AR009112A1 - Un derivado de 1h-pirido[3,4-b] indol-4-carboxamida, procedimientos para prepararlo, medicamento constituido por dicho derivado y composicion farmaceutica que contiene a dicho derivado. - Google Patents

Un derivado de 1h-pirido[3,4-b] indol-4-carboxamida, procedimientos para prepararlo, medicamento constituido por dicho derivado y composicion farmaceutica que contiene a dicho derivado.

Info

Publication number
AR009112A1
AR009112A1 ARP970104610A ARP970104610A AR009112A1 AR 009112 A1 AR009112 A1 AR 009112A1 AR P970104610 A ARP970104610 A AR P970104610A AR P970104610 A ARP970104610 A AR P970104610A AR 009112 A1 AR009112 A1 AR 009112A1
Authority
AR
Argentina
Prior art keywords
group
derivative
optionally substituted
alkyl
hydrogen
Prior art date
Application number
ARP970104610A
Other languages
English (en)
Original Assignee
Dupuis Laurent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dupuis Laurent filed Critical Dupuis Laurent
Publication of AR009112A1 publication Critical patent/AR009112A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Se refiere a un derivado de 1H-pirido[3,4-b]indol-4-carboxamida, que responde a la formula general (I) en la cual X es hidrogeno o un halogeno o ungrupo alquilo, alcoxi trifluorometilo o fenilmetoxi; R1 es el hidrogeno o un grupo alquilo,c iclopropilo, o fenilmetilo; R2 es ya sea un grupo alquiloeventualmente substituido o bien por un grupo fenilalquilo eventualmente substituido, o bien un grupo ciclohexilmetilo, o bien un grupo tienilmetilo, obien un grupo piridinilmetilo, obi en un grupo fenilo eventualmente substituido, o bien un grupo piridinilo, o bien un grupo 5-metil-1,2-oxazolilo, o bien un grupo 5-metil-1,3,4-tiadiazolilo, o bien un grupo naftalenilo; R3 y R4 son cada uno hidrogeno, o ungrupo alquilo, un grupo2-metoxietilo, hidroxialquilo, carboxialquilo, un grupo pirrolidinilo eventualmente substituido, o bien un grupo piperidinilo, o bien un grupomorfolinilo, o bien un grupo 4-metilpiperazinilo, o bien un grupoazetidinilo, o bien un grupo tiazolidinilo, y el enlace entre los átomos de carbono o enposiciones 3 y 4 es simple o doble. Aplicacion terapéutica. Se refiere además a procedimientos para prepararlo, a un medicamento constituido por dichoderivadoy a una composi cion farmacéutica que contiene a dicho derivado.
ARP970104610A 1996-10-08 1997-10-07 Un derivado de 1h-pirido[3,4-b] indol-4-carboxamida, procedimientos para prepararlo, medicamento constituido por dicho derivado y composicion farmaceutica que contiene a dicho derivado. AR009112A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9612229A FR2754262B1 (fr) 1996-10-08 1996-10-08 Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR009112A1 true AR009112A1 (es) 2000-03-08

Family

ID=9496449

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104610A AR009112A1 (es) 1996-10-08 1997-10-07 Un derivado de 1h-pirido[3,4-b] indol-4-carboxamida, procedimientos para prepararlo, medicamento constituido por dicho derivado y composicion farmaceutica que contiene a dicho derivado.

Country Status (33)

Country Link
US (1) US6075021A (es)
EP (1) EP0934319B1 (es)
JP (1) JP4227197B2 (es)
KR (1) KR100488095B1 (es)
CN (1) CN1089765C (es)
AR (1) AR009112A1 (es)
AT (1) ATE218567T1 (es)
AU (1) AU721102B2 (es)
BG (1) BG63751B1 (es)
BR (1) BR9711879A (es)
CA (1) CA2266376A1 (es)
CO (1) CO4910141A1 (es)
CY (1) CY2291B1 (es)
CZ (1) CZ298906B6 (es)
DE (1) DE69713124T2 (es)
DK (1) DK0934319T3 (es)
EE (1) EE03830B1 (es)
ES (1) ES2178008T3 (es)
FR (1) FR2754262B1 (es)
HK (1) HK1023338A1 (es)
HU (1) HUP9904623A3 (es)
IL (1) IL129018A0 (es)
NO (1) NO311938B1 (es)
NZ (1) NZ334708A (es)
PL (1) PL188244B1 (es)
PT (1) PT934319E (es)
RU (1) RU2180904C2 (es)
SK (1) SK282970B6 (es)
TR (1) TR199900712T2 (es)
TW (1) TW461889B (es)
UA (1) UA57037C2 (es)
WO (1) WO1998015552A1 (es)
ZA (1) ZA978970B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766823B1 (fr) * 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
BRPI0407052A (pt) * 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
JP2007534738A (ja) * 2004-04-26 2007-11-29 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤
WO2005103003A2 (en) * 2004-04-26 2005-11-03 Pfizer Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
KR20080015077A (ko) * 2005-05-05 2008-02-18 사노피-아벤티스 유.에스. 엘엘씨 안정한 나노입자 제형
EP1934220A1 (en) * 2005-10-07 2008-06-25 Pfizer Products Incorporated Inhibitors of the hiv integrase enzyme
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
CN101460476B (zh) * 2006-06-05 2013-12-04 诺瓦提斯公司 有机化合物
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
KR100688448B1 (ko) * 2006-12-06 2007-03-02 (주)경진건축사사무소 건축물 내부 조적구조

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724384B1 (fr) * 1994-09-14 1999-04-16 Cemaf Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Also Published As

Publication number Publication date
CN1089765C (zh) 2002-08-28
KR100488095B1 (ko) 2005-05-09
FR2754262A1 (fr) 1998-04-10
PL332643A1 (en) 1999-09-27
DK0934319T3 (da) 2002-09-30
CA2266376A1 (en) 1998-04-16
SK282970B6 (sk) 2003-01-09
CN1233248A (zh) 1999-10-27
CY2291B1 (en) 2003-07-04
JP4227197B2 (ja) 2009-02-18
EE9900155A (et) 1999-12-15
DE69713124D1 (de) 2002-07-11
RU2180904C2 (ru) 2002-03-27
WO1998015552A1 (fr) 1998-04-16
ZA978970B (en) 1998-04-20
TW461889B (en) 2001-11-01
HUP9904623A2 (hu) 2000-06-28
ES2178008T3 (es) 2002-12-16
PL188244B1 (pl) 2005-01-31
BR9711879A (pt) 1999-08-24
SK45199A3 (en) 2000-02-14
CO4910141A1 (es) 2000-04-24
EP0934319B1 (fr) 2002-06-05
HK1023338A1 (en) 2000-09-08
TR199900712T2 (xx) 1999-06-21
EP0934319A1 (fr) 1999-08-11
DE69713124T2 (de) 2003-01-30
US6075021A (en) 2000-06-13
CZ298906B6 (cs) 2008-03-12
AU4559497A (en) 1998-05-05
NO991624L (no) 1999-06-07
BG103301A (en) 2000-05-31
JP2001508403A (ja) 2001-06-26
NO311938B1 (no) 2002-02-18
UA57037C2 (uk) 2003-06-16
FR2754262B1 (fr) 1998-10-30
PT934319E (pt) 2002-10-31
HUP9904623A3 (en) 2001-03-28
NO991624D0 (no) 1999-04-06
CZ119399A3 (cs) 1999-07-14
ATE218567T1 (de) 2002-06-15
BG63751B1 (bg) 2002-11-29
AU721102B2 (en) 2000-06-22
EE03830B1 (et) 2002-08-15
IL129018A0 (en) 2000-02-17
NZ334708A (en) 2000-10-27
KR20000048992A (ko) 2000-07-25

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