DE69413398D1 - Positiv inotropische und lusitropische pyrrolochinolinonderivate - Google Patents

Positiv inotropische und lusitropische pyrrolochinolinonderivate

Info

Publication number
DE69413398D1
DE69413398D1 DE69413398T DE69413398T DE69413398D1 DE 69413398 D1 DE69413398 D1 DE 69413398D1 DE 69413398 T DE69413398 T DE 69413398T DE 69413398 T DE69413398 T DE 69413398T DE 69413398 D1 DE69413398 D1 DE 69413398D1
Authority
DE
Germany
Prior art keywords
pct
lusitropic
positive inotropic
pyrrolochinolinone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69413398T
Other languages
English (en)
Other versions
DE69413398T2 (de
Inventor
Eddy Freyne
Alfons Raeymaekers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of DE69413398D1 publication Critical patent/DE69413398D1/de
Publication of DE69413398T2 publication Critical patent/DE69413398T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE69413398T 1993-06-21 1994-06-15 Positiv inotropische und lusitropische pyrrolochinolinonderivate Expired - Fee Related DE69413398T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93201771 1993-06-21
PCT/EP1994/001960 WO1995000512A1 (en) 1993-06-21 1994-06-15 Positive inotropic and lusitropic pyrroloquinolinone derivatives

Publications (2)

Publication Number Publication Date
DE69413398D1 true DE69413398D1 (de) 1998-10-22
DE69413398T2 DE69413398T2 (de) 1999-04-15

Family

ID=8213908

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69413398T Expired - Fee Related DE69413398T2 (de) 1993-06-21 1994-06-15 Positiv inotropische und lusitropische pyrrolochinolinonderivate

Country Status (29)

Country Link
US (1) US5602134A (de)
EP (1) EP0707586B1 (de)
JP (1) JP2812804B2 (de)
KR (1) KR0181560B1 (de)
CN (1) CN1043765C (de)
AT (1) ATE171179T1 (de)
AU (1) AU679077B2 (de)
BG (1) BG62171B1 (de)
BR (1) BR9406899A (de)
CA (1) CA2163122C (de)
CZ (1) CZ284350B6 (de)
DE (1) DE69413398T2 (de)
FI (1) FI109124B (de)
HU (1) HU220670B1 (de)
IL (1) IL110055A (de)
LT (1) LT3447B (de)
LV (1) LV11545B (de)
MY (1) MY110751A (de)
NO (1) NO305366B1 (de)
OA (1) OA10202A (de)
PH (1) PH31308A (de)
PL (1) PL176783B1 (de)
RU (1) RU2129554C1 (de)
SG (1) SG49717A1 (de)
SI (1) SI9420041A (de)
SK (1) SK280400B6 (de)
TW (1) TW593317B (de)
WO (1) WO1995000512A1 (de)
ZA (1) ZA944382B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208497B2 (en) 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
EP1434765B1 (de) * 2001-09-14 2009-12-02 High Point Pharmaceuticals, LLC Substituierte piperidinen mit selektiver bindungsfähigkeit zu histamin h3-rezeptoren
US20030186963A1 (en) 2001-09-14 2003-10-02 Dorwald Florencio Zaragoza Substituted piperidines
TWI498115B (zh) * 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808953D0 (en) * 2008-05-16 2008-06-25 Shire Llc substituted quinazolines
RU2457208C2 (ru) * 2009-07-06 2012-07-27 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО "ПГФА Росздрава") 1H-ПИРРОЛО[3,4-b]ХИНОЛИН-3,9(2H,4H)-ДИОНЫ, ОБЛАДАЮЩИЕ ПРОТИВОТУБЕРКУЛЕЗНОЙ АКТИВНОСТЬЮ, И СПОСОБ ИХ ПОЛУЧЕНИЯ

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775674A (en) 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
NZ234186A (en) * 1989-07-07 1991-10-25 Janssen Pharmaceutica Nv Imidazo quinazolin-one derivatives and pharmaceutical compositions
CN1030196C (zh) * 1989-07-07 1995-11-01 詹森药业有限公司 增强收缩力和舒张力的-二氢咪唑并喹唑啉酮衍生物的制备方法
US5220023A (en) * 1989-07-18 1993-06-15 Janssen Pharmaceutica N.V. Glycine derivatives
US4943573A (en) 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas

Also Published As

Publication number Publication date
CA2163122A1 (en) 1995-01-05
TW593317B (en) 2004-06-21
LT3447B (en) 1995-10-25
LV11545B (en) 1997-08-20
IL110055A (en) 1997-09-30
AU679077B2 (en) 1997-06-19
FI109124B (fi) 2002-05-31
WO1995000512A1 (en) 1995-01-05
SK280400B6 (sk) 2000-01-18
EP0707586B1 (de) 1998-09-16
SG49717A1 (en) 1998-06-15
MY110751A (en) 1999-02-27
SI9420041A (en) 1996-08-31
JP2812804B2 (ja) 1998-10-22
ATE171179T1 (de) 1998-10-15
PH31308A (en) 1998-07-06
JPH09500108A (ja) 1997-01-07
RU2129554C1 (ru) 1999-04-27
HUT72090A (en) 1996-03-28
NO955028L (no) 1995-12-12
BG100209A (bg) 1996-07-31
CA2163122C (en) 2005-06-14
CZ284350B6 (cs) 1998-10-14
PL176783B1 (pl) 1999-07-30
PL312252A1 (en) 1996-04-01
LV11545A (lv) 1996-10-20
IL110055A0 (en) 1994-10-07
BR9406899A (pt) 1996-04-09
FI956143A (fi) 1995-12-20
KR0181560B1 (ko) 1999-05-01
SK159695A3 (en) 1997-01-08
CN1043765C (zh) 1999-06-23
BG62171B1 (bg) 1999-04-30
NO305366B1 (no) 1999-05-18
DE69413398T2 (de) 1999-04-15
EP0707586A1 (de) 1996-04-24
HU9501970D0 (en) 1995-09-28
ZA944382B (en) 1995-12-20
NO955028D0 (no) 1995-12-12
CZ336695A3 (en) 1996-03-13
US5602134A (en) 1997-02-11
LTIP1960A (en) 1995-01-31
AU7000894A (en) 1995-01-17
CN1125945A (zh) 1996-07-03
HU220670B1 (hu) 2002-04-29
FI956143A0 (fi) 1995-12-20
OA10202A (en) 1996-12-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee