BG63258B1 - 4-аминотетрахидробензизоксазолови или -изотиазолови съединения - Google Patents

4-аминотетрахидробензизоксазолови или -изотиазолови съединения Download PDF

Info

Publication number
BG63258B1
BG63258B1 BG101894A BG10189497A BG63258B1 BG 63258 B1 BG63258 B1 BG 63258B1 BG 101894 A BG101894 A BG 101894A BG 10189497 A BG10189497 A BG 10189497A BG 63258 B1 BG63258 B1 BG 63258B1
Authority
BG
Bulgaria
Prior art keywords
tetrahydro
benzisoxazole
nmr
mixture
added
Prior art date
Application number
BG101894A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG101894A (en
Inventor
Erik Falch
Jens Perregaard
Arne Schousboe
Povl Krogsgaard-Larsen
Bente Frolund
Lenz MOLTZEN
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of BG101894A publication Critical patent/BG101894A/xx
Publication of BG63258B1 publication Critical patent/BG63258B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nozzles (AREA)
BG101894A 1995-02-28 1997-09-16 4-аминотетрахидробензизоксазолови или -изотиазолови съединения BG63258B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK20795 1995-02-28
PCT/DK1996/000084 WO1996026929A1 (fr) 1995-02-28 1996-02-28 Composes 4-aminotetrahydrobenzisoxazole ou -isothiazole

Publications (2)

Publication Number Publication Date
BG101894A BG101894A (en) 1998-05-29
BG63258B1 true BG63258B1 (bg) 2001-07-31

Family

ID=8090951

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101894A BG63258B1 (bg) 1995-02-28 1997-09-16 4-аминотетрахидробензизоксазолови или -изотиазолови съединения

Country Status (31)

Country Link
US (2) US5998613A (fr)
EP (1) EP0812318B1 (fr)
JP (1) JPH11501016A (fr)
KR (1) KR100242675B1 (fr)
CN (1) CN1087290C (fr)
AT (1) ATE317391T1 (fr)
AU (1) AU697610B2 (fr)
BG (1) BG63258B1 (fr)
BR (1) BR9607443A (fr)
CA (1) CA2213127A1 (fr)
CZ (1) CZ290837B6 (fr)
DE (1) DE69635798T2 (fr)
DK (1) DK0812318T3 (fr)
EA (1) EA000380B1 (fr)
EE (1) EE03483B1 (fr)
ES (1) ES2253748T3 (fr)
FI (1) FI973519A (fr)
HK (1) HK1008527A1 (fr)
HU (1) HUP9800631A3 (fr)
IL (1) IL117295A (fr)
IS (1) IS2352B (fr)
NO (1) NO309474B1 (fr)
NZ (1) NZ301653A (fr)
PL (1) PL187404B1 (fr)
RO (1) RO119545B1 (fr)
SI (1) SI0812318T1 (fr)
SK (1) SK281879B6 (fr)
TR (1) TR199700873T1 (fr)
UA (1) UA43396C2 (fr)
WO (1) WO1996026929A1 (fr)
ZA (1) ZA961591B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9710536A (pt) 1996-07-24 1999-08-17 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
GB9622370D0 (en) 1996-10-28 1997-01-08 Merck Sharp & Dohme Therapeutic agents
US20030166554A1 (en) * 2001-01-16 2003-09-04 Genset, S.A. Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists
US20030185754A1 (en) * 2001-01-16 2003-10-02 Genset, S.A. Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists
US7417040B2 (en) * 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7378426B2 (en) * 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
KR101354335B1 (ko) * 2009-05-05 2014-02-19 에프. 호프만-라 로슈 아게 인지 장애의 치료에 사용되는 ｇａｂａ ａ 수용체 역 작용제로서의 아이속사졸-티아졸 유도체
AU2010266040B2 (en) 2009-06-25 2015-01-15 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds
CN105758807B (zh) * 2016-02-22 2019-01-29 山东出入境检验检疫局检验检疫技术中心 一种鉴别废润滑油的方法
AU2019230014A1 (en) 2018-03-05 2020-09-17 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2602643C2 (de) * 1976-01-24 1984-12-20 Bayer Ag, 5090 Leverkusen 1,2-Benzisothiazolinone-3, Verfahren zu ihrer Herstellung sowie Arzneimittel
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4514414A (en) * 1982-10-25 1985-04-30 Smithkline Beckman Corporation N-Substituted pyrrolidineacetic acids and their esters
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
DK288385D0 (da) * 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
IE60267B1 (en) * 1986-12-26 1994-06-29 Sankyo Co Centrally-acting muscle relaxants
US5321037A (en) * 1986-12-26 1994-06-14 Sankyo Company, Limited Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants
US5225412A (en) * 1991-04-29 1993-07-06 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides

Also Published As

Publication number Publication date
MX9706280A (es) 1998-06-30
HUP9800631A3 (en) 1998-12-28
PL321956A1 (en) 1998-01-05
NO309474B1 (no) 2001-02-05
ATE317391T1 (de) 2006-02-15
AU697610B2 (en) 1998-10-15
CZ290837B6 (cs) 2002-10-16
DE69635798T2 (de) 2006-08-17
EP0812318A1 (fr) 1997-12-17
JPH11501016A (ja) 1999-01-26
KR100242675B1 (ko) 2000-03-02
RO119545B1 (ro) 2004-12-30
ES2253748T3 (es) 2006-06-01
PL187404B1 (pl) 2004-07-30
TR199700873T1 (xx) 1998-01-21
CZ271197A3 (cs) 1998-03-18
ZA961591B (en) 1996-08-28
CN1087290C (zh) 2002-07-10
UA43396C2 (uk) 2001-12-17
NO973948L (no) 1997-08-27
IS2352B (is) 2008-04-15
SK281879B6 (sk) 2001-08-06
FI973519A0 (fi) 1997-08-27
EA000380B1 (ru) 1999-06-24
NO973948D0 (no) 1997-08-27
EA199700199A1 (ru) 1998-02-26
NZ301653A (en) 1998-12-23
US6174909B1 (en) 2001-01-16
EP0812318B1 (fr) 2006-02-08
KR19980702546A (ko) 1998-07-15
AU4713196A (en) 1996-09-18
CA2213127A1 (fr) 1996-09-06
BR9607443A (pt) 1998-05-26
IS4542A (is) 1997-08-13
EE03483B1 (et) 2001-08-15
DK0812318T3 (da) 2006-06-06
WO1996026929A1 (fr) 1996-09-06
IL117295A (en) 1999-11-30
US5998613A (en) 1999-12-07
SI0812318T1 (sl) 2006-06-30
HK1008527A1 (en) 1999-07-30
CN1176638A (zh) 1998-03-18
BG101894A (en) 1998-05-29
DE69635798D1 (de) 2006-04-20
EE9700197A (et) 1998-02-16
HUP9800631A2 (hu) 1998-08-28
SK115197A3 (en) 1998-02-04
IL117295A0 (en) 1996-06-18
FI973519A (fi) 1997-08-27

Similar Documents

Publication Publication Date Title
US20220281815A1 (en) Cyclopropyl-amide compounds as dual lsd1/hdac inhibitors
JPH09509155A (ja) プロテアーゼインヒビター
WO2004050646A1 (fr) Derives de 1, 2, 5-thiadiazolidin-3-one 1, 1 dioxyde utilises en tant qu'inhibiteurs de la proteine tyrosine phosphatase ptp1b
CZ284342B6 (cs) 2-Piperidino- a 2-pyrrolidiho-1-alkanolové deriváty a způsob jejich výroby
BG63258B1 (bg) 4-аминотетрахидробензизоксазолови или -изотиазолови съединения
JP2023548947A (ja) ベンジルアミンまたはベンジルアルコール誘導体およびその用途
KR20070046879A (ko) 5-ｈｔ7 수용체 안타고니스트
WO2015121212A1 (fr) Nouveaux composés présentant une activité d'inhibition sélective vis-à-vis de pde4d
JP3044055B2 (ja) １，２―エタンジオール誘導体およびその塩
KR20070046878A (ko) 5-ｈｔ7 수용체 안타고니스트
US6420566B2 (en) Pharmaceutical compositions containing a 4, 5-dihydro-1, 3-thiazol-2-ylamine derivative, novel derivatives and preparation thereof
NO149958B (no) Analogifremgangsmaate til fremstilling av cykloheksenderivater
JPH09507472A (ja) アミノスルホニル−フェニル−１ｈ−ピロール誘導体類、それらの製造方法およびそれらの使用
MXPA97006280A (en) Compounds 4-aminotetrahidrobenzisoxasol oisotia
DE69615696T2 (de) Heterocyclische verbindungen zur behandlung von myokard-ischemia
NO323263B1 (no) Heterosyklisk derivat, fremgangsmater for dets fremstilling, farmasoytiske sammensetninger som inneholder dette, anvendelse av dette for fremstilling av et preparat for medisinsk bruk samt nevnte derivat til bruk som medikament
ES2389754T3 (es) Nuevos derivados de tiofendiamina con estructura urea
HUT72744A (en) Derivatives of 3-hydroxyantranilic acid, their preparation, pharmaceutical compns. contg. them and use of the said compds.
IE880244L (en) Pilocarpine derivatives
US4994569A (en) 5,6-dihydro-4H-1,3-oxa(or thia)zine derivatives, their preparation and compositions containing them
KR20030017990A (ko) 4,5-디하이드로-티아졸-2-일아민 유도체 및 ｎｏ-신타제억제제로서의 이의 용도
WO1997005133A1 (fr) Promedicaments de 4[3-(trans-3-dimethylaminocyclobutyl)-1h-indol-5-yl-methyl]4(s) oxazolidin-2-one, leur preparation et utilisation en tant qu'agonistes de recepteurs de type 5ht1
WO2010126167A1 (fr) Dérivé de thiophène