BG62612B1 - Съединения, фармацевтични състави и методи за инхибиране наhiv обратна транскриптаза и за лечение на hiv инфекции, спин илиarc и методи за получаване на съединенията - Google Patents

Съединения, фармацевтични състави и методи за инхибиране наhiv обратна транскриптаза и за лечение на hiv инфекции, спин илиarc и методи за получаване на съединенията Download PDF

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Publication number
BG62612B1
BG62612B1 BG99383A BG9938395A BG62612B1 BG 62612 B1 BG62612 B1 BG 62612B1 BG 99383 A BG99383 A BG 99383A BG 9938395 A BG9938395 A BG 9938395A BG 62612 B1 BG62612 B1 BG 62612B1
Authority
BG
Bulgaria
Prior art keywords
substituted
unsubstituted
chloro
hiv
aids
Prior art date
Application number
BG99383A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG99383A (bg
Inventor
Steven D. Young
Susan F. Britcher
Linda S. Payne
Lekhanh O. Tran
William C. Lumma Jun.
Original Assignee
Merck & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26733517&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG62612(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co. filed Critical Merck & Co.
Publication of BG99383A publication Critical patent/BG99383A/bg
Publication of BG62612B1 publication Critical patent/BG62612B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG99383A 1992-08-07 1995-01-30 Съединения, фармацевтични състави и методи за инхибиране наhiv обратна транскриптаза и за лечение на hiv инфекции, спин илиarc и методи за получаване на съединенията BG62612B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92660792A 1992-08-07 1992-08-07
US5480593A 1993-04-27 1993-04-27
PCT/US1993/007376 WO1994003440A1 (en) 1992-08-07 1993-08-06 Benzoxazinones as inhibitors of hiv reverse transcriptase

Publications (2)

Publication Number Publication Date
BG99383A BG99383A (bg) 1995-09-29
BG62612B1 true BG62612B1 (bg) 2000-03-31

Family

ID=26733517

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99383A BG62612B1 (bg) 1992-08-07 1995-01-30 Съединения, фармацевтични състави и методи за инхибиране наhiv обратна транскриптаза и за лечение на hiv инфекции, спин илиarc и методи за получаване на съединенията

Country Status (37)

Country Link
EP (1) EP0582455B1 (no)
JP (1) JPH0780860B2 (no)
KR (1) KR100272387B1 (no)
CN (3) CN1051767C (no)
AT (1) ATE197295T1 (no)
AU (1) AU670300B2 (no)
BG (1) BG62612B1 (no)
CA (1) CA2101572C (no)
CZ (1) CZ290447B6 (no)
DE (4) DE69329608T2 (no)
DK (1) DK0582455T3 (no)
DZ (1) DZ1707A1 (no)
ES (1) ES2151897T3 (no)
FI (1) FI115457B (no)
GR (1) GR3034754T3 (no)
HK (1) HK1009267A1 (no)
HR (1) HRP931102B1 (no)
HU (1) HU223076B1 (no)
IL (1) IL106507A (no)
LU (2) LU90709I2 (no)
LV (1) LV12719B (no)
MX (1) MX192812B (no)
MY (1) MY109834A (no)
NL (2) NL300032I2 (no)
NO (3) NO304886B1 (no)
NZ (1) NZ255216A (no)
PL (2) PL175615B1 (no)
PT (1) PT582455E (no)
RO (1) RO113641B1 (no)
RU (1) RU2186775C2 (no)
SG (1) SG52698A1 (no)
SI (1) SI9300419B (no)
SK (1) SK282276B6 (no)
TW (2) TW382014B (no)
UA (1) UA42699C2 (no)
WO (1) WO1994003440A1 (no)
YU (1) YU49439B (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633405A (en) * 1995-05-25 1997-05-27 Merck & Co., Inc. Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one
US6147210A (en) * 1996-07-26 2000-11-14 Dupont Pharmaceuticals Company Practical synthesis of benzoxazinones useful as HIV reverse transcriptase inhibitors
AU3736197A (en) * 1996-07-26 1998-02-20 Du Pont Pharmaceuticals Company A practical synthesis of benzoxazinones useful as hiv reverse transcripta se inhibitors
ZA9711256B (en) 1996-12-16 1999-06-15 Du Pont Merck Pharma Asymmetric synthesis of benzoxazinones
US5932726A (en) * 1996-12-16 1999-08-03 Dupont Pharmaceuticals Company Asymmetric synthesis of benzoxazinones
CA2279198C (en) * 1997-02-05 2009-04-14 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
US5965729A (en) 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
BR9808486A (pt) * 1997-04-07 2000-05-23 Du Pont Pharm Co Processo para a preparação de um composto
US6124302A (en) * 1997-04-09 2000-09-26 Dupont Pharmaceuticals 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones useful as HIV reverse transcriptase inhibitors
KR20010023584A (ko) * 1997-09-03 2001-03-26 폴락 돈나 엘. 2ｒ-[1-하이드록시-1-트리플루오로메틸-3-사이클로프로필프로핀-2일]-4-클로로아닐린의 광학 순도를 향상시키는 방법
US5952528A (en) * 1997-09-03 1999-09-14 Merck & Co., Inc. Process for enhancing the optical purity
US20010014352A1 (en) 1998-05-27 2001-08-16 Udit Batra Compressed tablet formulation
HRP990182A2 (en) * 1998-06-11 2000-02-29 Du Pont Pharm Co Crystalline efavirenz
US6673372B1 (en) 1998-06-11 2004-01-06 Bristol-Myers Squibb Pharma Company Crystalline Efavirenz
EP1091939A1 (en) * 1998-06-30 2001-04-18 Du Pont Pharmaceuticals Company Substituted quinolin-2(1h)-ones useful as hiv reverse transcriptase inhibitors
SE9904652D0 (sv) * 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
US6946469B2 (en) 2001-03-28 2005-09-20 Bristol-Myers Squibb Pharma Company Cyanamide, alkoxyamino, and urea derivatives of 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones as HIV reverse transcriptase inhibitors
RU2344128C2 (ru) 2003-03-24 2009-01-20 Ф.Хоффманн-Ля Рош Аг Бензилпиридазиноны как ингибиторы обратной транскриптазы
WO2009044788A1 (ja) * 2007-10-05 2009-04-09 Banyu Pharmaceutical Co., Ltd. ベンゾオキサジノン誘導体
GB0720503D0 (en) 2007-10-22 2007-11-28 Angeletti P Ist Richerche Bio New compound
EP2448917A2 (de) 2009-07-03 2012-05-09 Archimica GmbH Verfahren zur enantioselektiven addition von organometallischen kohlenstoffnukleophilen an trifluormethylketone und verwendung des verfahrens in der synthese von hiv reverse transcriptase inhibitoren
AU2011209788C1 (en) 2010-01-27 2014-08-28 Viiv Healthcare Company Antiviral therapy
EP2471783A1 (en) 2010-12-23 2012-07-04 Esteve Química, S.A. Novel polymorphic form of efavirenz
CN103664816B (zh) * 2011-01-06 2016-03-02 中国科学院上海有机化学研究所 Hiv逆转录酶抑制剂依法韦伦类化合物的一锅法不对称合成工艺
CN102675125B (zh) * 2011-03-15 2015-02-18 中国科学院上海有机化学研究所 一种4-氯-2-三氟乙酰基苯胺及其类似物的简便高效合成方法
WO2020164218A1 (en) 2019-02-15 2020-08-20 Fujian Yongjing Technology Co., Ltd New process for friedel-crafts reaction, and catalyst therefore
CN110372625B (zh) * 2019-08-06 2022-11-01 常州大学 蓝光照射制备4-烷甲基-4-芳基-1,3-苯并噁嗪-2(4h)-酮的方法
CN113106473B (zh) * 2021-04-14 2022-02-18 南京工业大学 一种通过连续电化学微反应器装置制备1,3-苯并噁嗪衍生物的方法
EP4416134A1 (en) * 2021-10-15 2024-08-21 Merck Sharp & Dohme LLC Benzoxazinone derivatives as selective cytotoxic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3526621A (en) * 1966-08-03 1970-09-01 Farmaceutical Italia Soc Substituted 3,1-benzoxazin-2-one
US3562621A (en) * 1967-07-26 1971-02-09 Technipower Inc Inrush current limiting circuit for rectifier circuits with capacitive load
DE3217012A1 (de) * 1982-05-06 1983-11-10 Dr. Karl Thomae Gmbh, 7950 Biberach Benzoxazin-2-one, deren herstellung und diese verbindungen enthaltende arzneimittel
CA2032259A1 (en) * 1989-12-18 1991-06-19 Wayne J. Thompson Hiv protease inhibitors useful for the treatment of aids
IL99843A0 (en) * 1990-11-01 1992-08-18 Merck & Co Inc Synergistic combination of hiv reverse transcriptase inhibitors

Also Published As

Publication number Publication date
RO113641B1 (ro) 1998-09-30
LU91446I2 (fr) 2008-07-28
ES2151897T3 (es) 2001-01-16
HU223076B1 (hu) 2004-03-01
LV12719A (lv) 2001-09-20
JPH0780860B2 (ja) 1995-08-30
SK16195A3 (en) 1995-07-11
NO304886B1 (no) 1999-03-01
BG99383A (bg) 1995-09-29
SI9300419A (en) 1994-06-30
DK0582455T3 (da) 2000-11-27
HRP931102B1 (en) 2001-06-30
CN1051767C (zh) 2000-04-26
GR3034754T3 (en) 2001-02-28
LV12719B (lv) 2001-12-20
NL300032I2 (nl) 2001-04-02
JPH06184124A (ja) 1994-07-05
NL300032I1 (no) 2001-02-01
PL176679B1 (pl) 1999-07-30
EP0582455A1 (en) 1994-02-09
TW382014B (en) 2000-02-11
DE10199013I1 (de) 2001-05-23
ATE197295T1 (de) 2000-11-15
CZ290447B6 (cs) 2002-07-17
SK282276B6 (sk) 2002-01-07
HRP931102A2 (en) 1997-10-31
PL307348A1 (en) 1995-05-15
NO950424L (no) 1995-04-06
AU670300B2 (en) 1996-07-11
HUT71219A (en) 1995-11-28
LU90709I2 (fr) 2002-02-04
DE69329608D1 (de) 2000-12-07
CN1250652A (zh) 2000-04-19
NZ255216A (en) 1996-05-28
MX9304775A (es) 1994-05-31
PL175615B1 (pl) 1999-01-29
KR100272387B1 (ko) 2000-11-15
MY109834A (en) 1997-08-30
MX192812B (es) 1999-07-30
SG52698A1 (en) 1998-09-28
FI950508A0 (fi) 1995-02-06
CN1090277A (zh) 1994-08-03
IL106507A0 (en) 1993-11-15
CN1107505C (zh) 2003-05-07
CA2101572A1 (en) 1994-02-08
TWI233436B (en) 2005-06-01
NO2000004I1 (no) 2000-06-16
EP0582455B1 (en) 2000-11-02
DE69329608T2 (de) 2001-05-03
FI950508A (fi) 1995-02-06
CZ28695A3 (en) 1995-09-13
YU49439B (sh) 2006-03-03
WO1994003440A1 (en) 1994-02-17
FI115457B (fi) 2005-05-13
HK1009267A1 (en) 1999-05-28
DE122008000034I1 (de) 2008-10-02
PT582455E (pt) 2001-03-30
DZ1707A1 (fr) 2002-02-17
NO2008008I1 (no) 2008-06-30
IL106507A (en) 1997-11-20
CA2101572C (en) 2001-08-28
SI9300419B (sl) 2002-10-31
CN1221608A (zh) 1999-07-07
RU2186775C2 (ru) 2002-08-10
CN1318031C (zh) 2007-05-30
YU53093A (sh) 1996-10-09
NL300347I1 (nl) 2008-07-01
HU9500366D0 (en) 1995-03-28
AU4449693A (en) 1994-02-10
UA42699C2 (uk) 2001-11-15
KR950702970A (ko) 1995-08-23
RU95107403A (ru) 1996-11-20
NO950424D0 (no) 1995-02-06
DE10199013I2 (de) 2007-05-24

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