BG62002B1 - (-)-[[4-(1,4,5,6-тетрахидро-4-метил-6-оксо-3-пиридазинил)фенил]хидразоно]пропандинитрил - Google Patents

(-)-[[4-(1,4,5,6-тетрахидро-4-метил-6-оксо-3-пиридазинил)фенил]хидразоно]пропандинитрил Download PDF

Info

Publication number
BG62002B1
BG62002B1 BG97915A BG9791593A BG62002B1 BG 62002 B1 BG62002 B1 BG 62002B1 BG 97915 A BG97915 A BG 97915A BG 9791593 A BG9791593 A BG 9791593A BG 62002 B1 BG62002 B1 BG 62002B1
Authority
BG
Bulgaria
Prior art keywords
methyl
phenyl
oxo
tartaric acid
aminophenyl
Prior art date
Application number
BG97915A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG97915A (bg
Inventor
Pentti Nore
Erkki Honkanen
Reijo Baeckstroem
Tom Wikberg
Heimo Haikala
Jorma Haarala
Original Assignee
Orion-Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919100049A external-priority patent/GB9100049D0/en
Priority claimed from GB919118947A external-priority patent/GB9118947D0/en
Application filed by Orion-Yhtymae Oy filed Critical Orion-Yhtymae Oy
Publication of BG97915A publication Critical patent/BG97915A/bg
Publication of BG62002B1 publication Critical patent/BG62002B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Detergent Compositions (AREA)
BG97915A 1991-01-03 1993-06-29 (-)-[[4-(1,4,5,6-тетрахидро-4-метил-6-оксо-3-пиридазинил)фенил]хидразоно]пропандинитрил BG62002B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919100049A GB9100049D0 (en) 1991-01-03 1991-01-03 (-)-6-(4-(dicyanomethylidenehydrazino)phenyl)-4,5-dihydro-5-methylpyridazin-3(2h)one
GB919118947A GB9118947D0 (en) 1991-09-05 1991-09-05 Method for the optical resolution of racemic 6-(4-amino-phenyl)-methyl-pyridazin-3(2h)one and preparation of optically active derivatives thereof
PCT/FI1992/000003 WO1992012135A1 (fr) 1991-01-03 1992-01-03 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile

Publications (2)

Publication Number Publication Date
BG97915A BG97915A (bg) 1994-04-29
BG62002B1 true BG62002B1 (bg) 1998-12-30

Family

ID=26298204

Family Applications (1)

Application Number Title Priority Date Filing Date
BG97915A BG62002B1 (bg) 1991-01-03 1993-06-29 (-)-[[4-(1,4,5,6-тетрахидро-4-метил-6-оксо-3-пиридазинил)фенил]хидразоно]пропандинитрил

Country Status (32)

Country Link
US (3) US5424428A (fr)
EP (1) EP0565546B1 (fr)
JP (2) JP2635445B2 (fr)
KR (1) KR100207145B1 (fr)
AT (1) ATE119525T1 (fr)
AU (1) AU645399B2 (fr)
BG (1) BG62002B1 (fr)
BR (1) BR1100737A (fr)
CA (2) CA2099262C (fr)
CY (1) CY1878A (fr)
DE (1) DE69201640T2 (fr)
DK (1) DK0565546T3 (fr)
EE (1) EE02946B1 (fr)
ES (1) ES2070627T3 (fr)
FI (1) FI105183B (fr)
GB (1) GB2251615B (fr)
GE (1) GEP19991868B (fr)
HK (1) HK117395A (fr)
HR (1) HRP921251B1 (fr)
HU (1) HU218659B (fr)
IE (1) IE72101B1 (fr)
IL (2) IL100553A (fr)
LU (1) LU90920I2 (fr)
LV (1) LV11174B (fr)
NO (2) NO300682B1 (fr)
NZ (1) NZ241194A (fr)
PL (2) PL169435B1 (fr)
RO (1) RO111847B1 (fr)
RU (1) RU2118317C1 (fr)
SI (1) SI9112003A (fr)
WO (1) WO1992012135A1 (fr)
YU (1) YU48767B (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) * 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
JP2806192B2 (ja) * 1992-11-02 1998-09-30 日本曹達株式会社 血小板凝集抑制剤
EP0791584A4 (fr) * 1994-11-11 1997-11-19 Nippon Soda Co Compose optiquement actif
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) * 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
FI973804A (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia
FI974578A (fi) 1997-12-19 1999-06-20 Orion Yhtymae Oyj Menetelmä levosimendaanin antamiseksi
FI980901A (fi) 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaania säädellysti vapauttavia oraalisia koostumuksia
FI980902A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaanin stabiileja koostumuksia
FI104718B (fi) * 1998-06-18 2000-03-31 Orion Yhtymae Oyj [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä
US5905078A (en) * 1998-06-19 1999-05-18 Orion Corporation Use of a pyridazinone derivative
FI981473A (fi) * 1998-06-25 1999-12-26 Orion Yhtymae Oyj Menetelmä pulmonaalihypertension hoitamiseksi
GB9915179D0 (en) * 1999-06-29 1999-09-01 Orion Corp A method for the treatment or prevention of coronary graft vasospasm
FI109659B (fi) 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
US6911209B1 (en) 1999-10-22 2005-06-28 Orion Corporation Method of treating sick sinus syndrome with levosimendan
FI20001542A (fi) 2000-06-29 2001-12-30 Orion Yhtymae Oyj Menetelmä septisen sokin hoitamiseksi
FI20002526A (fi) * 2000-11-17 2002-05-18 Orion Yhtymae Oyj Pyridatsinonijohdannaisten uusi käyttö
FI20002525A (fi) 2000-11-17 2002-05-18 Orion Yhtymae Oyj Tulehduksenvastaisia aineita
FI20002755A0 (fi) 2000-12-15 2000-12-15 Orion Yhtymae Oyj Menetelmä erektiilin dysfunktion hoitamiseen
FI20010233A0 (fi) 2001-02-08 2001-02-08 Orion Corp Menetelmä sydämen vajaatoiminnan hoitoon
FI20011464A0 (fi) 2001-07-04 2001-07-04 Orion Corp Yhdistelmäterapia sydämen vajaatoiminnan hoitoon
FI20030015A0 (fi) * 2003-01-03 2003-01-03 Orion Corp Menetelmä munuaisten vajaatoiminnan hoitamiseksi
EP1612204A4 (fr) * 2003-03-31 2007-04-11 Daiichi Seiyaku Co Derive d'hydrazone
DE102004011512B4 (de) 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
US8980894B2 (en) * 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (fr) * 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Utilisation des inhibiteurs de PDE III pour la réduction de la taille du coeur chez des mammifères souffrant d'insufficances cardiaques
FI20040674A0 (fi) 2004-05-12 2004-05-12 Orion Corp Menetelmä tromboembolisten sairauksien estoon
FI20040675A0 (fi) * 2004-05-12 2004-05-12 Orion Corp Menetelmä sydämen hypertrofian hoitoon ja estoon
EP1758584A1 (fr) * 2004-05-28 2007-03-07 Abbott Laboratories Methodes de traitement d'un mammifere avant, pendant et apres un arret cardiaque
EP1858518A1 (fr) 2005-03-14 2007-11-28 Orion Corporation Traitement de combinaison pour ameliorer la diurese
WO2007054514A2 (fr) 2005-11-14 2007-05-18 Boehringer Ingelheim Vetmedica Gmbh Utilisation d'inhibiteurs de la pde iii pour le traitement d'une insuffisance cardiaque asymptomatique (occulte)
EP1920785A1 (fr) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Préparation liquide contenant un complexe du pimobendane et de la cyclodextrine
AU2008206903B2 (en) * 2007-01-17 2012-07-05 Orion Corporation Levosimendan for use in treating chronic valvular disease
ES2436716T3 (es) 2008-11-25 2014-01-03 Boehringer Ingelheim Vetmedica Gmbh Pimobendan para uso en el tratamiento de la cardiomiopatía hipertrófica en gatos
CA2767946A1 (fr) * 2009-07-14 2011-01-20 Cipla Limited Procede pour la preparation de levosimendan et intermediaires destines a etre utilises dans le procede
ES2924478T3 (es) 2012-03-15 2022-10-07 Boehringer Ingelheim Vetmedica Gmbh Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos
EP2970145B1 (fr) * 2013-03-11 2020-05-06 The Broad Institute, Inc. Composés et compositions utilisables en vue du traitement du cancer
CN105377235A (zh) 2013-07-19 2016-03-02 勃林格殷格翰动物保健有限公司 含有防腐的醚化的环糊精衍生物的液体水性药物组合物
CN104418810A (zh) * 2013-09-04 2015-03-18 北京博时安泰科技发展有限公司 一种左西孟旦的合成新路线
CN103554033A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 一种消旋体(±)- 6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的拆分方法
CN103554032A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法
BR112016011111B1 (pt) 2013-12-04 2022-11-16 Boehringer Ingelheim Vetmedica Gmbh Composições farmacêuticas aprimoradas de pimobendan
CN114699528A (zh) 2015-08-13 2022-07-05 布罗德研究所股份有限公司 用于表达pde3a或slfn12的癌症的组合物和方法
CN105784895B (zh) * 2015-10-30 2018-05-22 成都欣捷高新技术开发有限公司 一种用高效液相色谱仪检测左西孟旦中杂质的方法
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
EP3424908A1 (fr) 2017-07-07 2019-01-09 Melody Healthcare Pvt. Ltd. Procédé de préparation de levosimendan
US9962384B1 (en) * 2017-09-07 2018-05-08 Korea Institute Of Science And Technology Levosimendan compound for preventing or treating tau-related diseases
CN111548310B (zh) * 2020-05-12 2021-07-02 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型及其制备方法
CN111718299B (zh) * 2020-07-23 2023-03-10 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型b及其制备方法
US11760730B2 (en) 2021-01-11 2023-09-19 Navinta, Llc Process for the preparation of high purity Levosimendan

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB228004A (en) * 1924-01-24 1925-01-29 Daimler Co Ltd Improvements in locking devices for sliding windows
JPS58113180A (ja) * 1981-12-28 1983-07-05 Mitsui Toatsu Chem Inc ピリダジノン誘導体
JPS6193169A (ja) * 1984-10-12 1986-05-12 Sankyo Co Ltd ピリダジノン誘導体及びその製法
US4946842A (en) * 1985-07-05 1990-08-07 Smith Kline & French Laboratories Limited Novel guanidino pyridazinones as cardiac stimulants
JPH0629254B2 (ja) * 1986-09-08 1994-04-20 帝国臓器製薬株式会社 ピリダジノン誘導体
GB8824458D0 (en) * 1988-10-19 1988-11-23 Orion Yhtymae Oy Substituted pyridazinones
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile

Also Published As

Publication number Publication date
JPH06504275A (ja) 1994-05-19
FI932618A (fi) 1993-06-09
CA2099262A1 (fr) 1992-07-04
LV11174B (en) 1996-12-20
GEP19991868B (en) 1999-12-06
NZ241194A (en) 1993-06-25
BG97915A (bg) 1994-04-29
JPH09183767A (ja) 1997-07-15
DE69201640D1 (de) 1995-04-13
EE02946B1 (et) 1996-12-16
CA2314115C (fr) 2004-03-30
KR100207145B1 (ko) 1999-07-15
EP0565546A1 (fr) 1993-10-20
IL100553A0 (en) 1992-09-06
IL100553A (en) 1995-12-31
AU645399B2 (en) 1994-01-13
WO1992012135A1 (fr) 1992-07-23
IE920002A1 (en) 1992-07-15
GB2251615A (en) 1992-07-15
US5512571A (en) 1996-04-30
DK0565546T3 (da) 1995-05-22
HK117395A (en) 1995-07-28
JP3015748B2 (ja) 2000-03-06
NO932367D0 (no) 1993-06-28
KR930703266A (ko) 1993-11-29
NO300682B1 (no) 1997-07-07
RU2118317C1 (ru) 1998-08-27
BR1100737A (pt) 2000-03-21
ATE119525T1 (de) 1995-03-15
NO932367L (no) 1993-06-28
IL114028A (en) 1996-09-12
IE72101B1 (en) 1997-03-12
CA2314115A1 (fr) 1992-07-04
AU1153592A (en) 1992-08-17
IL114028A0 (en) 1995-10-31
HU9301911D0 (en) 1993-09-28
US5569657A (en) 1996-10-29
CY1878A (en) 1996-04-05
US5424428A (en) 1995-06-13
HRP921251B1 (en) 2000-06-30
PL169415B1 (pl) 1996-07-31
FI932618A0 (fi) 1993-06-09
HUT64754A (en) 1994-02-28
HU218659B (hu) 2000-10-28
RO111847B1 (ro) 1997-02-28
NO2001021I1 (no) 2001-12-03
YU48767B (sh) 1999-12-27
PL169435B1 (pl) 1996-07-31
GB2251615B (en) 1995-02-08
YU200391A (sh) 1994-05-10
JP2635445B2 (ja) 1997-07-30
CA2099262C (fr) 2002-03-12
HRP921251A2 (en) 1995-08-31
LV11174A (lv) 1996-04-20
EP0565546B1 (fr) 1995-03-08
FI105183B (fi) 2000-06-30
ES2070627T3 (es) 1995-06-01
GB9127145D0 (en) 1992-02-19
SI9112003A (sl) 1998-10-31
DE69201640T2 (de) 1995-08-10
LU90920I2 (en) 2002-07-17

Similar Documents

Publication Publication Date Title
BG62002B1 (bg) (-)-[[4-(1,4,5,6-тетрахидро-4-метил-6-оксо-3-пиридазинил)фенил]хидразоно]пропандинитрил
JP4493840B2 (ja) レボシメンダンの経口組成物
JPS5933264A (ja) ２−置換４−アミノ−６，７−ジメトキシキノリン
WO2020038457A1 (fr) Composé [1,2,4]triazolo[1,5-a]pyridine utilisé en tant qu'inhibiteur de jak et son utilisation
JP2024518991A (ja) アルキルカルボン酸化合物及びその使用
JP7395762B2 (ja) Ｊａｋキナーゼ関連疾患の治療のための薬物の調製におけるｊａｋ阻害剤の使用
KR920003892B1 (ko) 피롤리딘 화합물 및 약제학적 용도
JP7026852B2 (ja) チアジアゾール誘導体及びｇｌｓ１阻害剤としてのその使用
JPS6124579A (ja) 置換されたフエノキシアルキルアミノプロパノール
JPH03141257A (ja) ジヒドロピリジン誘導体
JP2024533411A (ja) ハロゲン置換のピリダジノン系化合物及びその使用
EP0424214A1 (fr) Dérivés de 5-[2-[[2-amino-2-oxoéthyl]méthylamino]éthyl]-2,3-dihydro-3-hydroxy-2-(4-méthoxy-phényl)-1,5(5H)-benzothiazépine-4-one, leur préparation et leur application en thérapeutique
WO2003011856A1 (fr) Derives d'aminoalkylimidazole, leur preparation et leur utilisation en therapeutique
JPS63115889A (ja) ２−アミノ−１，４−ジヒドロピリジン誘導体