BG107541A - Перфлуороалкилсъдържащи комплекси с полярни остатъци, метод за получаването и използването им - Google Patents
Перфлуороалкилсъдържащи комплекси с полярни остатъци, метод за получаването и използването им Download PDFInfo
- Publication number
- BG107541A BG107541A BG107541A BG10754103A BG107541A BG 107541 A BG107541 A BG 107541A BG 107541 A BG107541 A BG 107541A BG 10754103 A BG10754103 A BG 10754103A BG 107541 A BG107541 A BG 107541A
- Authority
- BG
- Bulgaria
- Prior art keywords
- mmol
- residue
- general formula
- calculated
- groups
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10040858A DE10040858C2 (de) | 2000-08-11 | 2000-08-11 | Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung |
PCT/EP2001/008500 WO2002013875A2 (de) | 2000-08-11 | 2001-07-23 | Perfluoralkylhaltige komplexe mit polaren resten, verfahren zu deren herstellung und ihre verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
BG107541A true BG107541A (bg) | 2004-01-30 |
Family
ID=7653176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG107541A BG107541A (bg) | 2000-08-11 | 2003-02-07 | Перфлуороалкилсъдържащи комплекси с полярни остатъци, метод за получаването и използването им |
Country Status (30)
Country | Link |
---|---|
EP (1) | EP1307237B9 (zh) |
JP (1) | JP2004506026A (zh) |
KR (2) | KR20030022381A (zh) |
CN (1) | CN1468113A (zh) |
AR (1) | AR035342A1 (zh) |
AT (1) | ATE359093T1 (zh) |
AU (2) | AU2001279777B2 (zh) |
BG (1) | BG107541A (zh) |
BR (1) | BR0113187A (zh) |
CA (1) | CA2419259A1 (zh) |
CZ (1) | CZ2003341A3 (zh) |
DE (2) | DE10040858C2 (zh) |
DK (1) | DK1307237T3 (zh) |
EE (1) | EE200300060A (zh) |
ES (1) | ES2284671T3 (zh) |
HR (1) | HRP20030171A2 (zh) |
HU (1) | HUP0300769A3 (zh) |
IL (1) | IL154329A0 (zh) |
MX (1) | MXPA03001286A (zh) |
NO (1) | NO20030649L (zh) |
NZ (1) | NZ524080A (zh) |
PL (1) | PL365367A1 (zh) |
PT (1) | PT1307237E (zh) |
RU (1) | RU2289579C2 (zh) |
SK (1) | SK286239B6 (zh) |
UA (1) | UA74004C2 (zh) |
UY (1) | UY26873A1 (zh) |
WO (1) | WO2002013875A2 (zh) |
YU (1) | YU10503A (zh) |
ZA (1) | ZA200301947B (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7344704B2 (en) | 2002-07-10 | 2008-03-18 | Schering Ag | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi |
DE10231799B4 (de) * | 2002-07-10 | 2006-10-05 | Schering Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben |
DE102005033903B4 (de) * | 2005-07-15 | 2007-08-09 | Bayer Schering Pharma Ag | Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel |
EP1904462A2 (de) * | 2005-07-15 | 2008-04-02 | Bayer Schering Pharma Aktiengesellschaft | Perfluoralkylhaltige komplexe, verfahren zu deren herstellung, sowie deren verwendung |
DE102005033902B3 (de) * | 2005-07-15 | 2007-04-05 | Schering Ag | Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel |
DE102006049821A1 (de) | 2006-10-18 | 2008-04-24 | Bayer Schering Pharma Aktiengesellschaft | Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung |
DE102007015598A1 (de) * | 2007-03-29 | 2008-10-02 | Heinrich-Heine-Universität Düsseldorf | Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren |
EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
CN110035996B (zh) | 2016-11-28 | 2022-08-09 | 拜耳医药股份公司 | 用于磁共振成像的新型高弛豫性钆螯合物 |
RU2681319C1 (ru) * | 2017-10-27 | 2019-03-06 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский экономический университет имени Г.В. Плеханова" (ФГБОУ ВО "РЭУ им. Г.В. Плеханова") | Ультраволокнистый биополимерный материал с бактерицидным эффектом |
KR20210095168A (ko) | 2018-11-23 | 2021-07-30 | 바이엘 악티엔게젤샤프트 | 조영 매체의 제형 및 그의 제조 방법 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4317588C2 (de) * | 1993-05-24 | 1998-04-16 | Schering Ag | Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung |
DE19603033A1 (de) * | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
DE19608278A1 (de) * | 1996-02-23 | 1997-08-28 | Schering Ag | Pharmazeutische Mittel enthaltend perfluoralkylhaltige Metallkomplexe, und ihre Verwendung in der Tumortherapie und interventioniellen Radiologie |
DE19729013A1 (de) * | 1997-07-03 | 1999-02-04 | Schering Ag | Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
DE19744004C1 (de) * | 1997-09-26 | 1999-07-22 | Schering Ag | Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging |
-
2000
- 2000-08-11 DE DE10040858A patent/DE10040858C2/de not_active Expired - Fee Related
-
2001
- 2001-07-23 SK SK155-2003A patent/SK286239B6/sk unknown
- 2001-07-23 BR BR0113187-7A patent/BR0113187A/pt not_active IP Right Cessation
- 2001-07-23 AT AT01958005T patent/ATE359093T1/de not_active IP Right Cessation
- 2001-07-23 UA UA2003032068A patent/UA74004C2/uk unknown
- 2001-07-23 RU RU2003105813/04A patent/RU2289579C2/ru not_active IP Right Cessation
- 2001-07-23 YU YU10503A patent/YU10503A/sh unknown
- 2001-07-23 AU AU2001279777A patent/AU2001279777B2/en not_active Ceased
- 2001-07-23 CA CA002419259A patent/CA2419259A1/en not_active Abandoned
- 2001-07-23 KR KR10-2003-7001937A patent/KR20030022381A/ko not_active Application Discontinuation
- 2001-07-23 DE DE50112336T patent/DE50112336D1/de not_active Expired - Fee Related
- 2001-07-23 HU HU0300769A patent/HUP0300769A3/hu unknown
- 2001-07-23 PL PL01365367A patent/PL365367A1/xx unknown
- 2001-07-23 EE EEP200300060A patent/EE200300060A/xx unknown
- 2001-07-23 ES ES01958005T patent/ES2284671T3/es not_active Expired - Lifetime
- 2001-07-23 KR KR1020087003857A patent/KR20080027397A/ko not_active Application Discontinuation
- 2001-07-23 PT PT01958005T patent/PT1307237E/pt unknown
- 2001-07-23 NZ NZ524080A patent/NZ524080A/en unknown
- 2001-07-23 MX MXPA03001286A patent/MXPA03001286A/es not_active Application Discontinuation
- 2001-07-23 DK DK01958005T patent/DK1307237T3/da active
- 2001-07-23 WO PCT/EP2001/008500 patent/WO2002013875A2/de active IP Right Grant
- 2001-07-23 JP JP2002519013A patent/JP2004506026A/ja not_active Withdrawn
- 2001-07-23 CZ CZ2003341A patent/CZ2003341A3/cs unknown
- 2001-07-23 IL IL15432901A patent/IL154329A0/xx not_active IP Right Cessation
- 2001-07-23 CN CNA018170765A patent/CN1468113A/zh active Pending
- 2001-07-23 AU AU7977701A patent/AU7977701A/xx active Pending
- 2001-07-23 EP EP01958005A patent/EP1307237B9/de not_active Expired - Lifetime
- 2001-08-07 UY UY26873A patent/UY26873A1/es not_active Application Discontinuation
- 2001-08-10 AR ARP010103832A patent/AR035342A1/es unknown
-
2003
- 2003-02-07 BG BG107541A patent/BG107541A/bg unknown
- 2003-02-10 NO NO20030649A patent/NO20030649L/no not_active Application Discontinuation
- 2003-03-10 ZA ZA200301947A patent/ZA200301947B/en unknown
- 2003-03-10 HR HR20030171A patent/HRP20030171A2/hr not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP3723219B2 (ja) | カスケードポリマー錯体、その製造方法及びこれらを含有する医薬 | |
JP3701678B2 (ja) | カスケードポリマー錯体、その製造方法及びこれらを含有する医薬 | |
JPH04288063A (ja) | モノ‐n‐置換1,4,7,10‐テトラアザシクロドデカン誘導体、その製造法および該化合物を含有する医薬調剤 | |
BG62914B1 (bg) | Метални комплекси, съдържащи перфлуороалкил, и използването им при nmr диагностики | |
US6083479A (en) | Contrast media for infarction and necrosis imaging | |
JP2002507977A (ja) | ペルフルオロアルキル含有のオリゴマー化合物、その製造方法およびnmr診断法におけるその使用 | |
EP0717737B1 (en) | Chelants as contrast enhancing agents | |
US20090297454A1 (en) | Perfluoroalkyl-Containing Complexes, Process For Their Production As Well As Their Use | |
BG107541A (bg) | Перфлуороалкилсъдържащи комплекси с полярни остатъци, метод за получаването и използването им | |
BG107540A (bg) | Перфлуороалкил-съдържащи комплекси със захарни остатъци, метод за тяхното получаване и използванетоим | |
US6019959A (en) | Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis | |
KR20080043762A (ko) | 퍼플루오로알킬 함유 착물, 그의 제조 방법 및 용도 | |
US6676928B2 (en) | Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use | |
JP5475454B2 (ja) | 過弗素化されたpeg基を有する金属キレート類、それらの製剤方法、及びそれらの使用 | |
KR100495846B1 (ko) | 거대고리형 금속 착물 카르복실산, 이의 용도 및 제조 방법 | |
US5919433A (en) | Macrocyclic metal complex carboxylic acids, their use as well as process for their production | |
JP2002521384A (ja) | 3−,8−置換された常磁性ジューテロポルフィリン誘導体、該誘導体を含有する医薬調剤、その製造法及び壊死及び梗塞の核磁気共鳴映像法のための使用 |