CO4910141A1 - DERIVADOS DE 1-H-PIRIDO[3,4-b]INDOL-4-CARBOXAMIDA Y SU PREPARACION - Google Patents

DERIVADOS DE 1-H-PIRIDO[3,4-b]INDOL-4-CARBOXAMIDA Y SU PREPARACION

Info

Publication number
CO4910141A1
CO4910141A1 CO97058251A CO97058251A CO4910141A1 CO 4910141 A1 CO4910141 A1 CO 4910141A1 CO 97058251 A CO97058251 A CO 97058251A CO 97058251 A CO97058251 A CO 97058251A CO 4910141 A1 CO4910141 A1 CO 4910141A1
Authority
CO
Colombia
Prior art keywords
group
alkyl
optionally substituted
phenyl
methyl
Prior art date
Application number
CO97058251A
Other languages
English (en)
Inventor
Evanno Yannick
Mireille Sevrin
Christian Maloizel
Legalloudec Odette
George Pascal
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of CO4910141A1 publication Critical patent/CO4910141A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Compuesto, eventualmente en forma de isómero óptico puro o demezcla de dichos isómeros, que responde a la fórmula general (I) en la cual X representa un átomo de hidrógeno o de halógeno o un grupo (C1 -C3 )alquilo, (C1 -C3 )alcoxi, trifluorometilo o fenilmetoxi, R1 representa un átomo de hidrógeno o un grupo (C1 -C3 )alquilo, ciclopropilo o fenilmetilo, R2 representa o bien un grupo (C1 -C3 )alquilo eventualmente substituido por un grupo metoxi, o bien un grupo fenil-(C1 -C3 )alquilo eventualmente substituido en el núcleo fenilo por un átomo de halógeno o un grupo metilo o metoxi, o bien un grupo ciclohexilmetilo, o un grupo tienilmetilo, o bien un grupo piridinilmetilo, o bien un grupo fenilo eventualmente substituido por uno o varios átomos de halógeno o un grupo (C1 -C3 )alquilo o (C1 -C3 )alcoxi, o bien un grupo piridinilo, o bien un grupo 5-metil-1,2-oxazolilo, o bien un grupo 5- metil-1,3,4-tiadiazolilo, o bien un grupo naftalenilo, R3 y R4 , independientemente uno de otro, representan cada uno un átomo de hidrógeno, un grupo (C1 -C3 )alquilo, un grupo 2-metoxietilo, un grupo hidroxi(C2 -C4 )alquilo, un grupo carboxi (C1 -C3 )alquilo, un grupo (C1 -C3 ) alcoxicarbonil (C1 -C3 )alquilo o un grupo fenil(C1 -C3 )alquilo, o bien forman juntos, con el átomo de nitrógeno que los lleva, o bien un grupo pirrolidinilo eventualmente substituido por un grupo hidroxi, etoxi, metoxicarbonilo o metoximetilo, o bien un grupo piperidinilo, o bien un grupo morfolinilo, o bien un grupo 4-metilpiperazinilo, o bien un grupo azetidinilo, o bien un grupo tiazolidinilo, y el enlace entre los átomos de carbono en posiciones 3 y 4 es simple o doble.
CO97058251A 1996-10-08 1997-10-06 DERIVADOS DE 1-H-PIRIDO[3,4-b]INDOL-4-CARBOXAMIDA Y SU PREPARACION CO4910141A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9612229A FR2754262B1 (fr) 1996-10-08 1996-10-08 Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CO4910141A1 true CO4910141A1 (es) 2000-04-24

Family

ID=9496449

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97058251A CO4910141A1 (es) 1996-10-08 1997-10-06 DERIVADOS DE 1-H-PIRIDO[3,4-b]INDOL-4-CARBOXAMIDA Y SU PREPARACION

Country Status (33)

Country Link
US (1) US6075021A (es)
EP (1) EP0934319B1 (es)
JP (1) JP4227197B2 (es)
KR (1) KR100488095B1 (es)
CN (1) CN1089765C (es)
AR (1) AR009112A1 (es)
AT (1) ATE218567T1 (es)
AU (1) AU721102B2 (es)
BG (1) BG63751B1 (es)
BR (1) BR9711879A (es)
CA (1) CA2266376A1 (es)
CO (1) CO4910141A1 (es)
CY (1) CY2291B1 (es)
CZ (1) CZ298906B6 (es)
DE (1) DE69713124T2 (es)
DK (1) DK0934319T3 (es)
EE (1) EE03830B1 (es)
ES (1) ES2178008T3 (es)
FR (1) FR2754262B1 (es)
HK (1) HK1023338A1 (es)
HU (1) HUP9904623A3 (es)
IL (1) IL129018A0 (es)
NO (1) NO311938B1 (es)
NZ (1) NZ334708A (es)
PL (1) PL188244B1 (es)
PT (1) PT934319E (es)
RU (1) RU2180904C2 (es)
SK (1) SK282970B6 (es)
TR (1) TR199900712T2 (es)
TW (1) TW461889B (es)
UA (1) UA57037C2 (es)
WO (1) WO1998015552A1 (es)
ZA (1) ZA978970B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766823B1 (fr) * 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) * 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
CA2513141A1 (en) * 2003-01-27 2004-08-12 Pfizer Inc. Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
BRPI0510306A (pt) * 2004-04-26 2007-09-04 Pfizer inibidores da enzima de hiv integrase,composição farmacêutica contendo os referidos inibidores bem como seu uso
EP1756103A2 (en) * 2004-04-26 2007-02-28 Pfizer, Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
BRPI0611433A2 (pt) * 2005-05-05 2010-09-08 Sanofi Aventis Us Llc formulações estáveis de nanopartìcula
EA200800758A1 (ru) * 2005-10-07 2008-08-29 Пфайзер Продактс Инк. Ингибиторы фермента интегразы вич
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
WO2007143597A2 (en) * 2006-06-05 2007-12-13 Novartis Ag Organic compounds
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
KR100688448B1 (ko) * 2006-12-06 2007-03-02 (주)경진건축사사무소 건축물 내부 조적구조

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724384B1 (fr) * 1994-09-14 1999-04-16 Cemaf Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Also Published As

Publication number Publication date
WO1998015552A1 (fr) 1998-04-16
ZA978970B (en) 1998-04-20
HUP9904623A3 (en) 2001-03-28
BG63751B1 (bg) 2002-11-29
FR2754262B1 (fr) 1998-10-30
EP0934319B1 (fr) 2002-06-05
CZ298906B6 (cs) 2008-03-12
PL188244B1 (pl) 2005-01-31
AU721102B2 (en) 2000-06-22
CN1089765C (zh) 2002-08-28
CN1233248A (zh) 1999-10-27
KR20000048992A (ko) 2000-07-25
NZ334708A (en) 2000-10-27
EE03830B1 (et) 2002-08-15
CA2266376A1 (en) 1998-04-16
TW461889B (en) 2001-11-01
PL332643A1 (en) 1999-09-27
BG103301A (en) 2000-05-31
NO311938B1 (no) 2002-02-18
NO991624D0 (no) 1999-04-06
DE69713124D1 (de) 2002-07-11
SK45199A3 (en) 2000-02-14
HK1023338A1 (en) 2000-09-08
AU4559497A (en) 1998-05-05
ATE218567T1 (de) 2002-06-15
NO991624L (no) 1999-06-07
US6075021A (en) 2000-06-13
SK282970B6 (sk) 2003-01-09
RU2180904C2 (ru) 2002-03-27
KR100488095B1 (ko) 2005-05-09
TR199900712T2 (xx) 1999-06-21
BR9711879A (pt) 1999-08-24
AR009112A1 (es) 2000-03-08
JP2001508403A (ja) 2001-06-26
EE9900155A (et) 1999-12-15
CZ119399A3 (cs) 1999-07-14
JP4227197B2 (ja) 2009-02-18
PT934319E (pt) 2002-10-31
FR2754262A1 (fr) 1998-04-10
DK0934319T3 (da) 2002-09-30
ES2178008T3 (es) 2002-12-16
UA57037C2 (uk) 2003-06-16
CY2291B1 (en) 2003-07-04
DE69713124T2 (de) 2003-01-30
IL129018A0 (en) 2000-02-17
EP0934319A1 (fr) 1999-08-11
HUP9904623A2 (hu) 2000-06-28

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