕДИНЕНИЕ-АНТАГОНИСТ НА АГРЕГИРАНЕТО НА ТРОМБОЦИТИТЕ - Google Patents

ФАРМАЦЕВТИЧЕН СЪСТАВ, ВКЛЮЧВАЩ СЪЕДИНЕНИЕ, ПРИТЕЖАВАЩО АНТИ- Хa АКТИВНОСТ И СЪЕДИНЕНИЕ-АНТАГОНИСТ НА АГРЕГИРАНЕТО НА ТРОМБОЦИТИТЕ Download PDF

Info

Publication number
BG64542B1
BG64542B1 BG103372A BG10337299A BG64542B1 BG 64542 B1 BG64542 B1 BG 64542B1 BG 103372 A BG103372 A BG 103372A BG 10337299 A BG10337299 A BG 10337299A BG 64542 B1 BG64542 B1 BG 64542B1
Authority
BG
Bulgaria
Prior art keywords
compound
activity
platelet aggregation
pharmaceutical composition
antagonist compound
Prior art date
Application number
BG103372A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103372A (en
Inventor
Andre Uzan
Alian Curaudeau
Robert LEADLEY
Christopher Dunwiddie
Mark Perrone
Original Assignee
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21861879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG64542(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone-Poulenc Rorer Pharmaceuticals Inc. filed Critical Rhone-Poulenc Rorer Pharmaceuticals Inc.
Publication of BG103372A publication Critical patent/BG103372A/xx
Publication of BG64542B1 publication Critical patent/BG64542B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BG103372A 1996-11-27 1999-04-29 ФАРМАЦЕВТИЧЕН СЪСТАВ, ВКЛЮЧВАЩ СЪЕДИНЕНИЕ, ПРИТЕЖАВАЩО АНТИ- Хa АКТИВНОСТ И СЪЕДИНЕНИЕ-АНТАГОНИСТ НА АГРЕГИРАНЕТО НА ТРОМБОЦИТИТЕ BG64542B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3187896P 1996-11-27 1996-11-27

Publications (2)

Publication Number Publication Date
BG103372A BG103372A (en) 2000-01-31
BG64542B1 true BG64542B1 (bg) 2005-07-29

Family

ID=21861879

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103372A BG64542B1 (bg) 1996-11-27 1999-04-29 ФАРМАЦЕВТИЧЕН СЪСТАВ, ВКЛЮЧВАЩ СЪЕДИНЕНИЕ, ПРИТЕЖАВАЩО АНТИ- Хa АКТИВНОСТ И СЪЕДИНЕНИЕ-АНТАГОНИСТ НА АГРЕГИРАНЕТО НА ТРОМБОЦИТИТЕ

Country Status (28)

Country Link
US (2) US6103705A (de)
EP (1) EP0946185B2 (de)
JP (1) JP4498471B2 (de)
KR (1) KR100512671B1 (de)
CN (1) CN1121224C (de)
AP (1) AP1390A (de)
AT (1) ATE283062T1 (de)
AU (1) AU754936B2 (de)
BG (1) BG64542B1 (de)
BR (1) BR9713141A (de)
CA (1) CA2272317C (de)
CZ (1) CZ298552B6 (de)
DE (1) DE69731763T3 (de)
DK (1) DK0946185T4 (de)
EA (1) EA002475B1 (de)
ES (1) ES2230624T5 (de)
HK (1) HK1023504A1 (de)
HU (1) HUP9903496A3 (de)
IL (1) IL129877A (de)
NO (1) NO327740B1 (de)
OA (1) OA11049A (de)
PL (1) PL189116B1 (de)
PT (1) PT946185E (de)
SI (1) SI0946185T2 (de)
SK (1) SK286024B6 (de)
UA (1) UA63929C2 (de)
WO (1) WO1998023279A1 (de)
ZA (1) ZA9710691B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9903496A3 (en) * 1996-11-27 2001-03-28 Aventis Pharmaceuticals Inc Co Pharmaceutical composition comprising a compound having anti-xa activity and a platelet aggregation antagonist compound
FR2764511B1 (fr) 1997-06-13 2000-09-08 Sanofi Sa Compositions pour le traitement et la prevention de la thrombose arterielle et utilisation d'un inhibiteur du facteur xa seul et/ou en combinaison avec un antiagregant plaquettaire
US6136794A (en) * 1998-02-02 2000-10-24 Merck & Co., Inc. Platelet aggregation inhibition using low molecular weight heparin in combination with a GP IIb/IIIa antagonist
AU1712700A (en) * 1998-11-18 2000-06-05 G.D. Searle & Co. Restoration of platelet aggregation by antibody administration after gpiib/iiia antagonist treatment
CZ20014665A3 (cs) * 1999-06-30 2002-05-15 Hamilton Civic Hospitals Research Development, Inc Prostředek s obsahem heparinu se střední molekulovou hmotností
ES2161615B1 (es) * 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa Composiciones de heparinas de muy bajo peso molecular.
US6969705B2 (en) * 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
CN1473061A (zh) * 2000-09-08 2004-02-04 ���ܶ�����ҽԺ�о���չ���޹�˾ 抗血栓形成的组合物
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
DE10141106A1 (de) * 2001-08-22 2003-03-13 Aventis Pharma Gmbh Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen
US20040171819A1 (en) * 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US7235543B2 (en) 2003-03-07 2007-06-26 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP4589919B2 (ja) 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
US7956046B2 (en) * 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
EP1537871A1 (de) * 2003-12-04 2005-06-08 Aventis Pharma S.A. Enoxaparin in der Tumorenbehandlung
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
KR100601429B1 (ko) * 2004-07-09 2006-07-14 주식회사 대우일렉트로닉스 기계식 전자렌지의 댐퍼 구동회로
EP2014296A1 (de) * 2007-07-10 2009-01-14 PAION Deutschland GmbH Neuartige Strategien zur Erhöhung der Reperfusion in einem verstopften Blutgefäß
AR067345A1 (es) * 2007-07-10 2009-10-07 Paion Deutschland Gmbh Uso de trombomodulina para la preparacion de un medicamento trombolitico
CN101783857B (zh) * 2009-05-12 2011-11-30 上海海事大学 一种基于fpga在高分辨率成像系统中的图像矩阵化预处理方法
IT1400232B1 (it) * 2010-05-07 2013-05-24 Advance Holdings Ltd Composizione farmaceutica topica comprendente eparina
WO2011149110A1 (en) 2010-05-28 2011-12-01 Daiichi Sankyo Company, Limited Novel composition for the prevention and/or treatment of thromboembolism
EP2508892A1 (de) * 2011-04-04 2012-10-10 Siemens Healthcare Diagnostics Products GmbH Kontrollen und Kit für Thrombozytenaktivitätsteste
RU2554803C1 (ru) * 2014-06-26 2015-06-27 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ профилактики развития послеоперационных венозных тромбоэмболических осложнений у пациентов с колоректальным раком

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
US4692435A (en) * 1978-11-06 1987-09-08 Choay, S.A. Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
DE3265781D1 (en) * 1981-05-21 1985-10-03 Akzo Nv New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
US4533549A (en) * 1983-01-04 1985-08-06 Lasker Sigmund E Antithrombotic agent
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
DK196886D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
DK196986D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
US4833155A (en) * 1986-11-25 1989-05-23 Syntex (U.S.A.) Inc. 3-(ω-(3,5,-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles, and anti-inflammatory uses thereof
EP0275748B1 (de) * 1986-12-15 1992-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Peptid-Derivate und deren Verwendung in der Therapie
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
KR940009084B1 (ko) * 1988-05-18 1994-09-29 체크 포인트 시스템스, 인코오퍼레이티드 자기 및 공명회로 검출용 안테나 시스템
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
US4992463A (en) * 1988-07-20 1991-02-12 Monsanto Company Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2066047A1 (en) * 1989-09-29 1991-03-30 Scott I. Klein Anti-thrombotic peptides and pseudopeptides
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
US5051405A (en) * 1989-10-10 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptides and pseudopeptides
US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
US5086069A (en) * 1990-02-05 1992-02-04 Rorer Pharmaceutical Corporation Anti-thrombotic peptide and pseudopeptide derivatives
US5064814A (en) * 1990-04-05 1991-11-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptide and pseudopeptide derivatives
IL99539A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
NZ239876A (en) * 1990-09-27 1993-12-23 Merck & Co Inc Glycyl-b-alanine derivatives and pharmaceutical compositions thereof.
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
DE4290097T1 (de) * 1991-01-24 1993-01-28 Aerojet-General Corp., Rancho Cordova, Calif., Us
SK120193A3 (en) * 1991-05-02 1994-07-06 Yeda Res & Dev Pharmaceutical composition for the prevention and/or treatment of pathological processes
AU3129993A (en) * 1991-11-08 1993-06-07 Massachusetts Institute Of Technology Localized oligonucleotide therapy
CA2159070A1 (en) * 1993-03-29 1994-10-13 William Frank Degrado Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia
RO115520B1 (ro) * 1993-10-15 2000-03-30 Rhone Poulenc Rorer Pharma Derivati peptidici azacicloalchilalcanoil si intermediari pentru obtinerea acestora
US5639469A (en) * 1994-06-15 1997-06-17 Minnesota Mining And Manufacturing Company Transmucosal delivery system
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5721214A (en) * 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
AU2202397A (en) * 1996-03-28 1997-10-17 G.D. Searle & Co. Iib/iiia antagonists co-administered with aspirin and/or heparin
HUP9903496A3 (en) * 1996-11-27 2001-03-28 Aventis Pharmaceuticals Inc Co Pharmaceutical composition comprising a compound having anti-xa activity and a platelet aggregation antagonist compound

Also Published As

Publication number Publication date
CN1238693A (zh) 1999-12-15
AP9901517A0 (en) 1999-06-30
EA002475B1 (ru) 2002-06-27
HUP9903496A3 (en) 2001-03-28
PL189116B1 (pl) 2005-06-30
CZ298552B6 (cs) 2007-10-31
US6103705A (en) 2000-08-15
AP1390A (en) 2005-04-15
PT946185E (pt) 2005-02-28
ZA9710691B (en) 1998-06-12
HK1023504A1 (en) 2000-09-15
BR9713141A (pt) 2000-02-08
NO992555D0 (no) 1999-05-27
DE69731763T3 (de) 2010-12-30
ES2230624T3 (es) 2005-05-01
KR100512671B1 (ko) 2005-09-07
NO992555L (no) 1999-05-27
DK0946185T4 (da) 2010-08-30
WO1998023279A1 (en) 1998-06-04
US20020032214A1 (en) 2002-03-14
IL129877A (en) 2004-08-31
SK286024B6 (sk) 2008-01-07
DE69731763D1 (de) 2004-12-30
CN1121224C (zh) 2003-09-17
AU5454698A (en) 1998-06-22
HUP9903496A2 (hu) 2000-10-28
UA63929C2 (uk) 2004-02-16
DE69731763T2 (de) 2005-06-30
ATE283062T1 (de) 2004-12-15
IL129877A0 (en) 2000-02-29
AU754936B2 (en) 2002-11-28
EA199900499A1 (ru) 2000-04-24
CA2272317C (en) 2001-01-30
ES2230624T5 (es) 2010-10-25
SI0946185T2 (sl) 2010-08-31
JP2001506603A (ja) 2001-05-22
NO327740B1 (no) 2009-09-14
EP0946185B2 (de) 2010-05-05
SI0946185T1 (en) 2005-06-30
EP0946185A1 (de) 1999-10-06
EP0946185A4 (de) 2001-06-27
DK0946185T3 (da) 2005-03-21
JP4498471B2 (ja) 2010-07-07
CZ174299A3 (cs) 1999-09-15
KR20000057265A (ko) 2000-09-15
EP0946185B1 (de) 2004-11-24
OA11049A (en) 2002-02-18
BG103372A (en) 2000-01-31
SK67399A3 (en) 2000-07-11

Similar Documents

Publication Publication Date Title
BG64542B1 (bg) ФАРМАЦЕВТИЧЕН СЪСТАВ, ВКЛЮЧВАЩ СЪЕДИНЕНИЕ, ПРИТЕЖАВАЩО АНТИ- Хa АКТИВНОСТ И СЪЕДИНЕНИЕ-АНТАГОНИСТ НА АГРЕГИРАНЕТО НА ТРОМБОЦИТИТЕ
Mombelli et al. Effect of heparin on plasma fibrinopeptide A in patients with acute myocardial infarction.
EP2374456B1 (de) Edoxaban dosierungsanleitung
Buchanan et al. Prevention of thrombus formation and growth by antithrombin III and heparin cofactor II-dependent thrombin inhibitors: importance of heparin cofactor II
Rogers et al. Effects of a factor Xa inhibitor, DX-9065a, in a novel rabbit model of venous thrombosis
JPH0859505A (ja) 抗凝血物質に対する解毒剤として用いるのに適した医薬およびその使用
CN113116885A (zh) 一种茶多酚类化合物在制备抗血栓药物中的应用
MXPA99005008A (en) PHARMACEUTICAL COMPOSITION COMPRISING A COMPOUND HAVING ANTI-Xa ACTIVITY AND A PLATELET AGGREGATION ANTAGONIST COMPOUND
JP2004507562A (ja) 抗血栓性組成物
Avecilla Transfusion Management of Patients Receiving Antithrombotic Therapy
Palareti et al. Anticoagulation: Heparins and Vitamin K Antagonists
Nevarre et al. Hypercoagulability and the management of anticoagulant therapy in surgical patients: review and recommendations
KR100231978B1 (ko) 아스피린 회합체 및 안티-Xa 올리고사카라이드를 함유하는 조성물과 아스피린 결합물내 안티-XA 올리고사카라이드의 용도
Vitamin et al. Perioperative management of patients receiving vitamin K antagonists
Shakur et al. Anticoagulation therapy