BG103301A - ПРОИЗВОДНИ НА 1Н-ПИРИДО[3,4-b]ИНДОЛ-4-КАРБОКСАМИД, МЕТОД ЗА ТЯХНОТО ПОЛУЧАВАНЕ И ИЗПОЛЗВАНЕТО ИМ КАТО ТЕРАПЕВТИЧНИ СРЕДСТВА - Google Patents

ПРОИЗВОДНИ НА 1Н-ПИРИДО[3,4-b]ИНДОЛ-4-КАРБОКСАМИД, МЕТОД ЗА ТЯХНОТО ПОЛУЧАВАНЕ И ИЗПОЛЗВАНЕТО ИМ КАТО ТЕРАПЕВТИЧНИ СРЕДСТВА

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Publication number
BG103301A
BG103301A BG103301A BG10330199A BG103301A BG 103301 A BG103301 A BG 103301A BG 103301 A BG103301 A BG 103301A BG 10330199 A BG10330199 A BG 10330199A BG 103301 A BG103301 A BG 103301A
Authority
BG
Bulgaria
Prior art keywords
group
alkyl
optionally
phenylalkyl
pyrido
Prior art date
Application number
BG103301A
Other languages
English (en)
Other versions
BG63751B1 (bg
Inventor
Yannick Evanno
Mireille Sevrin
Christian Maloizel
Odette Legalloudec
Pascal George
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of BG103301A publication Critical patent/BG103301A/bg
Publication of BG63751B1 publication Critical patent/BG63751B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Съединенията се използват като терапевтични средства. Те са с обща формула, в която Х означава водороден, или халогенен атом, или алкил, алкокси, трифлуорометил, или фенилметоксигрупа, R1 е водороден атом или алкилова, циклопропилова, или фенилметилова група, R2 означава в даден случай заместена алкилова група, или в даден случай заместена фенилалкилова, или циклохексилметилова, или тиенилметилова, или пиридинилметилова група, или в даден случай заместена фенилова група, или пиридинилова група, или 5-метил-1,2-оксазолилова група, или 5-метил-1,3,4-тиадиазолилова група, или нафтилова група, R3 и R4 независимо един от друг означава водороден атом, алкилова група, 2-метоксиетилова група, хидроксиалкилова група, карбоксиалкилова група, алкоксикарбонилалкилова група, или фенилалкилова група, или заедно с азотния атом, които са свързани образуват в даден случай заместена пиролидинилова група, или пиперидинилова група, или морфолинилова група, или 4-метилпиперазинилова група, или азетидинилова група или тиазолидинилова група, и връзката между въглероднитеатоми на 3-то и 4-то място е проста или двойна връзка.
BG103301A 1996-10-08 1999-03-31 ПРОИЗВОДНИ НА 1Н-ПИРИДО[3,4-b]ИНДОЛ-4-КАРБОКСАМИД, МЕТОД ЗА ТЯХНОТО ПОЛУЧАВАНЕ И ИЗПОЛЗВАНЕТО ИМ КАТО ТЕРАПЕВТИЧНИ СРЕДСТВА BG63751B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9612229A FR2754262B1 (fr) 1996-10-08 1996-10-08 Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
PCT/FR1997/001750 WO1998015552A1 (fr) 1996-10-08 1997-10-03 DERIVES DE 1H-PYRIDO[3,4-b]INDOLE-4-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (2)

Publication Number Publication Date
BG103301A true BG103301A (bg) 2000-05-31
BG63751B1 BG63751B1 (bg) 2002-11-29

Family

ID=9496449

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103301A BG63751B1 (bg) 1996-10-08 1999-03-31 ПРОИЗВОДНИ НА 1Н-ПИРИДО[3,4-b]ИНДОЛ-4-КАРБОКСАМИД, МЕТОД ЗА ТЯХНОТО ПОЛУЧАВАНЕ И ИЗПОЛЗВАНЕТО ИМ КАТО ТЕРАПЕВТИЧНИ СРЕДСТВА

Country Status (33)

Country Link
US (1) US6075021A (bg)
EP (1) EP0934319B1 (bg)
JP (1) JP4227197B2 (bg)
KR (1) KR100488095B1 (bg)
CN (1) CN1089765C (bg)
AR (1) AR009112A1 (bg)
AT (1) ATE218567T1 (bg)
AU (1) AU721102B2 (bg)
BG (1) BG63751B1 (bg)
BR (1) BR9711879A (bg)
CA (1) CA2266376A1 (bg)
CO (1) CO4910141A1 (bg)
CY (1) CY2291B1 (bg)
CZ (1) CZ298906B6 (bg)
DE (1) DE69713124T2 (bg)
DK (1) DK0934319T3 (bg)
EE (1) EE03830B1 (bg)
ES (1) ES2178008T3 (bg)
FR (1) FR2754262B1 (bg)
HK (1) HK1023338A1 (bg)
HU (1) HUP9904623A3 (bg)
IL (1) IL129018A0 (bg)
NO (1) NO311938B1 (bg)
NZ (1) NZ334708A (bg)
PL (1) PL188244B1 (bg)
PT (1) PT934319E (bg)
RU (1) RU2180904C2 (bg)
SK (1) SK282970B6 (bg)
TR (1) TR199900712T2 (bg)
TW (1) TW461889B (bg)
UA (1) UA57037C2 (bg)
WO (1) WO1998015552A1 (bg)
ZA (1) ZA978970B (bg)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766823B1 (fr) * 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2788776B1 (fr) 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2833953B1 (fr) 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) * 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
JP2006516606A (ja) * 2003-01-27 2006-07-06 ファイザー インコーポレイテッド Ｈｉｖインテグラーゼインヒビター、医薬組成物、およびそれらの使用
JP2007534739A (ja) * 2004-04-26 2007-11-29 ファイザー・インク ピロロピリジン誘導体及びｈｉｖインテグラーゼ酵素阻害剤としてのその使用
ES2292123T3 (es) * 2004-04-26 2008-03-01 Pfizer Inc. Inhibidores de la enzima integrasa de vih.
KR20080015077A (ko) * 2005-05-05 2008-02-18 사노피-아벤티스 유.에스. 엘엘씨 안정한 나노입자 제형
BRPI0616657A2 (pt) * 2005-10-07 2011-06-28 Pfizer Prod Inc inibidores da enzima hiv integrase
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
TW200815420A (en) * 2006-06-05 2008-04-01 Novartis Ag Organic compounds
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
KR100688448B1 (ko) * 2006-12-06 2007-03-02 (주)경진건축사사무소 건축물 내부 조적구조

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724384B1 (fr) * 1994-09-14 1999-04-16 Cemaf Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Also Published As

Publication number Publication date
EE9900155A (et) 1999-12-15
EP0934319B1 (fr) 2002-06-05
DE69713124D1 (de) 2002-07-11
UA57037C2 (uk) 2003-06-16
AR009112A1 (es) 2000-03-08
NO311938B1 (no) 2002-02-18
FR2754262A1 (fr) 1998-04-10
CO4910141A1 (es) 2000-04-24
PT934319E (pt) 2002-10-31
KR20000048992A (ko) 2000-07-25
HUP9904623A3 (en) 2001-03-28
DK0934319T3 (da) 2002-09-30
BG63751B1 (bg) 2002-11-29
JP4227197B2 (ja) 2009-02-18
CZ298906B6 (cs) 2008-03-12
NO991624D0 (no) 1999-04-06
TW461889B (en) 2001-11-01
ZA978970B (en) 1998-04-20
US6075021A (en) 2000-06-13
AU4559497A (en) 1998-05-05
CZ119399A3 (cs) 1999-07-14
WO1998015552A1 (fr) 1998-04-16
JP2001508403A (ja) 2001-06-26
PL188244B1 (pl) 2005-01-31
HUP9904623A2 (hu) 2000-06-28
SK282970B6 (sk) 2003-01-09
SK45199A3 (en) 2000-02-14
BR9711879A (pt) 1999-08-24
CA2266376A1 (en) 1998-04-16
EE03830B1 (et) 2002-08-15
CY2291B1 (en) 2003-07-04
IL129018A0 (en) 2000-02-17
CN1089765C (zh) 2002-08-28
KR100488095B1 (ko) 2005-05-09
DE69713124T2 (de) 2003-01-30
EP0934319A1 (fr) 1999-08-11
NO991624L (no) 1999-06-07
HK1023338A1 (en) 2000-09-08
NZ334708A (en) 2000-10-27
ES2178008T3 (es) 2002-12-16
AU721102B2 (en) 2000-06-22
ATE218567T1 (de) 2002-06-15
CN1233248A (zh) 1999-10-27
FR2754262B1 (fr) 1998-10-30
PL332643A1 (en) 1999-09-27
TR199900712T2 (xx) 1999-06-21
RU2180904C2 (ru) 2002-03-27

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