EE02946B1 - (-)-[[4-(1,4,5,6-tetrahüdro-4-metüül-6-okso-3-püridasinüül)fenüül]-hüdrasono]propaan dinitriil, selle valmistamismeetod, soolad, kompositsioonid, vaheühendid ja kasutamine - Google Patents

(-)-[[4-(1,4,5,6-tetrahüdro-4-metüül-6-okso-3-püridasinüül)fenüül]-hüdrasono]propaan dinitriil, selle valmistamismeetod, soolad, kompositsioonid, vaheühendid ja kasutamine

Info

Publication number
EE02946B1
EE02946B1 EE9400252A EE9400252A EE02946B1 EE 02946 B1 EE02946 B1 EE 02946B1 EE 9400252 A EE9400252 A EE 9400252A EE 9400252 A EE9400252 A EE 9400252A EE 02946 B1 EE02946 B1 EE 02946B1
Authority
EE
Estonia
Prior art keywords
pct
propanedinitrile
hydrazono
pyridazinyl
tetrahydro
Prior art date
Application number
EE9400252A
Other languages
English (en)
Estonian (et)
Inventor
Nore Pentti
Honkanen Erkki
B�Ckstr�M Reijo
Wikberg Tom
Haikala Heimo
Haarala Jorma
Original Assignee
Orion-Yhtym Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919100049A external-priority patent/GB9100049D0/en
Priority claimed from GB919118947A external-priority patent/GB9118947D0/en
Application filed by Orion-Yhtym Oy filed Critical Orion-Yhtym Oy
Publication of EE02946B1 publication Critical patent/EE02946B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
EE9400252A 1991-01-03 1994-11-17 (-)-[[4-(1,4,5,6-tetrahüdro-4-metüül-6-okso-3-püridasinüül)fenüül]-hüdrasono]propaan dinitriil, selle valmistamismeetod, soolad, kompositsioonid, vaheühendid ja kasutamine EE02946B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919100049A GB9100049D0 (en) 1991-01-03 1991-01-03 (-)-6-(4-(dicyanomethylidenehydrazino)phenyl)-4,5-dihydro-5-methylpyridazin-3(2h)one
GB919118947A GB9118947D0 (en) 1991-09-05 1991-09-05 Method for the optical resolution of racemic 6-(4-amino-phenyl)-methyl-pyridazin-3(2h)one and preparation of optically active derivatives thereof

Publications (1)

Publication Number Publication Date
EE02946B1 true EE02946B1 (et) 1996-12-16

Family

ID=26298204

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400252A EE02946B1 (et) 1991-01-03 1994-11-17 (-)-[[4-(1,4,5,6-tetrahüdro-4-metüül-6-okso-3-püridasinüül)fenüül]-hüdrasono]propaan dinitriil, selle valmistamismeetod, soolad, kompositsioonid, vaheühendid ja kasutamine

Country Status (32)

Country Link
US (3) US5424428A (xx)
EP (1) EP0565546B1 (xx)
JP (2) JP2635445B2 (xx)
KR (1) KR100207145B1 (xx)
AT (1) ATE119525T1 (xx)
AU (1) AU645399B2 (xx)
BG (1) BG62002B1 (xx)
BR (1) BR1100737A (xx)
CA (2) CA2314115C (xx)
CY (1) CY1878A (xx)
DE (1) DE69201640T2 (xx)
DK (1) DK0565546T3 (xx)
EE (1) EE02946B1 (xx)
ES (1) ES2070627T3 (xx)
FI (1) FI105183B (xx)
GB (1) GB2251615B (xx)
GE (1) GEP19991868B (xx)
HK (1) HK117395A (xx)
HR (1) HRP921251B1 (xx)
HU (1) HU218659B (xx)
IE (1) IE72101B1 (xx)
IL (2) IL100553A (xx)
LU (1) LU90920I2 (xx)
LV (1) LV11174B (xx)
NO (2) NO300682B1 (xx)
NZ (1) NZ241194A (xx)
PL (2) PL169435B1 (xx)
RO (1) RO111847B1 (xx)
RU (1) RU2118317C1 (xx)
SI (1) SI9112003A (xx)
WO (1) WO1992012135A1 (xx)
YU (1) YU48767B (xx)

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GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) * 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
JP2806192B2 (ja) * 1992-11-02 1998-09-30 日本曹達株式会社 血小板凝集抑制剤
US5856480A (en) * 1994-11-11 1999-01-05 Nippon Soda Co., Ltd. Optically active compound
GB9606474D0 (en) 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
FI973804A (fi) 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia
FI974578A (fi) * 1997-12-19 1999-06-20 Orion Yhtymae Oyj Menetelmä levosimendaanin antamiseksi
FI980902A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaanin stabiileja koostumuksia
FI980901A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaania säädellysti vapauttavia oraalisia koostumuksia
FI104718B (fi) * 1998-06-18 2000-03-31 Orion Yhtymae Oyj [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä
US5905078A (en) * 1998-06-19 1999-05-18 Orion Corporation Use of a pyridazinone derivative
FI981473A (fi) * 1998-06-25 1999-12-26 Orion Yhtymae Oyj Menetelmä pulmonaalihypertension hoitamiseksi
GB9915179D0 (en) 1999-06-29 1999-09-01 Orion Corp A method for the treatment or prevention of coronary graft vasospasm
FI109659B (fi) 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
EP1248620B1 (en) * 1999-10-22 2004-11-17 Orion Corporation A new use of levosimendan
FI20001542A (fi) * 2000-06-29 2001-12-30 Orion Yhtymae Oyj Menetelmä septisen sokin hoitamiseksi
FI20002526A (fi) * 2000-11-17 2002-05-18 Orion Yhtymae Oyj Pyridatsinonijohdannaisten uusi käyttö
FI20002525A (fi) 2000-11-17 2002-05-18 Orion Yhtymae Oyj Tulehduksenvastaisia aineita
FI20002755A0 (fi) * 2000-12-15 2000-12-15 Orion Yhtymae Oyj Menetelmä erektiilin dysfunktion hoitamiseen
FI20010233A0 (fi) 2001-02-08 2001-02-08 Orion Corp Menetelmä sydämen vajaatoiminnan hoitoon
FI20011464A0 (fi) 2001-07-04 2001-07-04 Orion Corp Yhdistelmäterapia sydämen vajaatoiminnan hoitoon
FI20030015A0 (fi) * 2003-01-03 2003-01-03 Orion Corp Menetelmä munuaisten vajaatoiminnan hoitamiseksi
EP1612204A4 (en) * 2003-03-31 2007-04-11 Daiichi Seiyaku Co HYDRAZONE DERIVATIVE
DE102004011512B4 (de) 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
FI20040675A0 (fi) * 2004-05-12 2004-05-12 Orion Corp Menetelmä sydämen hypertrofian hoitoon ja estoon
FI20040674A0 (fi) 2004-05-12 2004-05-12 Orion Corp Menetelmä tromboembolisten sairauksien estoon
AU2005249498B2 (en) * 2004-05-28 2010-06-24 Orion Corporation Methods for treating a mammal before, during and after cardiac arrest
EP1858518A1 (en) 2005-03-14 2007-11-28 Orion Corporation A combination treatment for enhancing diuresis
EP3210605A1 (en) 2005-11-14 2017-08-30 Boehringer Ingelheim Vetmedica GmbH Use of pde iii inhibitors for the treament of asymptomatic (occult) heart failure
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
US20100286150A1 (en) * 2007-01-17 2010-11-11 Fia Westerholm Levosimendan for use in treating chronic valvular disease
US8664252B2 (en) 2008-11-25 2014-03-04 Boehringer Ingelheim Vetmedica Gmbh Phosphodiesterase type III (PDE III) inhibitors or CA2+-sensitizing agents for the treatment of hypertrophic cardiomyopathy
WO2011007123A1 (en) * 2009-07-14 2011-01-20 Cipla Limited Process for preparing levosimendan and intermediates for use in the process
EP2825159B1 (en) 2012-03-15 2022-06-22 Boehringer Ingelheim Vetmedica GmbH Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
US9890127B2 (en) 2013-03-11 2018-02-13 The Broad Institute, Inc. Compounds and compositions for the treatment of cancer
AU2014292086B2 (en) 2013-07-19 2019-08-08 Boehringer Ingelheim Vetmedica Gmbh Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
CN104418810A (zh) * 2013-09-04 2015-03-18 北京博时安泰科技发展有限公司 一种左西孟旦的合成新路线
CN103554032A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法
CN103554033A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 一种消旋体(±)- 6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的拆分方法
EP2925305B1 (en) 2013-12-04 2016-07-27 Boehringer Ingelheim Vetmedica GmbH Improved pharmaceutical compositions of pimobendan
US11207320B2 (en) 2015-08-13 2021-12-28 The Broad Institute, Inc. Compositions and methods for cancer expressing PDE3A or SLFN12
CN105784895B (zh) * 2015-10-30 2018-05-22 成都欣捷高新技术开发有限公司 一种用高效液相色谱仪检测左西孟旦中杂质的方法
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
EP3424908A1 (en) 2017-07-07 2019-01-09 Melody Healthcare Pvt. Ltd. Process for preparation of levosimendan
US9962384B1 (en) * 2017-09-07 2018-05-08 Korea Institute Of Science And Technology Levosimendan compound for preventing or treating tau-related diseases
CN111548310B (zh) * 2020-05-12 2021-07-02 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型及其制备方法
CN111718299B (zh) * 2020-07-23 2023-03-10 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型b及其制备方法
US11760730B2 (en) 2021-01-11 2023-09-19 Navinta, Llc Process for the preparation of high purity Levosimendan

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JPS58113180A (ja) * 1981-12-28 1983-07-05 Mitsui Toatsu Chem Inc ピリダジノン誘導体
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JPH0629254B2 (ja) * 1986-09-08 1994-04-20 帝国臓器製薬株式会社 ピリダジノン誘導体
GB8824458D0 (en) * 1988-10-19 1988-11-23 Orion Yhtymae Oy Substituted pyridazinones
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile

Also Published As

Publication number Publication date
JPH06504275A (ja) 1994-05-19
LV11174A (lv) 1996-04-20
HU218659B (hu) 2000-10-28
IL100553A (en) 1995-12-31
IL114028A0 (en) 1995-10-31
NO932367D0 (no) 1993-06-28
LV11174B (en) 1996-12-20
NO300682B1 (no) 1997-07-07
CA2314115A1 (en) 1992-07-04
PL169415B1 (pl) 1996-07-31
IL114028A (en) 1996-09-12
JPH09183767A (ja) 1997-07-15
CA2314115C (en) 2004-03-30
NZ241194A (en) 1993-06-25
IE72101B1 (en) 1997-03-12
YU200391A (sh) 1994-05-10
ES2070627T3 (es) 1995-06-01
NO2001021I1 (no) 2001-12-03
JP2635445B2 (ja) 1997-07-30
DE69201640D1 (de) 1995-04-13
RU2118317C1 (ru) 1998-08-27
FI932618A (fi) 1993-06-09
RO111847B1 (ro) 1997-02-28
DE69201640T2 (de) 1995-08-10
HUT64754A (en) 1994-02-28
US5512571A (en) 1996-04-30
IL100553A0 (en) 1992-09-06
GB2251615A (en) 1992-07-15
PL169435B1 (pl) 1996-07-31
KR100207145B1 (ko) 1999-07-15
IE920002A1 (en) 1992-07-15
CY1878A (en) 1996-04-05
LU90920I2 (en) 2002-07-17
FI932618A0 (fi) 1993-06-09
JP3015748B2 (ja) 2000-03-06
CA2099262A1 (en) 1992-07-04
ATE119525T1 (de) 1995-03-15
BG97915A (bg) 1994-04-29
CA2099262C (en) 2002-03-12
HK117395A (en) 1995-07-28
AU645399B2 (en) 1994-01-13
HRP921251A2 (en) 1995-08-31
YU48767B (sh) 1999-12-27
US5569657A (en) 1996-10-29
DK0565546T3 (da) 1995-05-22
NO932367L (no) 1993-06-28
SI9112003A (sl) 1998-10-31
GB9127145D0 (en) 1992-02-19
US5424428A (en) 1995-06-13
HU9301911D0 (en) 1993-09-28
FI105183B (fi) 2000-06-30
EP0565546B1 (en) 1995-03-08
BR1100737A (pt) 2000-03-21
AU1153592A (en) 1992-08-17
WO1992012135A1 (en) 1992-07-23
HRP921251B1 (en) 2000-06-30
KR930703266A (ko) 1993-11-29
GEP19991868B (en) 1999-12-06
EP0565546A1 (en) 1993-10-20
GB2251615B (en) 1995-02-08
BG62002B1 (bg) 1998-12-30

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