BG108475A - Аерозолен състав на тобpамицин - Google Patents

Аерозолен състав на тобpамицин

Info

Publication number
BG108475A
BG108475A BG108475A BG10847503A BG108475A BG 108475 A BG108475 A BG 108475A BG 108475 A BG108475 A BG 108475A BG 10847503 A BG10847503 A BG 10847503A BG 108475 A BG108475 A BG 108475A
Authority
BG
Bulgaria
Prior art keywords
formulation
aerosolization
tobramycin
optimised
prophylaxis
Prior art date
Application number
BG108475A
Other languages
English (en)
Other versions
BG66328B1 (bg
Inventor
Chiara Malvolti
Raffaella Garzia
Original Assignee
Chiesi Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8177921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG108475(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farmaceutici S.P.A. filed Critical Chiesi Farmaceutici S.P.A.
Publication of BG108475A publication Critical patent/BG108475A/bg
Publication of BG66328B1 publication Critical patent/BG66328B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Изобретението се отнася до състав на тобрамицин за аерозолно приложение под формата на изотоничен разтвор без добавки и с оптимизирана стойност на рН, така че да се осигури съответен срок на годност при стайна температура. Съставът може да се използва за лечение и профилактика на остри и хронични ендобронхиални инфекции, по-специално причиняваните от бактерията Pseudomonas aeruginoza, свързвана с белодробни болести като муковисцидоза. а
BG108475A 2001-07-02 2003-12-19 Аерозолен състав на тобpамицин BG66328B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01116071A EP1273292B1 (en) 2001-07-02 2001-07-02 Optimised formulation of tobramycin for aerosolization
PCT/EP2002/006544 WO2003004005A1 (en) 2001-07-02 2002-06-14 Optimised formulation of tobramycin for aerosolization

Publications (2)

Publication Number Publication Date
BG108475A true BG108475A (bg) 2005-02-28
BG66328B1 BG66328B1 (bg) 2013-06-28

Family

ID=8177921

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108475A BG66328B1 (bg) 2001-07-02 2003-12-19 Аерозолен състав на тобpамицин

Country Status (27)

Country Link
US (5) US6987094B2 (bg)
EP (1) EP1273292B1 (bg)
JP (1) JP4262086B2 (bg)
KR (1) KR100910888B1 (bg)
CN (1) CN1234346C (bg)
AT (1) ATE267591T1 (bg)
AU (1) AU2002319226B2 (bg)
BG (1) BG66328B1 (bg)
BR (1) BRPI0211320B8 (bg)
CA (1) CA2452638C (bg)
CZ (1) CZ299348B6 (bg)
DE (1) DE60103527T2 (bg)
DK (1) DK1273292T3 (bg)
EA (1) EA006068B1 (bg)
EE (1) EE05392B1 (bg)
EG (1) EG24019A (bg)
ES (1) ES2222294T3 (bg)
HK (1) HK1068784A1 (bg)
HU (1) HU230807B1 (bg)
PL (1) PL202598B1 (bg)
PT (1) PT1273292E (bg)
SI (1) SI1273292T1 (bg)
SK (1) SK285806B6 (bg)
TN (1) TNSN03149A1 (bg)
TR (1) TR200401980T4 (bg)
WO (1) WO2003004005A1 (bg)
ZA (1) ZA200400026B (bg)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW465235B (en) 1998-09-17 2001-11-21 United Video Properties Inc Electronic program guide with digital storage
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
IT1317720B1 (it) * 2000-01-07 2003-07-15 Chiesi Farma Spa Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
DE60103527T2 (de) * 2001-07-02 2005-06-16 Chiesi Farmaceutici S.P.A. Optimierte Tobramycin-Formulierung zur Aerosolbildung
MXPA04005865A (es) 2001-12-19 2004-09-13 Nektar Therapeutics Suministro de aminoglucosidos a los pulmones.
MXPA04008372A (es) * 2002-03-01 2004-11-26 Chiesi Farma Spa Formulacion superfina de formoterol.
AU2004281532B2 (en) * 2003-10-15 2010-03-18 Pari Pharma Gmbh Liquid preparation containing tobramycin
US8442280B2 (en) * 2004-01-21 2013-05-14 Edda Technology, Inc. Method and system for intelligent qualitative and quantitative analysis of digital radiography softcopy reading
BRPI0509026A (pt) 2004-05-17 2007-09-18 Corus Pharma Inc formulação de aerossol, método para a prevenção e tratamento de infecção causada por bactéria do trato respiratório, e, solução
US8524735B2 (en) * 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
BRPI0616642A2 (pt) 2005-09-29 2011-06-28 Nektar Therapeutics formulações de antibióticos, doses unitárias, kits e métodos
US20090246146A1 (en) * 2008-01-25 2009-10-01 Botond Banfi Halides in the treatment of pathogenic infection
WO2010042549A1 (en) 2008-10-07 2010-04-15 Mpex Pharmaceuticals, Inc. Inhalation of levofloxacin for reducing lung inflammation
HUE038428T2 (hu) 2008-10-07 2018-10-29 Horizon Orphan Llc Aeroszol fluorokinolon készítmények javított farmakokinetika érdekében
AU2010216348B2 (en) * 2009-02-18 2015-01-22 Aradigm Corporation pH-modulated formulations for pulmonary delivery
PT2473170T (pt) 2009-09-04 2019-08-23 Horizon Orphan Llc Utilização de levofloxacina em aerossol para tratamento de fibrose cística
EP2388008A1 (en) 2010-05-14 2011-11-23 Combino Pharm, S.L. Stable, preservative-free, aqueous formulation for the administration by aerosolization comprising tobramycin
EP2593110B1 (en) 2010-07-12 2021-01-06 Xellia Pharmaceuticals ApS Treatment of lung infections by administration of tobramycin by aerolisation
EP2616079B1 (en) * 2010-09-13 2015-10-14 University of Zürich Treatment of bacterial infectious diseases
US10105356B2 (en) 2011-01-31 2018-10-23 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US10092552B2 (en) * 2011-01-31 2018-10-09 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
EP2567691B1 (en) 2011-09-12 2014-12-24 Meiji Seika Pharma Co., Ltd. Aqueous compositions comprising arbekacin
GB201208080D0 (en) 2012-05-09 2012-06-20 Norton Healthcare Ltd Tobramycin formulation
CN105534961B (zh) * 2015-12-30 2019-06-04 孙红娟 妥布霉素吸入溶液及其制备方法
CN105616345B (zh) * 2016-03-01 2018-08-21 上海方予健康医药科技有限公司 一种妥布霉素吸入组合物及其制备方法和用途
EP3551191A4 (en) * 2016-12-09 2020-09-09 EnBiotix, Inc. POTENTIALIZATION OF AMINOGLYCOSIDE FOR THE TREATMENT OF BACTERIAL PULMONARY INFECTION
CN108014099B (zh) * 2017-12-15 2019-03-01 武汉兴华智慧医药科技有限公司 一种吸入用妥布霉素溶液及其制备方法
GB2565941A (en) * 2018-11-27 2019-02-27 Norton Healthcare Ltd A process for preparing a formulation
CN113018443B (zh) * 2019-12-27 2022-09-13 海南斯达制药有限公司 治疗呼吸系统疾病的药物组合物及其制备方法
CN113952320B (zh) * 2021-09-18 2022-03-18 健康元药业集团股份有限公司 一种包含妥布霉素吸入溶液的药物组件及其用途

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361306A (en) * 1966-03-31 1968-01-02 Merck & Co Inc Aerosol unit dispensing uniform amounts of a medically active ingredient
US3622053A (en) * 1969-12-10 1971-11-23 Schering Corp Aerosol inhaler with flip-up nozzle
MX3864E (es) 1975-05-27 1981-08-26 Syntex Corp Un proceso para prepara el compuesto cristalino 6-fluiro-11b 21-dihiroxi-16 17-isopropilidendioxipregna-1 4-dien-3 20-diona
US4185100A (en) * 1976-05-13 1980-01-22 Johnson & Johnson Topical anti-inflammatory drug therapy
US4499108A (en) * 1983-06-08 1985-02-12 Schering Corporation Stable pleasant-tasting albuterol sulfate pharmaceutical formulations
GB8334494D0 (en) * 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
US4584320A (en) * 1985-01-03 1986-04-22 David Rubin Anti-asthmatic composition and method using 8,11,14,17-eicosatetraenoic acid
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
US5225183A (en) * 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
GB8828477D0 (en) 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
IE67185B1 (en) 1990-02-02 1996-03-06 Fisons Plc Propellant compositions
WO1992011236A1 (en) 1990-12-19 1992-07-09 Smithkline Beecham Corporation Aerosol formulations
US6006745A (en) * 1990-12-21 1999-12-28 Minnesota Mining And Manufacturing Company Device for delivering an aerosol
US5190029A (en) * 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
EP0504112A3 (en) 1991-03-14 1993-04-21 Ciba-Geigy Ag Pharmaceutical aerosol formulations
EP0585379B1 (en) 1991-05-21 1998-09-30 Abbott Laboratories Aerosol inhalation device
CZ282972B6 (cs) * 1991-08-29 1997-11-12 Broncho-Air Medizintechnik Ag Lékařský přístroj pro inhalování dávkovaných aerosolů
IL103238A (en) 1991-09-25 1995-07-31 Fisons Plc Pressed aerosol preparations
IL104068A (en) 1991-12-12 1998-10-30 Glaxo Group Ltd Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant
DE69218455T2 (de) 1991-12-18 1997-10-23 Minnesota Mining And Mfg. Co., Saint Paul, Minn. Aerosolzusammensetzungen für arzneimittelsuspensionen
DE4230876A1 (de) 1992-03-17 1993-09-23 Asta Medica Ag Druckgaspackungen unter verwendung von polyoxyethylen-glyceryl-oleaten
WO1994013263A1 (en) 1992-12-09 1994-06-23 Jager Paul D Stabilized medicinal aerosol solution formulations
SE9203743D0 (sv) * 1992-12-11 1992-12-11 Astra Ab Efficient use
AU4066693A (en) 1992-12-23 1994-07-19 Bernhard Hugemann Compacted drug body for use in the mechanical generation of inhalable active-substance particles
JPH08507792A (ja) 1993-03-17 1996-08-20 ミネソタ マイニング アンド マニュファクチャリング カンパニー ジオール−二酸から誘導される分散助剤を含むエーロゾル配合物
AU679511B2 (en) 1993-03-17 1997-07-03 Minnesota Mining And Manufacturing Company Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid
US6596260B1 (en) 1993-08-27 2003-07-22 Novartis Corporation Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol
DK0735884T3 (da) * 1993-12-20 2000-10-09 Minnesota Mining & Mfg Flunisolid-aerosolformuleringer
US5508269A (en) * 1994-10-19 1996-04-16 Pathogenesis Corporation Aminoglycoside formulation for aerosolization
GB9425160D0 (en) 1994-12-10 1995-02-08 Glaxo Group Ltd Medicaments
EE9700138A (et) 1994-12-22 1997-12-15 Astra Aktiebolag Aerosoolravimvormid
GB9426252D0 (en) 1994-12-24 1995-02-22 Glaxo Group Ltd Pharmaceutical composition
DE4446891A1 (de) 1994-12-27 1996-07-04 Falk Pharma Gmbh Stabile wäßrige Budesonid-Lösung
US5653961A (en) * 1995-03-31 1997-08-05 Minnesota Mining And Manufacturing Company Butixocort aerosol formulations in hydrofluorocarbon propellant
ES2276736T3 (es) * 1995-04-14 2007-07-01 Smithkline Beecham Corporation Inhalador medidor de dosis para propionato de flucticasona.
EP0820323B1 (en) 1995-04-14 2003-09-24 SmithKline Beecham Corporation Metered dose inhaler for salmeterol
KR19980703850A (ko) * 1995-04-14 1998-12-05 그레이엄브레레톤 베클로메타손 디프로피오네이트용 계량 흡입기
SI0820279T1 (en) 1995-04-14 2002-12-31 Smithkline Beecham Corporation Metered dose inhaler for albuterol
GB9612297D0 (en) 1996-06-11 1996-08-14 Minnesota Mining & Mfg Medicinal aerosol formulations
JP2000514085A (ja) 1996-07-08 2000-10-24 ローヌ―プーラン・ロウラー・リミテッド 医薬シクロスポリンａエーロゾル溶液処方物
WO1998003533A1 (en) 1996-07-24 1998-01-29 Oligos Etc. And Oligos Therapeutics, Inc. Antisense oligonucleotides as antibacterial agents
GB9616237D0 (en) 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations
GB9620187D0 (en) 1996-09-27 1996-11-13 Minnesota Mining & Mfg Medicinal aerosol formulations
IES80485B2 (en) 1996-12-04 1998-08-12 Bioglan Ireland R & D Ltd Pharmaceutical compositions and devices for their administration
US6413496B1 (en) * 1996-12-04 2002-07-02 Biogland Ireland (R&D) Limited Pharmaceutical compositions and devices for their administration
AU718967B2 (en) * 1997-02-05 2000-05-04 Jagotec Ag Medical aerosol formulations
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US5891419A (en) * 1997-04-21 1999-04-06 Aeropharm Technology Limited Environmentally safe flunisolide aerosol formulations for oral inhalation
US20010031244A1 (en) * 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
GB2326334A (en) 1997-06-13 1998-12-23 Chiesi Farma Spa Pharmaceutical aerosol compositions
BR7702049U (pt) 1997-09-05 1999-09-14 Chiesi Farma Spa Bico pulverizador para utilização em inalador oral para medicamentos aerossóis
NZ504021A (en) * 1997-10-17 2003-04-29 Systemic Pulmonary Delivery Lt Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication
US6045784A (en) * 1998-05-07 2000-04-04 The Procter & Gamble Company Aerosol package compositions containing fluorinated hydrocarbon propellants
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
US6451285B2 (en) * 1998-06-19 2002-09-17 Baker Norton Pharmaceuticals, Inc. Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant
US6241969B1 (en) * 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
DE19847969A1 (de) * 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Lagerfähig flüssige Formulierung mit Formoterol
CZ303154B6 (cs) * 1998-11-13 2012-05-09 Jagotec Ag Suchá prášková formulace k inhalaci obsahující stearát horecnatý
IT1303788B1 (it) * 1998-11-25 2001-02-23 Chiesi Farma Spa Formulazioni di aerosol medicinali.
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
US6290930B1 (en) * 1998-12-18 2001-09-18 Baker Norton Pharmaceuticals, Inc. Pharmaceutical solution aerosol formulations containing fluoroalkanes and budesonide
US6004537A (en) * 1998-12-18 1999-12-21 Baker Norton Pharmaceuticals, Inc. Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol
US6315985B1 (en) * 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
IT1317846B1 (it) * 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
IT1318514B1 (it) * 2000-05-12 2003-08-27 Chiesi Farma Spa Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
CZ303833B6 (cs) 2000-05-22 2013-05-22 Chiesi Farmaceutici S.P.A. Aerosolový prostredek
DE60103527T2 (de) * 2001-07-02 2005-06-16 Chiesi Farmaceutici S.P.A. Optimierte Tobramycin-Formulierung zur Aerosolbildung
EP1340492A1 (en) * 2002-03-01 2003-09-03 CHIESI FARMACEUTICI S.p.A. Aerosol formulations for pulmonary administration of medicaments having systemic effects
MXPA04008372A (es) * 2002-03-01 2004-11-26 Chiesi Farma Spa Formulacion superfina de formoterol.
EP1415647A1 (en) * 2002-10-23 2004-05-06 CHIESI FARMACEUTICI S.p.A. "Long-acting beta-2 agonists ultrafine formulations"
US20050083693A1 (en) * 2003-10-21 2005-04-21 Timothy Garrett Flag illumination fixture

Also Published As

Publication number Publication date
HU230807B1 (hu) 2018-06-28
EP1273292A1 (en) 2003-01-08
BRPI0211320B8 (pt) 2021-05-25
DE60103527D1 (de) 2004-07-01
CN1234346C (zh) 2006-01-04
BRPI0211320B1 (pt) 2015-08-18
SK16432003A3 (sk) 2004-06-08
US8168598B2 (en) 2012-05-01
PL367139A1 (en) 2005-02-21
CZ20033580A3 (cs) 2004-10-13
US20050163722A1 (en) 2005-07-28
HUP0400387A2 (hu) 2004-09-28
EE05392B1 (et) 2011-04-15
CA2452638C (en) 2010-10-05
ES2222294T3 (es) 2005-02-01
WO2003004005A1 (en) 2003-01-16
HK1068784A1 (en) 2005-05-06
EG24019A (en) 2008-03-25
SK285806B6 (sk) 2007-08-02
DE60103527T2 (de) 2005-06-16
US20120184502A1 (en) 2012-07-19
SI1273292T1 (en) 2004-12-31
ATE267591T1 (de) 2004-06-15
US20040186064A1 (en) 2004-09-23
US7939502B2 (en) 2011-05-10
EA006068B1 (ru) 2005-08-25
US6987094B2 (en) 2006-01-17
TNSN03149A1 (en) 2005-12-23
CZ299348B6 (cs) 2008-06-25
ZA200400026B (en) 2005-03-30
EP1273292B1 (en) 2004-05-26
KR20040018403A (ko) 2004-03-03
US20100098642A1 (en) 2010-04-22
JP2004535454A (ja) 2004-11-25
PL202598B1 (pl) 2009-07-31
US7696178B2 (en) 2010-04-13
EE200400050A (et) 2004-04-15
AU2002319226B2 (en) 2006-07-06
JP4262086B2 (ja) 2009-05-13
US20110212912A1 (en) 2011-09-01
DK1273292T3 (da) 2004-10-04
CA2452638A1 (en) 2003-01-16
TR200401980T4 (tr) 2004-09-21
BR0211320A (pt) 2004-09-28
KR100910888B1 (ko) 2009-08-05
EA200301305A1 (ru) 2004-06-24
PT1273292E (pt) 2004-10-29
CN1529589A (zh) 2004-09-15
BG66328B1 (bg) 2013-06-28

Similar Documents

Publication Publication Date Title
BG108475A (bg) Аерозолен състав на тобpамицин
SI1458360T1 (sl) Pulmonalno dajanje aminoglikozidov
HK1126134A1 (en) Liquid formulations for the prevention and treatment of mucosal diseases and disorders
WO2001089496A3 (en) Compositions and methods for treating otic, ophthalmic and nasal infections comprising quinolone antibiotics
WO2002054868A3 (en) Pulmonary delivery of polyene antifungal agents
BR0012750A (pt) Agente de limpeza para superfìcies cerâmicas vìtreas
ATE183080T1 (de) Neue und verbesserte aminoglykosidformulierung als aerosol
HK1111883A1 (en) Use of a composition for preventing or treating respiratory infections and acute otitis media in infants
YU91603A (sh) Kristalni oblici azitromicina
AU2003291227A8 (en) Antibacterial agents
AU1122202A (en) Therapeutic use of aerosolized s-nitrosoglutathione in cystic fibrosis
PL1633376T3 (pl) Środki do profilaktyki i leczenia objawów przeziębienia i grypopodobnych zawierające chelatowany cynk
YU102503A (sh) Kondenzovani pirimidinski dhfr inhibitori kao antibakterijska sredstva
AU2003303956A1 (en) Antibacterial agents
AU2003294565A8 (en) Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
AU2001267561A1 (en) Combination preparations of 3-n-formylhydroxylaminopropyl phosphonic acid derivatives or 3-n-acetylhydroxylaminopropyl phosphonic acid derivatives combined withspecific pharmaceutical active agents
PL365154A1 (en) Pharmaceutical compositions containing tobramycin and xanthan gum
WO2002057281A3 (en) Aminoglycosides as antibiotics
GB0104756D0 (en) Air ioniser to prevent infections from fungus or their spores
MD20000084A (en) Active principle in the hepatitis treatment