ES2178008T3 - Derivados de 1h-pirido(3,4-b)indol-5-carboxamida, su preparacion y susaplicaciones en teraeutica. - Google Patents

Derivados de 1h-pirido(3,4-b)indol-5-carboxamida, su preparacion y susaplicaciones en teraeutica.

Info

Publication number
ES2178008T3
ES2178008T3 ES97943932T ES97943932T ES2178008T3 ES 2178008 T3 ES2178008 T3 ES 2178008T3 ES 97943932 T ES97943932 T ES 97943932T ES 97943932 T ES97943932 T ES 97943932T ES 2178008 T3 ES2178008 T3 ES 2178008T3
Authority
ES
Spain
Prior art keywords
group
well
orchyl
represents hydrogen
optionally replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97943932T
Other languages
English (en)
Inventor
Yannick Evanno
Mireille Sevrin
Christian Maloizel
Odette Legalloudec
Pascal George
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of ES2178008T3 publication Critical patent/ES2178008T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA GENERAL (I) EN LA QUE X REPRESENTA HIDROGENO O UN HALOGENO O UN GRUPO ALQUILO, ALCOXILO, TRIFLUORMETILO O FENILMETOXI, R 1 REPRESENTA HIDROGENO O UN GRUPO ALQUILO, CICLOPROPILO O FENILMETILO, R 2 REPRESENTA O UN GRUPO ALQUILO OPCIONALMENTE SUSTITUIDO, O UN GRUPO FENILALQIULO OPCIONALMENTE SUSTITIUDO, O UN GRUPO CICLOHEXILMETILO, O UN GRUPO TIENILMETILO, O UN GRUPO PIRIDINILMETILO, O UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO, O UN GRUPO PIRIDINILO, O UN GRUPO 5 - METIL - 1,2 - OXAZOLILO, O UN GRUPO 5 - METIL - 1,3,4 - TIADAZOLILO, O UN GRUPO NAFTALENICO, R 3 Y R 4 REPRESE NTAN CADA UNO HIDROGENO O UN GRUPO ALQUILO, 2 - METOXIETILO, HIDROXIALQUILO, CARBOXIALQUILO, ALCOXICARBONILALQUILO O FENILALQUILO, O FORMAN JUNTO CON EL ATOMO DE NITROGENO LOS LLEVA, BIEN UN GRUPO PIRROLIDINILO OPCIONALMENTE SUSTITUIDO, BIEN UN GRUPO PIPERIDINILO, BIEN UN GRUPO MORFOLINILO, BIEN UN GRUPO 4 METILPIPERACINILO, BIEN UN GRUPO ACETIDINILO, BIEN UN GRUPO TIAZOLIDINILO Y EL ENLACE ENTRE LOS ATOMOS DE CARBONO EN POSICIONES 3 Y 4 ES SENCILLO O DOBLE.
ES97943932T 1996-10-08 1997-10-03 Derivados de 1h-pirido(3,4-b)indol-5-carboxamida, su preparacion y susaplicaciones en teraeutica. Expired - Lifetime ES2178008T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9612229A FR2754262B1 (fr) 1996-10-08 1996-10-08 Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ES2178008T3 true ES2178008T3 (es) 2002-12-16

Family

ID=9496449

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97943932T Expired - Lifetime ES2178008T3 (es) 1996-10-08 1997-10-03 Derivados de 1h-pirido(3,4-b)indol-5-carboxamida, su preparacion y susaplicaciones en teraeutica.

Country Status (33)

Country Link
US (1) US6075021A (es)
EP (1) EP0934319B1 (es)
JP (1) JP4227197B2 (es)
KR (1) KR100488095B1 (es)
CN (1) CN1089765C (es)
AR (1) AR009112A1 (es)
AT (1) ATE218567T1 (es)
AU (1) AU721102B2 (es)
BG (1) BG63751B1 (es)
BR (1) BR9711879A (es)
CA (1) CA2266376A1 (es)
CO (1) CO4910141A1 (es)
CY (1) CY2291B1 (es)
CZ (1) CZ298906B6 (es)
DE (1) DE69713124T2 (es)
DK (1) DK0934319T3 (es)
EE (1) EE03830B1 (es)
ES (1) ES2178008T3 (es)
FR (1) FR2754262B1 (es)
HK (1) HK1023338A1 (es)
HU (1) HUP9904623A3 (es)
IL (1) IL129018A0 (es)
NO (1) NO311938B1 (es)
NZ (1) NZ334708A (es)
PL (1) PL188244B1 (es)
PT (1) PT934319E (es)
RU (1) RU2180904C2 (es)
SK (1) SK282970B6 (es)
TR (1) TR199900712T2 (es)
TW (1) TW461889B (es)
UA (1) UA57037C2 (es)
WO (1) WO1998015552A1 (es)
ZA (1) ZA978970B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766823B1 (fr) 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788776B1 (fr) 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) * 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) * 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
JP2006516606A (ja) * 2003-01-27 2006-07-06 ファイザー インコーポレイテッド Ｈｉｖインテグラーゼインヒビター、医薬組成物、およびそれらの使用
JP2007534738A (ja) * 2004-04-26 2007-11-29 ファイザー・インク Ｈｉｖインテグラーゼ酵素の阻害剤
BRPI0510319A (pt) * 2004-04-26 2007-10-16 Pfizer inibidores da enzima integrase de hiv
CA2606861C (en) * 2005-05-05 2012-08-07 Sanofi-Aventis U.S. Llc Stable nanoparticle formulations
AP2008004400A0 (en) * 2005-10-07 2008-04-30 Pfizer Prod Inc Inhibitors of HIV integrase enzyme
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
PT2029572E (pt) * 2006-06-05 2011-02-09 Novartis Ag Compostos orgânicos
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
KR100688448B1 (ko) * 2006-12-06 2007-03-02 (주)경진건축사사무소 건축물 내부 조적구조

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724384B1 (fr) * 1994-09-14 1999-04-16 Cemaf Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Also Published As

Publication number Publication date
JP4227197B2 (ja) 2009-02-18
KR100488095B1 (ko) 2005-05-09
UA57037C2 (uk) 2003-06-16
BG103301A (en) 2000-05-31
FR2754262B1 (fr) 1998-10-30
NO311938B1 (no) 2002-02-18
AU721102B2 (en) 2000-06-22
JP2001508403A (ja) 2001-06-26
TR199900712T2 (xx) 1999-06-21
CN1089765C (zh) 2002-08-28
DE69713124D1 (de) 2002-07-11
HUP9904623A2 (hu) 2000-06-28
SK282970B6 (sk) 2003-01-09
CO4910141A1 (es) 2000-04-24
PT934319E (pt) 2002-10-31
ZA978970B (en) 1998-04-20
DK0934319T3 (da) 2002-09-30
ATE218567T1 (de) 2002-06-15
EE03830B1 (et) 2002-08-15
RU2180904C2 (ru) 2002-03-27
CZ119399A3 (cs) 1999-07-14
NO991624L (no) 1999-06-07
KR20000048992A (ko) 2000-07-25
AR009112A1 (es) 2000-03-08
CZ298906B6 (cs) 2008-03-12
HUP9904623A3 (en) 2001-03-28
CY2291B1 (en) 2003-07-04
NO991624D0 (no) 1999-04-06
BG63751B1 (bg) 2002-11-29
SK45199A3 (en) 2000-02-14
BR9711879A (pt) 1999-08-24
CA2266376A1 (en) 1998-04-16
PL188244B1 (pl) 2005-01-31
HK1023338A1 (en) 2000-09-08
EP0934319A1 (fr) 1999-08-11
WO1998015552A1 (fr) 1998-04-16
FR2754262A1 (fr) 1998-04-10
DE69713124T2 (de) 2003-01-30
US6075021A (en) 2000-06-13
PL332643A1 (en) 1999-09-27
CN1233248A (zh) 1999-10-27
IL129018A0 (en) 2000-02-17
NZ334708A (en) 2000-10-27
EE9900155A (et) 1999-12-15
EP0934319B1 (fr) 2002-06-05
TW461889B (en) 2001-11-01
AU4559497A (en) 1998-05-05

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