BG63043B1 - Заместени 1н-имидазоли, метод за тяхното получаване и приложението им като лекарствени средства - Google Patents

Заместени 1н-имидазоли, метод за тяхното получаване и приложението им като лекарствени средства Download PDF

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Publication number
BG63043B1
BG63043B1 BG100208A BG10020895A BG63043B1 BG 63043 B1 BG63043 B1 BG 63043B1 BG 100208 A BG100208 A BG 100208A BG 10020895 A BG10020895 A BG 10020895A BG 63043 B1 BG63043 B1 BG 63043B1
Authority
BG
Bulgaria
Prior art keywords
imidazole
naphthalenyl
imidazol
pharmaceutically acceptable
tetrahydro
Prior art date
Application number
BG100208A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG100208A (bg
Inventor
Jean-Pierre Geerts
Genevieve Motte
Edmond Differding
Jean-Pierre Henichart
Original Assignee
Ucb S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb S.A. filed Critical Ucb S.A.
Publication of BG100208A publication Critical patent/BG100208A/bg
Publication of BG63043B1 publication Critical patent/BG63043B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BG100208A 1994-12-14 1995-12-08 Заместени 1н-имидазоли, метод за тяхното получаване и приложението им като лекарствени средства BG63043B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (2)

Publication Number Publication Date
BG100208A BG100208A (bg) 1996-07-31
BG63043B1 true BG63043B1 (bg) 2001-02-28

Family

ID=10765918

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100208A BG63043B1 (bg) 1994-12-14 1995-12-08 Заместени 1н-имидазоли, метод за тяхното получаване и приложението им като лекарствени средства

Country Status (26)

Country Link
US (1) US5658938A (cg-RX-API-DMAC10.html)
EP (1) EP0717037A1 (cg-RX-API-DMAC10.html)
JP (1) JPH08208622A (cg-RX-API-DMAC10.html)
KR (1) KR960022474A (cg-RX-API-DMAC10.html)
CN (1) CN1054376C (cg-RX-API-DMAC10.html)
AR (1) AR002257A1 (cg-RX-API-DMAC10.html)
AU (1) AU693614B2 (cg-RX-API-DMAC10.html)
BG (1) BG63043B1 (cg-RX-API-DMAC10.html)
BR (1) BR9505815A (cg-RX-API-DMAC10.html)
CA (1) CA2165133A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ327195A3 (cg-RX-API-DMAC10.html)
EE (1) EE9500064A (cg-RX-API-DMAC10.html)
FI (1) FI955927L (cg-RX-API-DMAC10.html)
GB (1) GB9425211D0 (cg-RX-API-DMAC10.html)
HU (1) HUT73980A (cg-RX-API-DMAC10.html)
IL (1) IL116325A (cg-RX-API-DMAC10.html)
IS (1) IS4311A (cg-RX-API-DMAC10.html)
MX (1) MX9505063A (cg-RX-API-DMAC10.html)
NO (1) NO305316B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ280646A (cg-RX-API-DMAC10.html)
PL (1) PL311736A1 (cg-RX-API-DMAC10.html)
RO (1) RO113346B1 (cg-RX-API-DMAC10.html)
RU (1) RU2156239C2 (cg-RX-API-DMAC10.html)
SK (1) SK155095A3 (cg-RX-API-DMAC10.html)
TW (1) TW303362B (cg-RX-API-DMAC10.html)
ZA (1) ZA9510554B (cg-RX-API-DMAC10.html)

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WO2008100456A2 (en) * 2007-02-13 2008-08-21 Schering Corporation Functionally selective alpha2c adrenoreceptor agonists
KR101222412B1 (ko) * 2007-02-15 2013-01-15 에프. 호프만-라 로슈 아게 Ｔａａｒ1 리간드로서의 2-아미노옥사졸린
WO2009003868A2 (en) 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
JP2010531836A (ja) * 2007-07-03 2010-09-30 エフ．ホフマン−ラ ロシュ アーゲー ４−イミダゾリン及びそれらの抗うつ剤としての使用
CA2694362A1 (en) * 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
BRPI0815038A2 (pt) * 2007-08-02 2015-03-17 Hoffmann La Roche Uso de derivados de benzamida para o tratamento de transtornos do cns
KR101167773B1 (ko) * 2007-08-03 2012-07-24 에프. 호프만-라 로슈 아게 Ｔａａｒ１ 리간드로서의 피리딘카복스아마이드 및 벤즈아마이드 유도체
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
EP2257546B1 (en) 2008-02-21 2012-08-15 Merck Sharp & Dohme Corp. Functionally selective alpha2c adrenoreceptor agonists
CN102083805A (zh) * 2008-07-24 2011-06-01 弗·哈夫曼-拉罗切有限公司 4,5-二氢-唑-2-基衍生物
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
WO2010017120A1 (en) * 2008-08-04 2010-02-11 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
TW201026691A (en) 2008-10-07 2010-07-16 Schering Corp Biaryl spiroaminooxazoline analogues as alpha2C adrenergic receptor modulators
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) * 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
JP5872069B2 (ja) 2012-01-12 2016-03-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 微量アミン関連受容体（ｔａａｒ）としての複素環誘導体
BR112015004511B1 (pt) 2012-09-14 2022-08-02 F. Hoffmann-La Roche Ag Derivados de pirazol carboxamida como moduladores de taar para uso no tratamento de diversas desordens, tais como depressão, diabetes e doença de parkinson
MX361761B (es) 2012-09-17 2018-12-17 Hoffmann La Roche Derivados de triazol carboxamida.
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
WO2016030310A1 (en) 2014-08-27 2016-03-03 F. Hoffmann-La Roche Ag Substituted azetidine derivatives as taar ligands
MX2016016190A (es) 2014-08-27 2017-03-08 Hoffmann La Roche Derivados de pirazino[2,1-a]isoquinolina sustituida para el tratamiento de trastornos del sistema nervioso central.
EA036086B1 (ru) * 2016-03-17 2020-09-24 Фмк Корпорейшн Способ превращения s-энантиомера в его рацемическую форму
RS60825B1 (sr) 2016-03-17 2020-10-30 Hoffmann La Roche Aktivnost derivata 5-etiol-4-metil-pirazol-3-karboksamida kao agonista taar-a
CN116496261B (zh) * 2023-03-09 2025-06-27 中国人民解放军军事科学院军事医学研究院 4-(1h)-咪唑类衍生物及其医药用途
CN118684628B (zh) * 2024-05-20 2025-06-17 中国人民解放军军事科学院军事医学研究院 取代二氢茚基咪唑类化合物及其制备方法和用途

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Also Published As

Publication number Publication date
MX9505063A (es) 1997-01-31
SK155095A3 (en) 1997-02-05
AU693614B2 (en) 1998-07-02
BR9505815A (pt) 1998-01-06
PL311736A1 (en) 1996-06-24
CN1133837A (zh) 1996-10-23
NZ280646A (en) 1996-08-27
EP0717037A1 (fr) 1996-06-19
AR002257A1 (es) 1998-03-11
NO955034L (no) 1996-06-17
IS4311A (is) 1996-06-15
JPH08208622A (ja) 1996-08-13
FI955927A7 (fi) 1996-06-15
GB9425211D0 (en) 1995-02-15
IL116325A0 (en) 1996-03-31
AU4036895A (en) 1996-06-20
FI955927L (fi) 1996-06-15
HUT73980A (en) 1996-10-28
US5658938A (en) 1997-08-19
IL116325A (en) 1999-10-28
FI955927A0 (fi) 1995-12-11
CZ327195A3 (en) 1996-07-17
TW303362B (cg-RX-API-DMAC10.html) 1997-04-21
CN1054376C (zh) 2000-07-12
RU2156239C2 (ru) 2000-09-20
ZA9510554B (en) 1996-06-13
HU9503549D0 (en) 1996-02-28
BG100208A (bg) 1996-07-31
CA2165133A1 (en) 1996-06-15
RO113346B1 (ro) 1998-06-30
KR960022474A (ko) 1996-07-18
NO305316B1 (no) 1999-05-10
NO955034D0 (no) 1995-12-12
EE9500064A (et) 1996-06-17

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