DE69114644T2 - 4(5)-Imidazole fähig zur Inhibierung von Aromatase. - Google Patents

4(5)-Imidazole fähig zur Inhibierung von Aromatase.

Info

Publication number
DE69114644T2
DE69114644T2 DE69114644T DE69114644T DE69114644T2 DE 69114644 T2 DE69114644 T2 DE 69114644T2 DE 69114644 T DE69114644 T DE 69114644T DE 69114644 T DE69114644 T DE 69114644T DE 69114644 T2 DE69114644 T2 DE 69114644T2
Authority
DE
Germany
Prior art keywords
imidazoles
aromatase
chf2
chem
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69114644T
Other languages
English (en)
Other versions
DE69114644D1 (de
Inventor
Arto Johannes Karjalainen
Arja Marketta Kalapudas
Reino Olavi Pelkonen
Marja-Liisa Sodervall
Matti Antero Lahde
Risto Arvo Sakari Lammintausta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Publication of DE69114644D1 publication Critical patent/DE69114644D1/de
Application granted granted Critical
Publication of DE69114644T2 publication Critical patent/DE69114644T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DE69114644T 1990-09-21 1991-09-13 4(5)-Imidazole fähig zur Inhibierung von Aromatase. Expired - Fee Related DE69114644T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9020629A GB2248058B (en) 1990-09-21 1990-09-21 Aromatase inhibiting 4(5)-imidazoles

Publications (2)

Publication Number Publication Date
DE69114644D1 DE69114644D1 (de) 1995-12-21
DE69114644T2 true DE69114644T2 (de) 1996-05-15

Family

ID=10682560

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69114644T Expired - Fee Related DE69114644T2 (de) 1990-09-21 1991-09-13 4(5)-Imidazole fähig zur Inhibierung von Aromatase.

Country Status (20)

Country Link
EP (1) EP0476944B1 (de)
JP (1) JPH04230668A (de)
AT (1) ATE130295T1 (de)
AU (1) AU640817B2 (de)
CA (1) CA2051803A1 (de)
CZ (1) CZ280088B6 (de)
DE (1) DE69114644T2 (de)
FI (1) FI914254A (de)
GB (1) GB2248058B (de)
HU (1) HUT59107A (de)
IE (1) IE68934B1 (de)
IL (1) IL99472A (de)
LT (1) LT3441B (de)
LV (1) LV10095B (de)
NO (1) NO913712L (de)
NZ (1) NZ239800A (de)
PL (1) PL167741B1 (de)
PT (1) PT99019A (de)
RU (1) RU2036193C1 (de)
ZA (1) ZA917476B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9125924D0 (en) * 1991-06-18 1992-02-05 Orion Yhtymae Oy Stereoisomers of an imidazole derivative
GB9224144D0 (en) * 1992-11-18 1993-01-06 Erba Carlo Spa Phenyl-imidazolidinone derivatives and process for their preparation
JP2011507835A (ja) * 2007-12-21 2011-03-10 アンドレイ・アレクサンドロビッチ・イワシェンコ α−アドレナリン受容体、ドーパミン、ヒスタミン、イミダゾリン及びセロトニン受容体のリガンド並びにその使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
LU85747A1 (fr) * 1985-01-28 1986-08-04 Continental Pharma Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives
GB2210875B (en) * 1987-10-09 1991-05-29 Farmos Oy Aromatase inhibiting 4(5)-imidazoles
GB8818561D0 (en) * 1988-08-04 1988-09-07 Ici Plc Diphenylethane derivatives
GB2229719B (en) * 1989-03-30 1992-04-29 Farmos Oy Novel aromatase inhibiting 4(5)-imidazoles
GB2231568B (en) * 1989-03-31 1992-07-08 Farmos Oy New aromatase inhibiting 4(5)-imidazoles
JPH032168A (ja) * 1989-03-30 1991-01-08 Farmos Yhtymae Oy アロマターゼ阻害活性を有する新規な４（５）―イミダゾール

Also Published As

Publication number Publication date
JPH04230668A (ja) 1992-08-19
GB2248058A (en) 1992-03-25
AU640817B2 (en) 1993-09-02
HUT59107A (en) 1992-04-28
DE69114644D1 (de) 1995-12-21
LT3441B (en) 1995-10-25
LTIP582A (en) 1994-12-27
EP0476944B1 (de) 1995-11-15
FI914254A (fi) 1992-03-22
NZ239800A (en) 1993-11-25
IL99472A0 (en) 1992-08-18
LV10095B (en) 1995-02-20
CZ280088B6 (cs) 1995-10-18
PT99019A (pt) 1992-08-31
ZA917476B (en) 1992-05-27
IE68934B1 (en) 1996-07-24
RU2036193C1 (ru) 1995-05-27
IE913314A1 (en) 1992-02-25
AU8382691A (en) 1992-04-09
EP0476944A1 (de) 1992-03-25
PL291747A1 (en) 1992-10-19
FI914254A0 (fi) 1991-09-10
GB2248058B (en) 1994-09-14
CA2051803A1 (en) 1992-03-22
ATE130295T1 (de) 1995-12-15
PL167741B1 (pl) 1995-10-31
GB9020629D0 (en) 1990-10-31
CS286891A3 (en) 1992-04-15
NO913712D0 (no) 1991-09-20
LV10095A (lv) 1994-05-10
NO913712L (no) 1992-03-23
IL99472A (en) 1995-11-27
HU913019D0 (en) 1992-01-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee