BG62655B1 - Пептиди, способни да освобождават растежен хормон - Google Patents
Пептиди, способни да освобождават растежен хормон Download PDFInfo
- Publication number
- BG62655B1 BG62655B1 BG98489A BG9848994A BG62655B1 BG 62655 B1 BG62655 B1 BG 62655B1 BG 98489 A BG98489 A BG 98489A BG 9848994 A BG9848994 A BG 9848994A BG 62655 B1 BG62655 B1 BG 62655B1
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- BG
- Bulgaria
- Prior art keywords
- ala
- dphe
- trp
- phe
- growth hormone
- Prior art date
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- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
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- BRHPBVXVOVMTIQ-ZLELNMGESA-N l-leucine l-leucine Chemical compound CC(C)C[C@H](N)C(O)=O.CC(C)C[C@H](N)C(O)=O BRHPBVXVOVMTIQ-ZLELNMGESA-N 0.000 description 1
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
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- KJOMYNHMBRNCNY-UHFFFAOYSA-N pentane-1,1-diamine Chemical compound CCCCC(N)N KJOMYNHMBRNCNY-UHFFFAOYSA-N 0.000 description 1
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- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/748,350 US5663146A (en) | 1991-08-22 | 1991-08-22 | Polypeptide analogues having growth hormone releasing activity |
| PCT/US1992/007026 WO1993004081A1 (en) | 1991-08-22 | 1992-08-20 | Peptides having growth hormone releasing activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG98489A BG98489A (bg) | 1995-02-28 |
| BG62655B1 true BG62655B1 (bg) | 2000-04-28 |
Family
ID=25009088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG98489A BG62655B1 (bg) | 1991-08-22 | 1994-02-18 | Пептиди, способни да освобождават растежен хормон |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US5663146A (pt) |
| EP (1) | EP0605484B1 (pt) |
| JP (1) | JP3179489B2 (pt) |
| KR (1) | KR100247212B1 (pt) |
| CN (1) | CN1035256C (pt) |
| AT (1) | ATE172742T1 (pt) |
| AU (1) | AU666673B2 (pt) |
| BG (1) | BG62655B1 (pt) |
| BR (2) | BR9206398A (pt) |
| CA (1) | CA2116120C (pt) |
| CZ (1) | CZ293281B6 (pt) |
| DE (1) | DE69227462T2 (pt) |
| DK (1) | DK0605484T3 (pt) |
| ES (1) | ES2124263T3 (pt) |
| FI (2) | FI120095B (pt) |
| HU (1) | HU223664B1 (pt) |
| IL (1) | IL102848A (pt) |
| MX (1) | MX9204861A (pt) |
| NO (1) | NO314695B1 (pt) |
| NZ (1) | NZ244034A (pt) |
| PL (1) | PL169562B1 (pt) |
| RO (1) | RO112507B1 (pt) |
| RU (1) | RU2126014C1 (pt) |
| SK (1) | SK282895B6 (pt) |
| WO (1) | WO1993004081A1 (pt) |
| ZA (1) | ZA926337B (pt) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843941A (en) | 1993-05-14 | 1998-12-01 | Genentech, Inc. | Ras farnesyl transferase inhibitors |
| BR9408377A (pt) * | 1993-12-23 | 1997-08-19 | Novo Nordisk As | Composto composição farmacêutica processo para estimular a liberação de hormônio de crescimento da pituitária e uso do composto |
| CN1052730C (zh) * | 1993-12-23 | 2000-05-24 | 诺沃挪第克公司 | 具有生长激素释放特性的化合物 |
| US20020111461A1 (en) * | 1999-05-21 | 2002-08-15 | Todd C. Somers | Low molecular weight peptidomimetic growth hormone secretagogues |
| US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
| KR19990028303A (ko) * | 1995-06-22 | 1999-04-15 | 한센 핀 베네드, 안네 제헤르 | 성장호르몬 방출 특성을 가지는 화합물 |
| CN1127488C (zh) * | 1996-04-24 | 2003-11-12 | 诺沃挪第克公司 | 具有生长激素释放特性的化合物 |
| US6127341A (en) * | 1997-06-20 | 2000-10-03 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| WO1998058950A1 (en) | 1997-06-20 | 1998-12-30 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6329342B1 (en) | 1997-08-19 | 2001-12-11 | Eli Lilly And Company | Treatment of congestive heart failure with growth hormone secretagogues |
| ZA987383B (en) * | 1997-08-19 | 2000-02-17 | Lilly Co Eli | Treatment of congestive heart failure with growth hormone secretagogues. |
| DE69921611T2 (de) | 1998-01-16 | 2005-11-03 | Novo Nordisk A/S | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
| WO1999039730A1 (fr) * | 1998-02-09 | 1999-08-12 | Kaken Pharmaceutical Co., Ltd. | Preparation a administration orale contenant des peptides favorisant la secretion d'hormone de croissance |
| US6919315B1 (en) | 1998-06-30 | 2005-07-19 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6682908B1 (en) | 1998-07-10 | 2004-01-27 | Merck & Co., Inc. | Mouse growth hormone secretagogue receptor |
| EP1097170A1 (en) | 1998-07-13 | 2001-05-09 | Merck & Co., Inc. | Growth hormone secretagogue related receptors and nucleic acids |
| WO2000009538A2 (en) | 1998-08-10 | 2000-02-24 | Merck & Co., Inc. | Canine growth hormone secretagogue receptor |
| EP1159292A2 (en) | 1998-08-14 | 2001-12-05 | Administrators of The Tulane Educational Fund | Compounds having growth hormone releasing activity |
| US6639076B1 (en) | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
| US6696063B1 (en) | 1998-12-30 | 2004-02-24 | Applied Research Systems Ars Holding N.V. | Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy |
| AU759022B2 (en) * | 1999-02-18 | 2003-04-03 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives as growth hormone secretagogues |
| US7022677B1 (en) | 1999-02-18 | 2006-04-04 | Kaken Pharmaceutical Co., Ltd. | Amide derivatives as growth hormone secretagogues |
| US6828331B1 (en) * | 1999-02-19 | 2004-12-07 | Eli Lilly And Company | Growth hormone secretagogues |
| US20040192593A1 (en) * | 1999-07-26 | 2004-09-30 | Baylor College Of Medicine | Protease resistant ti-growth hormone releasing hormone |
| DE60023906T2 (de) * | 1999-07-26 | 2006-07-20 | Baylor College Of Medicine, Houston | Superaktive, wachstumshormone freisetzende hormonanaloge vom schwein |
| AU7685200A (en) * | 1999-10-12 | 2001-04-23 | Kaken Pharmaceutical Co., Ltd. | Powdery inhalational preparations and process for producing the same |
| UA73530C2 (uk) | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
| JP3498041B2 (ja) * | 2000-05-29 | 2004-02-16 | 科研製薬株式会社 | プラルモレリン含有点鼻用製剤 |
| EP1159964B1 (en) | 2000-05-31 | 2009-10-28 | Pfizer Products Inc. | Use of growth hormone secretagogues for stimulating gastrointestinal motility |
| US7855229B2 (en) | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7645898B2 (en) | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
| EP1355941A2 (en) | 2001-02-02 | 2003-10-29 | ConjuChem, Inc. | Long lasting growth hormone releasing factor derivatives |
| US7125840B2 (en) * | 2001-10-09 | 2006-10-24 | Eli Lilly And Company | Substituted dipeptides as growth hormone secretagogues |
| BR0213965A (pt) * | 2001-10-26 | 2005-03-15 | Baylor College Medicine | Composição e método para alterar as propriedades de massa corporal magra e ósseas em um indivìduo |
| US8853266B2 (en) | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US6831102B2 (en) | 2001-12-07 | 2004-12-14 | Bristol-Myers Squibb Company | Phenyl naphthol ligands for thyroid hormone receptor |
| WO2003049700A2 (en) | 2001-12-11 | 2003-06-19 | Advisys, Inc. | Growth hormone releasing hormone suplementation for treating chronically ill subjects |
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| EP1499731B1 (en) * | 2002-02-07 | 2011-05-25 | Baylor College Of Medicine | Modified pituitary gland development in offspring from expectant mother animals treated with growth hormone releasing hormone therapy |
| US7772433B2 (en) | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
| US7381730B2 (en) | 2002-03-15 | 2008-06-03 | Bristol-Myers Squibb Company | 3-arylquinazoline derivatives as selective estrogen receptor beta modulators |
| US20060167268A1 (en) * | 2002-04-09 | 2006-07-27 | Eli Lilly And Company, Patent Division, | Growth hormone secretagogues |
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| US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| TW200504021A (en) | 2003-01-24 | 2005-02-01 | Bristol Myers Squibb Co | Substituted anilide ligands for the thyroid receptor |
| WO2004069793A2 (en) | 2003-01-28 | 2004-08-19 | Bristol-Myers Squibb Company | Novel 2-substituted cyclic amines as calcium sensing receptor modulators |
| CA2513743C (en) * | 2003-01-28 | 2013-06-25 | Advisys, Inc. | Reducing culling in herd animals growth hormone releasing hormone (ghrh) |
| US7205322B2 (en) | 2003-02-12 | 2007-04-17 | Bristol-Myers Squibb Company | Thiazolidine compounds as calcium sensing receptor modulators |
| US7557143B2 (en) | 2003-04-18 | 2009-07-07 | Bristol-Myers Squibb Company | Thyroid receptor ligands |
| TW200424214A (en) * | 2003-04-21 | 2004-11-16 | Advisys Inc | Plasmid mediated GHRH supplementation for renal failures |
| US7265145B2 (en) | 2003-05-28 | 2007-09-04 | Bristol-Myers Squibb Company | Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method |
| US7459460B2 (en) | 2003-05-28 | 2008-12-02 | Bristol-Myers Squibb Company | Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
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- 1992-08-18 IL IL102848A patent/IL102848A/en not_active IP Right Cessation
- 1992-08-20 AU AU25416/92A patent/AU666673B2/en not_active Ceased
- 1992-08-20 AT AT92919262T patent/ATE172742T1/de active
- 1992-08-20 ES ES92919262T patent/ES2124263T3/es not_active Expired - Lifetime
- 1992-08-20 HU HU9400495A patent/HU223664B1/hu not_active IP Right Cessation
- 1992-08-20 SK SK204-94A patent/SK282895B6/sk not_active IP Right Cessation
- 1992-08-20 KR KR1019940700542A patent/KR100247212B1/ko not_active IP Right Cessation
- 1992-08-20 DE DE69227462T patent/DE69227462T2/de not_active Expired - Lifetime
- 1992-08-20 NZ NZ244034A patent/NZ244034A/en not_active IP Right Cessation
- 1992-08-20 BR BR9206398A patent/BR9206398A/pt not_active Application Discontinuation
- 1992-08-20 JP JP50458593A patent/JP3179489B2/ja not_active Expired - Lifetime
- 1992-08-20 CZ CZ1994400A patent/CZ293281B6/cs not_active IP Right Cessation
- 1992-08-20 PL PL92302434A patent/PL169562B1/pl not_active IP Right Cessation
- 1992-08-20 RU RU94016393A patent/RU2126014C1/ru not_active IP Right Cessation
- 1992-08-20 DK DK92919262T patent/DK0605484T3/da active
- 1992-08-20 RO RO94-00256A patent/RO112507B1/ro unknown
- 1992-08-20 EP EP92919262A patent/EP0605484B1/en not_active Expired - Lifetime
- 1992-08-20 CA CA002116120A patent/CA2116120C/en not_active Expired - Lifetime
- 1992-08-20 WO PCT/US1992/007026 patent/WO1993004081A1/en active Application Filing
- 1992-08-20 US US07/932,494 patent/US5776901A/en not_active Expired - Lifetime
- 1992-08-21 ZA ZA926337A patent/ZA926337B/xx unknown
- 1992-08-21 MX MX9204861A patent/MX9204861A/es unknown
- 1992-08-22 CN CN92110868A patent/CN1035256C/zh not_active Expired - Fee Related
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1994
- 1994-02-18 BG BG98489A patent/BG62655B1/bg unknown
- 1994-02-21 FI FI940807A patent/FI120095B/fi not_active IP Right Cessation
- 1994-02-21 NO NO19940592A patent/NO314695B1/no not_active IP Right Cessation
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