PL89131B1 - Isoindolino-quinoline derivs - useful as tranquillizers and anticonvulsants[FR2167217A1] - Google Patents

Isoindolino-quinoline derivs - useful as tranquillizers and anticonvulsants[FR2167217A1] Download PDF

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Publication number
PL89131B1
PL89131B1 PL1972159839A PL15983972A PL89131B1 PL 89131 B1 PL89131 B1 PL 89131B1 PL 1972159839 A PL1972159839 A PL 1972159839A PL 15983972 A PL15983972 A PL 15983972A PL 89131 B1 PL89131 B1 PL 89131B1
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PL
Poland
Prior art keywords
formula
carbon atoms
alkyl
acid addition
halogen
Prior art date
Application number
PL1972159839A
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Polish (pl)
Original Assignee
Chrysler Francefr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Chrysler Francefr filed Critical Chrysler Francefr
Publication of PL89131B1 publication Critical patent/PL89131B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
    • G03G15/00—Apparatus for electrographic processes using a charge pattern
    • G03G15/14—Apparatus for electrographic processes using a charge pattern for transferring a pattern to a second base
    • G03G15/16—Apparatus for electrographic processes using a charge pattern for transferring a pattern to a second base of a toner pattern, e.g. a powder pattern, e.g. magnetic transfer

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Title derivs are cpds of formula (I) (where X is halogen, 1-4C alkyl, 1-4C alkoxy, NO2 and/or H; Y is halogen, 1-4C alkyl, 1-4C alkoxy, CN, NO2 and/or H; and n is 0 or 1) and their acid addition salts. (I) in which n is 0 are obtained by reacting an alkali salt of a cpd of formula (II) with 1-chlorocarbonyl-4-methylpiperazine or by reacting a cpd of formula (II. -OH=-OCOOAr) (where Ar is opt. substituted aryl) with 1-methylpiperazine, and may be converted into (I) in which n is 1 by oxidn. [FR2167217A1]

Claims (1)

1. Zastrzezenie patentowe Sposób wytwarzania pochodnej izoindoliny o ogólnym wzorze 1, w którym X oznacza atomy lub grupy, jednakowe lub rózne, takie jak atom wodoru i chlorowca, grupe alkilowa zawierajaca 1—4 atomów wegla, grupe alkoksylowa, której czesc alkilowa zawiera 1—4 atomów wegla, grupe nitrowa, zas Y oznacza atomy lub grupy, jednakowe lub rózne, takie jak atom wodoru i chlorowca, grupe alkilowa, zawierajaca 1—4 atomów wegla, grupe alkoksylowa, której czesc alkilowa zawiera 1—4 atomów wegla, grupe cyjanowa i nitrowa, oraz ich soli addycyjnych z kwasami, znamienny tym, ze prowadzi sie reakcje 1-chlorokarbonylo-4-metylopiperazyny z sola alkaliczna, ewentualnie sporzadzona in situ, pochodnej izoindoliny o ogólnym wzorze 2, w którym X i Y maja wyzej podane znaczenie, nastepnie ewentualnie przeksztalca sie otrzymany produkt w sól addycyjna z kwasem. o- co-nO^-.cHj Wzór i W.-00 o Wzór -4 .. OH Wzór Z // o Wzór 3 Cl-CO-0-Ar Wzór S , PoligraCl Prac. PoligTaCUP PRL naklad 120+18 Cena 10 zl Urzedo Ptskw^ PfliskiBl R/.r.-:f'i!^-:-' '•¦ PLClaim 1. A process for the preparation of an isoindoline derivative of general formula I, in which X represents atoms or groups, identical or different, such as hydrogen and halogen, an alkyl group having 1-4 carbon atoms, an alkoxy group whose alkyl part contains 1-4 4 carbon atoms, nitro group, and Y represents atoms or groups, identical or different, such as hydrogen and halogen atom, alkyl group containing 1-4 carbon atoms, alkoxy group, the alkyl portion of which contains 1-4 carbon atoms, cyano and nitro, and their acid addition salts, characterized by reacting 1-chlorocarbonyl-4-methylpiperazine with an alkali salt, optionally prepared in situ, of an isoindoline derivative of the general formula where X and Y are as defined above, the product obtained is then optionally converted into an acid addition salt. o- co-nO ^ -. cHj Formula i W.-00 o Formula -4 .. OH Formula Z // o Formula 3 Cl-CO-0-Ar Formula S, PoligraCl Prac. PoligTaCUP PRL circulation 120 + 18 Price PLN 10 Office Ptskw ^ PfliskiBl R / .r .-: f'i! ^ -: - '' • ¦ PL
PL1972159839A 1972-01-10 1972-12-28 Isoindolino-quinoline derivs - useful as tranquillizers and anticonvulsants[FR2167217A1] PL89131B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7200650A FR2167217A1 (en) 1972-01-10 1972-01-10 Isoindolino-quinoline derivs - useful as tranquillizers and anticonvulsants

Publications (1)

Publication Number Publication Date
PL89131B1 true PL89131B1 (en) 1976-10-30

Family

ID=9091655

Family Applications (2)

Application Number Title Priority Date Filing Date
PL1972175094A PL92423B1 (en) 1972-01-10 1972-12-28 Isoindolino-quinoline derivs - useful as tranquillizers and anticonvulsants[FR2167217A1]
PL1972159839A PL89131B1 (en) 1972-01-10 1972-12-28 Isoindolino-quinoline derivs - useful as tranquillizers and anticonvulsants[FR2167217A1]

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL1972175094A PL92423B1 (en) 1972-01-10 1972-12-28 Isoindolino-quinoline derivs - useful as tranquillizers and anticonvulsants[FR2167217A1]

Country Status (10)

Country Link
JP (1) JPS5622780A (en)
AR (1) AR202800A1 (en)
AU (1) AU468083B2 (en)
CS (2) CS181748B2 (en)
ES (2) ES410489A1 (en)
FR (1) FR2167217A1 (en)
PL (2) PL92423B1 (en)
SU (2) SU488409A3 (en)
YU (2) YU35766B (en)
ZA (1) ZA73118B (en)

Also Published As

Publication number Publication date
YU35766B (en) 1981-06-30
ES410489A1 (en) 1975-12-01
FR2167217B1 (en) 1975-06-13
CS181748B2 (en) 1978-03-31
SU488409A3 (en) 1975-10-15
JPS5653310B2 (en) 1981-12-17
AR202800A1 (en) 1975-07-24
FR2167217A1 (en) 1973-08-24
JPS5622780A (en) 1981-03-03
CS181717B2 (en) 1978-03-31
SU499805A3 (en) 1976-01-15
AU5087673A (en) 1974-07-11
YU187473A (en) 1980-10-31
PL92423B1 (en) 1977-04-30
YU184773A (en) 1980-10-31
ES410490A1 (en) 1975-12-01
ZA73118B (en) 1973-09-26
AU468083B2 (en) 1975-12-18

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