BG63075B1 - Използване на хистидин за инхибиране на деамидирането на растежен хормон - Google Patents
Използване на хистидин за инхибиране на деамидирането на растежен хормон Download PDFInfo
- Publication number
- BG63075B1 BG63075B1 BG98806A BG9880694A BG63075B1 BG 63075 B1 BG63075 B1 BG 63075B1 BG 98806 A BG98806 A BG 98806A BG 9880694 A BG9880694 A BG 9880694A BG 63075 B1 BG63075 B1 BG 63075B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- growth hormone
- histidine
- human growth
- derivative
- pharmaceutical composition
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK204691A DK204691D0 (da) | 1991-12-20 | 1991-12-20 | Hidtil ukendt farmaceutisk praeparat |
| DK136492A DK136492D0 (da) | 1992-11-10 | 1992-11-10 | A pharmaceutical formulation |
| PCT/DK1992/000379 WO1993012812A1 (en) | 1991-12-20 | 1992-12-16 | A stabilized pharmaceutical formulation comprising growth hormone and histidine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG98806A BG98806A (bg) | 1995-02-28 |
| BG63075B1 true BG63075B1 (bg) | 2001-03-30 |
Family
ID=26065653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG98806A BG63075B1 (bg) | 1991-12-20 | 1994-05-30 | Използване на хистидин за инхибиране на деамидирането на растежен хормон |
Country Status (24)
| Country | Link |
|---|---|
| EP (2) | EP0618807B1 (hu) |
| JP (2) | JP2950617B2 (hu) |
| KR (1) | KR100266502B1 (hu) |
| AT (2) | ATE368472T1 (hu) |
| AU (1) | AU667503B2 (hu) |
| BG (1) | BG63075B1 (hu) |
| CA (1) | CA2125855C (hu) |
| CZ (1) | CZ283361B6 (hu) |
| DE (3) | DE69233704T2 (hu) |
| DK (1) | DK0618807T3 (hu) |
| ES (2) | ES2291264T3 (hu) |
| FI (1) | FI115116B (hu) |
| HU (1) | HUT69402A (hu) |
| IL (1) | IL104152A (hu) |
| MX (1) | MX9207374A (hu) |
| NL (1) | NL300126I1 (hu) |
| NO (1) | NO942300L (hu) |
| NZ (1) | NZ246556A (hu) |
| PT (1) | PT618807E (hu) |
| RO (1) | RO111990B1 (hu) |
| RU (1) | RU2122426C1 (hu) |
| SK (1) | SK279641B6 (hu) |
| UA (1) | UA41502C2 (hu) |
| WO (1) | WO1993012812A1 (hu) |
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| US5849700A (en) * | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
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| US5898030A (en) * | 1994-06-17 | 1999-04-27 | Applied Research Systems Ars Holding N.V | hGH containing pharmaceutical compositions |
| IL114030A (en) * | 1994-06-27 | 2000-08-13 | Hayashibara Biochem Lab | Saccharide composition with a lesser reducibility its preparation and compositions containing it |
| US5631225A (en) * | 1994-10-13 | 1997-05-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5547696A (en) * | 1994-10-13 | 1996-08-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5654278A (en) * | 1994-10-13 | 1997-08-05 | Novo Nordisk A/S | Composition and method comprising growth hormone and leucine |
| IL115592A (en) * | 1994-10-13 | 2000-07-26 | Novo Nordisk As | Stabilized pharmaceutical formulation comprising a growth hormone and leucine |
| ZA96122B (en) * | 1995-01-13 | 1996-07-24 | Novo Nordisk As | A pharmaceutical formulation |
| KR19980701351A (ko) * | 1995-01-13 | 1998-05-15 | 슈타르 피아 | 성장호르몬 및 Ｘ-Ｌｙｓ를 함유하는 안정화된 약제조제물(A STABILIZED PHARMACEUTICAL FORMULATION COMPRISING A GROWTH HORMONE AND X-Lys |
| US5705482A (en) * | 1995-01-13 | 1998-01-06 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5552385A (en) * | 1995-06-05 | 1996-09-03 | Novo Nordisk A/S | Pharmaceutical formulation |
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| ZA965367B (en) * | 1995-07-12 | 1997-01-23 | Novo Nordisk As | A pharmaceutical formulation |
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| KR100236393B1 (ko) * | 1996-02-02 | 1999-12-15 | 나까니시 히로유끼 | 사람성장호르몬을 함유하는 의약제제 |
| US20070179096A1 (en) | 1996-04-24 | 2007-08-02 | Novo Nordisk A/S | Pharmaceutical Formulation |
| US20020077461A1 (en) * | 1996-04-24 | 2002-06-20 | Soren Bjorn | Pharmaceutical formulation |
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| KR20080011353A (ko) | 2000-02-24 | 2008-02-01 | 몬산토 테크놀로지 엘엘씨 | 소마토트로핀의 지속적인 방출을 위한 비수성 주사제제들 |
| MXPA03000073A (es) | 2000-06-26 | 2003-09-25 | Monsanto Technology Llc | Formulaciones que contienen agente tensioactivo no acuoso para la liberacion prolongada de somatrotopina. |
| US6664234B1 (en) | 2000-06-30 | 2003-12-16 | Monsanto Technology Llc | Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin |
| JP2004515467A (ja) | 2000-08-07 | 2004-05-27 | ネクター セラピューティックス | 吸入可能な、噴霧乾燥した、最少の凝集物を有する４−ヘリックスバンドルタンパク質粉末 |
| ES2477996T3 (es) | 2000-08-11 | 2014-07-18 | Chugai Seiyaku Kabushiki Kaisha | Preparaciones estabilizadas que contienen un anticuerpo |
| NZ528260A (en) | 2001-05-18 | 2005-09-30 | Danisco | Method of improving dough and bread quality with the addition of an enzyme that hydrolyses a glycolipid and a phospholipid and incapable of hydrolysing a triglyceride or monoglyceride |
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| NZ571243A (en) * | 2002-12-31 | 2010-04-30 | Altus Pharmaceuticals Inc | Complexes of protein crystals and ionic polymers comprising human growth hormone and protamine |
| BRPI0413276B8 (pt) | 2003-08-05 | 2021-05-25 | Novo Nordisk As | derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica |
| EP1791933B1 (en) | 2004-07-16 | 2011-06-29 | Danisco A/S | Enzymatic oil-degumming method |
| SI1827483T1 (sl) * | 2004-12-15 | 2014-11-28 | Swedish Orphan Biovitrum Ab (Publ) | Terapevtske formulacije keratinocitnega rastnega faktorja |
| AU2005322019B2 (en) * | 2004-12-22 | 2010-08-26 | Ambrx, Inc. | Formulations of human growth hormone comprising a non-naturally encoded amino acid |
| KR20080038391A (ko) * | 2005-08-30 | 2008-05-06 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 페그화 성장 호르몬의 액체 제제 |
| WO2007033427A1 (en) * | 2005-09-23 | 2007-03-29 | Metabolic Pharmaceuticals Limited | Stabilisation of peptides with basic amino acids |
| ES2371361T3 (es) | 2005-12-28 | 2011-12-30 | Novo Nordisk A/S | Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones. |
| AU2007271150A1 (en) | 2006-07-07 | 2008-01-10 | Novo Nordisk Health Care Ag | New protein conjugates and methods for their preparation |
| JP2010513309A (ja) * | 2006-12-18 | 2010-04-30 | アルタス ファーマシューティカルズ インコーポレイテッド | ヒト成長ホルモン製剤 |
| EP2167032B1 (en) | 2007-06-13 | 2019-08-07 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
| BRPI0919946A2 (pt) | 2008-10-30 | 2016-02-16 | Novo Nordisk As | tratamento de diabetes melito usando injeções de insulina com frequência de injeção menor que diariamente |
| SI2889043T1 (sl) * | 2008-12-16 | 2019-08-30 | Genzyme Corporation | Sintetične vmesne spojine za pripravo konjugatov oligosaharid-protein |
| US9238878B2 (en) | 2009-02-17 | 2016-01-19 | Redwood Bioscience, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
| NZ600361A (en) | 2009-12-21 | 2014-06-27 | Ambrx Inc | Modified bovine somatotropin polypeptides and their uses |
| CN104017063A (zh) | 2009-12-21 | 2014-09-03 | Ambrx公司 | 经过修饰的猪促生长素多肽和其用途 |
| NZ607633A (en) * | 2010-09-21 | 2014-07-25 | Ferring Bv | Improved process for production of recombinant human growth hormone |
| RU2013123515A (ru) | 2010-10-27 | 2014-12-10 | Ново Нордиск А/С | Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами |
| CN103415621A (zh) | 2011-01-14 | 2013-11-27 | 雷德伍德生物科技股份有限公司 | 醛标记免疫球蛋白多肽及其使用方法 |
| EP3456315A1 (en) | 2012-06-05 | 2019-03-20 | Neuroderm Ltd | Compositions comprising apomorphine and organic acids and uses thereof |
| ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
| US10137172B2 (en) | 2013-04-30 | 2018-11-27 | Novo Nordisk A/S | Administration regime |
| US11559580B1 (en) * | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| US10702606B2 (en) | 2015-12-10 | 2020-07-07 | Menicon Co., Ltd. | Peptide composition |
| JP2019515677A (ja) | 2016-04-26 | 2019-06-13 | アール．ピー．シェーラー テクノロジーズ エルエルシー | 抗体複合体ならびにそれを作製および使用する方法 |
| CN112512561A (zh) * | 2018-05-25 | 2021-03-16 | 雷迪博士实验室有限公司 | 稳定的融合蛋白制剂 |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| RS64438B1 (sr) | 2018-10-26 | 2023-09-29 | Novo Nordisk As | Stabilne kompozicije semaglutida i njihova upotreba |
| WO2022197963A1 (en) * | 2021-03-19 | 2022-09-22 | Pfizer Inc. | Long-acting growth hormone compositions |
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| US4917685A (en) * | 1986-05-16 | 1990-04-17 | International Minerals & Chem. Corp. | Delivery device for the administration of stabilized growth promoting hormones |
| US4816568A (en) * | 1986-05-16 | 1989-03-28 | International Minerals & Chemical Corp. | Stabilization of growth hormones |
| EP0374120A3 (en) * | 1988-12-13 | 1991-07-31 | Monsanto Company | Comosition for controlled release of polypeptides |
| DK168790D0 (hu) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As |
-
1992
- 1992-12-16 DE DE69233704T patent/DE69233704T2/de not_active Expired - Lifetime
- 1992-12-16 RU RU94045932A patent/RU2122426C1/ru active
- 1992-12-16 DE DE10399015C patent/DE10399015I1/de active Granted
- 1992-12-16 AU AU33446/93A patent/AU667503B2/en not_active Ceased
- 1992-12-16 SK SK754-94A patent/SK279641B6/sk not_active IP Right Cessation
- 1992-12-16 DK DK93902089T patent/DK0618807T3/da active
- 1992-12-16 UA UA94005308A patent/UA41502C2/uk unknown
- 1992-12-16 EP EP93902089A patent/EP0618807B1/en not_active Expired - Lifetime
- 1992-12-16 AT AT01128974T patent/ATE368472T1/de not_active IP Right Cessation
- 1992-12-16 AT AT93902089T patent/ATE227583T1/de active
- 1992-12-16 KR KR1019940702139A patent/KR100266502B1/ko not_active IP Right Cessation
- 1992-12-16 RO RO94-01056A patent/RO111990B1/ro unknown
- 1992-12-16 ES ES01128974T patent/ES2291264T3/es not_active Expired - Lifetime
- 1992-12-16 ES ES93902089T patent/ES2185625T3/es not_active Expired - Lifetime
- 1992-12-16 CA CA002125855A patent/CA2125855C/en not_active Expired - Lifetime
- 1992-12-16 WO PCT/DK1992/000379 patent/WO1993012812A1/en active IP Right Grant
- 1992-12-16 NZ NZ246556A patent/NZ246556A/en unknown
- 1992-12-16 HU HU9401832A patent/HUT69402A/hu unknown
- 1992-12-16 JP JP5511361A patent/JP2950617B2/ja not_active Expired - Lifetime
- 1992-12-16 CZ CZ941507A patent/CZ283361B6/cs not_active IP Right Cessation
- 1992-12-16 PT PT93902089T patent/PT618807E/pt unknown
- 1992-12-16 DE DE69232847T patent/DE69232847T2/de not_active Expired - Lifetime
- 1992-12-16 EP EP01128974A patent/EP1197222B1/en not_active Expired - Lifetime
- 1992-12-17 MX MX9207374A patent/MX9207374A/es active IP Right Grant
- 1992-12-18 IL IL104152A patent/IL104152A/en not_active IP Right Cessation
-
1994
- 1994-05-30 BG BG98806A patent/BG63075B1/bg unknown
- 1994-06-17 NO NO942300A patent/NO942300L/no not_active Application Discontinuation
- 1994-06-17 FI FI942906A patent/FI115116B/fi not_active IP Right Cessation
-
1999
- 1999-02-03 JP JP11026405A patent/JPH11315031A/ja active Pending
-
2003
- 2003-05-01 NL NL300126C patent/NL300126I1/nl unknown
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