NO913712L - Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazol-derivater. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazol-derivater.

Info

Publication number
NO913712L
NO913712L NO91913712A NO913712A NO913712L NO 913712 L NO913712 L NO 913712L NO 91913712 A NO91913712 A NO 91913712A NO 913712 A NO913712 A NO 913712A NO 913712 L NO913712 L NO 913712L
Authority
NO
Norway
Prior art keywords
imidazole derivatives
preparation
therapeutic active
analogy procedure
active imidazole
Prior art date
Application number
NO91913712A
Other languages
English (en)
Other versions
NO913712D0 (no
Inventor
Arto Johannes Karjalainen
Arja Marketta Kalapudas
Reino Olavi Pelkonen
Marja-Liisa Soedervall
Matti Antero Laehde
Risto Arvo Sakari Lammintausta
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Publication of NO913712D0 publication Critical patent/NO913712D0/no
Publication of NO913712L publication Critical patent/NO913712L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Det beskrives nye imidazol-derivater med formel R'2 CH - C - (CH2)n R4 R5 R-, d) hvor Rlf R2, R\ og R'2, som kan være like eller forskjellige, er K, CH3, C2H5, C3H7/ OCH3; N02, NH2, CN, CF3/ CHF2, CH2F eller halogen; R' er H eller -CH, hvor R3 er H, CH3 eller halogen; R4 er H eller OH og R5 er H eller OH, eller hvor ,R4 og R5 sammen danner en binding, og n er \ til 4, og deres ugiftige, farmasøytisk akseptable salter. Forbindelsene oppviser aromatase- og desmolase-hemmende egenskaper. Selektivt aromatase-hemmende forbindelser er verdifulle ved behandling av østrogen-avhengige sykdommer, f.eks. brystkreft eller benign prostatahyperplasi (BPH). Analogifremgangsmåter for fremstilling av de nye derivatene er beskrevet.
NO91913712A 1990-09-21 1991-09-20 Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazol-derivater. NO913712L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9020629A GB2248058B (en) 1990-09-21 1990-09-21 Aromatase inhibiting 4(5)-imidazoles

Publications (2)

Publication Number Publication Date
NO913712D0 NO913712D0 (no) 1991-09-20
NO913712L true NO913712L (no) 1992-03-23

Family

ID=10682560

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91913712A NO913712L (no) 1990-09-21 1991-09-20 Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazol-derivater.

Country Status (20)

Country Link
EP (1) EP0476944B1 (no)
JP (1) JPH04230668A (no)
AT (1) ATE130295T1 (no)
AU (1) AU640817B2 (no)
CA (1) CA2051803A1 (no)
CZ (1) CZ280088B6 (no)
DE (1) DE69114644T2 (no)
FI (1) FI914254A (no)
GB (1) GB2248058B (no)
HU (1) HUT59107A (no)
IE (1) IE68934B1 (no)
IL (1) IL99472A (no)
LT (1) LT3441B (no)
LV (1) LV10095B (no)
NO (1) NO913712L (no)
NZ (1) NZ239800A (no)
PL (1) PL167741B1 (no)
PT (1) PT99019A (no)
RU (1) RU2036193C1 (no)
ZA (1) ZA917476B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9125924D0 (en) * 1991-06-18 1992-02-05 Orion Yhtymae Oy Stereoisomers of an imidazole derivative
GB9224144D0 (en) * 1992-11-18 1993-01-06 Erba Carlo Spa Phenyl-imidazolidinone derivatives and process for their preparation
WO2009082268A2 (ru) * 2007-12-21 2009-07-02 Alla Chem, Llc ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
LU85747A1 (fr) * 1985-01-28 1986-08-04 Continental Pharma Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives
GB2210875B (en) * 1987-10-09 1991-05-29 Farmos Oy Aromatase inhibiting 4(5)-imidazoles
GB8818561D0 (en) * 1988-08-04 1988-09-07 Ici Plc Diphenylethane derivatives
GB2231568B (en) * 1989-03-31 1992-07-08 Farmos Oy New aromatase inhibiting 4(5)-imidazoles
GB2229719B (en) * 1989-03-30 1992-04-29 Farmos Oy Novel aromatase inhibiting 4(5)-imidazoles
AU627559B2 (en) * 1989-03-30 1992-08-27 Farmos-Yhtyma Oy Novel aromatase inhibiting 4(5)-imidazoles

Also Published As

Publication number Publication date
PT99019A (pt) 1992-08-31
NO913712D0 (no) 1991-09-20
IL99472A (en) 1995-11-27
EP0476944A1 (en) 1992-03-25
FI914254A0 (fi) 1991-09-10
CA2051803A1 (en) 1992-03-22
AU8382691A (en) 1992-04-09
DE69114644T2 (de) 1996-05-15
FI914254A (fi) 1992-03-22
IE913314A1 (en) 1992-02-25
PL167741B1 (pl) 1995-10-31
IL99472A0 (en) 1992-08-18
RU2036193C1 (ru) 1995-05-27
IE68934B1 (en) 1996-07-24
CZ280088B6 (cs) 1995-10-18
DE69114644D1 (de) 1995-12-21
HUT59107A (en) 1992-04-28
GB2248058A (en) 1992-03-25
CS286891A3 (en) 1992-04-15
LTIP582A (en) 1994-12-27
ZA917476B (en) 1992-05-27
LV10095B (en) 1995-02-20
HU913019D0 (en) 1992-01-28
AU640817B2 (en) 1993-09-02
NZ239800A (en) 1993-11-25
ATE130295T1 (de) 1995-12-15
EP0476944B1 (en) 1995-11-15
PL291747A1 (en) 1992-10-19
GB9020629D0 (en) 1990-10-31
GB2248058B (en) 1994-09-14
LV10095A (lv) 1994-05-10
LT3441B (en) 1995-10-25
JPH04230668A (ja) 1992-08-19

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