BG104356A - Съединение на базата на азабензимидазол, метод занеговото получаване и използването му за модулиране на серин/ треонинова протеин киназна функция - Google Patents

Съединение на базата на азабензимидазол, метод занеговото получаване и използването му за модулиране на серин/ треонинова протеин киназна функция

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Publication number
BG104356A
BG104356A BG104356A BG10435600A BG104356A BG 104356 A BG104356 A BG 104356A BG 104356 A BG104356 A BG 104356A BG 10435600 A BG10435600 A BG 10435600A BG 104356 A BG104356 A BG 104356A
Authority
BG
Bulgaria
Prior art keywords
treonin
azabenzimidazole
serin
modulation
compounds based
Prior art date
Application number
BG104356A
Other languages
English (en)
Other versions
BG64784B1 (bg
Inventor
Gerald Mcmahon
Heinz Weinberger
Bernhard Kutscher
Harald App
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of BG104356A publication Critical patent/BG104356A/bg
Publication of BG64784B1 publication Critical patent/BG64784B1/bg

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретението се отнася до съединение на базата на азабензимидазол с формула@@до метод за неговото получаване и до използването му за модулиране на серин/треонинова протеинкиназна функция.
BG104356A 1997-09-26 2000-04-19 Съединение на базата на азабензимидазол, метод занеговото получаване и използването му за модулиране на серин/ треонинова протеин киназна функция BG64784B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6014597P 1997-09-26 1997-09-26

Publications (2)

Publication Number Publication Date
BG104356A true BG104356A (bg) 2000-12-29
BG64784B1 BG64784B1 (bg) 2006-04-28

Family

ID=22027657

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104356A BG64784B1 (bg) 1997-09-26 2000-04-19 Съединение на базата на азабензимидазол, метод занеговото получаване и използването му за модулиране на серин/ треонинова протеин киназна функция

Country Status (28)

Country Link
US (2) US6093728A (bg)
EP (1) EP1017384B1 (bg)
JP (1) JP2001517699A (bg)
KR (1) KR100547929B1 (bg)
CN (1) CN1167420C (bg)
AR (1) AR017266A1 (bg)
AT (1) ATE281834T1 (bg)
AU (1) AU748849B2 (bg)
BG (1) BG64784B1 (bg)
BR (1) BR9812682A (bg)
CA (1) CA2305370C (bg)
DE (1) DE69827516T2 (bg)
DK (1) DK1017384T3 (bg)
ES (1) ES2230719T3 (bg)
HK (1) HK1032206A1 (bg)
HU (1) HUP0004024A3 (bg)
IL (4) IL158649A0 (bg)
NO (1) NO325663B1 (bg)
NZ (2) NZ503432A (bg)
PL (1) PL191618B1 (bg)
PT (1) PT1017384E (bg)
RU (1) RU2230553C2 (bg)
SK (1) SK285357B6 (bg)
TR (1) TR200001546T2 (bg)
TW (1) TW581815B (bg)
UA (1) UA72448C2 (bg)
WO (1) WO1999016438A1 (bg)
ZA (1) ZA988797B (bg)

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Also Published As

Publication number Publication date
IL158649A (en) 2006-12-10
IL135109A0 (en) 2001-05-20
ES2230719T3 (es) 2005-05-01
BR9812682A (pt) 2000-08-22
IL158649A0 (en) 2004-05-12
EP1017384A1 (en) 2000-07-12
US6093728A (en) 2000-07-25
RU2230553C2 (ru) 2004-06-20
TW581815B (en) 2004-04-01
HUP0004024A3 (en) 2001-10-29
DK1017384T3 (da) 2005-01-31
WO1999016438A1 (en) 1999-04-08
ZA988797B (en) 1999-12-02
JP2001517699A (ja) 2001-10-09
ATE281834T1 (de) 2004-11-15
NZ503432A (en) 2002-11-26
KR20010015623A (ko) 2001-02-26
AR017266A1 (es) 2001-09-05
KR100547929B1 (ko) 2006-02-02
EP1017384B1 (en) 2004-11-10
AU748849B2 (en) 2002-06-13
PL191618B1 (pl) 2006-06-30
CA2305370C (en) 2006-11-28
TR200001546T2 (tr) 2000-10-23
UA72448C2 (en) 2005-03-15
HK1032206A1 (en) 2001-07-13
SK4152000A3 (en) 2002-02-05
PL339744A1 (en) 2001-01-02
BG64784B1 (bg) 2006-04-28
AU9578198A (en) 1999-04-23
NO20001555D0 (no) 2000-03-24
PT1017384E (pt) 2005-03-31
DE69827516T2 (de) 2005-12-01
HUP0004024A2 (hu) 2001-04-28
NO325663B1 (no) 2008-07-07
DE69827516D1 (de) 2004-12-16
US6855723B2 (en) 2005-02-15
CN1278172A (zh) 2000-12-27
CN1167420C (zh) 2004-09-22
US20030181480A1 (en) 2003-09-25
SK285357B6 (sk) 2006-11-03
NO20001555L (no) 2000-03-24
NZ517808A (en) 2003-07-25
IL135109A (en) 2007-07-04
CA2305370A1 (en) 1999-04-08

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