BG62171B1 - Пиролохинолинонови производни с позитивна инотропна илузитропна активност - Google Patents

Пиролохинолинонови производни с позитивна инотропна илузитропна активност Download PDF

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Publication number
BG62171B1
BG62171B1 BG100209A BG10020995A BG62171B1 BG 62171 B1 BG62171 B1 BG 62171B1 BG 100209 A BG100209 A BG 100209A BG 10020995 A BG10020995 A BG 10020995A BG 62171 B1 BG62171 B1 BG 62171B1
Authority
BG
Bulgaria
Prior art keywords
formula
compound
compounds
optionally substituted
pharmaceutically acceptable
Prior art date
Application number
BG100209A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG100209A (bg
Inventor
Eddy J. Freyne
Alfons H. Raeymaekers
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG100209A publication Critical patent/BG100209A/bg
Publication of BG62171B1 publication Critical patent/BG62171B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
BG100209A 1993-06-21 1995-12-08 Пиролохинолинонови производни с позитивна инотропна илузитропна активност BG62171B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93201771 1993-06-21
PCT/EP1994/001960 WO1995000512A1 (en) 1993-06-21 1994-06-15 Positive inotropic and lusitropic pyrroloquinolinone derivatives

Publications (2)

Publication Number Publication Date
BG100209A BG100209A (bg) 1996-07-31
BG62171B1 true BG62171B1 (bg) 1999-04-30

Family

ID=8213908

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100209A BG62171B1 (bg) 1993-06-21 1995-12-08 Пиролохинолинонови производни с позитивна инотропна илузитропна активност

Country Status (29)

Country Link
US (1) US5602134A (cs)
EP (1) EP0707586B1 (cs)
JP (1) JP2812804B2 (cs)
KR (1) KR0181560B1 (cs)
CN (1) CN1043765C (cs)
AT (1) ATE171179T1 (cs)
AU (1) AU679077B2 (cs)
BG (1) BG62171B1 (cs)
BR (1) BR9406899A (cs)
CA (1) CA2163122C (cs)
CZ (1) CZ284350B6 (cs)
DE (1) DE69413398T2 (cs)
FI (1) FI109124B (cs)
HU (1) HU220670B1 (cs)
IL (1) IL110055A (cs)
LT (1) LT3447B (cs)
LV (1) LV11545B (cs)
MY (1) MY110751A (cs)
NO (1) NO305366B1 (cs)
OA (1) OA10202A (cs)
PH (1) PH31308A (cs)
PL (1) PL176783B1 (cs)
RU (1) RU2129554C1 (cs)
SG (1) SG49717A1 (cs)
SI (1) SI9420041A (cs)
SK (1) SK280400B6 (cs)
TW (1) TW593317B (cs)
WO (1) WO1995000512A1 (cs)
ZA (1) ZA944382B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72611C2 (uk) * 2000-05-17 2005-03-15 Орто-Макнейл Фармацевтикал, Інк. Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази
US7208497B2 (en) 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
US20030186963A1 (en) 2001-09-14 2003-10-02 Dorwald Florencio Zaragoza Substituted piperidines
DE60234616D1 (de) * 2001-09-14 2010-01-14 High Point Pharmaceuticals Llc Substituierte piperidinen mit selektiver bindungsfähigkeit zu histamin h3-rezeptoren
GB0522715D0 (en) * 2005-11-08 2005-12-14 Helperby Therapeutics Ltd New use
TWI498115B (zh) * 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
GB0808953D0 (en) * 2008-05-16 2008-06-25 Shire Llc substituted quinazolines
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
RU2457208C2 (ru) * 2009-07-06 2012-07-27 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО "ПГФА Росздрава") 1H-ПИРРОЛО[3,4-b]ХИНОЛИН-3,9(2H,4H)-ДИОНЫ, ОБЛАДАЮЩИЕ ПРОТИВОТУБЕРКУЛЕЗНОЙ АКТИВНОСТЬЮ, И СПОСОБ ИХ ПОЛУЧЕНИЯ
CN120265631A (zh) * 2023-01-13 2025-07-04 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552884A (en) * 1984-01-13 1985-11-12 The Boots Company Plc Method of treating heart disease
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US4775674A (en) 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
SU1527588A1 (ru) * 1987-01-16 1989-12-07 Саратовский государственный медицинский институт Способ определени аллергических реакций на лекарственный препарат
CN1030196C (zh) * 1989-07-07 1995-11-01 詹森药业有限公司 增强收缩力和舒张力的-二氢咪唑并喹唑啉酮衍生物的制备方法
NZ234186A (en) * 1989-07-07 1991-10-25 Janssen Pharmaceutica Nv Imidazo quinazolin-one derivatives and pharmaceutical compositions
US5220023A (en) * 1989-07-18 1993-06-15 Janssen Pharmaceutica N.V. Glycine derivatives
US4943573A (en) 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas

Also Published As

Publication number Publication date
ATE171179T1 (de) 1998-10-15
IL110055A (en) 1997-09-30
CZ336695A3 (en) 1996-03-13
LT3447B (en) 1995-10-25
PL176783B1 (pl) 1999-07-30
DE69413398T2 (de) 1999-04-15
TW593317B (en) 2004-06-21
SG49717A1 (en) 1998-06-15
LTIP1960A (en) 1995-01-31
CZ284350B6 (cs) 1998-10-14
CN1043765C (zh) 1999-06-23
SK159695A3 (en) 1997-01-08
EP0707586A1 (en) 1996-04-24
BG100209A (bg) 1996-07-31
CA2163122C (en) 2005-06-14
AU7000894A (en) 1995-01-17
PH31308A (en) 1998-07-06
ZA944382B (en) 1995-12-20
SK280400B6 (sk) 2000-01-18
CA2163122A1 (en) 1995-01-05
CN1125945A (zh) 1996-07-03
DE69413398D1 (de) 1998-10-22
IL110055A0 (en) 1994-10-07
NO305366B1 (no) 1999-05-18
SI9420041A (en) 1996-08-31
HU9501970D0 (en) 1995-09-28
JPH09500108A (ja) 1997-01-07
RU2129554C1 (ru) 1999-04-27
KR0181560B1 (ko) 1999-05-01
WO1995000512A1 (en) 1995-01-05
NO955028D0 (no) 1995-12-12
AU679077B2 (en) 1997-06-19
US5602134A (en) 1997-02-11
HUT72090A (en) 1996-03-28
JP2812804B2 (ja) 1998-10-22
NO955028L (no) 1995-12-12
PL312252A1 (en) 1996-04-01
FI956143A0 (fi) 1995-12-20
OA10202A (en) 1996-12-18
BR9406899A (pt) 1996-04-09
LV11545A (lv) 1996-10-20
LV11545B (en) 1997-08-20
FI109124B (fi) 2002-05-31
MY110751A (en) 1999-02-27
EP0707586B1 (en) 1998-09-16
HU220670B1 (hu) 2002-04-29
FI956143L (fi) 1995-12-20

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