BG63498B1 - Метод за получаване на производни на 1-арил-1-цианоциклобутан - Google Patents

Метод за получаване на производни на 1-арил-1-цианоциклобутан Download PDF

Info

Publication number
BG63498B1
BG63498B1 BG102473A BG10247398A BG63498B1 BG 63498 B1 BG63498 B1 BG 63498B1 BG 102473 A BG102473 A BG 102473A BG 10247398 A BG10247398 A BG 10247398A BG 63498 B1 BG63498 B1 BG 63498B1
Authority
BG
Bulgaria
Prior art keywords
formula
dimethyl sulfoxide
solvent
temperature
water
Prior art date
Application number
BG102473A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG102473A (en
Inventor
John Barker
Michelle CLARK
Original Assignee
Knoll Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Aktiengesellschaft filed Critical Knoll Aktiengesellschaft
Publication of BG102473A publication Critical patent/BG102473A/xx
Publication of BG63498B1 publication Critical patent/BG63498B1/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/04Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Catalysts (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
BG102473A 1995-12-02 1998-05-21 Метод за получаване на производни на 1-арил-1-цианоциклобутан BG63498B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9524681.5A GB9524681D0 (en) 1995-12-02 1995-12-02 Chemical process
PCT/EP1996/005246 WO1997020810A1 (fr) 1995-12-02 1996-11-28 Procede de preparation de derives de 1-aryl-1-cyanocyclobutane

Publications (2)

Publication Number Publication Date
BG102473A BG102473A (en) 1999-05-31
BG63498B1 true BG63498B1 (bg) 2002-03-29

Family

ID=10784817

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102473A BG63498B1 (bg) 1995-12-02 1998-05-21 Метод за получаване на производни на 1-арил-1-цианоциклобутан

Country Status (28)

Country Link
US (1) US6545173B1 (fr)
EP (1) EP0863868B1 (fr)
JP (1) JP2000501402A (fr)
KR (1) KR19990071838A (fr)
CN (1) CN1075057C (fr)
AT (1) ATE199247T1 (fr)
AU (1) AU717603B2 (fr)
BG (1) BG63498B1 (fr)
BR (1) BR9611683A (fr)
CA (1) CA2235043A1 (fr)
CZ (1) CZ164798A3 (fr)
DE (1) DE69611835T2 (fr)
DK (1) DK0863868T3 (fr)
ES (1) ES2154848T3 (fr)
GB (1) GB9524681D0 (fr)
GR (1) GR3035572T3 (fr)
HU (1) HUP9903481A3 (fr)
IL (1) IL124341A (fr)
MX (1) MX9804022A (fr)
NO (1) NO309265B1 (fr)
NZ (1) NZ323896A (fr)
PL (1) PL185047B1 (fr)
PT (1) PT863868E (fr)
RU (1) RU2179168C2 (fr)
SI (1) SI0863868T1 (fr)
SK (1) SK282470B6 (fr)
TR (1) TR199800987T2 (fr)
WO (1) WO1997020810A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974838B2 (en) 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
US6339106B1 (en) 1999-08-11 2002-01-15 Sepracor, Inc. Methods and compositions for the treatment and prevention of sexual dysfunction
US6476078B2 (en) 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
US6331571B1 (en) 1998-08-24 2001-12-18 Sepracor, Inc. Methods of treating and preventing attention deficit disorders
US6399826B1 (en) 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
ATE294157T1 (de) * 2001-02-28 2005-05-15 Council Scient Ind Res Verfahren zur herstellung von 1- (cyan(aryl)methyl)cyclohexanol
US6504044B2 (en) 2001-02-28 2003-01-07 Council Of Scientific And Industrial Research Process for the preparation of 1-[cyano(aryl)methyl] cyclohexanol
WO2002083631A1 (fr) 2001-04-13 2002-10-24 Sepracor Inc. Procedes permettant la preparation de didesmethylsibutramine et d'autres derives de sibutramine
AT503354B1 (de) * 2006-02-22 2008-07-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von 3,4-disubstituierten phenylessigsäuren, sowie neue zwischenverbindungen
CZ300903B6 (cs) * 2008-06-09 2009-09-09 Lucební závody Draslovka a. s. Kolín Zpusob výroby cykloalkankarbonitrilu

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3526656A (en) 1967-05-25 1970-09-01 Parke Davis & Co (1-arylcyclobutyl)carbonyl carbamic acid derivatives
US4220591A (en) 1975-11-26 1980-09-02 Commonwealth Scientific And Industrial Research Organization Insecticidal esters
AU4244478A (en) 1977-12-19 1979-06-28 Commw Scient Ind Res Org Cyclobutane carboxylic acids and esters and insecticides
ZA821577B (en) * 1981-04-06 1983-03-30 Boots Co Plc Therapeutic agents
IE52768B1 (en) * 1981-04-06 1988-02-17 Boots Co Ltd 1-arylcyclobutylalkylamine compounds useful as therapeutic agents
ZA925185B (en) 1991-07-18 1993-04-29 Hoffmann La Roche Dithianes.
GB9127306D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
GB9309749D0 (en) 1993-05-12 1993-06-23 Boots Co Plc Therapeutic agents
NZ268587A (en) 1993-06-22 1998-01-26 Knoll Ag 1-cycloalkyl substituted tetrahydroisoquinoline derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
SI0863868T1 (en) 2001-06-30
ES2154848T3 (es) 2001-04-16
WO1997020810A8 (fr) 2000-10-05
HUP9903481A1 (hu) 2001-01-29
PL326926A1 (en) 1998-11-09
NO982474L (no) 1998-05-29
US6545173B1 (en) 2003-04-08
PL185047B1 (pl) 2003-02-28
BR9611683A (pt) 1999-03-02
DE69611835T2 (de) 2001-06-07
GR3035572T3 (en) 2001-06-29
NO309265B1 (no) 2001-01-08
IL124341A0 (en) 1998-12-06
WO1997020810A1 (fr) 1997-06-12
GB9524681D0 (en) 1996-01-31
EP0863868A1 (fr) 1998-09-16
NO982474D0 (no) 1998-05-29
NZ323896A (en) 2000-01-28
SK62698A3 (en) 1999-02-11
ATE199247T1 (de) 2001-03-15
AU1093997A (en) 1997-06-27
JP2000501402A (ja) 2000-02-08
CZ164798A3 (cs) 1998-09-16
TR199800987T2 (xx) 1998-09-21
CN1203585A (zh) 1998-12-30
DE69611835D1 (de) 2001-03-29
HUP9903481A3 (en) 2001-11-28
RU2179168C2 (ru) 2002-02-10
MX9804022A (es) 1998-09-30
IL124341A (en) 2001-09-13
CN1075057C (zh) 2001-11-21
DK0863868T3 (da) 2001-03-19
PT863868E (pt) 2001-06-29
CA2235043A1 (fr) 1997-06-12
BG102473A (en) 1999-05-31
KR19990071838A (ko) 1999-09-27
AU717603B2 (en) 2000-03-30
EP0863868B1 (fr) 2001-02-21
SK282470B6 (sk) 2002-02-05

Similar Documents

Publication Publication Date Title
JPH05155879A (ja) 2,3−(ジフルオロメチレンジオキシ)シンナモニトリル及びその製造方法
BG63498B1 (bg) Метод за получаване на производни на 1-арил-1-цианоциклобутан
WO2015180585A9 (fr) Procédé de production de thiaméthoxame
JP2928982B2 (ja) 4’−ブロモメチル−2−シアノビフェニルの製造法
JP3723464B2 (ja) 11−アミノ−3−クロロ−6,11−ジヒドロ−5,5−ジオキソ−6−メチル−ジベンゾ〔c,f〕〔1,2〕チアゼピンの製造方法及びチアネピンの合成への応用
AU2005257478A1 (en) Method for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethyl cyclopropane hydrochloride
CA2089271C (fr) Procede pour la preparation de chlorure de 3-trifluoromethylbenzyle
JP2009137955A (ja) シクロアルキルおよびハロアルキルo−アミノフエニルケトン類の改良された製造方法
CN113795478A (zh) 三氟甲基亚磺酰氯的制备方法
US20020087008A1 (en) Process for preparing 2-chloro-5-chloromethylthiazole
EP0558096B1 (fr) Procédé pour la préparation de dichloro-(2,2)-paracyclophanes
JPH0145456B2 (fr)
JP3042122B2 (ja) N−シアノアセトアミジン誘導体の製造方法
JP4038024B2 (ja) 1−クロロ−4−アリールブタン類の製造方法
NZ264871A (en) Process for the preparation of highly chlorinated paraffins
EP0031645B1 (fr) Procédé pour la préparation de composés azoiques
US4374256A (en) Process for the preparation of pyrryl-2-acetonitrile
JP2007204453A (ja) アルケニルメルカプタンの製造法
JP2003335758A (ja) ピリジン誘導体、その製造方法、及び除草剤中間体としての用途
US6069255A (en) Preparation of vinyl isothiocyanates
US20070088177A1 (en) Process for preparing dimethyl cyanimidocarbonate
JPH02240031A (ja) α―クロロアルキル芳香族炭化水素の製造方法
GB2037286A (en) Process for the preparation of substituted malonic acid dinitriles
JP2003040816A (ja) トリス(α−クロロアルキル)芳香族炭化水素の製造方法
BE521432A (fr)