LTIP582A - Aromatase inhibiting 4(5)-imidazoles - Google Patents
Aromatase inhibiting 4(5)-imidazolesInfo
- Publication number
- LTIP582A LTIP582A LTIP582A LTIP582A LTIP582A LT IP582 A LTIP582 A LT IP582A LT IP582 A LTIP582 A LT IP582A LT IP582 A LTIP582 A LT IP582A LT IP582 A LTIP582 A LT IP582A
- Authority
- LT
- Lithuania
- Prior art keywords
- chf2
- chem
- halogen
- imidazoles
- aromatase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Novel imidazole derivatives of the formula <CHEM> wherein R1, R2, R min 1 and R min 2, which can be the same or different, are H,CH3, C2H5, C3H7, OCH3, NO2, NH2, CN, CF3, CHF2, CHF2 or halogen; R min is H or <CHEM> where R3 is H, CH3 or halogen; R4 is H or OH and R5 is H or OH or R4 and R5 together form a bond and n is 1 to 4, and their non-toxic salts exhibit aromatase and desmolase inhibiting properties. Selective aromatase inhibiting compounds are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer or benign prostatic hyperplasia (BPH).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9020629A GB2248058B (en) | 1990-09-21 | 1990-09-21 | Aromatase inhibiting 4(5)-imidazoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP582A true LTIP582A (en) | 1994-12-27 |
| LT3441B LT3441B (en) | 1995-10-25 |
Family
ID=10682560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP582A LT3441B (en) | 1990-09-21 | 1993-05-31 | Aromatase inhibiting 4(5)-imidazoles |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0476944B1 (en) |
| JP (1) | JPH04230668A (en) |
| AT (1) | ATE130295T1 (en) |
| AU (1) | AU640817B2 (en) |
| CA (1) | CA2051803A1 (en) |
| CZ (1) | CZ280088B6 (en) |
| DE (1) | DE69114644T2 (en) |
| FI (1) | FI914254A (en) |
| GB (1) | GB2248058B (en) |
| HU (1) | HUT59107A (en) |
| IE (1) | IE68934B1 (en) |
| IL (1) | IL99472A (en) |
| LT (1) | LT3441B (en) |
| LV (1) | LV10095B (en) |
| NO (1) | NO913712L (en) |
| NZ (1) | NZ239800A (en) |
| PL (1) | PL167741B1 (en) |
| PT (1) | PT99019A (en) |
| RU (1) | RU2036193C1 (en) |
| ZA (1) | ZA917476B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9125924D0 (en) * | 1991-06-18 | 1992-02-05 | Orion Yhtymae Oy | Stereoisomers of an imidazole derivative |
| GB9224144D0 (en) * | 1992-11-18 | 1993-01-06 | Erba Carlo Spa | Phenyl-imidazolidinone derivatives and process for their preparation |
| WO2009082268A2 (en) * | 2007-12-21 | 2009-07-02 | Alla Chem, Llc | LIGANDS OF α-ADRENOCEPTORS AND OF DOPAMINE, HISTAMINE, IMIDAZOLINE AND SEROTONIN RECEPTORS AND THE USE THEREOF |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4605661A (en) * | 1984-06-18 | 1986-08-12 | Eli Lilly And Company | Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles |
| LU85747A1 (en) * | 1985-01-28 | 1986-08-04 | Continental Pharma | IMIDAZOLE DERIVATIVES, PREPARATION AND USE THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING DERIVATIVES |
| GB2210875B (en) * | 1987-10-09 | 1991-05-29 | Farmos Oy | Aromatase inhibiting 4(5)-imidazoles |
| GB8818561D0 (en) * | 1988-08-04 | 1988-09-07 | Ici Plc | Diphenylethane derivatives |
| GB2229719B (en) * | 1989-03-30 | 1992-04-29 | Farmos Oy | Novel aromatase inhibiting 4(5)-imidazoles |
| JPH032168A (en) * | 1989-03-30 | 1991-01-08 | Farmos Yhtymae Oy | Novel 4 (5)-imidazole having aromatase inhibitive activity |
| GB2231568B (en) * | 1989-03-31 | 1992-07-08 | Farmos Oy | New aromatase inhibiting 4(5)-imidazoles |
-
1990
- 1990-09-21 GB GB9020629A patent/GB2248058B/en not_active Revoked
-
1991
- 1991-09-10 FI FI914254A patent/FI914254A/en not_active Application Discontinuation
- 1991-09-12 AU AU83826/91A patent/AU640817B2/en not_active Ceased
- 1991-09-13 DE DE69114644T patent/DE69114644T2/en not_active Expired - Fee Related
- 1991-09-13 AT AT91308407T patent/ATE130295T1/en active
- 1991-09-13 EP EP91308407A patent/EP0476944B1/en not_active Expired - Lifetime
- 1991-09-13 IL IL9947291A patent/IL99472A/en not_active IP Right Cessation
- 1991-09-16 NZ NZ239800A patent/NZ239800A/en unknown
- 1991-09-17 PL PL91291747A patent/PL167741B1/en unknown
- 1991-09-18 CA CA002051803A patent/CA2051803A1/en not_active Abandoned
- 1991-09-19 ZA ZA917476A patent/ZA917476B/en unknown
- 1991-09-19 JP JP3239834A patent/JPH04230668A/en active Pending
- 1991-09-20 RU SU915001670A patent/RU2036193C1/en active
- 1991-09-20 HU HU913019A patent/HUT59107A/en unknown
- 1991-09-20 NO NO91913712A patent/NO913712L/en unknown
- 1991-09-20 IE IE331491A patent/IE68934B1/en not_active IP Right Cessation
- 1991-09-20 PT PT99019A patent/PT99019A/en not_active Application Discontinuation
- 1991-09-20 CZ CS912868A patent/CZ280088B6/en unknown
-
1993
- 1993-05-14 LV LVP-93-340A patent/LV10095B/en unknown
- 1993-05-31 LT LTIP582A patent/LT3441B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ280088B6 (en) | 1995-10-18 |
| PL167741B1 (en) | 1995-10-31 |
| JPH04230668A (en) | 1992-08-19 |
| GB2248058B (en) | 1994-09-14 |
| LV10095B (en) | 1995-02-20 |
| ZA917476B (en) | 1992-05-27 |
| PT99019A (en) | 1992-08-31 |
| IL99472A0 (en) | 1992-08-18 |
| HU913019D0 (en) | 1992-01-28 |
| DE69114644T2 (en) | 1996-05-15 |
| GB9020629D0 (en) | 1990-10-31 |
| CA2051803A1 (en) | 1992-03-22 |
| FI914254A0 (en) | 1991-09-10 |
| NO913712D0 (en) | 1991-09-20 |
| DE69114644D1 (en) | 1995-12-21 |
| ATE130295T1 (en) | 1995-12-15 |
| NO913712L (en) | 1992-03-23 |
| EP0476944A1 (en) | 1992-03-25 |
| GB2248058A (en) | 1992-03-25 |
| NZ239800A (en) | 1993-11-25 |
| IE913314A1 (en) | 1992-02-25 |
| CS286891A3 (en) | 1992-04-15 |
| AU8382691A (en) | 1992-04-09 |
| IE68934B1 (en) | 1996-07-24 |
| FI914254A (en) | 1992-03-22 |
| LT3441B (en) | 1995-10-25 |
| LV10095A (en) | 1994-05-10 |
| RU2036193C1 (en) | 1995-05-27 |
| PL291747A1 (en) | 1992-10-19 |
| EP0476944B1 (en) | 1995-11-15 |
| HUT59107A (en) | 1992-04-28 |
| AU640817B2 (en) | 1993-09-02 |
| IL99472A (en) | 1995-11-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO953254L (en) | Substituted azolone derivatives for the treatment of helicobacter diseases | |
| SE8600260D0 (en) | SUBSTITUTED INDOLOKINOXALINES | |
| EP0974584A4 (en) | Fused ring compounds, process for producing the same and use thereof | |
| GB2248058B (en) | Aromatase inhibiting 4(5)-imidazoles | |
| NO934688L (en) | Novel selective aromatase inhibiting 4 (5) imidazoles | |
| AU627559B2 (en) | Novel aromatase inhibiting 4(5)-imidazoles | |
| SI0945430T1 (en) | N-phenylacetoacetamides and process for their preparation | |
| YU54292A (en) | NEW 4 (5) -IMIDAZOLES THAT SELECTIVELY INHIBIT AROMATASE | |
| EP0989132A4 (en) | Process for producing halogenated beta-lactam compound | |
| DK0869957T3 (en) | 3 (2H) -Pyridazinone derivatives and pharmaceutical compositions containing these compounds | |
| DE3171737D1 (en) | Process for preparing n-pyrrolyl-pyridazineamine derivatives | |
| PL89131B1 (en) | Isoindolino-quinoline derivs - useful as tranquillizers and anticonvulsants[FR2167217A1] |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9A | Lapsed patents |
Effective date: 19970531 |