EA201790189A1 - Способы лечения злокачественного новообразования с использованием замещенных пирролопиримидиновых соединений, композиции на их основе - Google Patents

Способы лечения злокачественного новообразования с использованием замещенных пирролопиримидиновых соединений, композиции на их основе

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Publication number
EA201790189A1
EA201790189A1 EA201790189A EA201790189A EA201790189A1 EA 201790189 A1 EA201790189 A1 EA 201790189A1 EA 201790189 A EA201790189 A EA 201790189A EA 201790189 A EA201790189 A EA 201790189A EA 201790189 A1 EA201790189 A1 EA 201790189A1
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EA
Eurasian Patent Office
Prior art keywords
pyrropyrymidin
numer
substituted
compositions
compounds
Prior art date
Application number
EA201790189A
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English (en)
Inventor
Дань Чжу
Джон Бойлан
Шуйчань Сюй
Дженнифер Риггс
Тао Ши
Эндрю Вермсер
Дэвид Миколон
Гордафарид Деянат-Язди
Original Assignee
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
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Application filed by СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи filed Critical СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
Publication of EA201790189A1 publication Critical patent/EA201790189A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В настоящем документе предложены способы лечения или профилактики злокачественного новообразования, в частности, солидных опухолей и гематологических злокачественных новообразований, включающие введение индивиду, при необходимости, эффективного количества соединения формулы (I)
EA201790189A 2014-07-14 2015-07-13 Способы лечения злокачественного новообразования с использованием замещенных пирролопиримидиновых соединений, композиции на их основе EA201790189A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462024158P 2014-07-14 2014-07-14
PCT/US2015/040125 WO2016010886A1 (en) 2014-07-14 2015-07-13 Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof

Publications (1)

Publication Number Publication Date
EA201790189A1 true EA201790189A1 (ru) 2017-11-30

Family

ID=55066196

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790189A EA201790189A1 (ru) 2014-07-14 2015-07-13 Способы лечения злокачественного новообразования с использованием замещенных пирролопиримидиновых соединений, композиции на их основе

Country Status (9)

Country Link
US (2) US9623028B2 (ru)
EP (1) EP3169686A4 (ru)
JP (1) JP2017520603A (ru)
KR (1) KR20170024120A (ru)
CN (1) CN106715427A (ru)
AU (1) AU2015289929A1 (ru)
CA (1) CA2955009A1 (ru)
EA (1) EA201790189A1 (ru)
WO (1) WO2016010886A1 (ru)

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Publication number Publication date
KR20170024120A (ko) 2017-03-06
US9623028B2 (en) 2017-04-18
US20170173024A1 (en) 2017-06-22
EP3169686A4 (en) 2018-01-24
CN106715427A (zh) 2017-05-24
EP3169686A1 (en) 2017-05-24
AU2015289929A1 (en) 2017-03-02
US20160008365A1 (en) 2016-01-14
CA2955009A1 (en) 2016-01-21
WO2016010886A1 (en) 2016-01-21
JP2017520603A (ja) 2017-07-27

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