GB9118947D0 - Method for the optical resolution of racemic 6-(4-amino-phenyl)-methyl-pyridazin-3(2h)one and preparation of optically active derivatives thereof - Google Patents

Method for the optical resolution of racemic 6-(4-amino-phenyl)-methyl-pyridazin-3(2h)one and preparation of optically active derivatives thereof

Info

Publication number
GB9118947D0
GB9118947D0 GB919118947A GB9118947A GB9118947D0 GB 9118947 D0 GB9118947 D0 GB 9118947D0 GB 919118947 A GB919118947 A GB 919118947A GB 9118947 A GB9118947 A GB 9118947A GB 9118947 D0 GB9118947 D0 GB 9118947D0
Authority
GB
United Kingdom
Prior art keywords
pyridazin
racemic
phenyl
amino
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB919118947A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Priority to GB919118947A priority Critical patent/GB9118947D0/en
Publication of GB9118947D0 publication Critical patent/GB9118947D0/en
Priority to GB9127145A priority patent/GB2251615B/en
Priority to YU200391A priority patent/YU48767B/en
Priority to SI9112003A priority patent/SI9112003A/en
Priority to IL11402891A priority patent/IL114028A/en
Priority to IL10055391A priority patent/IL100553A/en
Priority to US08/081,360 priority patent/US5424428A/en
Priority to HU9301911A priority patent/HU218659B/en
Priority to CA002099262A priority patent/CA2099262C/en
Priority to DK92901317.5T priority patent/DK0565546T3/en
Priority to ES92901317T priority patent/ES2070627T3/en
Priority to RO93-00896A priority patent/RO111847B1/en
Priority to KR1019930701800A priority patent/KR100207145B1/en
Priority to EP92901317A priority patent/EP0565546B1/en
Priority to AT92901317T priority patent/ATE119525T1/en
Priority to AU11535/92A priority patent/AU645399B2/en
Priority to GEAP19922483A priority patent/GEP19991868B/en
Priority to JP4501428A priority patent/JP2635445B2/en
Priority to CA002314115A priority patent/CA2314115C/en
Priority to PCT/FI1992/000003 priority patent/WO1992012135A1/en
Priority to RU93052411A priority patent/RU2118317C1/en
Priority to DE69201640T priority patent/DE69201640T2/en
Priority to NZ241194A priority patent/NZ241194A/en
Priority to HR921251A priority patent/HRP921251B1/en
Priority to FI932618A priority patent/FI105183B/en
Priority to PL92310250A priority patent/PL169415B1/en
Priority to IE920002A priority patent/IE72101B1/en
Priority to PL92299920A priority patent/PL169435B1/en
Priority to NO932367A priority patent/NO300682B1/en
Priority to BG97915A priority patent/BG62002B1/en
Priority to EE9400252A priority patent/EE02946B1/en
Priority to US08/455,035 priority patent/US5512571A/en
Priority to US08/454,856 priority patent/US5569657A/en
Priority to HK117395A priority patent/HK117395A/en
Priority to LVP-95-358A priority patent/LV11174B/en
Priority to CY187896A priority patent/CY1878A/en
Priority to JP8308528A priority patent/JP3015748B2/en
Priority to BR1100737A priority patent/BR1100737A/en
Priority to FI972077A priority patent/FI109902B/en
Priority to NO2001021C priority patent/NO2001021I1/en
Priority to LU90920C priority patent/LU90920I2/en
Pending legal-status Critical Current

Links

GB919118947A 1991-01-03 1991-09-05 Method for the optical resolution of racemic 6-(4-amino-phenyl)-methyl-pyridazin-3(2h)one and preparation of optically active derivatives thereof Pending GB9118947D0 (en)

Priority Applications (41)

Application Number Priority Date Filing Date Title
GB919118947A GB9118947D0 (en) 1991-09-05 1991-09-05 Method for the optical resolution of racemic 6-(4-amino-phenyl)-methyl-pyridazin-3(2h)one and preparation of optically active derivatives thereof
GB9127145A GB2251615B (en) 1991-01-03 1991-12-20 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
YU200391A YU48767B (en) 1991-01-03 1991-12-27 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl]hydrazono] propanedinitrile, process for the preparation and intermediates
SI9112003A SI9112003A (en) 1991-01-03 1991-12-27 (-)-//4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl/hydrazono/propanedinitrile
IL11402891A IL114028A (en) 1991-01-03 1991-12-30 Process for the optical resolution of (+-)-6-(4-aminophenyl)-5-methyl pyridazin 3(2H) one and intermediates thereof
IL10055391A IL100553A (en) 1991-01-03 1991-12-30 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-phenyl]hydrazono]propanedinitrile pharmaceutically acceptable salts thereof and pharmaceutical compositions containing them
AU11535/92A AU645399B2 (en) 1991-01-03 1992-01-03 (-)-((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl)-hydrazono)propanedinitrile
RU93052411A RU2118317C1 (en) 1991-01-03 1992-01-03 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phen- -yl]hydrozono]propanedinitrile and its pharmaceutically acceptable salts, pharmaceutical composition based on thereof, method of synthesis of intermediate compound and method of synthesis of end compound
DE69201640T DE69201640T2 (en) 1991-01-03 1992-01-03 (-) - [[4- (1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL) PHENYL] -HYDRAZONO] PROPANDINITRILE.
CA002099262A CA2099262C (en) 1991-01-03 1992-01-03 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl]hydrazono]propanedinitrile
DK92901317.5T DK0565546T3 (en) 1991-01-03 1992-01-03 (-) - ((4- (1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl) hydrazono) propanedinitrile
ES92901317T ES2070627T3 (en) 1991-01-03 1992-01-03 PROCESS TO PREPARE (-) - ((4- (1,4,5,6-TETRAHIDRO-4-METHYL-6-OXO-3-PIRIDACINIL) FENIL) -HIDRAZONE) PROPANODINITRILO.
RO93-00896A RO111847B1 (en) 1991-01-03 1992-01-03 Optical izomer for the //4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-phenyl/hydr azono/propane dinitrile, preparation process thereof and intermediaries for the process making thereof
KR1019930701800A KR100207145B1 (en) 1991-01-03 1992-01-03 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl]-hydrazono] propanedinitrile
EP92901317A EP0565546B1 (en) 1991-01-03 1992-01-03 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile
AT92901317T ATE119525T1 (en) 1991-01-03 1992-01-03 (-)-((4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL>-HYDRAZONO>PROPANENITRILE.
HU9301911A HU218659B (en) 1991-01-03 1992-01-03 Process for producing (-) ((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridinazinyl)-phenyl)-hydrazyno)-propane-dinitryl and pharmaceutical compositions containing it
GEAP19922483A GEP19991868B (en) 1991-01-03 1992-01-03 (-)-[[4-(1,4,5,6-Tetrahydro-4-Methyl-6- oxo-3-Pyridazinyl)Phenyl]-Hydrazono¬]Propane¬di¬nit¬rile
JP4501428A JP2635445B2 (en) 1991-01-03 1992-01-03 (-)-[[4- (1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl] hydrazono] propanedinitrile
CA002314115A CA2314115C (en) 1991-01-03 1992-01-03 Process for the optical resolution of the racemic 6-(4-amino-phenyl)-5- methyl-pyridazin-3(2h)one
PCT/FI1992/000003 WO1992012135A1 (en) 1991-01-03 1992-01-03 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile
US08/081,360 US5424428A (en) 1991-01-03 1992-01-03 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]pr
NZ241194A NZ241194A (en) 1991-01-03 1992-01-06 The pure (-) enantiomer of ((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrozono)propanedinitrile, compositions and new intermediates
HR921251A HRP921251B1 (en) 1991-01-03 1992-11-12 (-)-//4-(1,4,5,6-tetrahydro-4-methlyl-6-oxo-3-pyridazinyl) yl/hydrazono/propanedinitrile
FI932618A FI105183B (en) 1991-01-03 1993-06-09 Process for the preparation of (-) - [[4- (1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl] hydrazono] propanedinitrile useful in the treatment of heart failure
PL92310250A PL169415B1 (en) 1991-01-03 1993-06-25 Method of obtaining essentially optically pure (-)- or (+)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazone]propanodinitrile
PL92299920A PL169435B1 (en) 1991-01-03 1993-06-25 Method of obtaining pure 6-(4-aminophenyl)-5-methyl pyridazin-3(2h)-one
IE920002A IE72101B1 (en) 1991-01-03 1993-06-25 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile
NO932367A NO300682B1 (en) 1991-01-03 1993-06-28 (-) - ££ 4- (1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl | hydrazono | propanedinitrile
BG97915A BG62002B1 (en) 1991-01-03 1993-06-29 (-)-//4-(1,4,5,6-terrahydro-4-methyl-6-oxo-pyridazinile)phenyl/-hy drazone/propandinitryl
EE9400252A EE02946B1 (en) 1991-01-03 1994-11-17 (-) - [[4- (1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl] -hydrazono] propanedinitrile, process for its preparation, salts, compositions, intermediates and uses
US08/455,035 US5512571A (en) 1991-01-03 1995-05-31 (-) 4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl!-hydra-zono!propanedinitrile
US08/454,856 US5569657A (en) 1991-01-03 1995-05-31 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile
HK117395A HK117395A (en) 1991-01-03 1995-07-20 (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile
LVP-95-358A LV11174B (en) 1991-01-03 1995-11-30 (-)-££4- (1,4,5,6- tetrahydro- 4- methyl- 6- oxo- 3- pyridazinyl ) phenyl-|- hydrazono| propanedinitrile
CY187896A CY1878A (en) 1991-01-03 1996-04-05 (-)-((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)-hydrazono)propanedinitrile
JP8308528A JP3015748B2 (en) 1991-01-03 1996-11-19 (±) -6- (4-aminophenyl) -5-methylpyridazin-3 (2H) one optical separation method and intermediate in the method
BR1100737A BR1100737A (en) 1991-01-03 1997-05-09 Compound; pharmaceutical composition; process for the optical resolution of (+ -) - 6- (4-aminophenyl) -5methyl pyridazin-3 (2h) one; process for the preparation of (nil) phenyl / hydrazone / propane dinitrile 08 (+) - [[4-yl / propane dinitrile; and diastereomeric intermediate salts
FI972077A FI109902B (en) 1991-01-03 1997-05-15 New cardiotonic agent, hypotensive and vasodilator - is optically pure (-)enantiomer of ((4-(1,4,5,6-tetra:hydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono)propane:di:nitrile
NO2001021C NO2001021I1 (en) 1991-01-03 2001-11-20 Levosimendan
LU90920C LU90920I2 (en) 1991-01-03 2002-05-17 Levosimendan (simday)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919118947A GB9118947D0 (en) 1991-09-05 1991-09-05 Method for the optical resolution of racemic 6-(4-amino-phenyl)-methyl-pyridazin-3(2h)one and preparation of optically active derivatives thereof

Publications (1)

Publication Number Publication Date
GB9118947D0 true GB9118947D0 (en) 1991-10-23

Family

ID=10700914

Family Applications (1)

Application Number Title Priority Date Filing Date
GB919118947A Pending GB9118947D0 (en) 1991-01-03 1991-09-05 Method for the optical resolution of racemic 6-(4-amino-phenyl)-methyl-pyridazin-3(2h)one and preparation of optically active derivatives thereof

Country Status (1)

Country Link
GB (1) GB9118947D0 (en)

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