DE69523298D1 - Aminostilbazolderivate und medikament - Google Patents

Aminostilbazolderivate und medikament

Info

Publication number
DE69523298D1
DE69523298D1 DE69523298T DE69523298T DE69523298D1 DE 69523298 D1 DE69523298 D1 DE 69523298D1 DE 69523298 T DE69523298 T DE 69523298T DE 69523298 T DE69523298 T DE 69523298T DE 69523298 D1 DE69523298 D1 DE 69523298D1
Authority
DE
Germany
Prior art keywords
bazole
style
medicine
derivatives
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69523298T
Other languages
English (en)
Other versions
DE69523298T2 (de
Inventor
Hiroyoshi Hidaka
Akira Matsuura
Masato Matsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WESTERN THERAPEUTICS INST NAGO
Nippon Shinyaku Co Ltd
Original Assignee
WESTERN THERAPEUTICS INST NAGO
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WESTERN THERAPEUTICS INST NAGO, Nippon Shinyaku Co Ltd filed Critical WESTERN THERAPEUTICS INST NAGO
Application granted granted Critical
Publication of DE69523298D1 publication Critical patent/DE69523298D1/de
Publication of DE69523298T2 publication Critical patent/DE69523298T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69523298T 1994-04-06 1995-04-05 Aminostilbazolderivate und medikament Expired - Lifetime DE69523298T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6825294 1994-04-06
PCT/JP1995/000658 WO1995027699A1 (fr) 1994-04-06 1995-04-05 Derive d'aminostilbazole et medicament

Publications (2)

Publication Number Publication Date
DE69523298D1 true DE69523298D1 (de) 2001-11-22
DE69523298T2 DE69523298T2 (de) 2002-06-27

Family

ID=13368389

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69523298T Expired - Lifetime DE69523298T2 (de) 1994-04-06 1995-04-05 Aminostilbazolderivate und medikament

Country Status (14)

Country Link
US (1) US5972976A (de)
EP (1) EP0754682B9 (de)
JP (1) JP3080405B2 (de)
KR (1) KR100293867B1 (de)
CN (1) CN1053658C (de)
AT (1) ATE207057T1 (de)
CA (1) CA2187214C (de)
DE (1) DE69523298T2 (de)
DK (1) DK0754682T3 (de)
ES (1) ES2165911T3 (de)
PT (1) PT754682E (de)
RU (1) RU2138482C1 (de)
TW (1) TW308586B (de)
WO (1) WO1995027699A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69824895T2 (de) * 1998-04-15 2005-06-30 Hidaka, Hiroyoshi, Nagoya Verfahren zur bestimmung des gens eines zielproteins mit hilfe eines medikamentes
DK1079851T3 (da) * 1998-05-12 2007-09-24 Greenville Hospital System Anvendelse af anti-prolactinmidler til behandling af cancer
EP1174427A4 (de) * 1999-04-23 2002-07-10 Nippon Shinyaku Co Ltd Pulverisierungsverfahren
US6521658B1 (en) 1999-05-28 2003-02-18 Abbott Laboratories Cell proliferation inhibitors
DE60034963D1 (de) * 1999-12-14 2007-07-05 Nippon Shinyaku Co Ltd Heterocyclische derivate und arzneistoffe
JP2004359545A (ja) * 2001-03-08 2004-12-24 D Western Therapeutics Institute 抗癌剤耐性克服剤
JP4228700B2 (ja) 2001-04-10 2009-02-25 日本新薬株式会社 慢性関節リウマチの治療剤
JPWO2002087577A1 (ja) 2001-04-26 2004-08-12 日本新薬株式会社 医薬
US6951875B2 (en) * 2001-10-29 2005-10-04 Hoffmann-La Roche Inc. Conjugated aromatic compounds with a pyridine substituent
FR2838437B1 (fr) * 2002-04-11 2004-06-04 Aventis Pharma Sa Procedes de preparation de combretastatines
EP1547596A4 (de) * 2002-09-06 2008-11-19 Western Therapeutics Inst Inc Medizinische zusammensetzung und verfahren zur behandlung von malignen tumoren und verwendung derselben
WO2006078941A2 (en) * 2005-01-20 2006-07-27 Sirtris Pharmaceuticals, Inc. Novel sirtuin activating compounds and methods of use thereof
WO2007137196A2 (en) * 2006-05-19 2007-11-29 Threshold Pharmaceuticals, Inc. Tubulin binding anti cancer compounds and prodrugs thereof
US20100198262A1 (en) * 2009-01-30 2010-08-05 Mckinley Laurence M Axial offset bone fastener system
MX2015014470A (es) * 2013-04-19 2016-02-22 Univ Arkansas Analogos de combretastatina.
UA119759C2 (uk) 2013-12-13 2019-08-12 Єврокем Агро Гмбх Суміш добрив, яка містить інгібітор нітрифікації
EP3125886A4 (de) 2014-03-31 2017-09-06 Bioventures, Llc Disubstituierte triazolanaloga
CN112110829B (zh) * 2019-06-19 2023-08-01 复旦大学 一种能结合α-突触核蛋白聚集体的小分子化合物、其制备方法及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69129611T2 (de) * 1990-08-20 1998-12-17 Eisai Co Ltd Sulfonamid-Derivate
JP2790926B2 (ja) * 1990-08-20 1998-08-27 エーザイ株式会社 スルホンアミド誘導体
JP2692467B2 (ja) * 1991-12-09 1997-12-17 ダイキン工業株式会社 空調制御装置の電力供給装置
JP3342485B2 (ja) * 1991-12-10 2002-11-11 塩野義製薬株式会社 芳香族スルホンアミド系ヒドロキサム酸誘導体

Also Published As

Publication number Publication date
EP0754682A4 (de) 1998-03-04
ES2165911T3 (es) 2002-04-01
EP0754682B9 (de) 2003-09-17
CN1145066A (zh) 1997-03-12
CA2187214A1 (en) 1995-10-19
EP0754682A1 (de) 1997-01-22
MX9604540A (es) 1997-09-30
TW308586B (de) 1997-06-21
JP3080405B2 (ja) 2000-08-28
DE69523298T2 (de) 2002-06-27
DK0754682T3 (da) 2002-02-04
US5972976A (en) 1999-10-26
KR970702253A (ko) 1997-05-13
ATE207057T1 (de) 2001-11-15
WO1995027699A1 (fr) 1995-10-19
CA2187214C (en) 2002-03-12
EP0754682B1 (de) 2001-10-17
RU2138482C1 (ru) 1999-09-27
PT754682E (pt) 2002-03-28
KR100293867B1 (ko) 2001-09-17
CN1053658C (zh) 2000-06-21

Similar Documents

Publication Publication Date Title
DE69523298T2 (de) Aminostilbazolderivate und medikament
DE60226912D1 (de) Chinolin- und Chianzolinderivate zur Behandlung von Tumoren
DK0590919T3 (da) Terapeutiske midler mod Parkinsons sygdom
PT787726E (pt) Novo composto, processo para a sua producao e agente tumoral
HU9603433D0 (en) Novel 4-6-diaryl-pyrimidine-derivatives and salts thereof
PT918776E (pt) Sintese total de acilfulvenos antitumorais
HUP0303272A2 (hu) Metabolikus modulátorként alkalmazható melonil-CoA dekarboxiláz inhibitor azol-származékok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
DE3869907D1 (de) Chinolincarbonsaeure-derivate.
EA200300982A1 (ru) Гетероциклические производные для лечения рака и других пролиферативных заболеваний
ATE232528T1 (de) Pyrimidinylpyrazolderivate
ATE294779T1 (de) Arylpiperidinopropanol und arylpiperazinopropanol derivate und die selbe enthaltende pharmazeutika
EP0974584A4 (de) Verbindungen mit kondensierten ringen, verfahren zu ihrer herstellung und ihre anwendung
ATE324362T1 (de) Neue vinylbenzolderivate
DE69828197D1 (de) Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut
ATE337300T1 (de) Hydroxylierte indirubinderivate
FI915025A (fi) 8-azabicyklo(3,2,1) oktylalkyltiazolidinoner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
FR2549064B1 (fr) Nouveaux derives de synergistines utiles pour la preparation de nouveaux medicaments antimicrobiens et leur preparation
FI951505A0 (fi) Uusi 7-subtituoitu oksa- tai atsasteroidiyhdiste
DE69501810D1 (de) Verwendung von 5-Thia-1,4-Diazabicyclo [4.2.0] Octane-3,8-dioxo Verbindungen in der Antitumor-Therapie

Legal Events

Date Code Title Description
8364 No opposition during term of opposition